Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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China anti-odor insole OEM service

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan OEM/ODM hybrid insole services

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Taiwan high-end foam product OEM/ODM

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Smart pillow ODM manufacturer Thailand

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Pillow ODM design and manufacturing company in Taiwan

GROVER, a new large language model trained on human DNA by researchers at Dresden University of Technology’s Biotechnology Center, can decode complex genomic information by treating DNA as a language. This innovative tool holds the potential to revolutionize genomics and accelerate personalized medicine. DNA is crucial for life, and its organization has been a significant scientific challenge. GROVER, a model developed by BIOTEC, decodes DNA like text, promising advancements in genomics and personalized medicine. DNA holds the essential information required to sustain life. Deciphering how this information is stored and organized has been one of the greatest scientific challenges of the past century. Now, with GROVER, a new large language model trained on human DNA, researchers can attempt to decode the intricate information concealed within our genome. Developed by a team at the Biotechnology Center (BIOTEC) of Dresden University of Technology, GROVER treats human DNA as text, learning its rules and context to extract functional information about DNA sequences. Published in Nature Machine Intelligence, this innovative tool has the potential to revolutionize genomics and accelerate personalized medicine. Since the discovery of the double helix, scientists have sought to understand the information encoded in DNA. 70 years later, it is clear that the information hidden in the DNA is multilayered. Only 1-2 % of the genome consists of genes, the sequences that code for proteins. “DNA has many functions beyond coding for proteins. Some sequences regulate genes, others serve structural purposes, and most sequences serve multiple functions at once. Currently, we don’t understand the meaning of most of the DNA. When it comes to understanding the non-coding regions of the DNA, it seems that we have only started to scratch the surface. This is where AI and large language models can help,” says Dr. Anna Poetsch, research group leader at the BIOTEC. DNA as a Language Large language models, like GPT, have transformed our understanding of language. Trained exclusively on text, the large language models developed the ability to use the language in many contexts. “DNA is the code of life. Why not treat it like a language?” says Dr. Poetsch. The Poetsch team trained a large language model on a reference human genome. The resulting tool named GROVER, or “Genome Rules Obtained via Extracted Representations”, can be used to extract biological meaning from the DNA. “GROVER learned the rules of DNA. In terms of language, we are talking about grammar, syntax, and semantics. For DNA this means learning the rules governing the sequences, the order of the nucleotides and sequences, and the meaning of the sequences. Like GPT models learning human languages, GROVER has basically learned how to ‘speak’ DNA,” explains Dr. Melissa Sanabria, the researcher behind the project. The team showed that GROVER can not only accurately predict the following DNA sequences but can also be used to extract contextual information that has biological meaning, e.g., identify gene promoters or protein binding sites on DNA. GROVER also learns processes that are generally considered to be “epigenetic”, i.e., regulatory processes that happen on top of the DNA rather than being encoded. “It is fascinating that by training GROVER with only the DNA sequence, without any annotations of functions, we are actually able to extract information on biological function. To us, it shows that the function, including some of the epigenetic information, is also encoded in the sequence,” says Dr. Sanabria. The DNA Dictionary “DNA resembles language. It has four letters that build sequences and the sequences carry a meaning. However, unlike a language, DNA has no defined words,” says Dr. Poetsch. DNA consists of four letters (A, T, G, and C) and genes, but there are no predefined sequences of different lengths that combine to build genes or other meaningful sequences. To train GROVER, the team had to first create a DNA dictionary. They used a trick from compression algorithms. “This step is crucial and sets our DNA language model apart from the previous attempts,” says Dr. Poetsch. “We analyzed the whole genome and looked for combinations of letters that occur most often. We started with two letters and went over the DNA, again and again, to build it up to the most common multi-letter combinations. In this way, in about 600 cycles, we have fragmented the DNA into ‘words’ that let GROVER perform the best when it comes to predicting the next sequence,” explains Dr. Sanabria. The Promise of AI in Genomics GROVER promises to unlock the different layers of genetic code. DNA holds key information on what makes us human, our disease predispositions, and our responses to treatments. “We believe that understanding the rules of DNA through a language model is going to help us uncover the depths of biological meaning hidden in the DNA, advancing both genomics and personalized medicine,” says Dr. Poetsch. Reference: “DNA language model GROVER learns sequence context in the human genome” by Melissa Sanabria, Jonas Hirsch, Pierre M. Joubert and Anna R. Poetsch, 23 July 2024, Nature Machine Intelligence. DOI: 10.1038/s42256-024-00872-0

A century-old buffalofish from Apache Lake, Arizona. Credit: University of Minnesota Duluth A recent study found some of the oldest animals in the world living in a place you wouldn’t expect: fishes in the Arizona desert. Scientists have identified the second-known genus of animals that boasts three or more species with lifespans exceeding a century. This remarkable find has the potential to expand research in various fields, including those focused on gerontology and vertebrate senescence, offering new insights into longevity. Importance and Misidentification Issues The study centers around a series of fish species within the Ictiobus genus, known as buffalofishes. Minnesota has native populations of each of the three species studied: bigmouth buffalo, smallmouth buffalo and black buffalo. The importance of this research is underscored by the fact that these fishes are often misidentified and lumped in with invasive species, like carp, and the fishing regulations in many places, including Minnesota, do not properly protect these species, and what could become a wealth of information about longevity and aging. Research Collaboration and Methods This new research from the University of Minnesota Duluth (UMD), recently published in Scientific Reports, was a collaboration between Alec Lackmann, PhD, an ichthyologist and assistant professor in the Department of Mathematics and Statistics of the Swenson College of Science and Engineering at UMD; other scientists including from North Dakota State University; and a group of conservation anglers who fish the Apache Lake reservoir in Arizona. “There is likely a treasure trove of aging, longevity, and negligible senescence information within the genus Ictiobus,” said Lackmann. “This study brings light to this potential and opens the door to a future in which a more complete understanding of the process of vertebrate aging can be realized, including for humans. The research begs the question: what is the buffalofishes fountain of youth?” University of Minnesota Angler Stuart Black displays a spectacular centenarian bigmouth buffalo from Apache Lake, Arizona. Credit: University of Minnesota Lackmann has studied buffalofishes before, and his research from 2019 went so far as to extend the previously thought maximum age of bigmouth buffalo from around 25 years of age, to more than 100 years of age by applying and validating a far more refined aging technique than had been used previously. Instead of examining the fish’s scale, “you extract what are called the otoliths, or earstones, from inside the cranium of the fish, and then thin section the stones to determine their age,” said Lackmann. Approximately 97 percent of fish species have otoliths. They’re tiny stone-like structures that grow throughout the fish’s lifetime, forming a new layer each year. When processed properly, scientists like Lackmann can examine the otolith with a compound microscope and count the layers, like the rings on a tree, and learn the age of the fish. Study Findings and Conservation Efforts Results of the study include: Unparalleled longevity for freshwater fishes. Namely, three species with lifespans of more than a century, with greater than 90 percent of the buffalofishes in Apache Lake more than 85 years old. The discovery that some of the original buffalofishes from the Arizona stocking in 1918 are likely still alive. A fishery of catch-and-release buffalofish angling that has not only increased our knowledge of fisheries, but also our understanding of how buffalofishes can be identified and recaptured across years, including uniquely-marked centenarians.  A robust citizens and scientists collaborative effort that has resulted in thorough and consistent scientific outreach and learning. Buffalofishes are native to central North America, including Minnesota, but those in this recent study were found in Apache Lake, a reservoir in the desert southwest. Originally reared in hatcheries and rearing ponds along the Mississippi River in the Midwest, the government stocked buffalofishes into Roosevelt Lake (upstream of Apache Lake), Arizona in 1918. While Roosevelt Lake was fished commercially, Apache Lake’s fish populations remained largely untouched until anglers recently learned how to consistently catch buffalofishes there on rod-and-line. When these catch-and-release conservation anglers noticed unique orange and black spots on many of the fish they were catching, they wanted to learn more about the markings, and found Lackmann’s previous research. An Arizona angler, Stuart Black, reached out and invited Lackmann to a fishing expedition at Apache Lake, where the fish collected would be donated to science. By studying the fishes collected at the angling event and analyzing their otoliths for age, Lackmann found that some of the buffalofishes from the 1918 Arizona stocking are likely still alive today, and that most of the buffalofishes in Apache Lake hatched during the early 1920s. More importantly, they discovered that the three different buffalofish species found in the lake had ages more than 100 years. To their knowledge, such longevity across multiple freshwater fish species is found nowhere else in the world.   For Lackmann, there are exciting possibilities for the future of studying this unique group of fish, with far-reaching implications. “These long-lived species of fishes and individuals could be monitored so that we can further study and understand their DNA, their physiology, their ability to fight infection and disease, and to compare these systems across the continuum of age,” said Lackmann. “The genus Ictiobus has the potential to prove of high value to the field of gerontology, and Apache Lake could become an epicenter for a variety of scientific research in the future.” Reference: “Centenarian lifespans of three freshwater fish species in Arizona reveal the exceptional longevity of the buffalofishes (Ictiobus)” by Alec R. Lackmann, Stuart A. Black, Ewelina S. Bielak-Lackmann and Jeffrey A. Lackmann, 20 October 2023, Scientific Reports. DOI: 10.1038/s41598-023-44328-8

A devastating fungus affecting amphibians worldwide may be countered by a newly discovered virus that infects it. Researchers at UC Riverside are exploring how this virus could be engineered to slow down or stop the spread of the fungal disease, potentially saving numerous amphibian species from decline or extinction. Scientists have discovered a virus that infects a deadly amphibian fungus, offering hope for combating a disease that has led to significant declines in frog and toad populations globally. A fungus devastating frogs and toads on nearly every continent may have an Achilles heel. Scientists have discovered a virus that infects the fungus, and that could be engineered to save the amphibians. The fungus, Batrachochytrium dendrobatidis or Bd, ravages the skin of frogs and toads, and eventually causes heart failure. To date it has contributed to the decline of over 500 amphibian species, and 90 possible extinctions including yellow-legged mountain frogs in the Sierras and the Panamanian golden frog. Virus as a Potential Savior A new paper in the journal Current Biology documents the discovery of a virus that infects Bd, and which could be engineered to control the fungal disease. The UC Riverside researchers who found the virus are excited about the implications of their discovery. In addition to helping them learn about how fungal pathogens rise and spread, it offers the hope of ending what they call a global amphibian pandemic. The Panamanian golden frog is nearing extinction. Credit: Brian Gratwicke/U.S. Fish & Wildlife Service Amphibians: Essential Environmental Indicators “Frogs control bad insects, crop pests, and mosquitoes. If their populations all over the world collapse, it could be devastating,” said UCR microbiology doctoral student and paper author Mark Yacoub. “They’re also the canary in the coal mine of climate change. As temperatures get warmer, UV light gets stronger, and water quality gets worse, frogs respond to that. If they get wiped out, we lose an important environmental signal,” Yacoub said. Genetic Research and Discoveries Bd was not prevalent before the late 1990s, but then, “all of a sudden frogs started dying,” Yacoub said. When they found the Bd-infecting virus, Yacoub and UCR microbiology professor Jason Stajich had been working on the population genetics of Bd, hoping to gain a better understanding about where it came from and how it is mutating. Spore-producing structures of the fungus Bd. Credit: Mark Yacoub/UCR Deciphering Viral and Fungal Interactions “We wanted to see how different strains of fungus differ in places like Africa, Brazil, and the U.S., just like people study different strains of COVID-19,” Stajich said. To do this, the researchers used DNA sequencing technology. As they examined the data, they noticed some sequences that did not match the DNA of the fungus. “We realized these extra sequences, when put together, had the hallmarks of a viral genome,” Stajich said. Previously, researchers have looked for Bd viruses but did not find them. The fungus itself is hard to study because complex procedures are required to keep it alive in a laboratory. The Challenge of Studying Bd and Its Virus “It is also a hard fungus to keep track of because they have a life stage where they’re motile, they have a flagellus, which resembles a sperm tail, and they swim around,” Stajich said. Additionally, the virus that infects Bd was hard to find because most known viruses that infect fungi, called mycoviruses, are RNA viruses. However, this virus is a single-stranded DNA virus. By studying the DNA, the researchers could see the virus stuck in the genome of the fungus. Bd colonies on a plate in the Stajich laboratory. Credit: Mark Yacoub/UCR Future Research and Amphibian Immunity It appears that only some strains of the fungus have the virus in their genome. But the infected ones seem to behave differently than the ones that don’t. “When these strains possess the virus they produce fewer spores, so it spreads more slowly. But they also might become more virulent, killing frogs faster,” Stajich said. Right now, the virus is essentially trapped inside the fungal genome. The researchers would eventually like to clone the virus and see if a manually infected strain of Bd also produces fewer spores. “Because some strains of the fungus are infected and some are not, this underscores the importance of studying multiple strains of a fungal species,” Yacoub said. Moving forward, the researchers are looking for insights into the ways that the virus operates. “We don’t know how the virus infects the fungus, how it gets into the cells,” Yacoub said. “If we’re going to engineer the virus to help amphibians, we need answers to questions like these.” In some places, it appears there are a few amphibian species acquiring resistance to Bd. “Like with COVID, there is a slow buildup of immunity. We are hoping to assist nature in taking its course,” Yacoub said. Reference: “An endogenous DNA virus in an amphibian-killing fungus associated with pathogen genotype and virulence” by Rebecca A. Clemons, Mark N. Yacoub, Evelyn Faust, L. Felipe Toledo, Thomas S. Jenkinson, Tamilie Carvalho, D. Rabern Simmons, Erik Kalinka, Lillian K. Fritz-Laylin, Timothy Y. James and Jason E. Stajich, 14 March 2024, Current Biology. DOI: 10.1016/j.cub.2024.02.062

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