Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Arch support insole OEM from China

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan custom product OEM/ODM services

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.China pillow OEM manufacturer

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.ODM pillow factory in Indonesia

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.China insole ODM service provider

Infection of human intestinal epithelial cells by Salmonella Typhimurium during spaceflight aboard NASA Space Shuttle mission STS-131. Credit: Graphic by Shireen Dooling for the Biodesign Institute at Arizona State University Astronauts face many challenges to their health, due to the exceptional conditions of spaceflight. Among these are a variety of infectious microbes that can attack their suppressed immune systems. Now, in the first study of its kind, Cheryl Nickerson, lead author Jennifer Barrila, and their colleagues describe the infection of human cells by the intestinal pathogen Salmonella Typhimurium during spaceflight. They show how the microgravity environment of spaceflight changes the molecular profile of human intestinal cells and how these expression patterns are further changed in response to infection. In another first, the researchers were also able to detect molecular changes in the bacterial pathogen while inside the infected host cells. The results offer fresh insights into the infection process and may lead to novel methods for combatting invasive pathogens during spaceflight and under less exotic conditions here on earth. The results of their efforts appear in the current issue of the Nature Publishing Group journal npj Microgravity. Mission control In the study, human intestinal epithelial cells were cultured aboard Space Shuttle mission STS-131, where a subset of the cultures were either infected with Salmonella or remained as uninfected controls. The new research uncovered global alterations in RNA and protein expression in human cells and RNA expression in bacterial cells compared with ground-based control samples and reinforces the team’s previous findings that spaceflight can increase infectious disease potential. Cheryl Nickerson is a researcher in the Biodesign Center for Fundamental and Applied Microbiomics and a professor in the School of Life Sciences at ASU. Credit: The Biodesign Institute at Arizona State University Nickerson and Barrila, researchers in the Biodesign Center for Fundamental and Applied Microbiomics, along with their colleagues, have been using spaceflight as a unique experimental tool to study how changes in physical forces, like those associated with the microgravity environment, can alter the responses of both the host and pathogen during infection. Nickerson is also a professor in the School of Life Sciences at ASU.  In an earlier series of pioneering spaceflight and ground-based spaceflight analogue studies, Nickerson’s team demonstrated that the spaceflight environment can intensify the disease-causing properties or virulence of pathogenic organisms like Salmonella in ways that were not observed when the same organism was cultured under conventional conditions in the laboratory.   The studies provided clues as to the underlying mechanisms of the heightened virulence and how it might be tamed or outwitted.  However, these studies were done when only the Salmonella were grown in spaceflight and the infections were done when the bacteria were returned to Earth. “We appreciate the opportunity that NASA provided our team to study the entire infection process in spaceflight, which is providing new insight into the mechanobiology of infectious disease that can be used to protect astronaut health and mitigate infectious disease risks,” Nickerson says of the new study. “This becomes increasingly important as we transition to longer human exploration missions that are further away from our planet.”   Probing a familiar adversary Salmonella strains known to infect humans continue to ravage society, as they have since antiquity, causing around 1.35 million foodborne infections, 26,500 hospitalizations, and 420 deaths in the United States every year, according to the Centers for Disease Control. The pathogen enters the human body through the ingestion of contaminated food and water, where it attaches and invades into intestinal tissue. The infection process is a dynamic dance between host and microbe, its rhythm dictated by the biological and physical cues present in the tissue’s environment. Despite decades of intensive research, scientists still have much to learn about the subtleties of pathogenic infection of human cells. Invasive bacteria like Salmonella have evolved sophisticated countermeasures to human defenses, allowing them to flourish under hostile conditions in the human stomach and intestine to stealthily evade the immune system, making them highly effective agents of disease. The issue is of particular medical concern for astronauts during spaceflight missions. Their immune systems and gastrointestinal function are altered by the rigors of space travel, while the effects of low gravity and other variables of the spaceflight environment can intensify the disease-causing properties of hitchhiking microbes, like Salmonella. This combination of factors poses unique risks for space travelers working hundreds of miles above the earth—far removed from hospitals and appropriate medical care. As technology advances, it is expected that space travel will become more frequent—for space exploration, life sciences research, and even as a leisure activity (for those who can afford it). Further, extended missions with human crews are on the horizon for NASA and perhaps space-voyaging companies like SpaceX, including trips to the Moon and Mars. A failure to keep bacterial infections at bay could have dire consequences. Hide and Seq In the current study, human intestinal epithelial cells, the prime target for invasive Salmonella bacteria, were infected with Salmonella during spaceflight. The researchers were keen to examine how the spaceflight setting affected the transcription of human and bacterial DNA into RNA, as well as the expression of the resulting suite of human proteins produced from the RNA code, products of a process known as translation. The research involved the close examination of transcriptional profiles of both the pathogenic Salmonella and the human cells they attack, as well as the protein expression profiles of the human cells to gauge the effects of the spaceflight environment on the host-pathogen dynamic. Jennifer Barrila, lead author of the new study, is a researcher in the Biodesign Center for Fundamental and Applied Microbiomics. Credit: The Biodesign Institute at Arizona State University To accomplish this, researchers used a revolutionary method known as dual RNA-Seq, which applied deep sequencing technology to enable their evaluation of host and pathogen behavior under microgravity during the infection process and permitted a comparison with the team’s previous experiments conducted aboard the Space Shuttle. The host and pathogen data recovered from spaceflight experiments were compared with those obtained when cells were grown on Earth in identical hardware and culture conditions (e.g., media, temperature). Earth and sky Earlier studies by Nickerson and her colleagues demonstrated that ground-based spaceflight analog cultures of Salmonella exhibited global changes in their transcriptional and proteomic (protein) expression, heightened virulence, and improved stress resistance—findings similar to those produced during their experiments on STS-115 and STS-123 Space Shuttle missions. However, these previous spaceflight studies were done when only the Salmonella were grown in spaceflight and the infections were done when the bacteria were returned to Earth. In contrast, the new study explores for the first time, a co-culture of human cells and pathogen during spaceflight, providing a unique window into the infection process. The experiment, called STL-IMMUNE, was part of the Space Tissue Loss payload carried aboard STS-131, one of the last four missions of the Space Shuttle prior to its retirement.  The human intestinal epithelial cells were launched into space (or maintained in a laboratory at the Kennedy Space Center for ground controls) in three-dimensional (3-D) tissue culture systems called hollow fiber bioreactors. The hollow fiber bioreactors each contained hundreds of tiny, porous straw-like fibers coated with collagen upon which the intestinal cells attached and grew. These bioreactors were maintained in the Cell Culture Module, an automated hardware system that pumped warm, oxygenated cell culture media through the tiny fibers to keep the cells healthy and growing until they were ready for infection with Salmonella.  Once in orbit, astronauts aboard STS-131 activated the hardware. Eleven days later, S. Typhimurium cells were automatically injected into a subset of the hollow fiber bioreactors, where they encountered their target—a layer of human epithelial cells. The RNA-Seq and proteomic profiles showed significant differences between uninfected intestinal epithelial cultures in space vs those on Earth. These changes involved major proteins important for cell structure as well as genes important for maintaining the intestinal epithelial barrier, cell differentiation, proliferation, wound healing, and cancer.  Based on their profiles, uninfected cells exposed to spaceflight may display a reduced capacity for proliferation, relative to ground control cultures. Infections far from home Human intestinal epithelial cells act as critical sentinels of innate immune function. The results of the experiment showed that spaceflight can cause global changes to the transcriptome and proteome of human epithelial cells, both infected and uninfected. During spaceflight, 27 RNA transcripts were uniquely altered in intestinal cells in response to infection, once again establishing the unique influence of the spaceflight environment on the host-pathogen interaction. The researchers also observed 35 transcripts that were commonly altered in both space-based and ground-based cells, with 28 genes regulated in the same direction. These findings confirmed that at least a subset of the infection biosignatures that are known to occur on Earth also occur during spaceflight.  Compared with uninfected controls, infected cells in both environments displayed gene regulation associated with inflammation, a signature effect of Salmonella infection. Bacterial transcripts were also simultaneously detected within the infected host cells and indicated upregulation of genes associated with pathogenesis, including antibiotic resistance and stress responses. The findings help pave the way for improved efforts to safeguard astronaut health, perhaps through the use of nutritional supplements or probiotic microbes. Ongoing studies of this kind, to be performed aboard the International Space Station and other space habitats, should further illuminate the many mysteries associated with pathogenic infection and the broad range of human illnesses for which they are responsible. “Before we began this study, we had extensive data showing that spaceflight completely reprogrammed Salmonella at every level to become a better pathogen,” Barrila says. “Separately, we knew that spaceflight also impacted several important structural and functional features of human cells that Salmonella normally exploits during infections on Earth. However, there was no data showing what would happen when both cell types met in the microgravity environment during infection. Our study indicates that there are some pretty big changes in the molecular landscape of the intestinal epithelium in response to spaceflight, and this global landscape appears to be further altered during infection with Salmonella.” Reference: “Evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium” by Jennifer Barrila, Shameema F. Sarker, Nicole Hansmeier, Shanshan Yang, Kristina Buss, Natalia Briones, Jin Park, Richard R. Davis, Rebecca J. Forsyth, C. Mark Ott, Kevin Sato, Cristine Kosnik, Anthony Yang, Cheryl Shimoda, Nicole Rayl, Diana Ly, Aaron Landenberger, Stephanie D. Wilson, Naoko Yamazaki, Jason Steel, Camila Montano, Rolf U. Halden, Tom Cannon, Sarah L. Castro-Wallace and Cheryl A. Nickerson, 9 March 2021, npj Microgravity. DOI: 10.1038/s41526-021-00136-w This work was done in collaboration with scientists from the NASA Johnson Space Center, NASA Ames Research Center, Japanese Aerospace Exploration Agency (JAXA), Tissue Genesis, and the Department of Defense (DoD).

A computer model of the novel protein structure in the cryptophyte’s antenna that traps sunlight energy. Credit: UNSW Scientists have identified the protein that was the missing evolutionary link between two ancient algae species – red algae and cryptophytes. An evolutionary mystery that had eluded molecular biologists for decades may never have been solved if it weren’t for the COVID-19 pandemic. “Being stuck at home was a blessing in disguise, as there were no experiments that could be done. We just had our computers and lots of time,” says Professor Paul Curmi, a structural biologist and molecular biophysicist with UNSW Sydney. Prof. Curmi is referring to research published recently in Nature Communications that details the painstaking unraveling and reconstruction of a key protein in a single-celled, photosynthetic organism called a cryptophyte, a type of algae that evolved over a billion years ago. Up until now, how cryptophytes acquired the proteins used to capture and funnel sunlight to be used by the cell had molecular biologists scratching their heads. They already knew that the protein was part of a sort of antenna that the organism used to convert sunlight into energy. They also knew that the cryptophyte had inherited some antenna components from its photosynthetic ancestors – red algae, and before that cyanobacteria, one of the earliest lifeforms on earth that are responsible for stromatolites. But how the protein structures fit together in the cryptophyte’s own, novel antenna structure remained a mystery – until Prof. Curmi, PhD student Harry Rathbone and colleagues from University of Queensland and University of British Columbia pored over the electron microscope images of the antenna protein from a progenitor red algal organism made public by Chinese researchers in March 2020. Unraveling the mystery meant the team could finally tell the story of how this protein had enabled these ancient single-celled organisms to thrive in the most inhospitable conditions – meters under water with very little direct sunlight to convert into energy. Prof. Curmi says the major implications of the work are for evolutionary biology. “We provide a direct link between two very different antenna systems and open the door for discovering exactly how one system evolved into a different system – where both appear to be very efficient in capturing light,” he says. “Photosynthetic algae have many different antenna systems which have the property of being able to capture every available light photon and transferring it to a photosystem protein that converts the light energy to chemical energy.” By working to understand the algal systems, the scientists hope to uncover the fundamental physical principles that underlie the exquisite photon efficiency of these photosynthetic systems.  Prof. Curmi says these may one day have application in optical devices including solar energy systems. Eating for two To better appreciate the significance of the protein discovery, it helps to understand the very strange world of single-celled organisms which take the adage “you are what you eat” to a new level. As study lead author, PhD student Harry Rathbone explains, when a single-celled organism swallows another, it can enter a relationship of endosymbiosis, where one organism lives inside the other and the two become inseparable. “Often with algae, they’ll go and find some lunch – another alga – and they’ll decide not to digest it. They’ll keep it to do its bidding, essentially,” Mr Rathbone says. “And those new organisms can be swallowed by other organisms in the same way, sort of like a matryoshka doll.” In fact, this is likely what happened when about one and a half billion years ago, a cyanobacterium was swallowed by another single-celled organism. The cyanobacteria already had a sophisticated antenna of proteins that trapped every photon of light. But instead of digesting the cyanobacterium, the host organism effectively stripped it for parts – retaining the antenna protein structure that the new organism – the red algae – used for energy. And when another organism swallowed a red alga to become the first cryptophyte, it was a similar story. Except this time the antenna was brought to the other side of the membrane of the host organism and completely remolded into new protein shapes that were equally as efficient at trapping sunlight photons. Evolution As Prof. Curmi explains, these were the first tiny steps towards the evolution of modern plants and other photosynthetic organisms such as seaweeds. “In going from cyanobacteria that are photosynthetic, to everything else on the planet that is photosynthetic, some ancient ancestor gobbled up a cyanobacteria which then became the cell’s chloroplast that converts sunlight into chemical energy. “And the deal between the organisms is sort of like, I’ll keep you safe as long as you do photosynthesis and give me energy.” One of the collaborators on this project, Dr. Beverley Green, Professor Emerita with the University of British Columbia’s Department of Botany says Prof. Curmi was able to make the discovery by approaching the problem from a different angle. “Paul’s novel approach was to search for ancestral proteins on the basis of shape rather than similarity in amino acid sequence,” she says. “By searching the 3D structures of two red algal multi-protein complexes for segments of protein that folded in the same way as the cryptophyte protein, he was able to find the missing puzzle piece.” Reference: “Scaffolding proteins guide the evolution of algal light harvesting antennas’ by Harry W. Rathbone, Katharine A. Michie, Michael J. Landsberg, Beverley R. Green and Paul M. G. Curmi, 25 March 2021, Nature Communications. DOI: 10.1038/s41467-021-22128-w

A study from Northwestern Medicine reveals that an individual’s genetic makeup might influence their ability to adhere to a strict vegetarian diet. Analyzing genetic data from the UK Biobank, the study found three genes closely related to vegetarianism, with 31 others potentially associated. These findings could lead to further research, potentially impacting dietary guidelines and the development of meat substitutes. Large Study Found Three Genes Strongly Linked to Vegetarianism First fully peer-reviewed, indexed study to look at the link between strict vegetarianism and genetics More people would like to be vegetarian than actually are. ‘We think it’s because there is something hard-wired here that people may be missing’ Findings open the door to further studies that could have important implications regarding dietary recommendations and the production of meat substitutes From Impossible Burger to “Meatless Mondays,” going meat-free is certainly in vogue. However, a person’s genetic makeup plays a role in determining whether they can stick to a strict vegetarian diet, according to a new Northwestern Medicine study. The findings open the door to further studies that could have important implications regarding dietary recommendations and the production of meat substitutes. “Are all humans capable of subsisting long-term on a strict vegetarian diet? This is a question that has not been seriously studied,” said corresponding study author Dr. Nabeel Yaseen, professor emeritus of pathology at Northwestern University Feinberg School of Medicine. A large proportion (about 48 to 64%) of self-identified “vegetarians” report eating fish, poultry, and/or red meat, which Yaseen said suggests environmental or biological constraints override the desire to adhere to a vegetarian diet. “It seems there are more people who would like to be vegetarian than actually are, and we think it’s because there is something hard-wired here that people may be missing.” Several Genes Involved in Lipid Metabolism, Brain Function To determine whether genetics contribute to one’s ability to adhere to a vegetarian diet, the scientists compared UK Biobank genetic data from 5,324 strict vegetarians (consuming no fish, poultry, or red meat) to 329,455 controls. All study participants were white Caucasian to attain a homogeneous sample and avoid confounding by ethnicity. The study identified three genes that are significantly associated with vegetarianism and another 31 genes that are potentially associated. Several of these genes, including two of the top three (NPC1 and RMC1), are involved in lipid (fat) metabolism and/or brain function, the study found. “One area in which plant products differ from meat is complex lipids,” Yaseen said. “My speculation is there may be lipid component(s) present in meat that some people need. And maybe people whose genetics favor vegetarianism are able to synthesize these components endogenously. However, at this time, this is mere speculation and much more work needs to be done to understand the physiology of vegetarianism.” The study was published on October 4 in the journal PLOS ONE. It is the first fully peer-reviewed and indexed study to look at the association between genetics and strict vegetarianism. Why Do Most People Eat Meat? Religious and moral considerations have been major motivations behind adopting a vegetarian diet, and recent research has provided evidence for its health benefits. And although vegetarianism is increasing in popularity, vegetarians remain a small minority of people worldwide. For example, in the U.S., vegetarians comprise approximately 3 to 4% of the population. In the U.K., 2.3% of adults and 1.9% of children are vegetarian. This raises the question of why most people still prefer to eat meat products. The driving factor for food and drink preference is not just taste, but also how an individual’s body metabolizes it, Yaseen said. For example, when trying alcohol or coffee for the first time, most people would not find them pleasurable, but over time, one develops a taste because of how alcohol or caffeine makes them feel. “I think with meat, there’s something similar,” Yaseen said. “Perhaps you have a certain component — I’m speculating a lipid component — that makes you need it and crave it.” If genetics influence whether someone chooses to be a vegetarian, what does that mean for those who don’t eat meat for religious or moral reasons? “While religious and moral considerations certainly play a major role in the motivation to adopt a vegetarian diet, our data suggest that the ability to adhere to such a diet is constrained by genetics,” Yaseen said. “We hope that future studies will lead to a better understanding of the physiologic differences between vegetarians and non-vegetarians, thus enabling us to provide personalized dietary recommendations and to produce better meat substitutes.” Reference: “Genetics of vegetarianism: A genome-wide association study” by Nabeel R. Yaseen, Catriona L. K. Barnes, Lingwei Sun, Akiko Takeda and John P. Rice, 4 October 2023, PLOS ONE. DOI: 10.1371/journal.pone.0291305 The study, titled “Genetics of Vegetarianism: A Genome-Wide Association Study,” was conducted in collaboration with scientists from Washington University in St. Louis and Edinburgh, United Kingdom.

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