Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan anti-odor insole OEM processing factory

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Graphene-infused pillow ODM Thailand

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Vietnam athletic insole OEM supplier

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Vietnam insole OEM manufacturer

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene insole manufacturer in Indonesia

A study by the Allen Institute for Brain Science, using an advanced mapping tool called BARseq, revealed that specific combinations of neurons provide distinct identities to brain regions in mice. Sensory experiences, such as vision, are crucial in maintaining these unique cellular signatures, as shown by the significant changes in the visual cortex when sight is deprived. This technique offers a new and efficient way to explore brain organization and the impact of sensory inputs on neural architecture. The study findings highlight the crucial impact of sensory experiences on brain development. Scientists have long understood that our brains are structured into distinct areas, each dedicated to specific functions. For example, the visual cortex handles what we see, and the motor cortex controls movement. However, the mechanisms of how these regions form—and how their neural building blocks differ—remain a mystery. A study published in Nature sheds new light on the brain’s cellular landscape. Researchers at the Allen Institute for Brain Science used an advanced method called BARseq to swiftly classify and map millions of neurons across nine mouse brains. They discovered that while brain regions share the same types of neurons, the specific combination of these cells gives each area a distinct ‘signature,’ akin to a cellular ID card. The team further explored how sensory inputs influence these cellular signatures. They discovered that mice deprived of sight experienced a major reorganization of cell types within the visual cortex, which blurred the distinctions with neighboring areas. These shifts were not confined to the visual area but occurred across half of cortical regions, though to a lesser extent. Mara Rue, Ph.D., co-lead author and scientist at the Allen Institute for Brain Science. Credit: Peter Kim/Allen Institute The study underscores the pivotal role of sensory experiences in shaping and maintaining each brain region’s unique cellular identity. “BARseq lets us see with unprecedented precision how sensory inputs affect brain development,” said Xiaoyin Chen, Ph.D., the study’s co-lead author and an Assistant Investigator at the Allen Institute. “These broad changes illustrate how important vision is in shaping our brains, even at the most basic level.” A powerful new brain mapping tool Previously, capturing single-cell data across multiple brains was challenging, said Mara Rue, Ph.D., co-lead author and a Scientist at the Allen Institute. But BARseq is cheaper and less time-consuming than similar mapping technologies, she said, enabling researchers to examine and compare brain-wide molecular architecture across multiple individuals. BARseq tags individual brain cells with unique RNA ‘barcodes’ to track their connections across the brain. This data, combined with gene expression analysis, allows scientists to pinpoint and identify vast numbers of neurons in tissue slices. For this study, the research team used BARseq as a standalone method to rapidly analyze gene expression in intact tissue samples. In just three weeks, the researchers mapped more than 9 million cells from eight brains. The scale and speed of BARseq provides scientists with a powerful new tool to delve deeper into the intricacies of the brain, Chen said. “BARseq allows us to move beyond mapping what a ‘model’ or ‘standard’ brain looks like and start to use it as a tool to understand how brains change and vary,” Chen said. “With this throughput, we can now ask these questions in a very systematic way, something unthinkable with other techniques.” Chen and Rue emphasized that the BARseq method is freely available. They hope their study encourages other scientists to use it to investigate the brain’s organizational principles or zoom in on cell types associated with disease. “This isn’t something that only the big labs can do,” Rue said. “Our study is a proof of principle that BARseq allows a wide range of people in the field to use spatial transcriptomics to answer their own questions.” Reference: “Whole-cortex in situ sequencing reveals input-dependent area identity” by Xiaoyin Chen, Stephan Fischer, Mara C. P. Rue, Aixin Zhang, Didhiti Mukherjee, Patrick O. Kanold, Jesse Gillis and Anthony M. Zador, 24 April 2024, Nature. DOI: 10.1038/s41586-024-07221-6

An artist interpretation of the hazy atmosphere of Archean Earth – a pale orange dot. Credit: NASA’s Goddard Space Flight Center/Francis Reddy Scientists review the extensive influence of microorganisms on Earth’s history, tracing their impact through isotopic and genetic evidence. The study highlights the connection between microbial activity and major environmental shifts, such as oxygen levels, which are crucial for understanding Earth’s evolution and assessing extraterrestrial habitability. NASA-supported scientists have examined the long and intricately linked history of microbial life and the Earth’s environment. By reviewing the current state of knowledge across fields like microbiology, molecular biology, and geology, the study looks at how microorganisms have both shaped and been shaped by chemical properties of our planet’s oceans, land, and atmosphere. The study combines data across multiple fields of study and discusses how information on the complicated history of life on our planet from a single field cannot be viewed in isolation. Understanding Microbial Fossils The first life on Earth was microbial. Today the vast majority of our planet’s biomass is still made up of tiny, single-celled microorganisms. Although they’re abundant, the history of microbes can be a challenge for astrobiologists to study. Microbes don’t leave bones, shells or other large fossils behind like dinosaurs, fish, or other large organisms. Because of this, scientists must look at different evidence to understand the evolution of microbial life through time. Rocks along the shoreline of Lake Salda in Turkey were formed over time by microbes that trap minerals in the water. These microbialites were once a major form of life on Earth. Credit: NASA/JPL-Caltech In order to study ancient microbes on Earth, astrobiologists look for isotopic fingerprints in rocks that can be used to identify the metabolisms of ancient communities. Metabolism refers to the conversion of food into energy, and happens in all living things. Many elements (think carbon (C), nitrogen (N), Sulfur (S), iron (Fe)) are involved in microbial metabolism. As microbes process these elements, they cause isotopic changes that scientists can spot in the rock record. Microbes also help to control how these elements are deposited and cycled in the environment, affecting geology and chemistry at both local and global scales (consider the role of microbes in the carbon cycle on Earth today). Genetic and Geological Insights Another way to study ancient microbial life is to look back along the evolutionary information contained in the genetics of life today. Combining this genetic information from molecular biology with geobiological information from the rock record can help astrobiologists understand the connections between the shared evolution of the early Earth and early life. For an example of geological evidence of microbial metabolism, we can consider the formation of banded iron formations (BIFs) on the ancient seafloor. These colorful layers of alternating iron- and silicon-rich sediment were formed from 3.8 billion to 1.8 billion years ago and are associated with some of the oldest rock formations on Earth. The red colors they exhibit are from their high iron content, showing us that the ocean of Earth was rich in iron during the 2 billion years in which these rocks were forming. Many microbial structures on the shores of Lake Salda in Turkey are exposed as water levels drop, allowing scientists to study relationships between life and the surrounding environment. Credit: Tim Lyons/UCR In the new study, the team of researchers provides a review of current knowledge, gleaning information into the early metabolisms used by microbial life, the timing of when these metabolisms evolved, and how these processes are linked to major chemical and physical changes on Earth, such as the oxygenation of the oceans and atmosphere. Evolution and Oxygenation Effects Over time, the prevalence of oxygen on Earth has varied dramatically, in the ocean, in the atmosphere, and on land. These changes impacted both the evolution of the biosphere and the environment. For instance, as the activity of photosynthetic organisms raised oxygen levels in the atmosphere, creating new environments for microbial life to inhabit. Different nutrients were made accessible to life to fuel growth. At the same time, microbes that couldn’t survive in the presence of oxygen had to adapt, perish, or find a way to survive in environments where oxygen didn’t persist, such as deep in the Earth’s subsurface. Photograph of a fossilized stromatolite in Australia. These ancient structures resulted from the activity of microorganisms that lived in layered, mat-like colonies. Credit: NASA/Mike Toillion The new study explains our understanding of how oxygen levels have changed over time and spatial scales. The authors map different types of microbial metabolism, such as photosynthesis, to this history to better understand the “cause-and-effect relationship” between oxygen and the evolution of life on Earth. The paper provides important context for major changes in the course of evolution for the biosphere and the planet. Biogeochemical Cycles and Evolutionary Impacts By carefully considering the history of different types of microbial metabolisms on Earth, the review paper shows how biogeochemical cycles on our planet are inextricably linked through time over both local and global scales. The authors also discuss significant gaps in our knowledge that limit interpretations. For instance, we do not know how large the young biosphere on Earth was, which limits our ability to estimate the global effects of various metabolisms during Earth’s earliest years. Similarly, when using genetic information to look back along the tree of life, scientists can estimate when certain genes first appeared (and thereby what types of metabolisms could have been used at the time in living cells). However, the evolution of a new type of metabolism at a point in history does not necessarily mean that that metabolism was common or had a large enough effect in the environment to leave evidence in the rock record. This is an illustration of exoplanet WASP-39 b, also known as Bocaprins. NASA’s James Webb Space Telescope provided the most detailed analysis of an exoplanet atmosphere ever with WASP-39 b analysis released in November 2022. Webb’s Near-Infrared Spectrograph (NIRSpec) showed unambiguous evidence for carbon dioxide in the atmosphere, while previous observations from NASA’s Hubble and Spitzer Space Telescopes, as well as other telescopes, indicate the presence of water vapor, sodium, and potassium. The planet probably has clouds and some form of weather, but it may not have atmospheric bands like those of Jupiter and Saturn. This illustration is based on indirect transit observations from Webb as well as other space and ground-based telescopes. Webb has not captured a direct image of this planet. Credit: NASA, ESA, CSA, Joseph Olmsted (STScI) Conclusion and Implications for Extraterrestrial Life According to the authors, “The history of microbial life marched in step with the history of the oceans, land and atmosphere, and our understanding remains limited by how much we still do not know about the environments of the early Earth.” The study also has wider implications in the search for life beyond Earth. Understanding the co-evolution of life and the environment can help scientists better understand the conditions necessary for a planet to be habitable. The interconnections between life and the environment also provide important clues in the search for biosignature gases in the atmospheres of planets that orbit distant stars. For more on this research, see New Insights Into Earth’s First Organisms Could Change How We Search for Extraterrestrial Life. Reference: “Co‐evolution of early Earth environments and microbial life” by Timothy W. Lyons, Christopher J. Tino, Gregory P. Fournier, Rika E. Anderson, William D. Leavitt, Kurt O. Konhauser and Eva E. Stüeken, 29 May 2024, Nature Reviews Microbiology. DOI: 10.1038/s41579-024-01044-y

Neurons Brain Signals Illustration When performing calculations, some neurons are active when adding, others when subtracting. The brain has neurons that fire specifically during certain mathematical operations. This is shown by a recent study conducted by the Universities of Tübingen and Bonn. The findings indicate that some of the neurons detected are active exclusively during additions, while others are active during subtractions. They do not care whether the calculation instruction is written down as a word or a symbol. The results have now been published in the journal Current Biology. Most elementary school children probably already know that three apples plus two apples add up to five apples. However, what happens in the brain during such calculations is still largely unknown. The current study by the Universities of Bonn and Tübingen now sheds light on this issue. Some neurons in the brain become active specifically in addition tasks, others in subtraction. Credit: Christian Burkert/Volkswagen-Stiftung/University of Bonn The researchers benefited from a special feature of the Department of Epileptology at the University Hospital Bonn. It specializes in surgical procedures on the brains of people with epilepsy. In some patients, seizures always originate from the same area of the brain. In order to precisely localize this defective area, the doctors implant several electrodes into the patients. The probes can be used to precisely determine the origin of the spasm. In addition, the activity of individual neurons can be measured via the wiring. Some Neurons Fire Only When Summing Up Five women and four men participated in the current study. They had electrodes implanted in the so-called temporal lobe of the brain to record the activity of nerve cells. Meanwhile, the participants had to perform simple arithmetic tasks. “We found that different neurons fired during additions than during subtractions,” explains Prof. Florian Mormann from the Department of Epileptology at the University Hospital Bonn. It was not the case that some neurons responded only to a “+” sign and others only to a “-” sign: “Even when we replaced the mathematical symbols with words, the effect remained the same,” explains Esther Kutter, who is doing her doctorate in Prof. Mormann’s research group. “For example, when subjects were asked to calculate ‘5 and 3’, their addition neurons sprang back into action; whereas for ‘7 less 4,’ their subtraction neurons did.” For the study, tiny electrodes were implanted in the brains of five women and four men to measure the activity of individual neurons. Credit: Christian Burkert/Volkswagen-Stiftung/University of Bonn This shows that the cells discovered actually encode a mathematical instruction for action. The brain activity thus showed with great accuracy what kind of tasks the test subjects were currently calculating: The researchers fed the cells’ activity patterns into a self-learning computer program. At the same time, they told the software whether the subjects were currently calculating a sum or a difference. When the algorithm was confronted with new activity data after this training phase, it was able to accurately identify during which computational operation it had been recorded. Prof. Andreas Nieder from the University of Tübingen supervised the study together with Prof. Mormann. “We know from experiments with monkeys that neurons specific to certain computational rules also exist in their brains,” he says. “In humans, however, there is hardly any data in this regard.” During their analysis, the two working groups came across an interesting phenomenon: One of the brain regions studied was the so-called parahippocampal cortex. There, too, the researchers found nerve cells that fired specifically during addition or subtraction. However, when summing up, different addition neurons became alternately active during one and the same arithmetic task. Figuratively speaking, it is as if the plus key on the calculator were constantly changing its location. It was the same with subtraction. Researchers also refer to this as “dynamic coding.” “This study marks an important step towards a better understanding of one of our most important symbolic abilities, namely calculating with numbers,” stresses Mormann. The two teams from Bonn and Tübingen now want to investigate exactly what role the nerve cells found play in this. Reference: “Neuronal codes for arithmetic rule processing in the human brain” by Esther F. Kutter, Jan Boström, Christian E. Elger, Andreas Nieder and Florian Mormann, 14 February 2022, Current Biology. DOI: 10.1016/j.cub.2022.01.054 The study was funded by the German Research Foundation (DFG) and the Volkswagen Foundation.

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