Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan custom insole OEM supplier

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Custom graphene foam processing China

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Cushion insole OEM solution China

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan insole ODM for global brands

Study authors (from left to right) Andrew K. Lau, Thomas Eng, and Deepanwita Banerjee stand in front of a two-liter bioreactor containing P. putida cells that are producing indigoidine, which causes the strong dark blue color of the liquid. This photo was taken at JBEI in July 2019. Credit: Berkeley Lab A new approach to modifying microbes’ metabolic processes will speed up production of innovative bio-based fuels, materials, and chemicals. Researchers from Lawrence Berkeley National Laboratory (Berkeley Lab) have achieved unprecedented success in modifying a microbe to efficiently produce a compound of interest using a computational model and CRISPR-based gene editing. Their approach could dramatically speed up the research and development phase for new biomanufacturing processes, and get cutting-edge bio-based products such as sustainable fuels and plastic alternatives on the shelves faster. The process uses computer algorithms — based on real-world experimental data — to identify what genes in a “host” microbe could be switched off to redirect the organism’s energy toward producing high quantities of a target compound, rather than its normal soup of metabolic products. Currently, many scientists in this field still rely on ad hoc, trial-and-error experiments to identify what gene modifications lead to improvements. Additionally, most microbes used in biomanufacturing processes that produce a nonnative compound — meaning the genes to make it have been inserted into the host genome — can only generate large quantities of the target compound after the microbe has reached a certain growth phase, resulting in slow processes that waste energy while incubating the microbes. A two-liter bioreactor containing an P. putida culture that has undergone metabolic rewiring to produce indigoidine all the time. Credit: Berkeley Lab The team’s streamlined metabolic rewiring process, coined “product/substrate pairing,” makes it so the microbe’s entire metabolism is linked to making the compound at all times. To test product/substrate pairing, the team performed experiments with a promising emerging host — a soil microbe called Pseudomonas putida — that had been engineered to carry the genes to make indigoidine, a blue pigment. The scientists evaluated 63 potential rewiring strategies and, using a workflow that systematically evaluates possible outcomes for desirable host characteristics, determined that only one of these was experimentally realistic. Then, they performed CRISPR interference (CRISPRi) to block the expression of 14 genes, as guided by their computational predictions. “We were thrilled to see that our strain produced extremely high yields of indigoidine after we targeted such a large number of genes simultaneously,” said co-lead author Deepanwita Banerjee, a postdoctoral researcher at the Joint BioEnergy Institute (JBEI), which is managed by Berkeley Lab. “The current standard for metabolic rewiring is to laboriously target one gene at a time, rather than many genes all at once,” she said, noting that before this paper there was only one previous study in metabolic engineering in which the authors targeted six genes for knockdown. “We have substantially raised the upper limit on simultaneous modifications by using powerful CRISPRi-based approaches. This now opens up the field to consider computational optimization methods even when they necessitate a large number of genetic modifications, because they can truly lead to transformative output,” said Banerjee. Co-lead author Thomas Eng, a JBEI research scientist, added, “With product/substrate pairing, we believe we can significantly reduce the time it takes to develop a commercial-scale biomanufacturing process with our rationally designed process. It’s daunting to think of the sheer number of research years and people hours spent on developing artemisinin (an antimalarial) or 1,3-butanediol (a chemical used to make plastics) — about five to 10 years from the lab notebook to pilot plant. Dramatically reducing R&D time scales is what we need to make tomorrow’s bioeconomy a reality,” he said. Examples of target compounds under investigation at Berkeley Lab include isopentenol, a promising biofuel; components of flame-retardant materials; and replacements for petroleum-derived starter molecules used in industry, such as nylon precursors. Many other groups use biomanufacturing to produce advanced medicines. Principal investigator Aindrila Mukhopadhyay explained that the team’s success came from its multidisciplinary approach. “Not only did this work require rigorous computational modeling and state-of-the-art genetics, we also relied on our collaborators at the Advanced Biofuels and Bioproducts Process Development Unit (ABPDU) to demonstrate that our process could hold its desirable features at higher production scales,” said Mukhopadhyay, who is the vice president of the biofuels and bioproducts division and director of the host engineering group at JBEI. “We also collaborated with the Department of Energy (DOE) Joint Genome Institute to characterize our strain. Not surprisingly, we anticipate many such future collaborations to examine the economic value of the improvements we obtained, and to delve deeper in characterizing this drastic metabolic rewiring.” Reference: “Genome-scale metabolic rewiring improves titers rates and yields of the non-native product indigoidine at scale” by Deepanwita Banerjee, Thomas Eng, Andrew K. Lau, Yusuke Sasaki, Brenda Wang, Yan Chen, Jan-Philip Prahl, Vasanth R. Singan, Robin A. Herbert, Yuzhong Liu, Deepti Tanjore, Christopher J. Petzold, Jay D. Keasling and Aindrila Mukhopadhyay, 23 October 2020, Nature Communications. DOI: 10.1038/s41467-020-19171-4 This work was supported by the DOE Office of Science. The DOE Joint Genome Institute is a DOE Office of Science user facility at Berkeley Lab.

The rice coral Montipora capitata in waters near the Hawai’i Institute of Marine Biology on Moku o Loʻe in Kāne’ohe Bay, Hawaii. Credit: D. Bhattacharya How to Identify Heat-Stressed Corals Researchers have found a novel way to identify heat-stressed corals, which could help scientists pinpoint the coral species that need protection from warming ocean waters linked to climate change, according to a Rutgers-led study. “This is similar to a blood test to assess human health,” said senior author Debashish Bhattacharya, a Distinguished Professor in the Department of Biochemistry and Microbiology in the School of Environmental and Biological Sciences at Rutgers University–New Brunswick. “We can assess coral health by measuring the metabolites (chemicals created for metabolism) they produce and, ultimately, identify the best interventions to ensure reef health. Coral bleaching from warming waters is an ongoing worldwide ecological disaster. Therefore, we need to develop sensitive diagnostic indicators that can be used to monitor reef health before the visible onset of bleaching to allow time for preemptive conservation efforts.” Coral reefs provide habitat, nursery, and spawning grounds for fish, food for about 500 million people along with their livelihoods, and coastline protection from storms and erosion. But global climate change threatens corals by warming ocean waters, resulting in coral bleaching and disease. Other threats to corals include sea-level rise, a more acidic ocean, unsustainable fishing, damage from vessels, invasive species, marine debris, and tropical cyclones, according to the National Oceanic and Atmospheric Administration. The study, published in the journal Science Advances, examined how Hawaiian stony corals respond to heat stress, with a goal of identifying chemical (metabolite) indicators of stress. Heat stress can lead to the loss of algae that live in symbiosis with corals, resulting in a white appearance (bleaching) and, potentially, the loss of reefs. Scientists subjected the heat-resistant Montipora capitata and heat-sensitive Pocillopora acuta coral species to several weeks of warm seawater in tanks at the Hawaiʻi Institute of Marine Biology. Then they analyzed the metabolites produced and compared them with other corals not subjected to heat stress. “Our work, for the first time, identified a variety of novel and known metabolites that may be used as diagnostic indicators for heat stress in wild coral before or in the early stages of bleaching,” Bhattacharya said. The scientists are validating their coral diagnosis results in a much larger study and the results look promising. The scientists are also developing a “coral hospital” featuring a new lab-on-a-chip device, which could check coral health in the field via metabolite and protein indicators. Reference: “Metabolomic shifts associated with heat stress in coral holobionts” by Amanda Williams, Eric N. Chiles, Dennis Conetta, Jananan S. Pathmanathan, Phillip A. Cleves, Hollie M. Putnam, Xiaoyang Su and Debashish Bhattacharya, 1 January 2021, Science Advances. DOI: 10.1126/sciadv.abd4210 The coral hospital work is in collaboration with Rutgers School of Engineering Professor Mehdi Javanmard and Xiaoyang Su, an assistant professor at Rutgers Robert Wood Johnson Medical School and director of the Rutgers Metabolomics Shared Resource at the Rutgers Cancer Institute of New Jersey. Rutgers co-lead authors for the Hawaii study include doctoral student Amanda Williams and Eric N. Chiles, research teaching specialist at Rutgers Cancer Institute of New Jersey. Other Rutgers co-authors include Jananan S. Pathmanathan, a post-doctoral associate, and Professor Su. Researchers at the University of Rhode Island and Stanford University contributed to the study.

DNA damage can persist unrepaired for years, particularly in blood stem cells, increasing the risk of mutations and cancer. This discovery challenges traditional views on mutation processes and highlights the need for further research to understand and address the causes of such persistent damage. In a groundbreaking shift in our understanding of mutations, researchers have discovered types of DNA damage in healthy cells that can remain unrepaired for years. While most types of DNA damage are repaired by the body’s natural DNA repair mechanisms, some forms of damage can evade these processes and persist for years, according to new research. This prolonged presence increases the likelihood of generating harmful mutations, which may eventually lead to cancer. Scientists from the Wellcome Sanger Institute and their collaborators studied the family trees of hundreds of single cells from several individuals. By analyzing shared mutation patterns among cells, they reconstructed these family trees, identifying common ancestral origins. Their findings revealed surprising patterns of mutation inheritance, indicating that certain DNA damage remains unrepaired over extended periods. For example, in blood stem cells, some forms of damage can persist for two to three years. The research, published in Nature, changes the way we think about mutations, and has implications for understanding the development of various cancers. Throughout our life, all of the cells in our body accumulate genetic errors in the genome, known as somatic mutations. These can be caused by damaging environmental exposures, such as smoking, as well as the everyday chemistry occurring in our cells. Mutation Origins and Persistent Damage DNA damage is distinct from a mutation. While a mutation is one of the standard four DNA bases (A, G, T or C) in the wrong place, similar to a spelling mistake, DNA damage is chemical alteration of the DNA, like a smudged unrecognizable letter. DNA damage can result in the genetic sequence being misread and copied during cell division – known as DNA replication – and this introduces permanent mutations that can contribute to the development of cancers. However, the DNA damage itself is usually recognized and mended quickly by repair mechanisms in our cells. If researchers can better understand the causes and mechanisms of mutations, they may be able to intervene and slow or remove them. In a new study, Sanger Institute scientists and their collaborators analyzed data in the form of family trees of hundreds of single cells from individuals. The family trees are constructed from patterns of mutations across the genome that are shared between cells – for example, cells with many shared mutations have a recent common ancestor cell and are closely related. The researchers collated seven published sets of these family trees, known as somatic phylogenies. The data set included 103 phylogenies from 89 individuals, spanning blood stem cells, bronchial epithelial cells, and liver cells. The team found unexpected patterns of mutation inheritance in the family trees, revealing that some DNA damage can persist unrepaired through multiple rounds of cell division. This was particularly evident in blood stem cells, where between 15 to 20 percent of the mutations resulted from a specific type of DNA damage that persists for two to three years on average, and in some cases longer. Implications for Cancer Development This means that during cell division, each time the cell attempts to copy the damaged DNA it can make a different mistake, leading to multiple different mutations from a single source of DNA damage. Importantly, this creates multiple chances of harmful mutations that could contribute to cancer. Researchers suggest that although these types of DNA damage occur rarely, their persistence over years means they can cause as many mutations as more common DNA damage. Overall, these findings change the way researchers think about mutations, and have implications for the development of cancer. Dr Michael Spencer Chapman, first author from the Wellcome Sanger Institute and the Barts Cancer Institute, said: “With these family trees, we can link the relationships of hundreds of cells from one person right back to conception, meaning we can track back through the divisions each cell has gone through. It’s these large-scale, novel datasets that have led us to this unexpected finding that some forms of DNA damage can last for a long time without being repaired. This study is a prime example of exploratory science – you don’t always know what you’re going to find until you look; you have to stay curious.” Emily Mitchell, an author from the Wellcome Sanger Institute, Wellcome-MRC Cambridge Stem Cell Institute and University of Cambridge, said: “When exploring family trees of blood stem cells in particular, we found a specific type of DNA damage that results in around 15 to 20 percent of the mutations in these cells, and can last for several years. It is unclear why this process is only found in blood stem cells and not other healthy tissues. Knowing that the DNA damage is long-lasting gives new routes to investigate what the damage actually is. As we continue to better understand the causes of mutations, we may one day be able to intervene and remove them.” Dr Peter Campbell, lead author previously from the Wellcome Sanger Institute and now Chief Scientific Officer at Quotient Therapeutics, said: “We have identified forms of DNA damage that manage to escape our DNA repair mechanisms and persist in the genome for days, months, or sometimes years. These findings don’t fit with what scientists have previously thought about the fundamentals of how mutations are acquired. This paradigm shift brings a new dimension to the way we think about mutations, and is important for the research community when designing future studies.” Reference: “Prolonged persistence of mutagenic DNA lesions in somatic cells” by Michael Spencer Chapman, Emily Mitchell, Kenichi Yoshida, Nicholas Williams, Margarete A. Fabre, Anna Maria Ranzoni, Philip S. Robinson, Lori D. Kregar, Matthias Wilk, Steffen Boettcher, Krishnaa Mahbubani, Kourosh Saeb Parsy, Kate H. C. Gowers, Sam M. Janes, Stanley W. K. Ng, Matt Hoare, Anthony R. Green, George S. Vassiliou, Ana Cvejic, Markus G. Manz, Elisa Laurenti, Iñigo Martincorena, Michael R. Stratton, Jyoti Nangalia, Tim H. H. Coorens and Peter J. Campbell, 15 January 2025, Nature. DOI: 10.1038/s41586-024-08423-8

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