Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Custom foam pillow OEM in Vietnam

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan graphene material ODM factory

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Taiwan eco-friendly graphene material processing factory

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.PU insole OEM production in Thailand

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene-infused pillow ODM China

An Arabidopsis meiotic cell imaged using super-resolution microscopy showing DNA in blue and the proteins HEI10 in red, ZYP1 in green and ASY1 in yellow. Credit: John Innes Centre A new discovery explains what determines the number and position of genetic exchanges that occur in sex cells, such as pollen and eggs in plants, or sperm and eggs in humans. When sex cells are produced by a special cell division called meiosis, chromosomes exchange large segments of DNA. This ensures that each new cell has a unique genetic makeup and explains why, with the exception of identical twins, no two siblings are ever completely genetically alike. These exchanges of DNA, or crossovers, are essential for generating genetic diversity, the driving force for evolution, and their frequency and position along chromosomes are tightly controlled. Co-first author of the study Dr. Chris Morgan explains the significance of this phenomenon: “Crossover positioning has important implications for evolution, fertility, and selective breeding. By understanding the mechanisms that drive crossover positioning we are more likely to be able to uncover methods to modify crossover positioning to improve current plant and animal breeding technologies.” Despite over a century of research, the cellular mechanism that determines where, and how many, crossovers form has remained mostly mysterious, a puzzle that has fascinated and frustrated many eminent scientists. The phrase “crossover interference” was coined in 1915 and describes the observation that when a crossover occurs at one location on a chromosome, it inhibits the formation of crossovers nearby. Using a cutting-edge combination of mathematical modeling and ‘3D-SIM’ super-resolution microscopy, a team of John Innes Centre researchers has solved this century-old mystery by identifying a mechanism that ensures that crossover numbers and positions are ‘just right’: not too many, not too few and not too close together. The team studied the behavior of a protein called HEI10 which plays an integral role in crossover formation in meiosis. Super-resolution microscopy revealed that HEI10 proteins cluster along chromosomes, initially forming lots of small groups. However, as time passes, the HEI10 proteins concentrate in only a small number of much larger clusters which, once they reach a critical mass, can trigger crossover formation. These measurements were then compared against a mathematical model which simulates this clustering, based on diffusion of the HEI10 molecules and simple rules for their clustering. The mathematical model was capable of explaining and predicting many experimental observations, including that crossover frequency could be reliably modified by simply altering the amount HEI10. Co-first author Dr. John Fozard explains: “Our study shows that data from super-resolution images of Arabidopsis reproductive cells is consistent with a mathematical ‘diffusion-mediated coarsening’ model for crossover patterning in Arabidopsis. The model helps us understand the patterning of crossovers along meiotic chromosomes.” The work builds on the John Innes Centre legacy of using plants as model organisms to study conserved and fundamental aspects of genetics. This same process was also studied by JIC alumni J.B.S Haldane and Cyril Darlington in the 1930s. The model also supports predictions that were made by another famous JIC alumnus, Robin Holliday, in the 1970s.  Corresponding author, Professor Martin Howard, adds: “This work is a great example of interdisciplinary research, where cutting-edge experiments and mathematical modeling were both needed to unlock the heart of the mechanism. One exciting future avenue will be to assess whether our model can successfully explain crossover patterning in other diverse organisms.” This research will be particularly valuable for cereal crops, such as wheat, in which crossovers are mostly restricted to specific regions of the chromosomes, preventing the full genetic potential of these plants from being available to plant breeders. Reference: “Diffusion-mediated HEI10 coarsening can explain meiotic crossover positioning in Arabidopsis” by Chris Morgan, John A. Fozard, Matthew Hartley, Ian R. Henderson, Kirsten Bomblies and Martin Howard, 3 August 2021, Nature Communications. DOI: 10.1038/s41467-021-24827-w

KAUST scientists have captured the moment DNA begins to unwind, revealing how helicases use ATP to initiate replication. This breakthrough uncovers energy-efficient mechanisms that could inspire nanotechnology designs. Scientists have provided the most detailed account yet of the earliest stages of DNA replication, an essential process for all life to grow and reproduce. For the first time, scientists have directly observed the very moment DNA begins to unravel, a critical molecular event that underpins its role as the carrier of genetic information. In a groundbreaking study published in Nature, researchers from King Abdullah University of Science and Technology (KAUST) have captured the initial steps of DNA replication, offering new insight into how cells accurately duplicate their genetic material, a process essential for life, growth, and reproduction. Using advanced cryo-electron microscopy combined with deep learning techniques, the teams led by KAUST Assistant Professor Alfredo De Biasio and Professor Samir Hamdan closely examined how the helicase enzyme, Simian Virus 40 Large Tumor Antigen, interacts with DNA. Their work reveals 15 distinct atomic-level states that detail how the helicase initiates and drives the unwinding of the DNA double helix. This achievement marks a major breakthrough not only in understanding helicase function but also in visualizing enzyme dynamics at atomic resolution—an unprecedented step forward in molecular biology. Understanding Helicase and Its Role While scientists have long known the importance of helicase in DNA replication, “they did not know how DNA, helicases, and ATP work together in a coordinated cycle to drive DNA unwinding,” De Biasio said. When Watson and Crick reported the double helix in 1953, they gave the scientific community a breakthrough understanding of how genetic information is stored and copied. For DNA to replicate, the helix must first unwind and break the DNA from a double strand into two single strands. A 3D reconstruction of a helicase interacting with DNA. The DNA is in the central channel, while the helicase consists of six differently colored monomers surrounding it. Credit: KAUST Upon binding, helicases melt the DNA, breaking the chemical bonds holding the double helix together. They then pull the two strands apart, allowing other enzymes to complete the replication. Without this first step, no DNA can be replicated. In this way, helicases are machines or, because of their size, nanomachines. ATP: The Fuel Driving the Unwinding If helicases are nanomachines, then ‘ATP’, or adenosine trisphosphate, is the fuel. Much like how burning gas drives the pistons of a car engine, burning ATP, the same fuel used to flex your muscles, causes the six pistons of a helicase to unwind DNA. The study found that as ATP is consumed, it reduces physical constraints that allow the helicase to proceed along the DNA, unwinding more and more of the double strand. Thus, ATP consumption acts a switch that increases the amount of entropy – or disorder – in the system, freeing the helicase to move along the DNA. “The helicase uses ATP not to pry DNA apart in one motion, but to cycle through conformational changes that progressively destabilize and separate the strands. ATP burning, or hydrolysis, functions like the spring in a mouse trap, snapping the helicase forward and pulling the DNA strands apart,” said De Biasio. Among the many discoveries made by the KAUST scientists was that two helicases melt the DNA at two sites at the same time to initiate the unwinding. The chemistry of DNA is such that nanomachines move along a single DNA strand in one direction only. By binding at two sites simultaneously, the helicases coordinate so that the winding can happen in both directions with an energy efficiency unique to natural nanomachines. That efficiency, explains De Biasio, makes the study of DNA replication more than an attempt to answer the most fundamental scientific questions about life, it also makes helicase models for the design of new nanotechnology. “From a design perspective, helicases exemplify energy-efficient mechanical systems. Engineered nanomachines using entropy switches could harness similar energy-efficient mechanisms to perform complex, force-driven tasks,” he said. Reference: “Structural dynamics of DNA unwinding by a replicative helicase” by Taha Shahid, Ammar U. Danazumi, Muhammad Tehseen, Lubna Alhudhali, Alice R. Clark, Christos G. Savva, Samir M. Hamdan and Alfredo De Biasio, 19 March 2025, Nature. DOI: 10.1038/s41586-025-08766-w

Hydra, a group of small aquatic animals, can regenerate their own heads by altering the regulation of their genes. Credit: David Plachetzki A new paper in Genome Biology and Evolution, published by Oxford University Press, maps out for the first time how Hydra, which are a group of small aquatic animals, can regenerate their own heads by changing the way that their genes are regulated, known as epigenetics. Hydra belong to the group of animals that consists of about 10,000 species divided into two major groups: Anthozoa (comprising of sea anemones, corals, and sea pens) and Medusozoa (sea wasps, jellyfish, and hydra). Hydra, which live in temperate and tropical regions, are commonly believed to be biologically immortal; Hydra stem cells have a capacity for unlimited self-renewal.  Whole-body regeneration occurs in a few animal species. The extent to which the genes and gene regulatory networks driving regeneration vary across species remains largely unexplored. Scientists still don’t understand the mechanism driving Hydra head regeneration. Previous studies have found evidence of regulation by multiple developmental pathways. Researchers have found several genes associated with head regeneration. To understand the rudiments controlling Hydra head regeneration, researchers first identified 27,137 elements that are active in one or more sections of the organism body or regenerating tissue. Researchers used histone modification ChIP-seq, a method used to analyze how proteins interact with DNA, to identify 9998 candidate proximal promoter and 3018 candidate enhancer-like regions respectively. Their research shows that a subset of these regulatory elements is remodeled during head regeneration and identifies a set of transcription factor motifs that are enriched in the regions activated during head regeneration. These enriched motifs included developmental transcription factors. This work identifies for the first time the specific candidate regulatory elements of the genome that change during Hydra head regeneration, which determine how organisms develop by turning on or off genes depending on need. “One exciting finding of this work is that the head regeneration and budding programs in Hydra are quite different, said the paper’s lead author, Aide Macias-Muñoz. “Even though the result is the same (a Hydra head), gene expression is much more variable during regeneration. Accompanying dynamic gene expression is dynamic chromatin remodeling at sites where developmental transcription factors bind. These findings suggest that complex developmental enhancers were present before the Cnidaria and Bilateria split.” Reference: “Coordinated gene expression and chromatin regulation during Hydra head regeneration” by Rabi Murad, Aide Macias-Muñoz, Ashley Wong, Xinyi Ma and Ali Mortazavi, 8 December 2021, Genome Biology and Evolution. DOI: 10.1093/gbe/evab221

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