Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Arch support insole OEM from China

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Breathable insole ODM development Vietnam

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Pillow OEM for wellness brands Vietnam

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.PU insole OEM production in Indonesia

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Indonesia anti-bacterial pillow ODM design

A species of crayfish thought to be extinct was found in Shelta Cave, where Dr. Matthew L. Niemiller is snorkeling (shown above). Credit: Amata Hinkle A cave inside Huntsville’s city was discovered to contain a small, rare crayfish that was previously believed to be extinct. A team led by an assistant professor at The University of Alabama in Huntsville (UAH) has uncovered a small, rare crayfish that was believed to have been extinct for 30 years in a cave in the City of Huntsville in northern Alabama. Crayfish are a type of freshwater crustaceans that look similar to small lobsters. The Shelta Cave Crayfish, scientifically known as Orconectes sheltae, was discovered by Dr. Matthew L. Niemiller’s team during 2019 and 2020 trips into Shelta Cave, its sole habitat. A study on the discoveries was published in the journal Subterranean Biology. The study was co-authored by Dr. Niemiller, an assistant professor of biological sciences at UAH, a member of the University of Alabama System. Authors include Nathaniel Sturm of the University of Alabama, Katherine E. Dooley, K. Denise Kendall Niemiller of UAH, and Dr. Niemiller. A 2,500-foot (760-meter) cave system that is owned and maintained by the National Speleological Society (NSS) is the crayfish’s home. It is discretely tucked under the NSS’s national headquarters in northwest Huntsville, and it is surrounded by busy roads. The Shelta Cave Crayfish is known to exist only in Shelta Cave. Credit: Dr. Matthew L. Niemiller “The crayfish is only a couple of inches long with diminutive pincers that are called chelae,” Dr. Niemiller says. “Interestingly, the crayfish has been known to cave biologists since the early 1960s but was not formally described until 1997 by the late Dr. John Cooper and his wife Martha.” Dr. Cooper, a biologist and speleologist who was a member of the NSS, studied the aquatic life in Shelta Cave with a particular focus on crayfish for his dissertation work in the late 1960s and early 1970s. Shelta Cave’s aquatic ecosystem was particularly diverse then, with at least 12 cave-dependent species documented, including three species of cave crayfishes. “No other cave system to date in the U.S. has more documented cave crayfishes co-occurring with each other,” Dr. Niemiller says. Collapse of Shelta Cave’s Aquatic Ecosystem But the aquatic ecosystem, including the Shelta Cave Crayfish, crashed sometime in the early 1970s. The crash may be related to a gate that was built to keep people out of the cave and yet still allows a grey bat maternity population to move freely in and out. “The initial design of the gate was not bat-friendly, and the bats ultimately vacated the cave system,” Dr. Niemiller says. “Coupled with groundwater pollution and perhaps other stressors, that all may have led to a perfect storm resulting in the collapse of the aquatic cave ecosystem.” Even before the decline in the aquatic cave community, the Shelta Cave Crayfish was never common compared to the other two species, Southern Cave Crayfish (Orconectes australis) and Alabama Cave Crayfish (Cambarus jonesi). “To the best of our knowledge, only 115 individuals had been confirmed from 1963 through 1975. Since then, only three have been confirmed – one in 1988 and the two individuals we report in 2019 and 2020,” Dr. Niemiller says. “After a couple of decades of no confirmed sightings and the documented dramatic decline of other aquatic cave life at Shelta Cave, it was feared by some, including myself, that the crayfish might now be extinct.” Rediscovery and Conservation Efforts While it’s encouraging that the Shelta Cave Crayfish still persists, he says scientists still haven’t rediscovered other aquatic species that once lived in the cave system, such as the Alabama Cave Shrimp and Tennessee Cave Salamander. “The groundwater level in Shelta Cave is the result of water that works its way naturally through the rock layers above the cave – called epikarst – from the surface,” says Dr. Niemiller. “However, urbanization in the area above the cave system may have altered rates at which water infiltrates into the cave and also increased rates of pollutants, such as pesticides and heavy metals entering the cave system.” The crayfish was rediscovered during an aquatic survey aimed at documenting all life that was encountered in the cave system. “I really wasn’t expecting to find the Shelta Cave Crayfish. My students, colleagues, and I had visited the cave on several occasions already leading up to the May 2019 trip,” Dr. Niemiller says. “We would be fortunate to see just a couple of Southern Cavefish and Southern Cave Crayfish during a survey.” While snorkeling in about 15 feet of water in North Lake located in the Jones Hall section of the cave, Dr. Niemiller spotted a smaller-sized cave crayfish below him. “As I dove and got closer, I noticed that the chelae, or pincers, were quite thin and elongated compared to other crayfish we had seen in the cave,” he says. “I was fortunate to swoop up the crayfish with my net and returned to the bank.” It was a female, measuring under an inch in carapace length, and had developing ova internally, so it was a mature adult. “We noted some other morphological characters, took photographs, acquired a tissue sample, and released the crayfish,” Dr. Niemiller says. “The second Shelta Cave Crayfish that we encountered was in August 2020 in the West Lake area,” he says. The team had searched much of the area and didn’t see much aquatic life. As they started to make their way out the lake passage to return to the surface, Nate Sturm, a master’s student in biology at the University of Alabama who had accompanied the lab for the trip, noticed a small white crayfish in an area that the team had previously walked through. “It was a male with thin and elongated chelae,” Dr. Niemiller says. “I had already walked ahead of the area and did not see the crayfish. Thank goodness for young eyes!” DNA Analysis and Conservation Challenges To aid identification, the team analyzed short fragments of mitochondrial DNA in the tissue samples collected. “We compared the newly generated DNA sequences with sequences already available for other crayfish species in the region,” Dr. Niemiller says. “A challenge we faced was that no DNA sequences existed prior to our study for the Shelta Cave Crayfish, so it was a bit of a process of elimination, so to speak.” While few crayfish are considered single-site endemics, in other words, known to exist in just one location, that’s somewhat more common in cave-dwelling species like the Shelta Cave Crayfish, he says. “A couple other cave crayfishes are known from single cave systems in the United States. A challenge we face when trying to conserve such species is determining whether they really are known from a single cave system, or might they have slightly larger distributions but we are hampered by our ability to study life underground.” Predation and Dietary Behavior of Shelta Cave Crayfish Outside of the dissertation work done by Dr. Cooper, little about the life history and ecology of the species is known. “The Southern Cavefish (Typhlichthys subterraneus) and Tennessee Cave Salamander (Gyrinophilus palleucus) may be predators of smaller young of the Shelta Cave Crayfish. Larger Southern Cave Crayfish and Alabama Cave Crayfish might also feed on small young,” Dr. Niemiller says. “We know nothing of the diet of the species, but it likely is an omnivore feeding on organic matter washed or brought into the cave, as well as small invertebrates such as copepods and amphipods.” Although this research occurred prior to the grant, Dr. Niemiller is currently conducting the first-ever comprehensive assessment of groundwater biodiversity in the central and eastern United States, a pioneering search for new species and a new understanding of the complex web of life that exists right under our feet. The research is funded by a five-year, $1.029 million National Science Foundation (NSF) CAREER award. He says knowing the health of populations of the tiny creatures that are dependent on groundwater is important. “Groundwater is critically important not just for the organisms that live in groundwater ecosystems, but for human society for drinking water, agriculture, etc.,” Dr. Niemiller says. “The organisms that live in groundwater provide important benefits, such as water purification and biodegradation,” he says. “They also can act like ‘canaries in the coal mine,’ indicators of overall groundwater and ecosystem health.” Reference: “Rediscovery and phylogenetic analysis of the Shelta Cave Crayfish (Orconectes sheltae Cooper & Cooper, 1997), a decapod (Decapoda, Cambaridae) endemic to Shelta Cave in northern Alabama, USA” by Katherine E. Dooley, K. Denise Kendall Niemiller, Nathaniel Sturm and Matthew L. Niemiller, 20 May 2022, Subterranean Biology. DOI: 10.3897/subtbiol.43.79993

Scientists have discovered an enzyme named PUCH, crucial in halting the spread of parasitic DNA sequences in our genome. This discovery could provide insights into how our body identifies and combats both internal threats (like genomic parasites) and external ones (such as viruses and bacteria). Researchers Have Discovered a New Enzyme That Defends DNA From “Jumping Genes” Professor René Ketting’s team at the Institute of Molecular Biology (IMB) in Mainz, Germany, along with Dr. Sebastian Falk’s group at the Max Perutz Labs in Vienna, Austria, have discovered a new enzyme, PUCH, which plays a key role in preventing the spread of parasitic DNA in our genomes. This breakthrough could offer a deeper understanding of how our systems recognize and combat pathogens, helping fend off infections. Our cells are under constant attack from millions of foreign intruders, such as viruses and bacteria. To keep us from getting sick, our bodies have an immune system – a whole army of cells that specializes in detecting and destroying these invaders. However, our cells face threats not only from external enemies but also from within. Genomic Parasites Populate a Large Part of the Genome An amazing 45 percent of our genome is comprised of thousands of genomic parasites, i.e., repetitive DNA sequences called transposable elements (TEs). TEs are found in all organisms but have no specific function. They can, however, be dangerous. TEs are also called “jumping genes” because they can copy and paste themselves into new locations in our DNA. This is a major problem because it can lead to mutations that cause our cells to stop working normally or to become cancerous. As such, almost half of our genome is engaged in a constant guerrilla war with the other half as TEs seek to multiply, while our cells try to prevent them from spreading. How do our cells combat these internal enemies? Fortunately, our cells have evolved a genomic defense system of specialized proteins whose job it is to hunt down TEs and prevent them from replicating. In a new paper published in Nature, René Ketting and Sebastian Falk together with their research teams report their discovery of PUCH – a completely new, previously unknown type of enzyme, which is key to this genomic defense system. They found that PUCH plays a crucial role in producing small molecules called piRNAs, which detect TEs when they attempt to “jump.” They then activate the genomic defense system to stop TEs before they paste themselves into new locations in our DNA. The researchers discovered PUCH in the cells of the roundworm C. elegans, a simple invertebrate often used in biological research. However, the findings may also shed light on how our own immune system works. PUCH is characterized by unique molecular structures called Schlafen folds. A Possible Link Between Innate Immunity and Genome Protection Enzymes with Schlafen folds are also found in mice and humans, where they appear to play a role in innate immunity, the body’s first line of defense against viruses and bacteria. For example, some Schlafen proteins interfere with the replication of viruses in humans. On the other hand, some viruses such as monkeypox viruses, for example, may also use Schlafen proteins to attack the cell’s defense system. René Ketting suspects that Schlafen proteins may have a wider, conserved role in immunity in many species, including humans. “Schlafen proteins may represent a previously unknown molecular link between immune responses in mammals and deeply conserved RNA-based mechanisms that control TEs,” said Ketting, who is also a Professor of Biology at Johannes Gutenberg University Mainz (JGU). If so, Schlafen proteins may represent a common defense mechanism against both external enemies like viruses and bacteria as well as internal ones such as TEs. “It’s conceivable that Schlafen proteins have been repurposed into enzymes that protect cells from infectious DNA sequences, such as TEs,” added Sebastian Falk. “This discovery may profoundly impact our understanding of innate immune biology.” Reference: “piRNA processing by a trimeric Schlafen-domain nuclease” by Nadezda Podvalnaya, Alfred W. Bronkhorst, Raffael Lichtenberger, Svenja Hellmann, Emily Nischwitz, Torben Falk, Emil Karaulanov, Falk Butter, Sebastian Falk and René F. Ketting, 27 September 2023, Nature. DOI: 10.1038/s41586-023-06588-2

Dr. Dylan Gomes led the team that deployed speaker arrays early in the spring to begin playback of whitewater river noise before most birds and bats were using this high elevation (5000-7000′) mountain area. Credit: Dr. Cory Toth While many might consider a walk in the woods to be a quiet, peaceful escape from their noisy urban life, we often don’t consider just how incredibly noisy some natural environments can be. Although we use soothing natural sounds in our daily lives — to relax or for meditation — the thunder of a mountain river or the crash of pounding surf have likely been changing how animals communicate and where they live for eons. A new experimental study published in the journal Nature Communications finds that birds and bats often avoid habitats swamped with loud whitewater river noise. Dr. Dylan Gomes, a recent PhD graduate of Boise State University and first author on the paper, summarizes the aims of the work this way, “naturally-loud environments have been largely neglected in ecological research. We aimed to test the hypothesis that intense natural noise can shape animal distributions and behavior by experimentally broadcasting whitewater river noise at a massive scale.” In fact, the scientists had to transport literal tons of gear across roadless terrain to place solar-powered speaker arrays in half of their 60 locations in the Pioneer Mountains of Idaho where they monitored bird and bat populations for two summers. The speaker arrays were arranged along riparian areas, filling each bubbling brook with the auditory experience of a rushing whitewater river. The team took advantage of their experimental approach to broadcast both realistic reproductions of river noise, as well as river noise that had been shifted upwards in frequency to understand how the noise caused changes in animal numbers. “The prevailing hypothesis for why many animals avoid noise is called masking. Masking occurs when noise overlaps in frequency (what we perceive as pitch) with a biological signal or cue. By broadcasting noise of different frequencies, we hoped to assess the role that masking of important sounds, such as birdsong, plays in the avoidance of noisy places,” said the senior author of the study, Dr. Jesse Barber of Boise State University. The scientists found that overlap between background noise and song frequency predicted bird declines until acoustic environments became about as loud as a highway, at which point other forces, such as an inability to hear predators and prey, likely become more important. Understanding how noise drives animals out of otherwise good habitats is clearly important, but what about the animals that stay behind? To study foraging in birds that remained in naturally-loud places the authors set out hundreds of caterpillar decoys made of clay across their study sites. By carefully examining the types of marks predators left in the clay, the scientists found that more noise meant less foraging by birds. This means that, even after controlling for the fact that fewer birds were found in loud places, birds were less efficient at visually hunting for these silent, decoy caterpillars in the presence of noise. This is not unlike the difficulty people can experience when trying to listen to a friend talk while a muted television is on, dividing our attention. To understand how bats that remained in noise-exposed areas fared, the team deployed two foraging puzzles to solve. The first was a “robo-moth” that lured in bats with its insect-like wing beats. The second was a speaker playing a “mix tape” of cricket and katydid calls and insect walking sounds. After almost 150 nights of data collection the scientists found that, as the world gets louder, some bats switch from listening for prey sounds to using echolocation. Dr. Gomes explains, “This behavioral switch is likely driven by prey calls and footsteps being masked by river noise and this type of problem-solving likely explains why some bats can remain near the ruckus of a raging whitewater river.” When putting all these pieces together, the authors argue that by studying how animals respond to noise sources that they have faced throughout their evolutionary history, we can get a better handle on how animals will deal with human-caused noise. Dr. Clinton Francis from California Polytechnic State University and Co-Principal Investigator of the study says, “our work showing that natural noise can structure where animals live and how they behave only increases the call to manage human-caused noise. The spatial and temporal footprint of anthropogenic noise is far greater than loud natural environments.” Reference: “Phantom rivers filter birds and bats by acoustic niche” by D. G. E. Gomes, C. A. Toth, H. J. Cole, C. D. Francis and J. R. Barber, 24 May 2021, Nature Communications. DOI: 10.1038/s41467-021-22390-y Other co-authors on this paper include Dr. Cory Toth, a former postdoctoral researcher and Hunter Cole, a current Master’s student, both members of the Barber Lab at Boise State University. This work was funded by the National Science Foundation and was conducted on land owned and managed by Lava Lake Ranch.

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