Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

🔗 Learn more or get in touch:
🌐 Website: https://www.deryou-tw.com/
📧 Email: shela.a9119@msa.hinet.net
📘 Facebook: facebook.com/deryou.tw
📷 Instagram: instagram.com/deryou.tw

China graphene sports insole ODM

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Thailand OEM/ODM hybrid insole services

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Taiwan graphene sports insole ODM

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Custom foam pillow OEM production factory in Taiwan

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Thailand graphene product OEM service

Illustration of human cancer cells. Have you ever wondered, what makes a cell become a cancer cell instead of normal tissue? Was it because of exposure to UV light or from smoking? Scientists at Yale University were wondering the same thing. They used a new molecular analysis to quantify how much specific genetic mutations contributed to the development of different cancers. They combined this with previous knowledge of the factors that can cause specific mutations that alter the genome in tissues. They are therefore able to assign a specific percentage of the blame to various factors in causing cancer to emerge. It isn’t just useful for people curious as to what caused their cancer to develop, it can also be used for public health benefits such as minimizing exposure to significant factors that can be prevented and quickly discovering new sources of cancer. Quantifying Factors Behind Cancer Growth A team of researchers led by Yale University scientists can now quantify the factors causing changes in the DNA that contribute most to cancer growth in tumors of most major tumor types. In a new paper published in the journal Molecular Biology and Evolution, they say that their new molecular analysis approach clarifies a long-standing debate about how much control humans have over cancer development over time. Looking at the instances of specific genetic mutations can reveal the extent to which preventable exposures like ultraviolet light caused tumor growth in 24 cancers, said Jeffrey Townsend, Ph.D., the Elihu Professor of Biostatistics in the Department of Biostatistics at Yale School of Public Health (YSPH). “We can now answer the question — to the best of our knowledge — ‘What is the underlying source of the key mutations that changed those cells to become a cancer instead of remaining normal tissue?’” he said. Some of the most common cancers in the United States are known to be highly preventable by human decisions. Skin cancers, such as melanoma, emerge in large part because of prolonged exposure to ultraviolet light, and lung cancers can often be traced back to tobacco use. But scientists have long struggled to gauge how much any individual’s tumor developed as a result of preventable actions versus aging or “chance.” Previously, scientists have demonstrated that they can reliably predict how certain factors cause specific mutations that alter the genome in tissues. By combining this knowledge with their method that quantifies the contribution of each mutation to cancer, Townsend and his colleagues showed the specific percentage of the blame to be assigned to known and unknown but identified factors in the emergence of cancer. Identifying Cancer Causes at a Personal Level “That gives us the last puzzle piece to connect what happened to your genome with cancer,” he explained. “This is really direct: We look in your tumor, and we see the signal written in your tumor of what caused that cancer.” They write in their report that some cancers are more controllable than others. “We can now answer the question — to the best of our knowledge — ‘What is the underlying source of the key mutations that changed those cells to become a cancer instead of remaining normal tissue?’” Jeffrey Townsend, Ph.D., Elihu Professor of Biostatistics and Professor of Ecology and Evolutionary Biology For example, preventable factors account for a large part of the formation of tumors of the bladder and skin. However, they found that prostate cancers and gliomas are largely attributable to internal age-associated processes. Local populations or professions who suffer from inordinately high levels of cancer may also be able to use the findings to discover instances of exposure to carcinogenic substances, Townsend suggested. The idea seems promising, he said, because capturing the proportion of factors could potentially expose the underlying causes which led to tumor growth. “It can be useful in terms of giving people feedback that lets them know what the causes of their cancer are,” he said. “Not everyone may wish to know. But on a personal level, it may be helpful to people to attribute their cancer to its cause.” Implications for Public Health and Future Research Not all genetic changes that lead to tumors are incorporated into the current approach, so that more research is needed to fully understand complex genetic changes like duplicated genes or chromosomes. Scientists continue to discover new factors that also lead to tumor growth, so Townsend cautioned that its current approaches do not provide a “complete accounting.” And his team’s method remains untried on many less-frequent cancers that the group has not yet studied. Still, the findings could help public health officials to quickly recognize sources of cancer before they lead to more tumors, thereby saving lives. “Public health intervention targeted at minimizing exposure to these preventable signatures would mitigate disease severity by preventing the accumulation of mutations that directly contribute to the cancer phenotype,” the researchers wrote in the study. Reference: “Attribution of cancer origins to endogenous, exogenous, and preventable mutational processes” by Vincent L. Cannataro, Jeffrey D. Mandell and Jeffrey P. Townsend, 26 April 2022, Molecular Biology and Evolution. DOI: 10.1093/molbev/msac084 Co-researcher Jeffrey Mandell works at the Yale Department of Computational and Biology Informatics as a Ph.D. student. Vincent Cannataro, the study’s first author, is an assistant professor of biology at Emmanuel College.

RNA Polymerase II. NIGMS-funded researchers led by Roger Kornberg solved the structure of RNA polymerase II. This is the enzyme in mammalian cells that catalyzes the transcription of DNA into messenger RNA, the molecule that in turn dictates the order of amino acids in proteins. For his work on the mechanisms of mammalian transcription, Kornberg received the Nobel Prize in Chemistry in 2006. Credit: David Bushnell, Ken Westover and Roger Kornberg, Stanford University Researchers have found an ancient protein fold that might explain how life’s basic building blocks became the complex systems we see today. This long-lost structure could help solve mysteries about early life and evolution. Discovery of a Lost Protein Fold Two RIKEN biologists have uncovered a previously unknown protein fold through lab experiments, offering fresh insights into the early evolution of life on Earth. This protein fold, completely absent in modern proteins, could fill a critical gap in our understanding of molecular evolution. Proteins that drive essential biological processes, such as gene expression and protein production, rely on various structural folds called β-barrel folds. However, the evolutionary pathways connecting these folds have remained unclear—until now. Through simulations, the researchers identified a likely ancient folding topology, named the double-zeta β-barrel (DZBB). This discovery sheds light on how complex biomolecular machines may have evolved from simpler precursors, offering a new perspective on the origins of life’s molecular complexity. Insights Into Protein Evolution “The discovery of this missing-link protein fold helps us understand the evolutionary relationship between many different proteins in a much simpler way than we had expected,” explains Shunsuke Tagami of the RIKEN Center for Biosystems Dynamics Research (BDR). DZBB resembles a compact cylinder made up of interlocking protein strands. The ancient, origami-like structure can transform into other key protein shapes with just a few tweaks, Tagami and BDR colleague Sota Yagi found. These DZBB assemblies serve as a versatile foundation for molecular evolution. Using synthetic biology techniques in the lab, the pair traced the progression of these ancient protein folds. They started with a fold found in DNA and RNA polymerases—enzymes responsible for genome replication and gene transcription. And they showed that, through simple and feasible mutation steps, they might have evolved into the folds found in modern ribosomal proteins, which are essential for synthesizing proteins in cells. Shunsuke Tagami (left), with colleague Sota Yagi (right), has discovered an ancient protein fold that offers insights into early molecular evolution and protein diversity. Credit: © 2024 RIKEN Challenges of AI in Protein Research This evolutionary progression required an intermediary structure, DZBB, which could only be uncovered experimentally—it couldn’t be predicted through computational methods, even using the latest machine-learning algorithms. This underscores the limitations of current artificial intelligence (AI) models in identifying such complex protein structures. “Because AI gives answers strongly influenced by the training dataset, experimental validation remains essential to make truly unexpected discoveries,” says Tagami. Implications of the DZBB Discovery The results may help solve a long-standing mystery about how primordial proteins evolved to manage genetic processes. DZBB’s metamorphic nature, which allows it to adopt multiple stable forms under different conditions, may have allowed molecular machinery in early life to rapidly diversify—much like animal species during the Cambrian explosion. The findings also raise an intriguing question: if DZBB was so critical to enabling the rise of molecular machines that govern the flow of genetic information within cells, then why is the folding topology no longer seen today? “DZBB may have been a temporary protein form that existed only during an evolutionary transition between ancient simple forms,” says Tagami. Reference: “An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins” by Sota Yagi, and Shunsuke Tagami, 18 July 2024, Nature Communications. DOI: 10.1038/s41467-024-50013-9

Researchers analyzed zinc isotopes in teeth and discovered that great white sharks make have contributed to the extinction of megalodon. Scientists investigated the diet of megalodon, the largest shark to have ever lived, using zinc isotopes. In a new study, researchers compared how high up the food chain megalodon and great white sharks feed, by analyzing the zinc stable isotope ratios in their teeth. They found that there was likely overlap in the prey of both species, and therefore, dietary competition with great white sharks may have contributed to the extinction of megalodon. Megatooth sharks like, Otodus megalodon, more commonly known as megalodon, lived between 23 and 3.6 million years ago in oceans around the globe and possibly reached as large as 20 meters (66 feet) in length. For comparison, the largest great white sharks today reach a total length of only six meters (20 feet). Many factors have been discussed to explain the gigantism and extinction of megalodon, with its diet and dietary competition often being thought of as key factors. In this study, researchers analyzed zinc stable isotope ratios in modern and fossil shark teeth from around the globe, including teeth of megalodon and modern and fossil great white sharks. This new method allows scientists to investigate an animal’s trophic level, which indicates how far up the food chain an animal feeds. Zinc stable isotope analysis of tooth enameloid, the highly mineralized part of teeth, is comparable to much more established nitrogen isotope analysis of tooth collagen, the organic tissue in tooth dentine, which is used to assess the degree of animal matter consumption. However, “on the timescales we investigate, collagen is not preserved, and traditional nitrogen isotope analysis is therefore not possible,” explains lead author Jeremy McCormack, a researcher at the Max Planck Institute for Evolutionary Anthropology and the Goethe-University Frankfurt. “Here, we demonstrate, for the first time, that diet-related zinc isotope signatures are preserved in the highly mineralized enameloid crown of fossil shark teeth,” adds Thomas Tütken, professor at the Johannes Gutenberg University’s Institute of Geosciences. Tooth size comparison between extinct Early Pliocene Otodus megalodon tooth and a modern great white shark. Credit: © MPI for Evolutionary Anthropology Comparison of Zinc Isotope Signals in Fossil and Modern Sharks Using this new method, the team compared the tooth zinc isotope signature of multiple extinct Early Miocene (20.4 to 16.0 million years ago) and Early Pliocene (5.3 to 3.6 million years ago) species with those of modern sharks. “We noticed a coherence of zinc isotope signals in fossil and modern analog taxa, which boosts our confidence in the method and suggests that there may be minimal differences in zinc isotope values at the base of marine food webs, a confounding factor for nitrogen isotope studies,” explains Sora Kim, a professor from the University of California Merced. Subsequently, the researchers analyzed the zinc isotope ratios in megalodon teeth from the Early Pliocene and those in earlier megatooth sharks, Otodus chubutensis, from the Early Miocene as well as contemporaneous and modern great white sharks to investigate the impact these iconic species had on past ecosystems and each other. “Our results show, that both megalodon and its ancestor were indeed apex predators, feeding high up their respective food chains,” says Michael Griffiths, professor at the William Paterson University. “But what was truly remarkable is that zinc isotope values from Early Pliocene shark teeth from North Carolina, suggest largely overlapping trophic levels of early great white sharks with the much larger megalodon.” Lead author Jeremy McCormack isolating zinc from shark tooth samples by column chromatography in metal-free clean laboratory. Credit: © MPI for Evolutionary Anthropology Dietary Competition of Megalodon With Great White Sharks “These results likely imply at least some overlap in prey hunted by both shark species,” notes Kenshu Shimada, professor at DePaul University, Chicago. “While additional research is needed, our results appear to support the possibility for dietary competition of megalodon with Early Pliocene great white sharks.” New isotope methods such as zinc provide a unique window into the past. “Our research illustrates the feasibility of using zinc isotopes to investigate the diet and trophic ecology of extinct animals over millions of years, a method that can also be applied to other groups of fossil animals including our own ancestors,” concludes McCormack. Reference: “Trophic position of Otodus megalodon and great white sharks through time revealed by zinc isotopes” by Jeremy McCormack, Michael L. Griffiths, Sora L. Kim, Kenshu Shimada, Molly Karnes, Harry Maisch, Sarah Pederzani, Nicolas Bourgon, Klervia Jaouen, Martin A. Becker, Niels Jöns, Guy Sisma-Ventura, Nicolas Straube, Jürgen Pollerspöck, Jean-Jacques Hublin, Robert A. Eagle and Thomas Tütken, 31 May 2022, Nature Communications. DOI: 10.1038/s41467-022-30528-9

DVDV1551RTWW78V