Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Graphene cushion OEM production factory in Taiwan

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Innovative insole ODM solutions in Vietnam

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Vietnam sustainable material ODM solutions

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan neck support pillow OEM

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.ODM pillow factory in Vietnam

The study found that feeding history affects synapses on dopamine neurons as well as dopamine release. The findings imply that young individuals may suffer long-term consequences, particularly in terms of cognitive flexibility. Few studies have examined the impact that feast or famine has on the developing brain in isolation from other variables that contribute to adversity, despite the fact that food insecurity is an issue for a rising proportion of the American population, made much worse by the coronavirus pandemic. University of California, Berkeley researchers have simulated the impacts of food insecurity on young mice and discovered long-lasting changes later in life. “We show that irregular access to food in the late juvenile and early adolescent period affects learning, decision-making, and dopamine neurons in adulthood,” said Linda Wilbrecht, UC Berkeley professor of psychology and member of the Helen Wills Neuroscience Institute. Cognitive Flexibility and Learning Affected by Food Access One key behavioral difference involved cognitive flexibility: the ability to generate new solutions when the world changes. “Mice searching for rewards might be inflexible, sticking to only one strategy even when it no longer yields a reward, or they might be flexible and quickly try out new strategies. We found that the stability of the food supply mice had when they were young governed how flexible they were under different conditions when they were grown up,” she said. Epidemiological studies have connected childhood and teenage food insecurity to later-life weight gain, as well as learning difficulties and worse math, reading, and vocabulary scores. However, other poverty-related factors, such as maternal depression and environmental stressors, confound these studies. The new research was designed to investigate the developmental and behavioral effects of food insecurity in a controlled environment that would not be achievable with human subjects. Real-World Implications for Food Programs and Nutrition The findings have ramifications for humans. Policymakers recognize the need for good nutrition from infancy through high school, with federally supported free or reduced-price breakfast and lunch programs offered in schools around the country. The federal Supplemental Nutrition Assistance Program (SNAP) also offers subsidies to help poor families supplement their food budgets. These meal programs have shown effects on low-income families, particularly improved academic performance and graduation rates. But there may be times when kids cannot access food programs, such as during summer vacation. Programs may also inadvertently create a feast and famine cycle when benefits are distributed with weeks between payments, potentially leaving impoverished families unable to afford food at the end of each payment cycle. According to a recent report from the U.S. Department of Agriculture, 6.2% of households with children — 2.3 million households total — were food insecure in 2021. “I think that we have to understand that even transient food insecurity matters, the brain doesn’t just catch up later. Food insecurity can have long-term impacts on how someone’s brain functions,” Wilbrecht said. “The ability to learn and make decisions is something that’s developing during childhood and adolescence, and we are seeing how these critical skills are impacted by access to food. Access to food is something that we can address in this county. Feeding and benefits programs exist, and we can make them better by making access to benefits or food more reliable and consistent. Supporting brain development is a good reason to support food programs.” The research, conducted with UC Berkeley faculty members Helen Bateup, Stephan Lammel, and their lab colleagues, was recently published in the journal Current Biology. Flexibility Under Changing Rules Wilbrecht and her colleagues, including Robert Wood Johnson Foundation Health and Society Scholar Ezequiel Galarce, mimicked human food insecurity in mice by delivering food on an irregular schedule while still allowing enough food to maintain a safe body weight. This food regimen began a week before puberty onset in mice, equivalent to late childhood in humans, and continued for 20 days through the equivalent of late teen ages in mice. Another group of mice was offered food whenever they wanted it. They then tested cognition in adulthood using foraging tasks where mice searched a changing environment for rewards. For example, a behavior — in this case, learning which odor led to the Honey Nut Cheerios — might be successful for a short time, but not forever. A second odor now predicted where the reward was hidden. The well-fed and food-insecure mice were tested as adults in both certain and uncertain settings, with noticeable differences in cognitive flexibility. Food-insecure mice were more flexible in uncertain situations than well-fed mice, while well-fed mice were more flexible in more stable situations. “You would have to test in the field to see how these different flexibility profiles affect survival,” she said. “The findings are nuanced, but hopeful because we identify both gain and loss of function in learning and decision-making that are wrought by the experience of scarcity.” While the effect of food insecurity on cognition in male mice was robust, female mice showed no effect on cognition. “This is one of the most robust behavioral effects we’ve ever seen when we’ve been modeling adversity,” Wilbrecht said. Food insecurity had other decidedly negative effects in female mice, however. Those females who were food insecure when growing up tended to become overweight when given unrestricted food in adulthood, something mirrored in humans who’ve grown up with food insecurity. Male mice showed no such effect. Neurological Changes in the Brain’s Reward System Doctoral student Wan Chen Lin and researchers in the Bateup and Lammel labs also looked at the brain’s reward network, which is governed by the neurotransmitter dopamine, and found changes there, as well, in male mice. “We found that the neurons in the dopamine system, which is critical for learning, decision-making, and reward-related behaviors, like addiction, were significantly altered in both their inputs and their outputs,” Wilbrecht said. “It suggests there are more broadscale changes in the learning and decision-making systems in the brain.” For example, the researchers saw changes in the synapses of dopamine neurons that project to the nucleus accumbens and also found changes in dopamine release in the dorsal striatum. These dopamine neurons have been shown to play a role in learning and decision-making in numerous other studies. The researchers are continuing their studies of food-insecure mice to determine if they are more susceptible as adults to addictive behaviors, which are associated with the dopamine network. Reference: “Transient food insecurity during the juvenile-adolescent period affects adult weight, cognitive flexibility, and dopamine neurobiology” by Wan Chen Lin, Christine Liu, Polina Kosillo, Lung-Hao Tai, Ezequiel Galarce, Helen S. Bateup, Stephan Lammel and Linda Wilbrecht, 20 July 2022, Current Biology. DOI: 10.1016/j.cub.2022.06.089 The study was funded by the National Institutes of Health and the Robert Wood Johnson Foundation. Bateup is a Chan Zuckerberg Biohub investigator and a Weill Neurohub investigator.

A groundbreaking study analyzing ancient DNA has revealed instances of Down and Edwards syndrome in prehistoric human remains, dating back as far as 4,500 years. This research indicates that individuals with these conditions were valued and integrated members of their ancient societies, offering new insights into the treatment and recognition of chromosomal disorders in history. Above are the remains of individual “CRU001”, who the researchers discovered had Down syndrome. The remains were found at a site in Spain dating to the Iron Age. Credit: Photograph from the Government of Navarre and J.L. Larrion. By analyzing ancient DNA, an international team of researchers has uncovered cases of chromosomal disorders, including what could be the first case of Edwards syndrome ever identified from prehistoric remains. The team identified six cases of Down syndrome and one case of Edwards syndrome in human populations that were living in Spain, Bulgaria, Finland, and Greece from as long ago as 4,500 years before today. Discovery of Chromosomal Disorders The research indicated that these individuals were buried with care, and often with special grave goods, showing that they were appreciated as members of their ancient societies. The global collaborative study, led by first author Dr Adam “Ben” Rohrlach of the University of Adelaide, and senior author Dr Kay Prüfer of the Max Planck Institute for Evolutionary Anthropology, involved screening DNA from approximately 10,000 ancient and pre-modern humans for evidence of autosomal trisomies, a condition where people carry an extra (third) copy of one of the first 22 chromosomes. Methodology and Findings “Using a new statistical model, we screened the DNA extracted from human remains from the Mesolithic, Neolithic, Bronze, and Iron Ages all the way up to the mid-1800s. We identified six cases of Down syndrome,” says Dr Rohrlach, a statistician from the University of Adelaide’s School of Mathematical Sciences. “While we expected that people with Down syndrome certainly existed in the past, this is the first time we’ve been able to reliably detect cases in ancient remains, as they can’t be confidently diagnosed by looking at the skeletal remains alone.” Down syndrome occurs when an individual carries an extra copy of chromosome 21. The researchers were able to find these six cases using a novel Bayesian approach to accurately and efficiently screen tens of thousands of ancient DNA samples. “The statistical model identifies when an individual has approximately 50 percent too much DNA that comes from one specific chromosome,” says Dr Patxuka de-Miguel-Ibáñez of the University of Alicante, and lead osteologist for the Spanish sites. “We then compared the remains of the individuals with Down syndrome for common skeletal abnormalities such as irregular bone growth, or porosity of the skull bones, which may help to identify future cases of Down syndrome when ancient DNA can’t be recovered.” Additional Discoveries and Cultural Insights The study also uncovered one case of Edwards syndrome, a rare condition caused by three copies of chromosome 18, that comes with far more severe symptoms than Down syndrome. The remains indicated severe abnormalities in bone growth and an age of death of approximately 40 weeks gestation. All of the cases were detected in perinatal or infant burials, but from different cultures and time periods. “These individuals were buried according to either the standard practices of their time or were in some way treated specially. This indicates that they were acknowledged as members of their community and were not treated differently in death,” says Dr Rohrlach. “Interestingly, we discovered the only case of Edwards syndrome, and a noticeable increase in cases of Down syndrome, in individuals from the Early Iron Age in Spain. The remains could not confirm that these babies survived to birth, but they were among the infants buried within homes at the settlement, or within other important buildings,” says Professor Roberto Risch, co-author and archaeologist from The Autonomous University of Barcelona. “We don’t know why this happened, as most people were cremated during this time, but it appears as if they were purposefully choosing these infants for special burials.” Reference: “Cases of trisomy 21 and trisomy 18 among historic and prehistoric individuals discovered from ancient DNA” by Adam Benjamin Rohrlach, Maïté Rivollat, Patxuka de-Miguel-Ibáñez, Ulla Moilanen, Anne-Mari Liira, João C. Teixeira, Xavier Roca-Rada, Javier Armendáriz-Martija, Kamen Boyadzhiev, Yavor Boyadzhiev, Bastien Llamas, Anthi Tiliakou, Angela Mötsch, Jonathan Tuke, Eleni-Anna Prevedorou, Naya Polychronakou-Sgouritsa, Jane Buikstra, Päivi Onkamo, Philipp W. Stockhammer, Henrike O. Heyne, Johannes R. Lemke, Roberto Risch, Stephan Schiffels, Johannes Krause, Wolfgang Haak and Kay Prüfer, 20 February 2024, Nature Communications. DOI: 10.1038/s41467-024-45438-1 The research was part of a large collaborative project involving researchers from the University of Adelaide, including Dr. Adam “Ben” Rohrlach, Dr. Jonathan Tuke, and Associate Professor Bastien Llamas, as well as researchers from across the world, including at the Max Planck Institute for Evolutionary Anthropology in Germany where the data was generated.

In this image, cells (blue) are stressed due to the build-up and storage of lysosomes (yellow). The Hospital for Sick Children (SickKids) New research indicates that inflammation in macrophages caused by lysosomal dysfunction contributes to severe symptoms in lysosomal storage diseases. Targeting specific pathways in these cells may offer new therapeutic options for these genetic conditions. Inflammation in an immune cell may be responsible in part for some severe symptoms in a group of rare genetic conditions called lysosomal storage diseases (LSDs). This is according to new research from The Hospital for Sick Children (SickKids). LSDs affect about one in 7,700 live births worldwide. Children with the condition typically present at a young age with progressive neurodegeneration. Many children with LSDs die prematurely, and current treatments focus on symptom management. Until now, the role of macrophages in the immune system and LSDs was not well known, but new research published today (July 12) in Nature Cell Biology led by Drs. Spencer Freeman, a Scientist in the Cell Biology program, Ruiqi Cai, a senior postdoctoral fellow and the first author of the study, and Ori Scott, a Transition Clinician Scientist in the Cell Biology program and a Staff Physician in the Division of Immunology & Allergy, identified that macrophage inflammation may contribute to LSD symptoms. Macrophage cells take in and digest a large amount of nutrients to aid in the regular function of the immune system. To break down and recycle these nutrients, the cells rely on tiny organelles called lysosomes. When functional, a lysosome can break down large sugars into small sugars, which are then used as an energy source. In LSDs, these macrophage lysosomes become swollen and filled with waste. On the publication of these findings, Freeman, Cai and Scott share how LSDs affect the immune system and how reducing inflammation could potentially improve or prevent symptoms in children with LSDs. What is different about macrophages in patients with LSDs? In LSD macrophages, swollen lysosomes try to avoid bursting open and spilling their contents – which would cause the cell to die. To do this, lysosomes open a channel that moves sodium out of the lysosomes, followed by water, to keep them smaller. This creates a message: the lysosome and the cell are stressed. The stressed macrophages then send out an “SOS” signal by releasing a substance called MCP-1 (monocyte chemoattractant protein 1) that tells other macrophages: “please come and help.” As a result, many more macrophages move into the tissue. When there are too many macrophages in a tissue, and they all secrete MCP-1, this can cause inflammation and damage to the tissue. How might your findings help patients with LSDs? Our findings suggest that blocking the sodium channel or the MCP-1 receptor in macrophages could reduce the inflammation and tissue damage in LSDs. There are already drugs that target these molecules, some of which are used for other inflammatory conditions such as rheumatoid arthritis. We are planning to test these drugs in pre-clinical models, and hopefully translate the results to clinical trials for patients with LSDs. By studying what causes severe symptoms in children with LSDs, we may identify better treatments for patients affected by these devastating conditions. What are the next steps for your research? We are continuing to explore how the lysosome regulates macrophage function and inflammation in LSDs and other conditions including neurodegenerative diseases. We hope that by understanding the molecular mechanisms of lysosome dysfunction and inflammation we can identify novel targets for drug development and improve the quality of life of patients with LSDs and other related conditions, like Parkinson’s disease. When we study individuals with rare pediatric conditions, the benefits reach beyond these individuals and their families and extend to everyone by improving our knowledge of the complexities of human biology. Reference: “Pressure sensing of lysosomes enables control of TFEB responses in macrophages” by Ruiqi Cai, Ori Scott, Gang Ye, Trieu Le, Ekambir Saran, Whijin Kwon, Subothan Inpanathan, Blayne A. Sayed, Roberto J. Botelho, Amra Saric, Stefan Uderhardt and Spencer A. Freeman, 12 July 2024, Nature Cell Biology. DOI: 10.1038/s41556-024-01459-y This research was funded by the Canadian Institutes of Health Research (CIHR), the German Research Foundation, the Hightech Agenda Bavaria, the European Research Council, and Toronto Metropolitan University.

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