Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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China sustainable material ODM solutions

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Innovative insole ODM solutions in China

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Private label insole and pillow OEM Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan ergonomic pillow OEM supplier

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene cushion OEM factory in Vietnam

Rockefeller University researchers have developed TrackerSci, a groundbreaking method for tracking the development and aging of brain cells, which could revolutionize the understanding of neurological diseases and aging. This technique has uncovered shifts in cell production in aging brains and has broader applications for studying cell dynamics across various organs. TrackerSci is a new tool for tracking brain cell development and aging, offering fresh insights into cellular changes over a lifetime and potential applications in various organ studies. Hospital nurseries routinely place soft bands around the tiny wrists of newborns that hold important identifying information such as name, sex, mother, and birth date. Researchers at Rockefeller University are taking the same approach with newborn brain cells—but these neonates will keep their ID tags for life, so that scientists can track how they grow and mature, as a means for better understanding the brain’s aging process. Advancements in Cell Tracking As described in a new paper in the journal Cell, the new method developed by Rockefeller geneticist Junyue Cao and his colleagues is called TrackerSci (pronounced “sky”). This low-cost, high-throughput approach has already revealed that while newborn cells continue to be produced through life, the kinds of cells being produced greatly vary at different ages. This groundbreaking work, led by co-first authors Ziyu Lu and Melissa Zhang from Cao’s lab, promises to influence not only the study of the brain but also broader aspects of aging and disease across the human body. “The cell is the basic functional unit of our body, so changes to the cell essentially underlie virtually every disease and the aging process,” says Cao, head of the Laboratory of Single-Cell Genomics and Population Dynamics. “If we can systematically characterize the different cells and their dynamics using this novel technique, we may get a panoramic view of the mechanisms of many diseases and the enigma of aging.” Rare and Powerful New cells are continuously produced in the adult mammalian brain, a critical process associated with memory, learning, and stress. They develop from progenitor cells—descendants of adult stem cells that differentiate into specialized cell types. How this process unfolds, however, has been largely unknown, both because of technological limitations and cell rarity. Finding progenitor cells in the brain is a needle-in-haystack endeavor; in mammals, they account for a mere .5 percent of all brain cells. That number drops to .1 percent in later stages of life—a downward shift due to cellular instability, a core characteristic of disease and aging. Cao studies how tissues and organs maintain stable populations of cells—a hallmark of health—so he and his team wanted to investigate how different cellular populations develop, and whether these varied neuronal cells decline in the same way or forge different paths. Tracking their cellular lifespans from birth to maturity would reveal not just differences, but also when they appeared. His lab specializes in optimizing methods for single-cell sequencing, an increasingly popular approach to analysis that homes in on the genetic expression and molecular dynamics of individual cells. Cao’s group uses combinatorial indexing, a sophisticated yet cost-effective technique that allows for the simultaneous analysis of millions of cells. This method uniquely tags cellular molecules with distinct barcodes that correlate to each cell’s unique molecular assembly. With TrackerSci, Cao and his colleagues have fine-tuned this technique even further. This enhancement enables the meticulous labeling and tracking of the dynamics of rare progenitor cells in mammalian organs. “It’s like an ID card and GPS tracker combined,” Cao says. Aging Brain: Surprising Cellular Shifts For the current study, the researchers analyzed more than 10,000 newborn progenitor cells from across entire mouse brains spanning three ages (young, mature, and elderly) with a synthetic molecule known as 5-ethynyl-2-deoxyuridine (EdU). As these newborn cells differentiated, proliferated, and dispersed, EdU continued to label their DNA, functioning like a GPS tracker. This innovative technique allowed the researchers to analyze tens of thousands of gene expressions and the chromatin landscapes of these newborn cells as they grew into families of cell types with different molecular functions. “We were able to quantify cellular proliferation and differentiation rates of many cell types across the entire brain in a single experiment, which wasn’t possible using conventional approaches,” Cao says. “Those only capture static information—the current molecular state of a cell at a single moment. But TrackerSci captures dynamic information over time. It’s like other methods take snapshots, and we shoot a film.” Some clear—and surprising—characters emerged from these movies. Most strikingly, there were radical shifts in the type of cells generated, depending on the age of the mouse. For example, the number of progenitors that become neurons, the essential communicative cells of the brain, is higher in young brains. The same is the case for a range of glial cells, which create a stable environment for neurons by ensheathing them, providing nutrients, and defending against pathogens—all important for a young, still-developing organ. The opposite is true in the elderly brain. Progenitor cells rarely become either neurons or glial cells; in fact, virtually every type of brain cell plummets. Most lost are dentate gyrus neuroblasts, which are essential for creating neurons in the hippocampus, a region linked to memory and diseases like Alzheimer’s. In comparison to the adult brain, the number of these cells drops by 16-fold in the elderly brain. Instead, immune cells and microglia, a kind of macrophage, proliferate in the aging brain. But rather than protect the brain, they convert into an inflammatory cellular state specific to aging—and these cells are produced at a higher rate. In short, the aging brain creates more of the cells that create more problems for the aging brain. The Sci’s the Limit Cao says TrackerSci could be used to track the regenerative capacity of many organs. “We’re not a brain lab,” he notes. “We also tested the protocol for profiling progenitor cells in the lung, colon, pancreas, and many different organs.” Other organs have far higher proportions of progenitor cells than brains do; newborn progenitors account for more than 20 percent of the cells in the colon, for instance. A few years ago, Cao demonstrated the potential for analyzing cell population dynamics in human fetal development by creating a cellular atlas using a similar combinatorial indexing method. TrackerSci is one of several single-sequencing techniques to recently emerge from Cao’s lab. Another, called PerturbSci-Kinetics, developed by graduate student Zihan Xu, decodes the genome-wide regulatory network that underlies RNA temporal dynamics by coupling scalable single-cell genomics with high-throughput genetic perturbations, or manipulations that can influence gene function. The method was recently described in a paper in Nature Biotechnology. Reference: “Tracking cell-type-specific temporal dynamics in human and mouse brains” by Ziyu Lu, Melissa Zhang, Jasper Lee, Andras Sziraki, Sonya Anderson, Zehao Zhang, Zihan Xu, Weirong Jiang, Shaoyu Ge, Peter T. Nelson, Wei Zhou and Junyue Cao, 28 September 2023, Cell. DOI: 10.1016/j.cell.2023.08.042

Illustration of a human cell cross-section. UH Researchers Receive $1.2 Million Grant to Peer into Ribosomes Two University of Houston researchers are developing a type of spectroscopy to help understand how ribosomes make proteins deep within cells, the discovery of which could potentially guide drug design to treat cancers and viral infections. Spectroscopy measures the interaction between light and matter to determine characteristics and volume of cellular matter. Ribosomes in Protein Assembly In cellular biology, ribosomes are work horses, veritable factories inside cells, whose job is to make proteins. The instructions that tell the ribosome how to work come from messenger RNA, which contains codes on making proteins, actually called codons. One mistake in defining an upstream codon will be propagated to the rest of the messenger like the domino effect, which spells disaster to the cell. During protein assembly, the ribosome must be precise in moving from one codon to the next, a process known as translocation. On the other hand, many viruses contain genomic sequences that are designed to slip on certain codons to re-define the protein composition after that codon, in a process called frameshifting. Yuhong Wang, professor of biology and biochemistry and Shoujun Xu, professor of chemistry, are developing a new imaging technique with super-resolution to peer into ribosomes. Credit: UH “We are developing a multiplexed super-resolution force spectroscopy to investigate high-fidelity and frameshifting translocations,” said Yuhong Wang, professor of biology and biochemistry. Wang and Shoujun Xu, professor of chemistry, received a $1.2 million grant from the National Institute of General Medical Sciences to support their research. “We will measure the power strokes from elongation factors (EF-G) and their mutants, which are the enzymes to interact with ribosome during translocation, on normal and viral mRNA sequences and in the presence of antibiotics,” said Xu. “Our research will provide new methodology that can be applied to other biological systems.” Potential Applications in Drug Design Scientifically, the team is building a new model of ribosome translocation with sub-codon steps and providing potential drug targets for related diseases. “For example, by tuning down and up the EF-G’s activity in cancer cells and low-functioning neuron cells, the diseases can be treated, anti-viral drugs can be designed that only target the specific viral frameshifting motifs,” said Wang.

Researchers have discovered a brain circuit in mice that inhibits eating when nauseous, pinpointing unique amygdala nerve cells that operate differently from those activated during satiety, highlighting the complex regulation of appetite. A neural pathway suppresses appetite when experiencing nausea. Feeling full, nauseous, or anxious can all contribute to a decrease in appetite. Postponing meals may be the body’s natural way to avoid additional harm and allow for recovery. Scientists at the Max Planck Institute for Biological Intelligence have discovered a specific brain pathway that stops mice from eating when they experience nausea. The decisive role is played by special nerve cells in the amygdala – a brain region involved when emotions run high. The cells are activated during nausea and elicit appetite-suppressing signals. The findings highlight the complex regulation of eating behavior, as the loss of appetite during nausea is controlled by different circuits than during satiety. An upcoming exam, a boat trip on the high seas, or the next germ at the daycare center all have one thing in common: they can really upset our stomach. Stress, motion sickness, or certain infections can make us feel sick. It seems logical that we don’t eat in these circumstances and wait for the situation to improve. As a result, nausea and decreased appetite usually go hand in hand. Or have you ever felt sick and really wanted to eat at the same time? Specialized nerve cells in the amygdala are activated during nausea and elicit appetite-suppressing signals. Credit: MPI for Biological Intelligence/ Julia Kuhl What seems logical is a healthy defense mechanism of our body – but it has to be activated first. Clearly, the brain plays a central role in this: it is the control center for the body’s energy balance and regulates eating behavior. So how does the brain prevent us from eating when we feel sick? Researchers in Rüdiger Klein’s department have gained new insights into this topic in mice. They focused on the amygdala, a brain region that regulates emotions, also those related to eating. It contains neurons that promote eating and those that inhibit appetite. For example, a known inhibitory cell type is activated when we are full, but how this works in the case of nausea is not well understood. Nausea activates nerve cells Wenyu Ding, first author of the new study, now discovered another cell group in the amygdala that has a negative influence on appetite. Unlike the previously known cell type, these cells are not activated by satiety, but when feeling nauseous. When the researchers artificially switched on the cells, even hungry mice stopped eating. Conversely, switching the cells off resulted in the mice eating, even when feeling sick. This Sketchnote summarizes the most important findings of the new paper. Credit: MPI for Biological Intelligence / Christina Bielmeier To better understand how this cell type exerts its appetite-suppressing function, the researchers analyzed the underlying circuit: where do the cells get their information from and to which cells and brain areas do they send their projections? The following picture emerged: When a mouse feels sick, this information reaches the brain and eventually the amygdala. There, the new cell type is activated and sends its inhibitory signals to distant brain regions, including the so-called parabrachial nucleus, a brain stem region that receives a lot of information about the internal state of the body. This stands in contrast to the circuit of the previously known cell type, which mainly interacts with neighboring cells within the amygdala. It becomes clear that the loss of appetite during satiety is not the same as the loss of appetite during nausea. In the brain, different cells and circuits are responsible for this – a complicated matter and perhaps a small consolation the next time we feel sick. Most importantly, the new study provides important insights into how the brain and the amygdala in particular regulate eating behavior. This is the prerequisite for a better understanding of the many diseases associated with dysregulated eating behavior in humans. Reference: “Nausea-induced suppression of feeding is mediated by central amygdala Dlk1-expressing neurons” by Wenyu Ding, Helena Weltzien, Christian Peters and Rüdiger Klein, 27 March 2024, Cell Reports. DOI: 10.1016/j.celrep.2024.113990

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