Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Breathable insole ODM development Thailand

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan OEM insole and pillow supplier

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Custom graphene foam processing Vietnam

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.High-performance graphene insole OEM Indonesia

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan neck support pillow OEM

A groundbreaking study by Yunha Hwang and team has developed gLM, an AI system that decodes the complex language of genomics from extensive microbial data. This innovation enables a deeper understanding of gene functions and regulations, leading to new discoveries in genomics. gLM exemplifies the potential of AI in advancing life sciences and tackling global challenges. Credit: SciTechDaily.com Artificial Intelligence (AI) systems, like ChatGPT, have taken the world by storm. Thre isn’t much they don’t have a hand in, from recommending the next binge-worthy TV show to helping navigate through traffic. But, can AI systems learn the language of life and help biologists reveal exciting breakthroughs in science? In a new study published in Nature Communications, an interdisciplinary team of researchers led by Yunha Hwang, PhD candidate in the Department of Organismic and Evolutionary Biology (OEB) at Harvard, have pioneered an artificial intelligence (AI) system capable of deciphering the intricate language of genomics. Genomic language is the source code of biology. It describes the biological functions and regulatory grammar encoded in genomes. The researchers asked can we develop an AI engine to “read” the genomic language and become fluent in the language, understanding the meaning, or functions and regulations, of genes? The team fed the microbial metagenomic data set, the largest and most diverse genomic dataset available, to the machine to create the Genomic Language Model (gLM). The Challenge of Genomic Data “In biology, we have a dictionary of known words and researchers work within those known words. The problem is that this fraction of known words constitutes less than one percent of biological sequences,” said Hwang, “the quantity and diversity of genomic data is exploding, but humans are incapable of processing such a large amount of complex data.” Large language models (LLMs), like GPT4, learn meanings of words by processing massive amounts of diverse text data that enables understanding the relationships between words. Genomic language model (gLM) learns from highly diverse metagenomic data, sourced from microbes inhabiting various environments including the ocean, soil, and human gut. With this data, gLM learns to understand the functional “semantics” and regulatory “syntax” of each gene by learning the relationship between the gene and its genomic context. gLM, like LLMs, is a self-supervised model – this means that it learns meaningful representations of genes from data alone and does not require human-assigned labels. Unveiling the Unknown in Genomics Researchers have sequenced some of the most commonly studied organisms like people, E. coli, and fruit flies. However, even for the most studied genomes, the majority of the genes remain poorly characterized. “We’ve learned so much in this revolutionary age of ‘omics’, including how much we don’t know,” said senior author Professor Peter Girguis, also in OEB at Harvard. “We asked, how can we glean meaning from something without relying on a proverbial dictionary? How do we better understand the content and context of a genome?” The study demonstrates that gLM learns enzymatic functions and co-regulated gene modules (called operons), and provides genomic context that can predict gene function. The model also learns taxonomic information and context-dependencies of gene functions. Strikingly, gLM does not know which enzyme it is seeing, nor what bacteria the sequence comes from. However, because it has seen many sequences and understands the evolutionary relationships between the sequences during training, it is able to derive the functional and evolutionary relationships between sequences. The Potential of gLM in Biology “Like words, genes can have different “meanings” depending on the context they are found in. Conversely, highly differentiated genes can be “synonymous” in function. gLM allows for a much more nuanced framework for understanding gene function. This is in contrast to the existing method of one-to-one mapping from sequence to annotation, which is not representative of the dynamic and context-dependent nature of the genomic language,” said Hwang. Hwang teamed with co-authors Andre Cornman (an independent researcher in machine learning and biology), Sergey Ovchinnikov (former John Harvard Distinguished Fellow and current Assistant Professor at MIT), and Elizabeth Kellogg (Associate Faculty at St. Jude Children’s Research Hospital) to form an interdisciplinary team with strong backgrounds in microbiology, genomes, bioinformatics, protein science, and machine learning. “In the lab, we are stuck in a step-by-step process of finding a gene, making a protein, purifying it, characterizing it, etc. and so we kind of discover only what we already know,” Girguis said. gLM, however, allows biologists to look at the context of an unknown gene and its role when it’s often found in similar groups of genes. The model can tell researchers that these groups of genes work together to achieve something, and it can provide the answers that do not appear in the “dictionary”. “Genomic context contains critical information for understanding the evolutionary history and evolutionary trajectories of different proteins and genes,” Hwang said. “Ultimately, gLM learns this contextual information to help researchers understand the functions of genes that previously were unannotated.” “Traditional functional annotation methods typically focus on one protein at a time, ignoring the interactions across proteins. gLM represents a major advancement by integrating the concept of gene neighborhoods with language models, thereby providing a more comprehensive view of protein interactions,” stated Martin Steinegger (Assistant Professor, Seoul National University), an expert in bioinformatics and machine learning, who was not involved in the study. With genomic language modeling, biologists can discover new genomic patterns and uncover novel biology. gLM is a significant milestone in interdisciplinary collaboration driving advancements in the life sciences. “With gLM we can gain new insights into poorly annotated genomes,” said Hwang. “gLM can also guide experimental validation of functions and enable discoveries of novel functions and biological mechanisms. We hope gLM can accelerate the discovery of novel biotechnological solutions for climate change and bioeconomy.” Reference: “Genomic language model predicts protein co-regulation and function” by Yunha Hwang, Andre L. Cornman, Elizabeth H. Kellogg, Sergey Ovchinnikov and Peter R. Girguis, 3 April 2024, Nature Communications. DOI: 10.1038/s41467-024-46947-9

Manatees in Florida are more populous today than in the past, thriving due to both conservation efforts and environmental changes that accompany human activity. Historic accounts reveal manatee populations increased in the 1800s and 1900s alongside human populations. A new study highlights that Florida manatees are more numerous now than ever before, likely due to improved conservation efforts and environmental changes. While historically considered rare, manatees have benefited from the same human activities that threaten their existence, indicating a need for updated conservation strategies. Manatee Conservation Issues Florida manatees face significant threats from human activity, yet their populations are currently thriving more than ever before. This finding comes from a study published today (November 20, 2024) in the open-access journal PLOS ONE by Thomas J. Pluckhahn from the University of South Florida and David K. Thulman from George Washington University. Known as an iconic species and a focus of conservation efforts, Florida manatees are vulnerable to environmental changes and collisions with watercraft. However, little is understood about their historical populations, particularly before modern human impact. This knowledge gap makes it challenging for conservationists to set informed goals for sustaining healthy manatee populations. Manatees and tourists crowd the Three Sisters Spring at Crystal River, Florida, on a cold morning. Credit: Thomas J. Pluckhahn Study Findings on Manatee Population Trends In this study, the authors investigate manatee populations between 12,000 BC and the mid-20th century by compiling records of manatee remains from archaeological sites as well as historical accounts of manatee sightings from newspapers, journals, and other sources. The data indicates that manatees were quite rare during most of this time period before increasing in population size and distribution during the 1800s and 1900s, coincident with increasing human populations. This population growth is likely related to expanded conservation laws, improved public perception of manatees, and warming water temperatures due to climate change and power plant construction. Implications for Future Conservation Efforts Despite their modern reputation as a rare species, these results suggest that Florida manatees are more abundant today than any previous time in North American human history. Many of the anthropogenic changes that endanger the species today are also likely responsible for their population growth over the past two centuries. The authors note that manatee conservation goals cannot simply aim for a return to pre-modern population conditions, and that a detailed understanding of their history and ecological relationship with humans will be necessary to establish healthy conservation goals. The authors add: “Manatees are among Florida’s most iconic species, so the possibility that they were not common here until the modern era is surprising. There is a lot of uncertainty regarding changes the Anthropocene will bring in the future, as human-caused climate change accelerates. But our study serves as a reminder that we don’t even fully understand the changes that have already occurred across the modern era. We think there are lessons from that history which might be helpful for managing a better future for both people and manatees in Florida.” Reference: “Historical ecology reveals the “surprising” direction and extent of shifting baselines for the Florida manatee (Trichechus manatus latirostis)” by Thomas J. Pluckhahn and David K. Thulman, 20 November 2024, PLOS ONE. DOI: 10.1371/journal.pone.0313070

One of the newly described species, the Alagoas Screech Owl. Credit: Gustavo Malacco Recordings of owls’ screeches used to help tell species apart. The Amazon rainforest is teeming with creatures unknown to science—and that’s just in broad daylight. After dark, the forest is a whole new place, alive with nocturnal animals that have remained even more elusive to scientists than their day-shift counterparts. In a new paper in Zootaxa, researchers described two new species of screech owls that live in the Amazon and Atlantic forests, both of which are already critically endangered. “Screech owls are considered a well-understood group compared to some other types of organisms in these areas,” says John Bates, curator of birds at the Field Museum in Chicago and one of the study’s authors. “But when you start listening to them and comparing them across geography, it turns out that there are things that people hadn’t appreciated. That’s why these new species are being described.” “Not even professional ornithologists who have worked on owls for their entire lives would agree about the actual number of species found in this group, so a study like ours has been awaited for a really long time,” says Alex Aleixo, head of the research team responsible for the study, and currently curator of birds at the Finnish Museum of Natural History in the University of Helsinki, Finland. One of the newly described species, the Xingu Screech Owl. Credit: Kleiton Silva The newly-discovered screech owls are cousins of the Eastern Screech Owls that are common in the United States. “They’re cute little owls, probably five or six inches long, with tufts of feathers on their heads,” says Bates. “Some are brown, some are gray, and some are in between.” Until this study, the new species were lumped together with the Tawny-bellied Screech Owl and the Black-capped Screech Owl, which are found throughout South America. Teasing out the differences between the species started with years of fieldwork in the Amazon rainforest as well as the Atlantic forest running along the eastern part of Brazil and surrounding countries. Bates, who usually conducts fieldwork during the day, says that doing fieldwork in the rainforest at night comes with new challenges. “For me, it’s more a feeling of fascination than being scared, but at the same time, you’re running into spider webs. If you’re wearing a headlight you see the eyeshine of the nocturnal animals. One time I was stepping over a log and I looked down and there was a tarantula the size of my hand just sitting there,” says Bates. “If I had been a kid I would have been scared to death.” The owls that the researchers were looking for live in the trees, often a hundred feet above the forest floor. That makes studying them difficult. But the researchers had a secret weapon: the screech owls’ namesake screech. Lead author Sidnei Dantas working with owl specimens at the Field Museum. Credit: John Bates, Field Museum “To draw the birds out, we used tape recordings,” explains Bates. “We’d record their calls and then play them back. The owls are territorial, and when they heard the recordings, they came out to defend their territory.” The scientists compared the birds’ calls and found that there were variations in the sounds they made, indicative of different species. They also examined the birds’ physical appearances and took tissue samples so they could study the owls’ DNA at the Field Museum’s Pritzker DNA Lab. Altogether, 252 specimens, 83 tape recordings, and 49 genetic samples from across the range of the Tawny-bellied Screech Owl complex in South America were analyzed. A significant number of specimens were collected by the research team itself, especially the study’s lead author Sidnei Dantas, who spent a good share of his time in graduate school searching for and tape-recording screech owls in South American rainforests. In addition, natural history collections and their materials collected over the centuries were essential to complete the study´s unprecedented sampling. “The study would not have been possible if it were not for the great biological collections in Brazil and USA which I visited during my work, and that sent us essential material, either genetic or morphological. This highlights the importance of such research institutions for the progress of science and hence of the countries they represent,” says Dantas, who conducted the study as part of his PhD dissertation at the Goeldi Museum in Belém and is currently working as a nature guide in Brazilian Amazonia. The combination of genetic variation, physical differences, and unique vocalizations led the team to describe two new species in addition to the previously known Tawny-bellied Screech Owl: the Xingu Screech Owl and the Alagoas Screech Owl. The Xingu owl’s scientific name is in honor of Sister Dorothy May Stang, an activist who worked with Brazilian farmers to develop sustainable practices and fight for their land rights; its common name is for the area where the owl is found near the Xingu River. The Alagoas owl’s name is a reference to the northeastern Brazilian state of Alagoas where the owl is primarily found. While the owls are new to science, they’re already in danger of disappearing forever. “Both new species are threatened by deforestation,” says Jason Weckstein, associate curator of Ornithology in the Academy of Natural Sciences of Drexel University and associate professor in the university’s Department of Biodiversity, Earth, and Environmental Science. “The Xingu Screech Owl is endemic to the most severely burned area of the Amazon by the unprecedented 2019 fires, and the Alagoas Screech Owl should be regarded as critically endangered given the extensive forest fragmentation in the very small area where it occurs,” says Weckstein, who is a co-author and began work on this project as a postdoctoral researcher at the Field Museum. Bates says he hopes that the study will shed light on how varied the Amazon and Atlantic forests are and how simply protecting certain areas isn’t enough to preserve the forests’ biodiversity. “If you just say, ‘Well, you know Amazonia is Amazonia, and it’s big,’ you don’t end up prioritizing efforts to keep forests from being cut in these different parts of Amazonia. That could mean losing entire faunas in this region,” says Bates. In addition to the study’s conservation implications, the authors highlight the international collaboration that made the work possible. “This study shows how important it is to train the next generation of scientists at a global level,” says Bates. “That means having students like Sidnei come from Brazil and work in the Field’s Pritzker Lab and measure specimens in our collection for their research. It’s a great thing to build those connections.” Reference: “Multi-character taxonomic review, systematics, and biogeography of the Black-capped/Tawny-bellied Screech Owl (Megascops atricapilla-M. watsonii) complex (Aves: Strigidae)” by Sidnei M. Dantas, Jason D. Weckstein, John Bates, Joiciane N. Oliveira, Therese A. Catanach and Alexandre Aleixo, 26 March 2021, Zootaxa. DOI: 10.11646/zootaxa.4949.3.1

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