Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Breathable insole ODM development Taiwan

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Eco-friendly pillow OEM manufacturer Thailand

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Taiwan anti-bacterial pillow ODM design

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.ODM pillow factory in Thailand

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Arch support insole OEM factory from Taiwan

The research sheds new light on how sex determines the mechanisms by which various synapses monitor and regulate dopamine signaling. A study in mice reveals a surprising difference between male and female dopamine synapses supporting attention, movement, motivation, and pleasure. Almost all neuropsychiatric disorders have different prevalences, ages of onset, and clinical symptoms in men and women. Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) are two conditions with significant sex bias, with about four males diagnosed for every one female. Randy Blakely, Ph.D., professor of biomedical science in FAU’s Schmidt College of Medicine and executive director of the FAU Stiles-Nicholson Brain Institute. Credit: Florida Atlantic University It is unclear whether this skewed ratio results from the roles played in brain development by sex-specific DNA sequences or hormones, or if it represents how biological mechanisms and environmental factors elicit behavioral patterns differently in males and females. Role of Dopamine in ADHD and ASD Regardless of origin, changed behavior in these disorders indicates a change in the function of important brain circuits set up throughout development, refined throughout life, and coordinated by the actions of brain chemicals called neurotransmitters. Dopamine is a crucial neurotransmitter whose powerful actions enable motor initiation and coordination, motivation, reward, and social behavior, as well as attention and higher cognitive function. It also plays an important role in the behaviors changed by ADHD and ASD. Although dopamine-sensitive brain circuits engaged in these processes have been under scrutiny for decades, and in the case of ADHD, are the target of medications such as Adderall and Ritalin, the intrinsic sex-dependent differences in these pathways that could guide more precise diagnoses and treatments have only recently begun to be elucidated. Dopamine Disposal Mechanisms To better understand how dopamine levels at brain synapses are managed, neuroscientists from Florida Atlantic University, along with collaborators at the University of North Dakota School of Medicine and Health Sciences, have now added a significant piece to this puzzle by establishing key differences in the molecular dopamine disposal machinery in the brains of male and female mice. The new research published in the journal Molecular Psychiatry and led by Randy Blakely, Ph.D., professor of biomedical science in FAU’s Schmidt College of Medicine and executive director of the FAU Stiles-Nicholson Brain Institute, provides new insight into how sex determines the mechanisms by which distinct synapses monitor and regulate dopamine signaling. Moreover, the impact of the sex differences described is particularly pronounced when the mice express a human genetic variant found in boys with either ADHD or ASD. “Often, due to assumptions that sex hormone variation will cloud data interpretations, and that use of one sex will cut animal use and costs in half without a loss of key insights, many researchers using animal models to study brain disorders work chiefly with males, even more reasonable when modeling disorders that exhibit male bias,” said Blakely. In a prior study, looking for genetic changes in dopamine regulatory genes in children with ADHD, Blakely and his team identified a gene variant that alters the function of the dopamine transporter (DAT) in a peculiar way. Normally DAT acts to remove dopamine from synapses, acting like a nanoscale dopamine vacuum cleaner. When the DAT variant was expressed in cells, however, it “ran backward,” spitting out dopamine rather than efficiently removing it. After engineering the variant into the genome of mice, Blakely’s team found changes in behavior and drug responses predicted by this anomalous DAT behavior, with an emphasis on traits linked to pathways related to locomotor activation, habitual behavior, and impulsivity. Notably, these studies were performed exclusively with male mutant mice. Blakely and Adele Stewart, Ph.D., first author of the report, a research assistant professor of biomedical science in FAU’s Schmidt College of Medicine and a member of the FAU Stiles-Nicholson Brain Institute, recognized there was more to be done, particularly with respect to how females would handle the mutation. Would the DAT mutation impact the same brain regions and behaviors in females as it had done in males? Sex Differences in Brain Pathways and Behaviors The answer is a resounding no. Females show effects of the mutation in brain regions unaffected in males and vice versa. Further work revealed that this switch is due to a circuit flip in how brain pathways in males and females use a key DAT regulator protein to magnify the backward activity of the transporter. The behavioral consequences of this region-specific, sex-biased pattern of DAT regulation are profound, with the mutant DAT altering behaviors in a pattern unique to each sex. For example, mutant females appeared more anxious and had issues with novelty recognition compared to wild-type females. Males on the other hand are less social and display increased perseverative behavior, changes not seen in females. “Our work clearly shows that the female mutant DAT mice are not ‘protected’ from the impact of the mutation, but rather, exhibit a unique set of behavioral changes linked to an ingrained, sex-biased architecture of the dopamine system,” said Stewart. “The same variant also has been found in two unrelated boys with ASD, a disorder that often also displays comorbid ADHD.” Interestingly, the only reported clinical occurrence of the DAT variant in a female involved a diagnosis of bipolar disorder (BPD). Both the mania and depression associated with BPD have been suggested to be linked to altered dopamine signaling. Blakely’s group also has reported high impulsivity traits in a female carrier of the same mutation studied in this latest paper, suggesting that overlap of traits linked to dopamine can also occur between the sexes, or perhaps the forms of impulsivity (e.g. waiting versus action) may be involved. Diagnosis and Treatment A “resilience” framework often is used to explain discrepancies in the sex bias observed in neuropsychiatric disorders. However, recent evidence suggests that sex bias can be due, at least in part, to differences in symptomology and associated comorbidities and the resultant failure of current diagnostic instruments to assure the identification of the same disorder in both sexes. “While we understand that there are biological differences between rodent and human brains, studies like ours provide an important opportunity to explore biological mechanisms that contribute to sex differences in risk for neuropsychiatric diseases,” said Stewart. “What our study shows is that behavioral generalizations across the sexes may limit diagnosis of mental illness, particularly if one sex translates alterations into outward signs such as hyperactivity and aggression versus more internal manifestations such as learning, memory, and mood, even when the same molecular pathology is at work. What is more, our work supports the idea that treatment strategies should be cognizant of the sex-dependence of neuronal signaling mechanisms rather than assuming treatment that what is good for the goose is good for the gander. In fact, such therapies may either not be good for the gander at all, or good for a completely different kind of disorder.” The research provides a clear example of how genetic changes can have sex-dependent effects on physiology and behavior, depending on whether other co-regulatory genes are naturally expressed by the same cells. “Because the basis for the differential response to the DAT mutation is the presence or absence of DAT regulation in these two areas, the implications do not just apply to the few individuals with the genetic variant nor are limited to ADHD and ASD,” said Blakely. “Investigators exploring other disorders linked to altered dopamine signaling should consider whether the mechanism we have uncovered could drive sex-dependent features of these diseases. By extension, we now need to consider whether the mechanism we have uncovered contributes to sex-dependent ways in which dopamine signaling drives normal behavior.” Reference: “Behaviorally penetrant, anomalous dopamine efflux exposes sex and circuit dependent regulation of dopamine transporters” by Adele Stewart, Felix P. Mayer, Raajaram Gowrishankar, Gwynne L. Davis, Lorena B. Areal, Paul J. Gresch, Rania M. Katamish, Rodeania Peart, Samantha E. Stilley, Keeley Spiess, Maximilian J. Rabil, Faakhira A. Diljohn, Angelica E. Wiggins, Roxanne A. Vaughan, Maureen K. Hahn and Randy D. Blakely, 18 September 2022, Molecular Psychiatry. DOI: 10.1038/s41380-022-01773-7 The study was funded by the National Institutes of Health (NIH).

Differentiated immortalized bovine stem cells with fully expressed muscle proteins (blue = nuclei; magenta = myogenin; green = myosin). Scale approx 1 mm. Credit: Andrew Stout, Tufts University Minimizing the necessity for animal biopsies, stem cells offer a potentially endless source for cultured meat. For cellular agriculture—a technique that grows meat in bioreactors—to successfully feed millions, numerous technological hurdles must be conquered. The production of muscle cells from sources such as chicken, fish, cows, and more will need to increase to the point where millions of metric tons are yielded annually. Researchers at the Tufts University Center for Cellular Agriculture (TUCCA) have made strides toward this objective by developing immortalized bovine muscle stem cells (iBSCs). These cells possess a rapid growth rate and the ability to divide hundreds of times, potentially even indefinitely, furthering the potential for large-scale meat production. Implications for the Future of Cultivated Meat This advance, described in the journal ACS Synthetic Biology, means that researchers and companies around the globe can have access to and develop new products without having to source cells repeatedly from farm animal biopsies. The production of cell-cultured meat will require muscle and fat cells with a very high capacity to grow and divide. While cell-grown meat has garnered media attention with examples such as the FDA preliminary approval of cultured chicken, and even a hamburger grown with mastodon DNA, the products are still expensive and difficult to scale up. Normal muscle stem cells drawn from live animals to start a culture typically divide only about 50 times before they start to get “old” and are no longer viable. While it is theoretically possible for these stem cells to produce a substantial amount of meat, the immortalized cells developed by the TUCCA team offer several advantages. One is the possibility of producing significantly more mass for meat production. Lowering Barriers for Cellular Agriculture Research Another advantage is that by making the immortalized cells widely available, they will lower the barrier of entry for other researchers to explore cellular agriculture — finding ways to reduce costs and overcome challenges to scaled-up production. “Typically, researchers have had to do their own isolations of stem cells from animals, which is expensive and laborious, or use model cell lines from less relevant species, like mouse muscle cells,” said Andrew Stout, a graduate student at TUCCA and lead researcher on the project, “Using these new persistent bovine cell lines, their studies can be more relevant, literally getting right to the meat of the matter.” Two steps were key to transforming regular bovine muscle stem cells into the immortalized bovine muscle stem cells. Most cells, as they divide and age, begin to lose DNA at the ends of their chromosomes, which are called telomeres, like worn ropes that get frayed with use. This can lead to errors when the DNA is being copied or repaired. It can also cause genes to be lost and, eventually, cells to die. The researchers engineered the bovine stem cells to constantly rebuild their telomeres, effectively keeping their chromosomes “youthful” and ready for another round of replication and cell division. The second step to immortalizing the cells was to make them continuously produce a protein that stimulates a critical stage of cell division. This effectively turbocharges the process and helps the cells to grow faster. Muscle stem cells are not the final product that one wants to eat. They must not only divide and grow, but also differentiate into mature muscle cells just like, or at least very similar to, the muscle cells that we eat in a steak or fillet. Stout and his research team found that the new stem cells did indeed differentiate into mature muscle cells, although not entirely identical to animal muscle cells or muscle cells from conventional bovine stem cells. “It’s possible that they are matured enough to replicate the flavor and texture of natural meat,” said Stout, “That’s something we will have to explore further. They are doubling at a very rapid rate, so they might just need a little more time to reach full maturity.” “While some may question whether it is safe to ingest immortalized cells, in fact, by the time the cells have been harvested, stored, cooked, and digested, there is no viable path to continued growth,” said David Kaplan, Stern Family professor of biomedical engineering at Tufts and director of TUCCA. “Like natural meat we eat today, the cells simply become inert material that we hope will taste delicious and provide a wide range of nutritious benefits.” Reference: “Immortalized Bovine Satellite Cells for Cultured Meat Applications” by Andrew J. Stout, Miles J. Arnett, Kristin Chai, Tina Guo, Lishu Liao, Addison B. Mirliani, Miriam L. Rittenberg, Michelle Shub, Eugene C. White, John S. K. Yuen Jr., Xiaoli Zhang and David L. Kaplan, 5 May 2023, ACS Synthetic Biology. DOI: 10.1021/acssynbio.3c00216 The study was funded by the U.S. Department of Agriculture.

A study reveals that variations in the gut environment affect the composition and activity of gut bacteria, explaining why microbiomes differ and why people react differently to the same foods. A groundbreaking study from the University of Copenhagen has shed light on the intricate relationship between the gut environment and gut bacteria. Researchers discovered that changes in the gut’s internal conditions significantly influence the composition and activity of gut bacteria. These findings help explain why each person has a unique microbiome and may also clarify why individuals react differently to the same foods. A Voyage of Discovery Through the Gut In 2021, 50 participants swallowed a capsule about the size of a thumb joint during breakfast. The capsule traveled through the stomach, small intestine, and large intestine, collecting data on pH, temperature, and pressure along the way. It exited the body in the participants’ stool within 12 to 72 hours. Researchers quickly observed significant differences in both gut environments and transit times between individuals. “We could see, for example, that it took 2 hours for the capsule to pass through the small intestine in some people and 10 hours in others,” explained Associate Professor Henrik Roager from the Department of Nutrition, Exercise and Sports at the University of Copenhagen, who led the study. “Since we already know that we absorb most of our nutrients in the small intestine, differences in the travel time in the small intestine probably have an impact on how much of the nutrients we absorb and how much passes on to the large intestine, where the gut bacteria kick in.” Previously, gut activity was typically studied through stool samples analyzed alongside dietary intake. The capsule provides a more precise and dynamic understanding of how conditions change throughout the gut. “The capsule means that we can collect information that may help explain individual differences in digestion, nutrient uptake, and bowel movement patterns,” said Roager. “This provides us with far greater knowledge than we have previously been able to obtain via dietary patterns and stool samples.” Technical Mechanisms and Digestive Tracking In their journey through the digestive system, the capsule and the food came first of all to the stomach. Here, the capsule registered a very low pH value, because in the stomach acid is released that breaks down the food. Then the food and the capsule moved into the small intestine. Here, gut cells release the alkaline bicarbonate that neutralizes the stomach acid, and it is here that nutrients are absorbed. The indigestible remainder of the food and the capsule were then passed on to the large intestine, where the food was fermented by the gut bacteria. The gut bacteria produce fatty acids, which cause the pH value to fall again in the first part of the colon. However, the pH value increases incrementally along the length of the large intestine as the fatty acids are gradually absorbed through the wall of the gut and the activity of the gut bacteria changes. “The capsule registered all these changes in pH values, and we can estimate how long the food was in the different parts of the gut on the basis of the changes in pH. We know that pH is a crucial factor in bacterial growth and activity, so it made perfect sense that we could see that gut environment and pH are linked to differences in the composition and activity of the gut bacteria. This means that the environmental conditions we each have in our gut can help explain why we have different bacteria in the gut,” says Henrik Roager. Implications for Personalized Nutrition According to Associate Professor Henrik Roager, the new knowledge could be very useful for future nutritional guidelines. “Our results show that we are all unique – also in our gut,” says Henrik Roager. “We are used to assuming that we all digest and absorb food in the same way and to the same extent, but we can also see that this is not always the case. Our study provides further evidence that individuals react differently to food – and here differences in our gut environment could very well play an important role.” The results indicate that the physiology and environment of the gut play an important role in the individual differences in the human gut microbiome and metabolism. Study Overview and Methodology The capsules swallowed by the 50 subjects measured 26 x 13 mm. The test subjects consumed the capsule at the same time as a standardized breakfast, which consisted of rye bread with butter and jam, a boiled egg, a portion of plain yogurt with nuts and blueberries, and a glass of water. Reference: “Gut physiology and environment explain variations in human gut microbiome composition and metabolism” by Nicola Procházková, Martin F. Laursen, Giorgia La Barbera, Eirini Tsekitsidi, Malte S. Jørgensen, Morten A. Rasmussen, Jeroen Raes, Tine R. Licht, Lars O. Dragsted and Henrik M. Roager, 27 November 2024, Nature Microbiology. DOI: 10.1038/s41564-024-01856-x The study was led by Nicola Procházková, who was a PhD student and postdoc at the Department of Nutrition, Exercise and Sports, at the University of Copenhagen from 2020-2024. The study is published in the respected scientific journal Nature Microbiology. It was carried out in collaboration with researchers from DTU Food and KU Leuven, Belgium, and it is part of the Challenge project PRIMA. The study is supported by the Novo Nordisk Foundation.

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