Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Pillow ODM design company in Indonesia

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Graphene cushion OEM factory in China

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.High-performance graphene insole OEM China

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Thailand insole ODM for global brands

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan custom insole OEM supplier

Within the glass platform of this microscope slide, researchers recreated two anatomical structures involved in the spread of pancreatic cancer. Credit: Purdue University photo/John Underwood What makes pancreatic cancer so deadly is its covert and quick spread. Now, a “time machine” built by Purdue University engineers has shown a way to reverse the course of cancer before it spreads throughout the pancreas. “These findings open up the possibility of designing a new gene therapy or drug because now we can convert cancerous cells back into their normal state,” said Bumsoo Han, a Purdue professor of mechanical engineering and program leader of the Purdue Center for Cancer Research. Han has a courtesy appointment in biomedical engineering. The time machine that Han’s lab built is a lifelike reproduction of a pancreatic structure called the acinus, which produces and secretes digestive enzymes into the small intestine. Pancreatic cancer tends to develop from chronic inflammation that happens when a mutation has caused these digestive enzymes to digest the pancreas itself. If there were a way to go back in time to reprogram the cancerous acinar cells that produce those enzymes, then it might be possible to completely reset the pancreas. Purdue researchers used this experimental setup to reprogram pancreatic cancer cells back into their normal state. Credit: Purdue University photo/John Underwood For the past decade, Stephen Konieczny, professor emeritus in Purdue’s Department of Biological Sciences, has studied a potential reset button: a gene called PTF1a. “The PTF1a gene is absolutely critical for normal pancreas development. If you lack the PTF1a gene, you don’t develop a pancreas,” Konieczny said. “So, our whole idea was, if we turn the PTF1a gene back on in a pancreatic cancer cell, what happens? Will we revert the cancer phenotype? Indeed, that’s exactly what happens.” Konieczny collaborated with Han’s lab to take these findings in molecular biology studies to the next level by testing them in a realistic model of the acinus – the time machine. The published study is featured on the cover of a recent issue of Lab on a Chip, a journal by the Royal Society of Chemistry. Researchers typically investigate possible pancreatic cancer treatment approaches in animal models, but it can take months for pancreatic cancer to develop in an animal. Having a way to study cancer development and treatment concepts in a microenvironment that is just as realistic would save time and give researchers more control over the model. Bumsoo Han, professor of mechanical engineering, has built a realistic model of a pancreatic structure that acts as a “time machine” to understand cancer and reverse its spread. Credit: Purdue University photo/John Underwood The model that Purdue researchers developed overcomes a major challenge in accurately capturing the anatomical complexity of the acinus, a circular cavity lined with cells. “From an engineering perspective, creating this kind of three-dimensional cavity is not trivial. So, figuring out a way to build this cavity is an innovation in itself,” Han said. Han’s lab already had experience building a realistic model of another pancreatic structure, the duct, where cancer grows after emerging from the acinus. The researchers took this knowledge and developed a new technique that builds both the duct and acinus in a two-step “viscous fingering” process. Here’s how it works: The model, a postage-stamp-size glass platform on top of a microscope slide, has two interconnected chambers. Loading a collagen solution into one chamber fills the finger-like shape of a pancreatic duct, which bulges and then expands to create the cavity structure of the acinus in the second chamber. Dropping cancerous human cells into the acinar chamber made the model even more realistic. Konieczny’s lab engineered the PTF1a gene of a pancreatic cancer cell line to turn on in the presence of doxycycline, a compound commonly used in antibiotics. Once the gene was activated, the cells started constructing the rest of the acinus in Han’s model, indicating that they were no longer cancerous and had been reprogrammed. “In this model, not only do the cancerous cells become reprogrammed, but for the first time, we’re able to show the normal three-dimensional architecture of the acinus, which looks very similar to the same structures we see in a healthy pancreas,” Konieczny said. Han’s lab is currently conducting experiments exploring a possible gene therapy based on these findings. Reference: ” Engineering of a functional pancreatic acinus with reprogrammed cancer cells by induced PTF1a expression” by Stephanie M. Venis, Hye-ran Moon, Yi Yang, Sagar M. Utturkar, Stephen F. Konieczny and Bumsoo Han, 9 August 2021, Lab on a Chip. DOI: 10.1039/D1LC00350J This study was partially supported by grants from the National Institutes of Health, the Walther Embedding Program in Physical Sciences in Oncology, and the Purdue Center for Cancer Research, which is one of only seven National Cancer Institute Basic Laboratory Cancer Centers in the nation.

Recent research used a database to study over 2900 orchid species, highlighting their diverse and specialized pollination strategies, including high reliance on deceit. While orchids have contributed significantly to understanding floral adaptations, much remains to be discovered, especially regarding orchid species in underrepresented regions. A Global Database of Pollination Data for Almost 3000 Orchid Species A recent study published in the Botanical Journal of the Linnean Society utilized a database to highlight the astonishing diversity of specialized pollination tactics orchids possess, which vary across the world. The recently published database contains over 2900 orchid species, detailing information on the identity of their pollinators and how they attract them. Importantly, the database reveals patterns of reproductive biology by habitat, geography, and taxonomy. “From these data, we identify general patterns and knowledge gaps limiting our understanding of orchid biology at the global level,” Dr Phillips said. Charles Darwin used orchids to study evolution, believing their elaborate flower was an adaptation to enhance the probability of transferring pollen between plants – thereby increasing their offspring’s fitness. “Because of the unusual floral traits and often unconventional pollination attraction strategies, orchids have been at the forefront of understanding floral adaptations to pollinators,” Dr Phillips said. Indeed, Darwin famously predicted that the Madagascan orchid Angraecum sesquipedale – with its 40 cm long nectar spur – would be pollinated by a moth with an equally long and outlandish proboscis. Using the new database, the research paper, led by Dr. James Ackerman from the University of Puerto Rico, found that over 75% of orchid species are dependent on pollinators for reproduction. Interestingly, almost half of the orchids studied did not provide any kind of reward for visiting animals – instead, they used deceit to attract pollinators. As is the case for many orchids, the Dragon Orchid (Caladenia barbarossa) is pollinated by just a single species of insect. Here, pollination occurs via a male thynnine wasp, which is sexually attracted to the flower through mimicry of the wasp’s sex pheromones. In this photo the male wasp removes and deposits pollen in the process of attempting to copulate with the flower. Credit: Dr Ryan Phillips, La Trobe University Orchids tended to specialize on just one main pollinator species – be they living in the rainforests of Costa Rica or the montane grasslands of South Africa – but this trend was even stronger for those using deception. Study co-author, Dr. Noushka Reiter, said that “specializing on one pollinator species leaves many orchids particularly vulnerable to anthropogenic threats including climate change. With the loss of pollinators, we would also lose these pollinator-dependent orchid species.” The pollination strategies developed by orchids read like a crime thriller – indeed, Australia is the world epicenter of pollination by sexual mimicry, where a host of different insect groups – from wasps to bees to gnats – are duped by this elaborate rouse. In South Africa, orchids mimic carrion, on Reunion Island they mimic rainforest fruits and in Brazil, they mimic the smell of aphids – all with the aim of deceiving pollinators. More romantically, in the American tropics, 100s of orchid species provide fragrance to certain bees, which collect them and incorporate them into their courtship bouquet. Science Fiction? In Australia, there is even a sexually deceptive orchid known as Caladenia barbarella – which means little beard in Latin (in reference to the flower) but also refers to the comic book character of the same name who was infamous for her sexual exploits. Dr. Phillips said that a surprising finding of the database was that “a hallmark of the orchid family is the high proportion of species that employ deceit to attract pollinators by exploiting the sensory abilities of pollinators via chemical, visual or tactile stimuli, generally in combination,” he said. Orchids exhibit two major forms of deceit. The first involves food deception, whereby the orchid may look or smell like a type of food to attract a pollinator. The second form of deceitful pollination is sexual deception, where male pollinators are enticed to visit flowers that provide visual, tactile, and/or olfactory signals that are indicative of a female insect. “The floral signals can be so persuasive that insects attempt copulation and may even ejaculate,” Dr Phillips said. “I’ve even had the wasps fly in through the car window at the traffic lights and start making love to the orchids specimens on the front seat”. Far from being a freak occurrence, this strategy is now known from 20 genera around the world, including 100s of orchid species. To date, a third means of deception, known as brood-site deception, which typically involves mimicry of larval food such as mushrooms, dung, and carrion to attract female flies looking for a food source on which to lay eggs – was considered more common in some other families of flowering plants and rarely seen in orchids. According to the Database: In terms of scientific study, Australasia and Africa have 15 and 20% coverage of their orchid diversity, respectively, whereas orchid floras of Temperate Asia, Tropical Asia, and South America are much under-represented Approximately 76% of orchid species are entirely dependent on pollinators for reproduction. Highly specialized pollination systems are frequent, with approximately 55% of orchids studied having just a single known pollinator species. 54% of orchid species offer pollinator rewards, and about half of those (51%) produce nectar. Orchids that are pollinated by insects collecting floral fragrances account for 24% of the rewarding species, whereas those that produce floral oils account for c. 15%. The remaining 10% comprises species that offer trichomes (food hairs, pseudopollen), resins, pollen, or sleep sites. Deception, including food, brood-site, and sexual deception, was recorded in 46% of the species in the database. Food deception was the most frequently recorded means of deception accounting for 60% of deceptive species. Sexual deception accounted for 38% of the records for pollination by deceit and is present in 20 orchid genera. Wasps and bees are the group that make up the most common type of pollinator with flies and mosquitoes coming in a close second The authors caution that there is much data collecting yet to be done. “Despite containing over 2900 species, our database covers less than 10% of the family. While they are centres of orchid diversity, the tropical regions of Africa, Southern America, and Asia, are significantly under-represented in orchid pollination studies, especially among epiphytic orchids,” Dr Phillips said. “The study of orchid pollination provides a tremendous opportunity to discover new and bizarre pollination strategies and to understand the adaptations that flowering plants to attract pollinators. While the tropics is the big unknown in orchid biology, many of the best-known Australian orchids have not been studied in detail. “Aside from scientific interest, this has important practical implications for conservation, given that many orchid species are reliant on one primary pollinator species for their persistence,” Dr Phillips said. Reference: “Beyond the various contrivances by which orchids are pollinated: global patterns in orchid pollination biology” by James D Ackerman, Ryan D Phillips, Raymond L Tremblay, Adam Karremans, Noushka Reiter, Craig I Peter, Diego Bogarín, Oscar A Pérez-Escobar and Hong Liu, 11 March 2023, Botanical Journal of the Linnean Society. DOI: 10.1093/botlinnean/boac082

The gene that the scientists uncovered makes sure that actin’s, a major component of our cell skeleton, final form is produced. The Gene Matures the Skeleton of the Cell “I’m a professional pin-in-a-haystack seeker,” geneticist Thijn Brummelkamp responded when asked why he succeeds at finding proteins and genes that others have missed, despite the fact that some have remained elusive for as long as forty years. His research group at the Netherlands Cancer Institute has once again identified one of these “mystery genes” – the gene that guarantees the final form of the protein actin, a key component of our cell skeleton – is produced. These findings were recently published in the journal Science. Actin is one of the most common molecules in a cell and a key component of the cell skeleton, which is why cell biologists are particularly interested in it. In our lifetime, we produce more than 100 kilograms of actin. It is present in large amounts in all cell types and has a variety of functions, including giving cells structure and making them firmer, playing a key role in cell division, propelling cells forward, and giving our muscles strength. People who have defective actin proteins often have muscle disease. Much is known about actin’s function, but how is the final version of this vital protein produced and which gene is responsible? “We didn’t know,” says Brummelkamp, whose mission is to find out the function of our genes. Microscopy image of actin. (Actin is yellow, cell core is blue). Credit: Peter Haarh/ Netherlands Cancer Institute Genetics in Haploid Human Cells Brummelkamp has developed a number of unique methods for this purpose over the course of his career, which allowed him to be the first to inactivate genes on a large scale for his genetics research in human cells twenty years ago. “You can’t crossbreed people like fruit flies, and see what happens.” Since 2009, Brummelkamp and his team have been using haploid cells – cells containing only one copy of each gene instead of two (one from your father and one from your mother). While this combination of two genes forms the basis of our entire existence, it also creates unwanted noise when conducting a genetics experiment because mutations usually occur in just one version of a gene (the one from your father, for example) and not the other. Multi-Purpose Method for Genetics in Human Cells Together with other researchers, Brummelkamp uses this multi-purpose method to find the genetic causes of particular conditions. He has already shown how the Ebola virus and a number of other viruses, as well as certain forms of chemotherapy, manage to enter a cell. He also investigated why cancer cells are resistant to certain types of therapy and discovered a protein found in cancer cells that acts as a brake on the immune system. This time he went looking for a gene that matures actin – and as a result, the skeleton of the cell. In Search of Scissors Before a protein is completely “finished” – or mature, as the researchers describe it in Science – and can fully perform its function in the cell, it usually has to be stripped of a specific amino acid first. This amino acid is then cut from a protein by a pair of molecular scissors. This is also what occurs with actin. It was known on which side of the actin the relevant amino acid is cut off. However, no one managed to find the enzyme that acts as scissors in this process. Peter Haahr, a postdoc in Brummelkamp’s group, worked on the following experiment: first, he caused random mutations (mistakes) in random haploid cells. Then he selected the cells containing the immature actin by adding a fluorescently labeled antibody to his cells that fit in the exact spot where the amino acid is cut off. As a third and final step, he investigated which gene mutated after this process. They Called It ‘ACTMAP’ Then came the “eureka”-moment: Haahr had traced down the molecular scissors that cut the essential amino acid from actin. Those scissors turned out to be controlled by a gene with a previously unknown function; one no researcher had ever worked with. This means that the researchers were able to name the gene themselves, and they settled on ACTMAP (ACTin MAturation Protease). To test whether a lack of ACTMAP leads to issues in living things, they switched off the gene in mice. They observed that the actin in the cell skeleton of these mice remained unfinished, as expected. They were surprised to find that the mice did stay alive, but suffered from muscle weakness. The researchers conducted this research together with scientists from VU Amsterdam. More Scissors Found in the Skeleton of the Cell ACTMAP is not the first mystery gene discovered by Brummelkamp that plays a role in our cell skeleton function. Using the same method, his group has been able to detect three unknown molecular scissors over recent years that cut an amino acid from tubulin, the other main component of the cell skeleton. These scissors allow tubulin to perform its dynamic functions properly inside the cell. The last scissors (MATCAP) were discovered and described in Science this year. Through this earlier work on the cell skeleton, Brummelkamp managed to arrive at actin. Mission: Mapping Out All 23.000 Genes “Unfortunately, our new discovery about actin doesn’t tell us how to cure certain muscular conditions,” says Thijn Brummelkamp. “But we have provided new fundamental knowledge about the cell skeleton that may be useful to others later.” Moreover, Brummelkamp, whose mission is to be able to map out the function of all of our 23,000 genes one day, can tick another new gene off his gigantic list. After all, we don’t know what half of our genes do, which means that we cannot intervene when something goes wrong. Reference: “Actin maturation requires the ACTMAP/C19orf54 protease” by Peter Haahr, Ricardo A. Galli, Lisa G. van den Hengel, Onno B. Bleijerveld, Justina Kazokaitė-Adomaitienė, Ji-Ying Song, Lona J. Kroese, Paul Krimpenfort, Marijke P. Baltissen, Michiel Vermeulen, Coen A. C. Ottenheijm and Thijn R. Brummelkamp, 29 September 2022, Science. DOI: 10.1126/science.abq5082

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