Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan pillow ODM development factory

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.China eco-friendly graphene material processing

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Latex pillow OEM production in Thailand

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Orthopedic pillow OEM solutions Thailand

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Vietnam custom neck pillow ODM

Manipulating astrocytes’ acidity in mice influences memory retention, with acidification impairing and alkalinization preserving long-term memories, offering insights into memory treatment approaches. Tohoku University’s study reveals that manipulating astrocytes in mice’s brains impacts memory retention. Acidifying astrocytes hinders long-term memories, whereas alkalinizing them preserves these memories, indicating a possible method for treating memory-related disorders. One of the brain’s most remarkable capabilities is its ability to store information as memories, enabling us to learn from past mistakes. While some memories remain clear and vivid, others fade away. Unlike computers, which save data uniformly, our brains selectively retain only those memories deemed significant. Researchers at Tohoku University have discovered that astrocytes, a special type of cell that surrounds neurons in the brain, play a crucial role in this memory selection process. Their experiments showed that artificially acidifying astrocytes does not affect short-term memory but does prevent the long-term retention of memories. The findings were detailed in the journal GLIA. Glial manipulation interferes with the long-term consolidation of fear memories. By artificially manipulating the state of astrocytes, it may become possible to prevent the long-term consolidation of unpleasant memories that could lead to trauma. Credit: ©Hiroki Yamao, Ko Matsui Optogenetics and Memory Experiments in Mice The researchers implemented a technique called “optogenetics” to manipulate the astrocytes by shining light onto them through optical fibers inserted in the mice’s brains. This enabled researchers to directly stimulate and either acidify or alkalinize the astrocytes in that area. They focused on the functions of astrocytes in the amygdala, a brain region known to be crucial for regulating emotion and fear. Selective suppression of long-term memory formation through ChR2 photoactivation of amygdala astrocytes. The experiments suggest the presence of parallel processes governing short-term and long-term memory formation, respectively. Credit: ©Hiroki Yamao, Ko Matsui A mild electrical shock was delivered to mice in an experiment chamber. When placed back in the same chamber, the mice remembered the shock and froze as a natural response. In comparison, the mice who had their astrocytes acidified immediately after the mild shock were able to hold onto the fear memory temporarily, but they forgot it by the next day. This shows that acidifying the astrocytes did not affect short-term memory but prevented the memories from being remembered long-term. Mice inherently possess a selective filtering mechanism that enhances the memory of intense experiences; however, this filtering function was inhibited by ArchT photoactivation of astrocytes in the amygdala. Additionally, the natural forgetting process over three weeks was suppressed by the light stimulation of ArchT-expressing astrocytes. Credit: ©Hiroki Yamao, Ko Matsui Implications for Memory Formation and PTSD Treatment A different effect was seen for mice who had their astrocytes alkalinized. When tested three weeks later, control mice typically showed signs of forgetting, demonstrated by a decrease in freezing responses. However, mice whose astrocytes were alkalinized immediately after a strong shock still displayed strong fear responses even after three weeks. This suggests that astrocytes play a key role in determining whether memories are erased or preserved for a long time, immediately after a traumatic event. While it is generally believed that memories are formed in a continuous process whereby short-term memories gradually solidify and become long-term memories, this research suggests they may actually develop in parallel. “We believe that this could change the way we understand memory formation,” says Professor Ko Matsui of the Super-network Brain Physiology lab at Tohoku University, who led the research. He added, “The effect of astrocytes on memory likely also depends on various contexts, including mental, social, or environmental factors.” Astrocytes are capable of triggering fear. Astrocyte ChR2 photoactivation alone induced freezing responses akin to those observed after receiving an electric foot shock. In contrast, astrocyte ArchT photoactivation suppressed the freezing responses following a footshock. Credit: ©Hiroki Yamao, Ko Matsui Lead investigator Hiroki Yamao believes astrocytes could hold the key to understanding emotional changes and memory formation. “This may be just a glimpse of how astrocytes affect emotional information processing,” Yamao explains. “Our next goal is to uncover the mechanisms by which astrocytes regulate emotional memory. Understanding these processes could pave the way for therapies that prevent traumatic memories from forming, offering a valuable approach to treating disorders like post-traumatic stress disorder (PTSD) by intervening in memory formation.” Reference: “Astrocytic determinant of the fate of long-term memory” by Hiroki Yamao and Ko Matsui, 04 November 2024, Glia. DOI: 10.1002/glia.24636

Researchers at the University of Montana uncovered genetic traits that help highland mice maintain healthy pregnancies at high altitudes, hinting at evolutionary strategies against hypoxia-related complications and opening avenues for human medical advancements. Researchers found that highland deer mice have genetic adaptations that protect fetal growth in low-oxygen conditions. The findings could help develop treatments for pregnancy complications in humans. Pregnancy at elevated altitudes often leads to low birth weights and various complications. These issues are seen across a broad spectrum of mammals, from deer mice to humans. A study from the University of Montana has uncovered genetic factors that enable specific highland mouse communities to protect their developing fetuses in these higher terrains. The research was recently published in the Proceedings of the National Academy of Sciences. Evolutionary Adaptations to Hypoxia “Understanding how deer mice survive and thrive at high elevations not only informs our understanding of basic evolutionary processes, it may also one day provide clues for treating a range of related disorders in humans,” said Zac Cheviron, a UM researcher and biology associate professor. The work was led by Kate Wilsterman, a UM postdoctoral researcher who has since joined the faculty of Colorado State University. Cheviron, UM biology Professor Jeff Good, and former UM postdoctoral researcher Rena Schweizer were her chief collaborators in Montana. Researchers (left to right) Rena Schweizer, Zac Cheviron, and Jeff Good, shown here in a University of Montana lab, studied how deer mice protect developing fetuses at higher elevations. Credit: UM photo by Ridley Hudson Their research shows that fetal growth is adversely affected by decreased oxygen at high elevations in mice that are native to low elevations. Mice native to high elevations, however, have genetic differences that provide placental modifications that protect fetuses from hypoxia, which is a lack of oxygen to the fetus. This pattern is similar to that observed in humans, such as people of Tibetan or Andean ancestry. These human populations also protect fetal growth at high elevations, but researchers have little understanding of how it is achieved. Cheviron said one of the most exciting aspects of their work was the discovery that many genes that seem to target fetal growth in their study species – highland deer mice – also have been associated with placental physiology in people. Genetic Clues for Human Pregnancy Complications “This suggests that the genetic and physiological mechanisms that underlie healthy pregnancies at high elevation may have deep evolutionary roots,” he said. “We might be able to use this insight to develop new treatments to improve pregnancy outcomes in humans.” During the study, lowland mice experienced stunted fetal growth in hypoxia conditions, but highland mice avoided negative effects by altering their placentas. Potential Applications for Human Medicine “If we can understand how deer mice have ‘solved’ the problem of hypoxia for fetal growth,” Wilsterman said, “we may eventually be able to identify targets for treatment development in humans or be in a better position to identify where things are going wrong in gestational diseases that involve hypoxia.” She said future studies will examine the tissue-level changes they discovered among deer mice. They also hope to identify the genetic variants that contribute to how specific cell types respond to hypoxia. Reference: “Adaptive structural and functional evolution of the placenta protects fetal growth in high-elevation deer mice” by Kathryn Wilsterman, Emily C. Moore, Rena M. Schweizer, Kirksey Cunningham, Jeffrey M. Good and Zachary A. Cheviron, 12 June 2023, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2218049120

This scanning electron microscopy image captures the moment where degranulating mast cells (pseudo-colored in sepia) attract and start to incorporate living neutrophils (pseudo-colored in cyan), forming cell-in-cell structures where mast cells trap living neutrophils inside them. Credit: Marcus Frank & Karoline Schulz, Universitätsmedizin Rostock, Germany Researchers have discovered a surprising interaction between mast cells and neutrophils in allergic reactions, using specialized microscopy. Mast cells can trap and engulf neutrophils, creating a cell-in-cell structure known as “mast cell intracellular trap” (MIT). This interaction boosts mast cell function and could lead to new approaches for treating allergies and inflammatory diseases. The findings also highlight the intricate relationships among immune cells and their roles in inflammation and immune defense. Understanding Inflammation: Body’s Protective Response Inflammation is the body’s response to harmful stimuli, characterized by heat, pain, redness, swelling, and loss of tissue function. When balanced, inflammation protects the body by clearing harmful agents and initiating tissue repair. However, excessive inflammation can cause tissue destruction and disease. Key players in this process are various immune cells, which work together during inflammation. The type of immune cells involved often varies depending on the harmful stimulus, influencing the outcome of the inflammatory response. Immune Cell Trapping During Allergic Responses Mast cells, residing in tissues and critical for initiating inflammation, are filled with granules containing pro-inflammatory substances. These granules are released upon encountering potential dangers, including allergens, causing allergic reactions. In many people, mast cells also react to seemingly harmless environmental factors, which then act as allergens and cause allergies. The interaction between mast cells and other immune cells at sites of allergic responses has been largely unexplored. A research group at the Max Planck Institute of Immunobiology and Epigenetics used specialized microscopy to visualize the real-time dynamics of activated mast cells and other cell types during allergic reactions in living mouse tissues. Led by Tim Lämmermann, since October 2023 Director at the Institute of Medical Biochemistry at the University of Münster, the team discovered a surprising interaction: neutrophils were found inside mast cells. “We could hardly believe our eyes: living neutrophils were sitting inside living mast cells. This phenomenon was completely unexpected and probably would not have been discovered in experiments outside a living organism and highlights the power of intravital microscopy,” says Tim Lämmermann. Pulling a Neutrophil Trick To Trap Neutrophils Neutrophils are frontline defenders of our immune system, responding quickly and broadly to potential threats. They circulate in the blood and quickly exit blood vessels at sites of inflammation. They are well-equipped to combat invaders such as bacteria or fungi by engulfing the invaders, releasing antimicrobial substances, or forming web-like traps known as “neutrophil extracellular traps.” Additionally, neutrophils can communicate with each other and form cell swarms to combine their individual functions for the protection of healthy tissue. While much is known about neutrophils’ role in infections and sterile injuries, their role in inflammation caused by allergic reactions is less understood. “It quickly became clear that the double-pack immune cells were no mere coincidence. We wanted to understand how mast cells trap their colleagues and why they do it,” explains Michael Mihlan, first and co-corresponding author of the study published today (August 2) in the journal Cell. Once the team was able to mimic the neutrophil trapping observed in living tissue in cell culture, they we were able to identify the molecular pathways involved in this process. The researchers found that mast cells release leukotriene B4, a substance commonly used by neutrophils to initiate their own swarming behavior. By secreting this substance, mast cells attract neutrophils. Once the neutrophils are close enough, mast cells engulf them into a vacuole, forming a cell-in-cell structure that the researchers refer to as a “mast cell intracellular trap” (MIT). “It is ironic that neutrophils, which create web-like traps made of DNA and histones to capture microbes during infections, are now trapped themselves by mast cells under allergic conditions,” says Tim Lämmermann. Advancing Our Understanding of Inflammatory and Allergic Reactions With the help of an international team, the researchers confirmed the formation of MITs in human samples and investigated the fate of the two cell types involved after trapping. They found that trapped neutrophils eventually die, and their remains get stored inside mast cells “This is where the story takes an unexpected turn. Mast cells can recycle the material from the neutrophils to boost their own function and metabolism. In addition, mast cells can release the newly acquired neutrophil components in a delayed manner, triggering additional immune responses and helping to sustain inflammation and immune defense,” says Michael Mihlan. “This new understanding of how mast cells and neutrophils work together adds a whole new layer to our knowledge of allergic reactions and inflammation. It shows that mast cells can use neutrophils to boost their own capabilities – an aspect that could have implications for chronic allergic conditions where inflammation occurs repeatedly,” says Tim Lämmermann. The researchers have already begun investigating this interaction in mast cell-mediated inflammatory diseases in humans, exploring whether this discovery could lead to new approaches to treating allergies and inflammatory diseases. Reference: “Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay” by Michael Mihlan, Stefanie Wissmann, Alina Gavrilov, Lukas Kaltenbach, Marie Britz, Kristin Franke, Barbara Hummel, Andrea Imle, Ryo Suzuki, Manuel Stecher, Katharina M. Glaser, Axel Lorentz, Peter Carmeliet, Takehiko Yokomizo, Ingo Hilgendorf, Ritwick Sawarkar, Alba Diz-Muñoz, Joerg M. Buescher, Gerhard Mittler, Marcus Maurer, Karoline Krause, Magda Babina, Luise Erpenbeck, Marcus Frank, Angelika S. Rambold and Tim Lämmermann, 2 August 2024, Cell. DOI: 10.1016/j.cell.2024.07.014

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