Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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ODM ergonomic pillow solution factory Taiwan

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.ODM pillow for sleep brands Thailand

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Indonesia flexible graphene product manufacturing

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.High-performance graphene insole OEM Indonesia

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Thailand insole ODM design and production

Microorganisms are crucial in maintaining the sulfur cycle, influencing climate processes. Research has discovered diverse and multifunctional sulfate-reducing microorganisms, capable of simultaneous sulfate reduction and oxygen respiration, upending previous scientific consensus. (Artistic concept.) Study on environmentally relevant microorganisms shows greater diversity than previously assumed. A team of researchers has shown that there is an incredibly high biodiversity of environmentally relevant microorganisms in nature. This diversity is at least 4.5 times greater than previously known. The researchers recently published their findings in the prestigious journals Nature Communications and FEMS Microbiology Reviews. The hidden world of microorganisms is often overlooked, even though many climate-relevant processes are influenced by microorganisms, often associated with an incredible diversity of species within the groups of bacteria and archaea (“primitive bacteria”). For example, sulfate-reducing microorganisms convert a third of the organic carbon in marine sediments into carbon dioxide. This produces toxic hydrogen sulfide. On the positive side, sulfur-oxidizing microorganisms quickly use this as an energy source and render it harmless. “These processes also play an important role in lakes, bogs, and even in the human gut to keep nature and health in balance,” says Prof. Michael Pester, Head of the Department of Microorganisms at the Leibniz Institute DSMZ and Professor at the Institute of Microbiology at Technische Universität Braunschweig. A study examined the metabolism of one of these novel microorganisms in more detail, revealing a multifunctionality that was previously unattainable. Extremely high species diversity of sulphate-reducing microorganisms discovered. Sulfate reducers are now found in a total of 27 phyla within the bacteria and archaea instead of the six previously known. Credit: DSMZ The Sulfur Cycle’s Critical Balance The sulfur cycle is one of the most important and oldest biogeochemical cycles on our planet. At the same time, it is closely linked to the carbon and nitrogen cycles, underlining its importance. It is mainly driven by sulfate-reducing and sulphur-oxidising microorganisms. On a global scale, sulfate reducers convert about a third of the organic carbon that reaches the seafloor each year. In return, sulfur oxidizers consume about a quarter of the oxygen in marine sediments. When these ecosystems become unbalanced, the activities of these microorganisms can rapidly lead to oxygen depletion and the accumulation of toxic hydrogen sulfide. This leads to the formation of ‘dead zones’ where animals and plants can no longer survive. This not only causes economic damage, for example to fisheries, but also social damage through the destruction of important local recreational areas. It is therefore important to understand which microorganisms keep the sulfur cycle in balance and how they do this. The published results show that the species diversity of sulfate-reducing microorganisms includes at least 27 phyla (strains). Previously, only six phyla were known. By comparison, 40 phyla are currently known in the animal kingdom, with vertebrates belonging to only one phylum, the Chordata. Schematic representation of the degradation of plant pectin – both by sulphate reduction and by respiration with oxygen in a newly discovered acidobacterium. Credit: DSMZ   Newly Discovered Multifunctional Bacterial Species The researchers were able to assign one of these novel “sulfate reducers” to the little-researched phylum of acidobacteriota and to study it in a bioreactor. Using cutting-edge methods from environmental microbiology, they were able to show that these bacteria can obtain energy from both sulfate reduction and oxygen respiration. These two pathways are normally mutually exclusive in all known microorganisms. At the same time, the researchers were able to show that the sulfate-reducing acidobacteriota can break down complex plant carbohydrates such as pectin – another previously unknown property of “sulfate reducers.” The researchers have thus turned textbook knowledge on its head. They show that complex plant compounds can be degraded under oxygen exclusion not only by the coordinated interaction of different microorganisms, as previously thought, but also by a single bacterial species via a shortcut. Dr. Stefan Dyskma (left) and Prof. Dr. Michael Pester next to a bioreactor at the DSMZ, in which novel “sulfate reducers” could be studied. Credit: DSMZ Another new finding is that these bacteria can use both sulfate and oxygen for this purpose. Researchers at the DSMZ and Technische Universität Braunschweig are currently investigating how the new findings affect the interplay of the carbon and sulfur cycles and how they are linked to climate-relevant processes. References: “Oxygen respiration and polysaccharide degradation by a sulfate-reducing acidobacterium” by Stefan Dyksma and Michael Pester, 10 October 2023, Nature Communications. DOI: 10.1038/s41467-023-42074-z “Global diversity and inferred ecophysiology of microorganisms with the potential for dissimilatory sulfate/sulfite reduction” by Muhe Diao, Stefan Dyksma, Elif Koeksoy, David Kamanda Ngugi, Karthik Anantharaman, Alexander Loy and Michael Pester, 5 October 2023, FEMS Microbiology Reviews. DOI: 10.1093/femsre/fuad058

This image shows Murembo, a Great Tusker from Tsavo, Kenya’s largest protected area. Credit: John Marais A study reported in the journal Current Biology has both good news and bad news for the future of African elephants. While about 18 million square kilometers of Africa — an area bigger than the whole of Russia — still has suitable habitat for elephants, the actual range of African elephants has shrunk to just 17%of what it could be due to human pressure and the killing of elephants for ivory. “We looked at every square kilometer of the continent,” says lead author Jake Wall of the Mara Elephant Project in Kenya. “We found that 62% of those 29.2 million square kilometers is suitable habitat.” The findings suggest that, if released from human pressures, including the threat of being killed for their ivory, elephants still have great potential for recovery into areas where the human footprint is light. They note that those 18 million square kilometers include many areas where there is still room for peaceful coexistence between humans and elephants as well as others where that prospect is clearly not realistic. This image shows thirsty elephants approaching the Gemsbokvlakte Waterhole in Etosha National Park. Credit: Roy Terlien Like many wildlife species, it’s long been clear that African elephant populations and their geographic range were shrinking due to killing for ivory, habitat loss, and the growth of human populations. But African savannah and forest elephants can live in many environments, from semi-deserts to tropical swamp forests. Wall’s team wanted to better understand how elephants are using the space that’s available to them and what’s driving their ranging patterns. To analyze the suitability of habitats over the entire continent at a kilometer-level scale, Wall and his colleagues drew on data from GPS-tracking collars fitted to 229 elephants across Africa by Save the Elephants and its partners over a 15-year period. Using Google Earth Engine, a satellite imagery computing platform, they looked at the vegetation, tree cover, surface temperature, rainfall, water, slope, aggregate human influence, and protected areas in the areas the elephants traversed. This allowed them to determine which habitats can support elephants and the extremes of conditions that they currently can tolerate. “Combining three powerful tools — GPS telemetry, continent-wide remote sensing at a fine resolution, and a suite of analytical techniques — has allowed us to see what factors now control the movements and lives of these two hugely ecologically important species — and where, if circumstances change, they could range more widely across their historical African home,” said Samantha Strindberg of the Wildlife Conservation Society. The researchers uncovered vast areas of potentially suitable habitat for elephants in the Central African Republic and the Democratic Republic of Congo. The researchers note that forests in those areas recently held hundreds of thousands of elephants but today hold only about 5,000 to 10,000. The study also highlighted the extreme habitats that African elephants do not visit. This image shows elephants on the move. Credit: David Griffin “The major no-go areas include the Sahara, Danakil, and Kalahari deserts, as well as urban centers and high mountaintops,” said Iain Douglas-Hamilton, the founder of Save the Elephants. “That gives us an idea of what the former range of elephants might have been. However, there’s a dearth of information about the status of African elephants between the end of Roman times and the arrival of the first European colonizers.” The tracking data also show that elephants living in protected areas tend to have smaller home ranges. The researchers suggest that’s probably because they feel unsafe ranging into unprotected lands. The study notes that approximately 57% of the current elephant range is outside of protected areas, highlighting the limited space presently reserved for their safety. To secure long-term survival of elephants, the researchers say that habitat protection, protection of elephants themselves from illegal killing, and an ethic of human-elephant coexistence will be essential. “Elephants are generalist mega-herbivores that can occupy fringe habitats,” Wall says. “Their range may have shrunk, but if we gave them the chance, they could spread back to former parts of it.” Unfortunately, trends are headed in the wrong direction. “The human footprint is increasing at an accelerated rate and expected to double by 2050, with between 50% and 70% of the planet already experiencing anthropogenic disturbance,” the researchers write. “Fragmentation of wildlife habitats by humans has resulted in only 7% of wildlife habitat patches being larger than 100 km2. Development scenarios that accommodate the spatial needs of wildlife leaving large, low-human impact areas of intact habitat, and especially formally protected areas, are urgently required. In the face of increasing human pressures, proactive landscape planning at the local, national, and continental scales are critical, as well as fostering an ethic of human-elephant coexistence, if the future of elephants is to be secured.” Read African Elephants Have Plenty of Habitat if Spared From the Ivory Trade for more on this research. Reference: “Human footprint and protected areas shape elephant range across Africa” by Jake Wall, George Wittemyer, Brian Klinkenberg, Valerie LeMay, Stephen Blake, Samantha Strindberg, Michelle Henley, Fritz Vollrath, Fiona Maisels, Jelle Ferwerda and Iain Douglas-Hamilton, 1 April 2021, Current Biology. DOI: 10.1016/j.cub.2021.03.042 This work was supported by the European Commission and a Canadian National Science and Research Council (NSERC) award. Please see paper for full acknowledgments.

A human blastocyst-like synthetic embryo called blastoid showing the presence of an enveloping layer of extra-embryonic cells, a blastocoel-like cavity, epiblast cells (green, giving rise to the future embryo) and hypoblast cells (red, giving rise to the future amnion). iMiGSeq was used to sequence mtDNA in a single blastoid to model the dynamics of mtDNA mutations during human embryogenesis. Credit: © 2023 KAUST; Mo Li A high-throughput single-cell single-mitochondrial genome sequencing technology known as iMiGseq has provided new insights into mutations of mitochondrial DNA (mtDNA) and offers a platform for assessing mtDNA editing strategies and genetic diagnosis of embryos prior to their implantation. The development of a new high-throughput single-cell single-mitochondrial genome sequencing technology, called iMiGseq, has enabled researchers to uncover previously hidden mutations in mitochondrial DNA (mtDNA) that cause maternally inherited diseases. By allowing for complete sequencing of individual mtDNA in single cells, the iMiGseq method has provided a platform for assessing mtDNA editing strategies, genetic diagnosis of embryos prior to implantation, and understanding the links between mtDNA mutations and complex diseases. The technology has also revealed complex patterns of pathogenic mtDNA mutations, including single nucleotide variants and large structural variants, that were undetectable with conventional next-generation sequencing. Additionally, iMiGseq has shown the potential risks of unintended off-target mutations in a mitochondrial genome editing method called mitoTALEN, highlighting the need for more sensitive methods to assess the safety of editing strategies. An international team of researchers, led by KAUST stem cell biologist Mo Li, has now quantitatively depicted the genetic maps of mtDNA in single human oocytes (immature eggs) and blastoids (stem cell-based synthetic embryos).[1] This has revealed molecular features of rare mtDNA mutations that cause maternally inherited diseases. Mitochondria, the “powerhouses” of cells, play a crucial role in cellular communication and metabolism. Human mtDNA is a circular genome containing 37 genes, encoding 13 proteins and a noncoding D-loop region. Heteroplasmic mutations, inherited from egg cells, can cause congenital diseases, like maternally inherited Leigh syndrome, and are associated with late-onset complex diseases. “Next-generation sequencing has been used to sequence mtDNA and implicated heteroplasmic mutations as significant contributors to metabolic disease. Yet the understanding of mtDNA mutations remains limited due to the constraints of traditional sequencing technologies,” says lead author Chongwei Bi. “Our new iMiGseq method is significant because it enables complete sequencing of individual mtDNA in single cells, allowing for unbiased, high-throughput base-resolution analysis of full-length mtDNA,” says Bi. iMiGseq resolves several key questions in the field. Insights into mtDNA Mutations in Disease Models Using third-generation nanopore sequencing technology, the researchers have characterized mtDNA heteroplasmy in single cells and described the genetic features of mtDNA in single oocytes. They have examined mtDNA in induced pluripotent stem cells derived from patients with Leigh syndrome or neuropathy, ataxia or retinitis pigmentosa (NARP). This has revealed complex patterns of pathogenic mtDNA mutations, including single nucleotide variants and large structural variants. “We were able to detect rare mutations with frequencies far below the traditional detection threshold of one percent,” says Mo Li. In another experiment using the new technology, iMiGseq revealed the potential risks of unexpected large increases in the frequency of off-target mutations, known as heteroplasmy, in a mitochondrial genome editing method called mitoTALEN – a genome editing tool that cuts a specific sequence in mitochondrial DNA. It is used to cut a mutation that causes mitochondrial encephalomyopathy and stroke-like episodes syndrome in patient-derived induced pluripotent stem cells. “This highlights the advantages of full-length mtDNA haplotype analysis for understanding mitochondrial DNA heteroplasmy change; other distant mtDNA genetic variants may be unintentionally affected by the editing of a genetically linked disease-relevant mutation and there is a need for ultrasensitive methods to assess the safety of editing strategies,” says Li. Rare Mutations in Human Oocytes and Blastoids The researchers also used iMiGseq to analyze single human oocytes from healthy donors and single human blastoids, synthetic embryos made from stem cells, to identify rare mutations undetectable with conventional next-generation sequencing. These low-level heteroplasmic mutations, potentially inherited through the female germline, are linked to mitochondrial diseases and cancer.[2] The iMiGseq method provides a novel means to accurately depict the complete haplotypes of individual mtDNA in single cells, offering an ideal platform for explaining the cause of mitochondrial mutation-related diseases, evaluating the safety of various mtDNA editing strategies and unraveling the links between mtDNA mutations, aging and the development of complex diseases. References: “Quantitative haplotype-resolved analysis of mitochondrial DNA heteroplasmy in Human single oocytes, blastoids, and pluripotent stem cells” by Chongwei Bi, Lin Wang, Yong Fan, Baolei Yuan, Samhan Alsolami, Yingzi Zhang, Pu-Yao Zhang, Yanyi Huang, Yang Yu, Juan Carlos Izpisua Belmonte and Mo Li, 4 April 2023, Nucleic Acids Research. DOI: 10.1093/nar/gkad209 “Single-cell individual full-length mtDNA sequencing by iMiGseq uncovers unexpected heteroplasmy shifts in mtDNA editing” by Chongwei Bi, Lin Wang, Yong Fan, Baolei Yuan, Gerardo Ramos-Mandujano, Yingzi Zhang, Samhan Alsolami, Xuan Zhou, Jincheng Wang, Yanjiao Shao, Pradeep Reddy, Pu-Yao Zhang, Yanyi Huang, Yang Yu, Juan Carlos Izpisua Belmonte and Mo Li, 31 March 2023, Nucleic Acids Research. DOI: 10.1093/nar/gkad208

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