Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Ergonomic insole ODM support Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Thailand athletic insole OEM supplier

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Ergonomic insole ODM support Vietnam

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene insole OEM factory Indonesia

Scavenging amphipods from Kongsfjorden, Svalbard. Credit: Alfred Wegener Institute / Charlotte Havermans First observation of marine invertebrates eating live and dead jellyfish during Arctic winter. In the dark and cold of the months-long polar night, food resources are limited. Some groups of marine organisms in the polar regions overcome this challenge by going into a metabolic resting state in winter, surviving on reserves accumulated during the short growth season. But others, such as several species of marine zooplankton, have evolved a different strategy: they shift from a specialized to an omnivorous diet during the polar night, profiting from a wide range of potentially less rewarding foods that are available throughout the year. Now, scientists have shown that one key source of food for such seasonal Arctic omnivores has been overlooked until now: dead and living jellyfish. The results are published in Frontiers in Marine Science. Pink helmet jellyfish, a hydrozoan. Credit: C. Havermans “Here we show for the first time that jellyfish – thought to be typically poor in nutrients – are nevertheless an important food source for amphipods during the Arctic polar night,” said Annkathrin Dischereit, a doctoral student at the Alfred Wegener Institute in Germany, and the article’s first author. “For example, we found evidence that some amphipods feast on ‘jelly-falls’, naturally sunken jellyfish carcasses. Other species may also prey on living jellyfish.” Ctenophore or comb jelly. Credit: C. Havermans Research Expedition and Findings In January and February 2022, Dischereit and others from the Helmholtz Young Investigator Group ARJEL at the Alfred Wegener Institute took part in an expedition to the German-French AWIPEV research station on Svalbard. Venturing out in a small boat from Kongsfjorden, Svalbard, the researchers found its waters to be teeming with jellyfish: not just ‘true jellyfish’ like the lion’s mane jellyfish, but also hydrozoans like the thimble-shaped pink helmet jellyfish, colonial siphonophores, and unrelated comb jellies or ctenophores. The researchers sampled the local amphipods – crustaceans between five and 20 millimeters long – with nets and baited traps. They had chosen to focus on amphipods because they are locally abundant and important components of the fjord systems. The catch mainly consisted of four species: Orchomenella minuta and Anonyx sarsi, scavenging amphipods in the superfamily Lysianassoidea, and two distantly related Gammarus species. DNA Metabarcoding of Ingested Prey The researchers dissected the guts out of each amphipod, and then used DNA metabarcoding to identify the remains of prey within. Jellyfish DNA from multiple species predominated in the guts of both Gammarus species, together with traces from algae and crustaceans. Jellyfish DNA was likewise found, but less abundant, in A. sarsi and O. minuta, proving that all four species studied routinely consume jellyfish tissue. The authors conclude that A. sarsi and O. minuta seem to opportunistically feed on jelly-falls, while both Gammarus may in addition prey on live comb jellies. The French-German AWIPEV research station on Svalbard, where the research was done. Credit: E-Horvath (AWI) Fish – living or dead – were likewise important food for both A. sarsi and O. minuta, together with polychaete worms, crustaceans, and mollusks. Dischereit et al. also found that between 27% and 60% of the sampled amphipods had empty guts. This confirms that food scarcity and starvation are a challenge to marine invertebrates during the polar night, even for species that can shift to a more omnivorous diet. Sampling marine organisms with handnets on Svalbard. Credit: E Horvath (AWI) Paradigm Shift on Jellyfish “There has been a recent paradigm shift in the marine biology literature that recognizes that far from being a ‘trophic dead-end’, jellyfish are in fact eaten by a wide range of organisms. Our observations corroborate this major change in how scientists view the role of jellyfish in the food web,” said Dr Charlotte Havermans, the leader of the 2022 expedition and the study’s last author. “Because jellyfish tissue is quickly digested, they may have been overlooked as a prey item in previous studies, which unlike our study relied on visual identification of food items to determine the diet of Arctic invertebrates.” The scientists at the AWIPEV research station on Svalbard. Credit: G. Tran ‘Atlantification’ and the New Arctic Today, the Arctic is warming at a record rate compared to the rest of the world, and jellyfish species from the Atlantic Ocean have been observed to spread northward. This ‘Atlantification’ may make jellyfish even more important as a resource within Arctic food webs. “To get a better idea of the role of jellyfish in the Arctic marine food web, and how this may change when their populations increase in the ‘new Arctic’, we plan to further investigate the diet of other invertebrates and fish that potentially feed on jellyfish. Questions remain, for example, whether jellyfish are a regular part of the diet of amphipods or whether they are simply a survival food during the polar night,” concluded Dischereit. Inventorizing catch from baited traps. Credit: C. Havermans Reference: “DNA metabarcoding reveals a diverse, omnivorous diet of Arctic amphipods during the polar night, with jellyfish and fish as major prey” by Annkathrin Dischereit, Jan Beermann, Benoit Lebreton, Owen S. Wangensteen, Stefan Neuhaus and Charlotte Havermans, 9 January 2024, Frontiers in Marine Science. DOI: 10.3389/fmars.2024.1327650

Macaques in the shade on Cayo Santiago. Credit: Lauren Brent A new study explores how Hurricane Maria’s devastation led to significant changes in the social behavior of rhesus macaques on Puerto Rico’s Monkey Island. By destroying much of their habitat, the hurricane created a situation where macaques that were more tolerant and less aggressive had a survival advantage due to their increased ability to share scarce resources like shade. New research reveals that a devastating hurricane transformed a monkey society by shifting the balance of advantages and disadvantages in social interactions. Hurricane Maria hit Puerto Rico in 2017, killing more than 3,000 people. It also destroyed 63% of vegetation on Cayo Santiago (also known as Monkey Island), which is home to a population of rhesus macaques. Even now, tree cover remains far below pre-hurricane levels and – in this hot part of the world – that makes shade a scarce and precious resource for the macaques. The new study, led by the universities of Pennsylvania and Exeter and published in the journal Science, shows the storm damage altered the evolutionary benefits of tolerating others and sharing shade – giving a survival advantage to tolerant macaques. With many ecosystems changing rapidly due to human activity, this study is an example of a species adapting its social strategy to survive. Impact on Macaque Behavior “In response to the drastic changes caused by the hurricane, macaques persistently increased tolerance and decreased aggression towards each other,” said Dr Camille Testard, from the University of Pennsylvania. “This enabled more macaques to access scarce shade, which is critical for survival.” Dr Testard added: “We examined 10 years of data on the strength and number of macaques’ social ties, before and after the hurricane. Before the hurricane, tolerating others had no impact on the risk of death. Afterward, macaques that displayed more than average social tolerance – and were, therefore, better able to share shade – were 42% less likely to die than those that were less tolerant.” This represents a sudden change in “selection pressure” – the evolutionary benefits or costs of different traits or behaviors. Social behavior was assessed by recording aggression and how often individuals were seen sitting together. Broader Implications and Conclusion “Macaques aren’t the best at sharing resources – be they food or shade. They are well known to live in an aggressive, highly competitive society,” said Professor Lauren Brent, from the University of Exeter. “But in the heat caused by ecological changes, often around 40C, the macaques had to share space or die.” Dr Testard added: “To access shade, they need to tolerate – and be tolerated by – others, and we found that this tolerance spills over into other daily interactions. Macaques that began sharing shade also spend time together in the mornings, before the day’s heat forces them to seek shade. In effect, the hurricane changed the rules of the game in the monkeys’ society.” Professor Brent added: “For group-living animals, social relationships may allow them to cope with disturbances in the environment, including human-induced climate change. We were surprised the macaques’ social behavior was so flexible, making them resilient to this environmental change, but some species may not display this same flexibility.” Reference: “Ecological disturbance alters the adaptive benefits of social ties” by C. Testard, C. Shergold, A. Acevedo-Ithier, J. Hart, A. Bernau, J. E. Negron-Del Valle, D. Phillips, M. M. Watowich, J. I. Sanguinetti-Scheck, M. J. Montague, N. Snyder-Mackler, J. P. Higham, M. L. Platt and L. J. N. Brent, 20 June 2024, Science. DOI: 10.1126/science.adk0606 The research team included Arizona State University and New York University. Funders included the National Institutes of Health, the European Research Council, the National Science Foundation, and the Royal Society.

Scientists have discovered that AP2A1 controls cellular aging, making it a promising target for anti-aging therapies. Suppressing AP2A1 reverses aging in cells, while increasing it accelerates senescence. Researchers from Osaka University have discovered that the protein subunit AP2A1 may play a role in the unique structural organization of senescent cells. There are countless products on the market that claim to restore a youthful appearance by reducing wrinkles or tightening the jawline. But what if aging could be reversed at the cellular level? Researchers in Japan may have uncovered a way to do just that. A recent study published in Cellular Signaling by scientists at Osaka University identifies a key protein that regulates the transition between “young” and “old” cell states. As the body ages, senescent cells—older, less active cells—accumulate in various organs. These cells are significantly larger than younger ones and display structural changes, including altered organization of stress fibers, which are essential for movement and interaction with their environment. “We still don’t understand how these senescent cells can maintain their huge size,” says lead author of the study Pirawan Chantachotikul. “One intriguing clue is that stress fibers are much thicker in senescent cells than in young cells, suggesting that proteins within these fibers help support their size.” Graphical abstract. Credit: Chantachotikul et al., Osaka University The Role of AP2A1 in Cellular Senescence To explore this possibility, the researchers examined AP2A1 (Adaptor Protein Complex 2, Alpha 1 Subunit). AP2A1 is a protein that is upregulated in the stress fibers of senescent cells, including fibroblasts, which create and maintain the skin’s structural and mechanical characteristics, and epithelial cells. The researchers eliminated AP2A1 expression in older cells and overexpressed AP2A1 in young cells to determine the effect on senescence-like behaviors. “The results were very intriguing,” explains Shinji Deguchi, senior author. “Suppressing AP2A1 in older cells reversed senescence and promoted cellular rejuvenation, while AP2A1 overexpression in young cells advanced senescence.” Furthermore, the researchers found that AP2A1 is often closely associated with integrin β1, a protein that helps cells latch onto the scaffolding-like collagen matrix that surrounds them, and that both AP2A1 and integrin β1 move along stress fibers within cells. In addition, integrin β1 strengthened cell–substrate adhesions in fibroblasts; this might explain the cause of the raised or thickened structures characteristic of senescent cells. “Our findings suggest that senescent cells maintain their large size through improved adhesion to the extracellular matrix via AP2A1 and integrin β1 movement along enlarged stress fibers,” concludes Chantachotikul. Given that AP2A1 expression is so closely linked to signs of aging in senescent cells, it could potentially be used as a marker for cellular aging. The research team’s work may also provide a new treatment target for diseases that are associated with old age. Reference: “AP2A1 modulates cell states between senescence and rejuvenation” by Pirawan Chantachotikul, Shiyou Liu, Kana Furukawa and Shinji Deguchi, 21 January 2025, Cellular Signalling. DOI: 10.1016/j.cellsig.2025.111616

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