Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Graphene insole manufacturer in Thailand

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Pillow OEM for wellness brands Indonesia

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.China graphene material ODM solution

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Graphene sheet OEM supplier Taiwan

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene insole OEM factory Vietnam

Insulin is a hormone produced by the pancreas that regulates blood sugar levels in the body. A new study conducted by the University of Würzburg suggests that exercise could curb the production of this hormone. Researchers discovered that insulin-producing cells are inhibited during activity, promoting energy use, and reactivated afterward, aiding recovery. Insulin is a vital hormone that plays a crucial role in regulating sugar metabolism in humans and other organisms. The mechanisms by which it performs this task are well understood. However, less is known about the control of insulin-secreting cells and the resulting insulin secretion. Researchers from the Biocenter of Julius-Maximilians-Universität (JMU) Würzburg in Germany have made new discoveries about the control of insulin secretion in their recent study published in Current Biology. The team, led by Dr. Jan Ache, used the fruit fly Drosophila melanogaster as a model organism. Interestingly, this fly also releases insulin after eating, but unlike humans, the hormone is not produced by pancreas cells, but rather by nerve cells in the brain. The figure shows the relationship between the movement and regulation of insulin-producing cells in the fruit fly. Credit: Sander Liessem / University of Wuerzburg Electrophysiological Measurements in Active Flies The JMU group figured out that the physical activity of the fly has a strong effect on its insulin-producing cells. For the first time, the researchers measured the activity of these cells electrophysiologically in walking and flying Drosophila. The result: when Drosophila starts to walk or fly, its insulin-producing cells are immediately inhibited y. When the fly stops moving, the activity of the cells rapidly increases again and shoots up above normal levels. “We hypothesize that the low activity of insulin-producing cells during walking and flight contributes to the provision of sugars to meet the increased energy demand,” says Dr. Sander Liessem, first author of the publication. “We suspect that the increased activity after exercise helps to replenish the fly’s energy stores, for example in the muscles.” Blood Sugar Plays No Role in Regulation The JMU team was also able to demonstrate that the fast, behavior-dependent inhibition of insulin-producing cells is actively controlled by neural pathways. “It is largely independent of changes in the sugar concentration in the fly’s blood,” explains co-author Dr. Martina Held. It makes a lot of sense for the organism to anticipate an increased energy demand in this way to prevent extreme fluctuations in blood sugar levels. Insulin Has Hardly Changed in Evolution Do the results allow conclusions to be drawn about humans? Probably. “Although the release of insulin in fruit flies is mediated by different cells than in humans, the insulin molecule and its function have hardly changed in the course of evolution,” says Jan Ache. In the past 20 years, using Drosophila as a model organism, many fundamental questions have already been answered that could also contribute to a better understanding of metabolic defects in humans and associated diseases, such as diabetes or obesity. Less Insulin Means Longevity “One exciting point is that reduced insulin activity contributes to healthy aging and longevity,” Sander Liessem tells us. This has already been shown in flies, mice, humans, and other species. The same applies to an active lifestyle. “Our work shows a possible link explaining how physical activity could positively affect insulin regulation via neuronal signaling pathways.” Further Steps in the Research Next, Jan Ache’s team plans to investigate which neurotransmitters and neuronal circuits are responsible for the activity changes observed in insulin-producing cells in the fly. This is likely going to be challenging: A plethora of messenger substances and hormones are involved in neuromodulatory processes, and individual substances can have opposite or complementary effects in combination. The group is now analyzing the many ways in which insulin-producing cells process input from the outside. They are also investigating other factors that could have an influence on the activity of these cells, for example, the age of the fly or their nutritional state. “In parallel, we are investigating the neuronal control of walking and flight behavior,” explains Jan Ache. The long-term goal of his group, he says, is to bring these two research questions together: How does the brain control walking and other behaviors, and how does the nervous system ensure that the energy balance is regulated accordingly? Reference: “Behavioral state-dependent modulation of insulin-producing cells in Drosophila” by Sander Liessem, Martina Held, Rituja S. Bisen, Hannah Haberkern, Haluk Lacin, Till Bockemühl and Jan M. Ache, 28 December 2022, Current Biology. DOI: 10.1016/j.cub.2022.12.005

Hofstenia miamia, three-banded panther worms. Credit: Mansi Srivastava and Kathleen Mazza-Curll The formation of adult pluripotent stem cells in Hofstenia miamia was traced to two embryonic cells using advanced genetic tools. These findings illuminate stem cell regulation and evolutionary mechanisms. Stem cells are a remarkable biological wonder that have the ability to repair, replace and regenerate cells. In most animals and humans, stem cells are limited to generating only specific types of cells. For example, hair stem cells will only produce hair, and intestine stem cells will only produce intestines. However, many distantly-related invertebrates have stem cell populations that are pluripotent in adult animals, meaning they can regenerate virtually any missing cell type, a process known as whole-body regeneration. Despite the presence of these adult pluripotent stem cells (aPSCs) in various animal species such as sponges, hydras, planarian flatworms, acoel worms, and some sea squirts, the mechanism of how they are produced remains unknown in any species. In a new study published in the journal Cell researchers in the Department of Organismic and Evolutionary Biology at Harvard University have identified the cellular mechanism and molecular trajectory for the formation of aPSCs in the acoel worm, Hofstenia miamia. Images showing how single cells of the embryo were specifically and systematically converted to red color for this study. Credit: Julian Kimura H. miamia, also known as the three-banded panther worm, is a species that can fully regenerate using aPSCs called “neoblasts.” Chop H. miamia into pieces and each piece will grow a new body including everything from a mouth to the brain. Senior author Professor Mansi Srivastava collected H. miamia in the field many years ago because of its regenerative ability. Once back in the lab, H. miamia began to produce many embryos that could easily be studied. Transgenesis Unlocks New Avenues in Stem Cell Research In a previous study by Srivastava and co-author postdoctoral researcher Lorenzo Ricci developed a protocol for transgenesis in H. miamia. Transgenesis is a process that introduces something into the genome of an organism that is not normally part of that genome. This method allowed lead author Julian O. Kimura (Ph.D.’22) to pursue his question of how these stem cells are made. “One common characteristic among animals that can regenerate is the presence of pluripotent stem cells in the adult body,” said Kimura. “These cells are responsible for re-making missing body parts when the animal is injured. By understanding how animals like H. miamia make these stem cells, I felt we could better understand what gives certain animals regenerative abilities.” A pair of cells at the 16-cell stage embryo converted to red color. Over time, the cells divides to make more cells, go inside the embryo, and form the stem cells of the hatched worm. Credit: Julian Kimura There are some unifying features of these stem cell populations in adult animals such as the expression of a gene called Piwi. But in no species so far has anyone been able to figure out how these stem cells are made in the first place. “They’ve mostly been studied in the context of adult animals,” said Srivastava, “and in some species, we know a little bit about how they might be working, but we don’t know how they are made.” The researchers knew that worm hatchlings contain aPSCs, so reasoned they must be made during embryogenesis. Ricci used transgenesis to create a line that caused embryo cells to glow in fluorescent green due to the introduction of the protein Kaede into the cell. Kaede is photo-convertible, which means shining a laser beam with a very specific wavelength on the green will convert it to a red color. You can then zap the cells with a laser to turn individual green cells of the embryo into a red color. “Using transgenic animals with photo-conversion is a very new twist we devised in the lab to figure out the fates of embryonic cells,” said Srivastava. Kimura applied this method to perform lineage tracing by letting the embryos grow and watching what happens. A single cell at the 8-cell stage embryo converted to red color. Over time, the cell divides to make many more cells, which end up making most of the skin of the hatched worm. Credit: Julian Kimura Mapping Early Embryonic Development of Stem Cells Kimura followed the embryo’s development as it split from a single cell to multiple cells. Early division of these cells is marked by stereotyped cleavage, which means embryo-to-embryo cells divide in the exact same pattern such that cells can be named and studied consistently. This raised the possibility that perhaps every single cell has a unique purpose. For instance, at the eight-cell stage, it’s possible the top, left corner cell makes a certain tissue, while the bottom, right cell makes another tissue. To determine the function of each cell, Kimura systematically performed photo-conversion for each of the cells of the early embryo, creating a full fate map at the eight-cell stage. He then tracked the cells as the worm grew into an adult that still carried the red labeling. The repetitious process of following each individual cell again and again across many embryos made it possible for Kimura to trace where each cell was working. At the sixteen-cell stage embryo, he found a very specific pair of cells that gave rise to cells that looked to be the neoblasts. “This really excited us,” said Kimura, “but there was still the possibility that neoblasts were arising from multiple sources in the early embryo, not just the two pairs found at the sixteen-cell stage. Finding cells that simply resembled neoblasts in appearance wasn’t definitive evidence that they truly were neoblasts, we needed to show that they behaved like neoblasts as well.” To be certain, Kimura put this particular set of cells, called 3a/3b in H. miamia, on trial. In order to be the neoblasts the cells must satisfy all of the known properties of stem cells. Are the progeny of those cells making new tissue during regeneration? The researchers found that yes, the progeny of only those cells made new tissue during regeneration. Another defining property is the level of gene expression in stem cells, which must have hundreds of genes expressed. To determine if 3a/3b fit this property, Kimura took the progeny with 3a/3b glowing in red and all other cells glowing in green and used a sorting machine that separated the red and green cells. He then applied single-cell sequencing technology to ask, which genes are being expressed in the red cells and in the green cells. That data confirmed that at the molecular level, only the progeny of the 3a/3b cells matched stem cells and not the progeny of any other cell. “That was definitive confirmation of the fact that we found the cellular source of the stem cell population in our system,” said Kimura. “But, importantly, knowing the cellular source of stem cells now gives us a way to capture the cells as they mature and define what genes are involved in making them.” Single-Cell Data Sheds Light on Stem Cell Formation Kimura generated a huge dataset of embryonic development at the single-cell level detailing which genes were being expressed in all of the cells in embryos from the beginning to the end of development. He allowed the converted 3a/3b cells to develop a little bit further, but not all the way to the hatchling stage. He then captured these cells using the sorting technology. By doing this Kimura could clearly define which genes were specifically being expressed in the lineage of cells that make the stem cells. “Our study reveals a set of genes that could be very important controllers for the formation of stem cells,” said Kimura. “Homologues of these genes have important roles in human stem cells and this is relevant across species.“ “Julian started in my lab wanting to study how stem cells are made in the embryo,” said Srivastava, “and it’s an incredible story that when he graduated he had figured it out.” The researchers plan to continue digging deeper into the mechanism of how these genes are working in the stem cells of Hofstenia miamia, which will help to tell how nature evolved a way to make and maintain pluripotent stem cells. Knowing the molecular regulators of aPSCs will allow researchers to compare these mechanisms across species, revealing how pluripotent stem cells have evolved across animals. Reference: “Embryonic origins of adult pluripotent stem cells” by Julian O. Kimura, D. Marcela Bolaños, Lorenzo Ricci, and Mansi Srivastava, 8 December 2022, Cell. DOI: 10.1016/j.cell.2022.11.008

A multidisciplinary team led by associate professor Hong Chen at Washington University in St. Louis has developed a novel, noninvasive method to induce a torpor-like state in mammals by targeting the central nervous system with ultrasound. The technique, which involves stimulating the hypothalamus preoptic area in the brain, was shown to effectively reduce body temperature and metabolic rate in mice, leading to a state of torpor, which is a natural mechanism used by some animals to survive extreme conditions. Credit: Image courtesy Chen laboratory, Washington University in St. Louis Scientists at Washington University in St. Louis have developed a method to induce a torpor-like state in mammals using ultrasound stimulation of the brain, according to a study in Nature Metabolism. The noninvasive technique could potentially be used in scenarios like space flights or for patients with severe health conditions to conserve energy and heat. Some mammals and birds have a clever way to preserve energy and heat by going into torpor, during which their body temperature and metabolic rate drop to allow them to survive potentially fatal conditions in the environment, such as extreme cold or lack of food. While a similar condition was proposed for scientists making flights to space in the 1960s or for patients with life-threatening health conditions, safely inducing such a state remains elusive. Hong Chen, an associate professor at Washington University in St. Louis, and a multidisciplinary team induced a torpor-like state in mice by using ultrasound to stimulate the hypothalamus preoptic area in the brain, which helps to regulate body temperature and metabolism. In addition to the mouse, which naturally goes into torpor, Chen and her team induced torpor in a rat, which does not. Their findings, published on May 25 in the journal Nature Metabolism, show the first noninvasive and safe method to induce a torpor-like state by targeting the central nervous system. Chen’s team used ultrasound to safely, noninvasively induce a torpor-like state in mice, rats. Credit: Video courtesy Chen laboratory, Washington University in St. Louis Chen, associate professor of biomedical engineering at the McKelvey School of Engineering and of radiation oncology at the School of Medicine, and her team, including Yaoheng (Mack) Yang, a postdoctoral research associate, created a wearable ultrasound transducer to stimulate the neurons in the hypothalamus preoptic area. When stimulated, the mice showed a drop in body temperature of about 3 degrees Celsius for about one hour. In addition, the mice’s metabolism showed a change from using both carbohydrates and fat for energy to only fat, a key feature of torpor, and their heart rates fell by about 47%, all while at room temperature. Controlled Hypothermia and Hypometabolism The team also found that as the acoustic pressure and duration of the ultrasound increased, so did the depth of the lower body temperature and slower metabolism, known as ultrasound-induced hypothermia and hypometabolism (UIH). “We developed an automatic closed-loop feedback controller to achieve long-duration and stable ultrasound-induced hypothermia and hypometabolism by controlling of the ultrasound output,” Chen said. “The closed-loop feedback controller set the desired body temperature to be lower than 34 °C (93.2 °F), which was previously reported as critical for natural torpor in mice. This feedback-controlled UIH kept the mouse body temperature at 32.95 °C (91.31 °F) for about 24 hours and recovered to normal temperature after ultrasound was off.” “UIH has the potential to address the long sought-after goal of achieving noninvasive and safe induction of the torpor-like state, which has been pursued by the scientific community at least since the 1960s.” Hong Chen To learn how ultrasound-induced hypothermia and hypometabolism is activated, the team studied the dynamics of the activity of neurons in the hypothalamus preoptic area in response to ultrasound. They observed a consistent increase in neuronal activity in response to each ultrasound pulse, which aligned with the changes in body temperature in the mice. “These findings revealed that UIH was evoked by ultrasound activation of hypothalamus preoptic area neurons,” Yang said. “Our finding that transcranial stimulation of the hypothalamus preoptic area was sufficient to induce UIH revealed the critical role of this area in orchestrating a torpor-like state in mice.” The TRPM2 Ion Channel Chen and her team also wanted to find the molecule that allowed these neurons to activate with ultrasound. Through genetic sequencing, they found that ultrasound activated the TRPM2 ion channel in the hypothalamus preoptic area neurons. In a variety of experiments, they showed that TRPM2 is an ultrasound-sensitive ion channel and contributed to the induction of UIH. In the rat, which does not naturally go into torpor or hibernation, the team delivered ultrasound to the hypothalamus preoptic area and found a decrease in skin temperature, particularly in the brown adipose tissue region, as well as about a 1 degree C (1.8 degrees F) drop in core body temperature, resembling natural torpor. This multidisciplinary team consists of Jonathan R. Brestoff, MD, PhD, an assistant professor of pathology and immunology at the School of Medicine; Alexxai V. Kravitz, an associate professor of psychiatry, of anesthesiology and of neuroscience at the School of Medicine, and Jianmin Cui, a professor of biomedical engineering at the McKelvey School of Engineering, all at Washington University in St. Louis. The team also includes Michael R. Bruchas, a professor of anesthesiology and of pharmacology at the University of Washington. “UIH has the potential to address the long sought-after goal of achieving noninvasive and safe induction of the torpor-like state, which has been pursued by the scientific community at least since the 1960s,” Chen said. “Ultrasound stimulation possesses a unique capability to noninvasively reach deep brain regions with high spatial and temporal precision in animal and human brains.” Reference: “Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound” by Yaoheng Yang, Jinyun Yuan, Rachael L. Field, Dezhuang Ye, Zhongtao Hu, Kevin Xu, Lu Xu, Yan Gong, Yimei Yue, Alexxai V. Kravitz, Michael R. Bruchas, Jianmin Cui, Jonathan R. Brestoff and Hong Chen, 25 May 2023, Nature Metabolism. DOI: 10.1038/s42255-023-00804-z This work was supported by the National Institutes of Health (R01MH116981, UG3MH126861, R01EB027223, and R01EB030102). JRB is supported by NIH (DP5 OD028125) and Burroughs Wellcome Fund (CAMS #1019648).

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