Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Orthopedic pillow OEM solutions Indonesia

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Orthopedic pillow OEM solutions Thailand

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Indonesia insole OEM manufacturer

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Customized sports insole ODM China

A new study of the extinct fossil ape Lufengpithecus from China offers groundbreaking insights into human bipedalism’s evolutionary origins. By analyzing the semicircular canals of the inner ear, researchers from the IVPP, YICRA, and NYU found evidence of locomotor patterns ancestral to bipedalism. The study highlights the significant role of environmental changes in the evolution of ape and human locomotion, contributing to our understanding of how human bipedalism evolved from a diverse ancestral locomotor repertoire. Credit: Illustration by Xiaocong Guo; image courtesy of Xijun Ni, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences A recent investigation into a 7–8-million-year-old fossil ape from China, called Lufengpithecus, provides new insights into the development of bipedalism in humans. The study, published in The Innovation, was conducted by a team from the Institute of Vertebrate Paleontology and Paleoanthropology (IVPP) of the Chinese Academy of Sciences, the Yunnan Institute of Cultural Relics and Archaeology (YICRA), and New York University (NYU). Humans and our closest relatives, the living apes, display a remarkable diversity of locomotor abilities, from walking upright on two legs to climbing and clambering in trees to walking using all four limbs. Scientists have long been fascinated by the question of how our unique bipedal stance and movement evolved from a quadrupedal (walking on four limbs) ancestor. However, earlier studies of the diverse locomotor repertoires of living apes, as well as evidence from their fossil record, did not allow the reconstruction of a definitive history of the evolution of human bipedalism. Most studies of the evolution of ape locomotion have focused on the bones of the limbs, shoulders, pelvis, and spine (the postcranial skeleton) and their linkages to the range of locomotor behaviors seen in living apes and humans. In contrast, the researchers in this study used a novel approach that focused on studying the inner ear. Novel Approach in Research “The semicircular canals, located in the skull between our brain and the external ear, are critical for our sense of balance and position when we move, and they provide a fundamental component of our locomotion that most people are probably unaware of. The size and shape of the semicircular canals have mathematical correlation with how mammals, including apes and humans, move around their environment. Using modern imaging techniques, we are able to visualize the internal structure of fossil skulls and study the anatomical details of the semicircular canals to reveal how extinct mammals moved,” said Zhang Yinan, first author of the study and an IVPP Ph.D. student. Lufengpithecus was slightly smaller than a chimpanzee and lived during the Miocene Epoch between 6.2 and 12.5 million years ago in what is now Yunnan Province in southwestern China. Lufengpithecus is known from various parts of its skeleton, including several skulls collected by paleontologists at IVPP and YICRA. Severe compression and distortion of these skulls obscured the bony ear region, however, leading previous researchers to believe that the delicate semicircular canals were not preserved. “When we scanned the skulls with our state-of-the-art 3D multiscaling and multimodal imaging system at the IVPP we were quite surprised to see the inner ear and its bony semicircular canals. We used high-resolution digital data to create an accurate virtual reconstruction of the delicate structures of the bony canals. We then compared these scans with those of other living and fossil apes and humans from Asia, Europe, and Africa. Our analyses show that early apes shared a locomotor repertoire that was ancestral to human bipedalism,” said Prof. Ni Xijun of IVPP, project leader and corresponding author of the study. Insights into Ape and Human Locomotion Using the evolutionary tree of apes to analyze and compare the size and shape of the semicircular canals and related features of the inner ear, the researchers identified several key nodes in the evolutionary history of ape locomotion. The locomotor behavior of most fossil apes and their reconstructed ancestral states do not resemble living apes. This means that extinct apes did not move exactly like living apes and humans, and the postcranial skeletons of living apes may not provide the best analogs for reconstructing the locomotion of extinct species. Later, the human lineage diverged from the great apes with the acquisition of bipedalism, as seen in Australopithecus, an early human relative from Africa. The international team also proposed that cooler global temperatures, beginning ~3.2 million years ago, may have been an important environmental catalyst in promoting the locomotor diversification of apes and humans. “Our study points to a three-step evolution of human bipedalism. First, the earliest apes moved in the trees in a style that was most similar to aspects of the way that gibbons in Asia do today. Second, the last common ancestor of apes and humans was similar in its locomotor repertoire to Lufengpithecus, using a combination of climbing and clambering, forelimb suspension, bipedalism, and quadrupedalism. It is from this broad ancestral locomotor repertoire that human bipedalism evolved,” said co-author Prof. Terry Harrison of NYU. The remarkable diversity of locomotor patterns found in fossil apes and their living relatives was an important aspect of their success for millions of years in Eurasia and Africa. A specialized lineage of African apes later developed a unique mode of bipedal locomotion that eventually led to humans. Reference: “Lufengpithecus inner ear provides evidence of a common locomotor repertoire ancestral to human bipedalism” by Yinan Zhang, Xijun Ni, Qiang Li, Thomas Stidham, Dan Lu, Feng Gao, Chi Zhang and Terry Harrison, 14 February 2024, The Innovation. DOI: 10.1016/j.xinn.2024.100580

A Stanford study on mice decision-making reveals that hunger and thirst modulate goals rather than directly influencing choices, highlighting the brain’s role in navigating conflicting needs. Credit: SciTechDaily.com Making choices can be difficult. We often face dilemmas where selecting one option means missing out on another. This concept applies to everyone, including a hungry mouse, where every bit of food matters. But what if the stakes are higher than just picking between tiny food scraps and a piece of cheese? Stanford researchers investigated how mice resolve conflicts between basic needs in a study recently published in the journal Nature. They presented mice that were both hungry and thirsty with equal access to food and water and watched to see what happened next. The behavior of the mice surprised the scientists. Some gravitated first toward water, while others chose food. Then, with seemingly “random” periods of indulgence, they switched back and forth. In their study, PhD candidate Ethan Richman, lead author of the paper, and colleagues in the departments of Biology, Psychiatry and Behavioral Sciences, and Bioengineering explored why. This work builds on years of collaboration between co-senior authors Karl Deisseroth, the D.H. Chen Professor at Stanford Medicine, and Liqun Luo, the Ann and Bill Swindells Professor in the School of Humanities and Sciences, to understand how the brain keeps the body alive. Buridan’s what? “There’s this old philosophical quandary called Buridan’s Ass,” explained Richman, “where you have a donkey that is equally hungry and thirsty and equally far from food and water.” The concept was posited by philosophers Aristotle, Jean Buridan, and Baruch Spinoza, in different forms. The question was whether the donkey would choose one need over the other or remain stubbornly in the middle. But animals are constantly making choices. We must satisfy our needs to maintain homeostasis. Richman and colleagues wanted to know how the brain directs traffic through conflicting signals to flout Buridan. They call their behavioral experiment “Buridan’s Assay.” If hunger or thirst directly motivated a mouse to eat or drink, it would switch as soon as one need outweighed the other. When needs were equal, the mouse would be stuck. This is not what the researchers observed. “Our data indicate that thirst and hunger don’t act as direct forces on behavior,” said Richman. “Instead, they modulate behavior more indirectly. They’re influencing what we think of as the current goal of the mouse.” A mouse’s goal We often think of choices as a decisive moment. The researchers wanted to understand when and where choices between food and water originate in the brain. Using recent advances in recording technology, they monitored activity from individual neurons spread across the mouse brain. To their surprise, neuron activity patterns throughout the brain predicted the mouse’s choice, even before it was presented with options. “Instead of a single moment of choice, the mouse’s brain is constantly broadcasting its current goal,” said Richman. “Outcomes of the hardest choices you make – when options are closely balanced in importance, but the categories are fundamentally different – may have to do with the state your brain happened to be in, even before the choice was presented,” said Deisseroth. “That’s an interesting outcome and it helps us understand aspects of human behavior better.” Exploring the random The researchers found that hungry and thirsty mice often make the same choice repeatedly before suddenly switching. “In eating mode, the mouse will just eat and eat. In drinking mode, it will drink and drink,” said Luo. “But there is an aspect of randomness that causes them to switch between these two. That way, in the long run, they fulfill both needs, even if at any given time they are only choosing one.” To test this apparent randomness, the researchers ran another experiment, this time with hungry mice. As the mice ate, scientists introduced thirst through a technique called optogenetics. With optogenetics, they used light to activate neurons causing thirst. Sometimes the mice switched to water, and sometimes they ignored it and kept eating. The level of thirst was the same each time, leading the researchers to conclude there is a key randomness influencing the mouse’s goal. The scientists were perplexed by the interplay between this randomness and the relative intensities of hunger and thirst. To better understand it, they turned to mathematical modeling. Inspired by a conceptual resemblance between their results and a distant field of physics, the researchers borrowed, tweaked, and simulated several equations. “We were extremely surprised and excited to find that a few simple equations from a seemingly unrelated discipline could closely predict aspects of mouse behavior and brain activity,” said Richman. The results of their modeling suggested that the brain activity relating to the mouse’s goal is constantly in motion. It gets trapped by needs like hunger and thirst. To escape and transition from one goal to another, the mouse relies on a lucky series of random activity. This work establishes the importance of the brain’s shifting baseline state when it comes to decision-making. In the future, the researchers will explore what sets the tone and why decisions don’t always make sense. Beyond Buridan “In terms of Buridan’s Ass, we can say that the donkey’s mind is made up before it is given a choice,” says Richman, “and if it has to wait, then its choice may spontaneously switch.” Clinical applications for this work in the human context are a bit more complex. “As a psychiatrist, I often think about how we make healthy (adaptive) or harmful (maladaptive) decisions,” said Deisseroth. (Maladaptive behaviors impact people’s ability to make decisions in their best interest and they are common in psychiatric disorders.) “It’s very hard for family and friends to see loved ones act against their own survival drives. It may help to understand the choices made as reflecting the underlying dynamical landscape of the patient’s brain, affected by the disorder more than by the patient’s conscious volition.” Although this work might not explain human behavior, it begins to reveal an important framework for decision-making. “This is basic discovery science that depends on pretty advanced neuro-engineering, but at the core, we address universal questions that people think about and experience all the time,” said Deisseroth. “It’s exciting to develop and apply modern tools to address these very old, deep, and personal questions.” Reference: “Neural landscape diffusion resolves conflicts between needs across time” by Ethan B. Richman, Nicole Ticea, William E. Allen, Karl Deisseroth and Liqun Luo, 8 November 2023, Nature. DOI: 10.1038/s41586-023-06715-z This work was funded by the National Science Foundation, the National Institutes of Health, and the Gatsby Foundation.

Research using fruit flies has revealed activin signaling as a key mechanism in gut plasticity, influencing its ability to shrink and expand in response to nutrient availability. This finding has implications for understanding organ adaptation and opens new pathways for exploring treatments for colorectal cancer linked to activin signaling disruptions. One of the most striking examples of gut plasticity can be observed in animals that are exposed to prolonged periods of fasting, such as hibernating animals or phyton snakes that goes for months without eating, where the gut shrinks with as much as 50%, but recovers in size following a few days of re-feeding. Importantly, the capacity of the gut to undergo resizing is broadly conserved. Hence, in humans, an increase in gut size is observed during pregnancy, which facilitates the uptake of nutrients to support the growth of the fetus. The Colombani Andersen lab at the section of Cell & Neurobiology, Department of Biology, University of Copenhagen uses the fruit fly, Drosophila, to study the mechanisms that regulate gut plasticity. The results have just been published in the scientific journal Nature Communications. “Taking advantage of the broad genetic toolbox available in the fruit fly, we have investigated the mechanisms underpinning nutrient-dependent gut resizing,” says Dr. Ditte S. Andersen. Mechanisms of Gut Resizing Discovered The results show that nutrient deprivation results in an accumulation of progenitor cells that fail to differentiate into the mature cells causing the gut to shrink. Upon refeeding these stalled progenitor cells readily differentiate into mature cells to promote regrowth of the gut. Ditte S. Andersen continues: “We have identified activins as critical regulators of this process. In nutrient-restrictive conditions, activin signaling is strongly repressed, while it is reactivated and required for progenitor maturation and gut resizing in response to refeeding. Activin-dependent resizing of the gut is physiologically important as inhibition of activin signaling reduces survival of flies to intermittent fasting.” Regulators of organ plasticity are essential for host adaptation to an ever-changing environment, however, the same signals are often deregulated in cancers. Indeed, mutations affecting activin signaling are frequent in cancer cells in a variety of tissues. Our study provides a starting point for investigating the link between aberrant activin signaling and the development of colorectal cancers and sets the stage for exploring the efficiency of anti-activin therapeutic ­strategies in treating colorectal cancers. Reference: “Drosophila activins adapt gut size to food intake and promote regenerative growth” by Christian F. Christensen, Quentin Laurichesse, Rihab Loudhaief, Julien Colombani and Ditte S. Andersen, 4 January 2024, Nature Communications. DOI: 10.1038/s41467-023-44553-9

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