Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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China eco-friendly graphene material processing

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.One-stop OEM/ODM solution provider China

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Smart pillow ODM manufacturer Vietnam

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan graphene material ODM solution

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan OEM factory for footwear and bedding solutions

In a new study, Neil Hammerschlag, Ph.D., and colleagues used multiple approaches to evaluate the effects of ocean warming on tiger shark movements in the Western North Atlantic. Credit: Bianca Rangel Climate change is pushing tiger sharks in the western North Atlantic into warmer, unprotected waters, increasing their exposure to fishing and potentially upsetting marine ecosystems. A new study led by scientists at the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science revealed that the locations and timing of tiger shark movement in the western North Atlantic Ocean have changed from rising ocean temperatures. These climate-driven changes have subsequently shifted tiger shark movements outside of protected areas, leaving the sharks more vulnerable to commercial fishing. Temperature Impact on Tiger Shark Habitats The movements of tiger sharks, (Galeocerdo cuvier) the largest cold-blooded apex predator in tropical and warm-temperate seas, are constrained by the need to stay in warm waters. While waters off the U.S. northeast coastline have historically been too cold for tiger sharks, temperatures have warmed significantly in recent years making them suitable for the tiger shark. Research Findings on Migration Patterns “Tiger shark annual migrations have expanded poleward, paralleling rising water temperatures,” said Neil Hammerschlag, director of the UM Shark Research and Conservation Program and lead author of the study. “These results have consequences for tiger shark conservation, since shifts in their movements outside of marine protected areas may leave them more vulnerable to commercial fishing.” Hammerschlag and the research team discovered these climate-driven changes by analyzing nine years of tracking data from satellite-tagged tiger sharks, combined with nearly forty years of conventional tag and recapture information supplied by the National Oceanic and Atmospheric Administration (NOAA) Cooperative Shark Tagging Program and satellite derived sea-surface temperature data. Implications of Shifted Tiger Shark Migrations The study found that during the last decade, when ocean temperatures were the warmest on record, for every one-degree Celsius increase in water temperatures above average, tiger shark migrations extended farther poleward by roughly 250 miles (over 400 kilometers) and sharks also migrated about 14 days earlier to waters off the U.S. northeastern coast. The results may have greater ecosystem implications. “Given their role as apex predators, these changes to tiger shark movements may alter predator-prey interactions, leading to ecological imbalances, and more frequent encounters with humans,” said Hammerschlag. Reference: “Ocean warming alters the distributional range, migratory timing, and spatial protections of an apex predator, the tiger shark (Galeocerdo cuvier)” by Neil Hammerschlag, Laura H. McDonnell, Mitchell J. Rider, Garrett M. Street, Elliott L. Hazen, Lisa J. Natanson, Camilla T. McCandless, Melanie R. Boudreau, Austin J. Gallagher, Malin L. Pinsky and Ben Kirtman, 13 January 2022, Global Change Biology. DOI: 10.1111/gcb.16045 The study’s authors include: Neil Hammerschlag, Laura McDonnell, Mitchell Rider, Ben Kirtman from the UM Rosenstiel School; Garrett Street and Melanie Boudreau from Mississippi State University; Elliott Hazen, Lisa Natanson, Camilla McCandless from NOAA Fisheries; Austin J. Gallagher from Beneath the Waves; and Malin Pinsky from Rutgers University. The Batchelor Foundation, Disney Conservation Fund, Wells Fargo, Guy Harvey Ocean Foundation, the Herbert W. Hoover Foundation, the International Seakeepers Society, Oceana, Hoff Productions for National Geographic, and the West Coast Inland Navigation District provided support for the study.

In addition to competing for resources, living cells actively kill and eat each other. New explorations of these “cell-in-cell” phenomena show they are not restricted to cancer cells but are a common facet of living organisms, across the tree of life. Credit: Jason Drees for the Biodesign Institute at Arizona State University New research reveals that cell-in-cell phenomena, where one cell consumes another, are common across all life forms and important for normal biological functions, not just associated with cancer. In a recent review paper, Carlo Maley and his team at Arizona State University explore the cell-in-cell phenomena where one cell engulfs and sometimes consumes another. The study shows that cases of this behavior, including cell cannibalism, are widespread across the tree of life. The findings challenge the common perception that cell-in-cell events are largely restricted to cancer cells. Rather, these events appear to be common across diverse organisms, from single-celled amoeba to complex multicellular animals. The widespread occurrence of such interactions in non-cancer cells suggests that these events are not inherently “selfish” or “cancerous” behaviors. Rather, the researchers propose that cell-in-cell phenomena may play crucial roles in normal development, homeostasis, and stress response across a wide range of organisms. The study argues that targeting cell-in-cell events as an approach to treating cancer should be abandoned, as these phenomena are not unique to malignancy. By demonstrating that occurrences span a wide array of life forms and are deeply rooted in our genetic makeup, the research invites us to reconsider fundamental concepts of cellular cooperation, competition, and the intricate nature of multicellularity. The study opens new avenues for research in evolutionary biology, oncology, and regenerative medicine. The new research, published in the Nature journal Scientific Reports, is the first to systematically investigate cell-in-cell phenomena across the tree of life. The group’s findings could help redefine the understanding of cellular behavior and its implications for multicellularity, cancer, and the evolutionary journey of life itself. Carlo Maley is a researcher with the Biodesign Center for Biocomputing, Security and Society; professor in the School of Life Sciences at ASU; and director of the Arizona Cancer Evolution Center. Credit: The Biodesign Institute at Arizona State University “We first got into this work because we learned that cells don’t just compete for resources — they actively kill and eat each other,” Maley says. “That’s a fascinating aspect of the ecology of cancer cells. But further exploration revealed that these phenomena happen in normal cells, and sometimes neither cell dies, resulting in an entirely new type of hybrid cell.” Maley is a researcher with the Biodesign Center for Biocomputing, Security and Society; professor in the School of Life Sciences at ASU; and director of the Arizona Cancer Evolution Center. The study was conducted in collaboration with first author Stefania E. Kapsetaki, formerly with ASU and now a researcher at Tufts University, and Luis Cisneros, formerly with ASU and currently a researcher at Mayo Clinic. From Selfish to Cooperative Cell Interactions Cell-in-cell events have long been observed but remain poorly understood, especially outside the context of immune responses or cancer. The earliest genes responsible for cell-in-cell behavior date back over 2 billion years, suggesting the phenomena play an important, though yet-to-be-determined, role in living organisms. Understanding the diverse functions of cell-in-cell events, both in normal physiology and disease, is important for developing more effective cancer therapies. The review delves into the occurrence, genetic underpinnings, and evolutionary history of cell-in-cell phenomena, shedding light on a behavior once thought to be an anomaly. The researchers reviewed more than 500 articles to catalog the various forms of cell-in-cell phenomena observed across the tree of life. The study describes 16 different taxonomic groups in which cell-in-cell behavior is found to occur. The cell-in-cell events were classified into six distinct categories based on the degree of relatedness between the host and prey cells, as well as the outcome of the interaction (whether one or both cells survived). A wide spectrum of cell-in-cell behaviors are highlighted in the study, ranging from completely selfish acts, where one cell kills and consumes another, to more cooperative interactions, where both cells remain alive. For example, the researchers found evidence of “heterospecific killing,” where a cell engulfs and kills a cell of a different species, across a wide range of unicellular, facultatively multicellular, and obligate multicellular organisms. In contrast, “conspecific killing,” where a cell consumes another cell of the same species, was less common, observed in only three of the seven major taxonomic groups examined. Obligate multicellular organisms are those that must exist in a multicellular form throughout their life cycle. They cannot survive or function as single cells. Examples include most animals and plants. Facultative multicellular organisms are organisms that can exist either as single cells or in a multicellular form depending on environmental conditions. For example, certain types of algae may live as single cells in some conditions but form multicellular colonies in others. The team also documented cases of cell-in-cell phenomena where both the host and prey cells remained alive after the interaction, suggesting these events may serve important biological functions beyond just killing competitors. “Our categorization of cell-in-cell phenomena across the tree of life is important for better understanding the evolution and mechanism of these phenomena,” Kapsetaki says. “Why and how exactly do they happen? This is a question that requires further investigation across millions of living organisms, including organisms where cell-in-cell phenomena may not yet have been searched for.” Ancient Genes In addition to cataloging the diverse cell-in-cell behaviors, the researchers also investigated the evolutionary origins of the genes involved in these processes. Surprisingly, they found that many of the key cell-in-cell genes emerged long before the evolution of obligate multicellularity. “When we look at genes associated with known cell-in-cell mechanisms in species that diverged from the human lineage a very long time ago, it turns out that the human orthologs (genes that evolved from a common ancestral gene) are typically associated with normal functions of multicellularity, like immune surveillance,” Cisneros says. In total, 38 genes associated with cell-in-cell phenomena were identified, and 14 of these originated over 2.2 billion years ago, predating the common ancestor of some facultatively multicellular organisms. This suggests that the molecular machinery for cell cannibalism evolved before the major transitions to complex multicellularity. The ancient cell-in-cell genes identified in the study are involved in a variety of cellular processes, including cell-cell adhesion, phagocytosis (engulfment), intracellular killing of pathogens, and regulation of energy metabolism. This diversity of functions indicates that cell-in-cell events likely served important roles even in single-celled and simple multicellular organisms well before the emergence of complex multicellular life. Reference: “Cell-in-cell phenomena across the tree of life” by Stefania E. Kapsetaki, Luis H. Cisneros and Carlo C. Maley, 29 March 2024, Scientific Reports. DOI: 10.1038/s41598-024-57528-7

Beta rhythms between 14-30 Hz are crucial for cognitive control, influencing how the brain processes information and could help diagnose and treat cognitive disorders. Credit: SciTechDaily.com Bursts of brain rhythms with “beta” frequencies control where and when neurons in the cortex process sensory information and plan responses. Studying these bursts would improve understanding of cognition and clinical disorders, researchers write. The brain processes information on many scales. Individual cells electrochemically transmit signals in circuits but at the large scale required to produce cognition, millions of cells act in concert, driven by rhythmic signals at varying frequencies. Studying one frequency range in particular, beta rhythms between about 14-30 Hz, holds the key to understanding how the brain controls cognitive processes—or loses control in some disorders—a team of neuroscientists argues in a new review article. Beta Rhythms in Cognitive Control Drawing on experimental data, mathematical modeling, and theory, the scientists make the case that bursts of beta rhythms control cognition in the brain by regulating where and when higher gamma frequency waves can coordinate neurons to incorporate new information from the senses or formulate plans of action. Beta bursts, they argue, quickly establish flexible but controlled patterns of neural activity for implementing intentional thought. “Cognition depends on organizing goal-directed thought, so if you want to understand cognition, you have to understand that organization,” said co-author Earl K. Miller, Picower Professor in The Picower Institute for Learning and Memory and the Department of Brain and Cognitive Sciences at MIT. “Beta is the range of frequencies that can control neurons at the right spatial scale to produce organized thought.” Data from a 2018 study by the authors shows bursts of brain wave power (warmer colors) at gamma (higher) and beta (lower) frequencies during a working memory task. When beta bursts appear, there are no gamma bursts. But when stimuli (S1) and (S2) are presented, an absence of beta allows gamma bursts to encode the information. Credit: Miller Lab/MIT Picower Institute Miller and colleagues Mikael Lundqvist, Jonatan Nordmark, and Johan Liljefors at the Karolinska Institutet and Pawel Herman at the KTH Royal Institute of Technology in Sweden, write that studying bursts of beta rhythms to understand how they emerge and what they represent would not only help explain cognition, but also aid in diagnosing and treating cognitive disorders. “Given the relevance of beta oscillations in cognition, we foresee a major change in the practice for biomarker identification, especially given the prominence of beta bursting in inhibitory control processes … and their importance in ADHD, schizophrenia and Alzheimer’s disease,” they write in the journal Trends in Cognitive Sciences. Beta Data Experimental studies covering several species including humans, a variety of brain regions, and numerous cognitive tasks have revealed key characteristics of beta waves in the cortex, the authors write: Beta rhythms occur in quick but powerful bursts; they inhibit the power of higher frequency gamma rhythms; and though they originate in deeper brain regions, they travel within specific locations of cortex. Considering these properties together, the authors write that they are all consistent with precise and flexible regulation, in space and time, of the gamma rhythm activity that experiments show carry signals of sensory information and motor plans. “Beta bursts thus offer new opportunities for studying how sensory inputs are selectively processed, reshaped by inhibitory cognitive operations and ultimately result in motor actions,” the authors write. For one example, Miller and colleagues have shown in animals that in the prefrontal cortex in working memory tasks, beta bursts direct when gamma activity can store new sensory information, read out the information when it needs to be used, and then discard it when it’s no longer relevant. For another example, other researchers have shown that beta rises when human volunteers are asked to suppress a previously learned association between word pairs, or to forget a cue because it will no longer be used in a task. In a paper last year, Lundqvist, Herman, Miller and others cited several lines of experimental evidence to hypothesize that beta bursts implement cognitive control spatially in the brain, essentially constraining patches of the cortex to represent the general rules of a task even as individual neurons within those patches represent the specific contents of information. For example, if the working memory task is to remember a pad lock combination, beta rhythms will implement patches of cortex for the general steps “turn left,” “turn right,” “turn left again,” allowing gamma to enable neurons within each patch to store and later recall the specific numbers of the combination. The two-fold value of such an organizing principle, they noted, is that the brain can rapidly apply task rules to many neurons at a time and do so without having to re-establish the overall structure of the task if the individual numbers change (i.e. you set a new combination). Another important phenomenon of beta bursts, the authors write, is that they propagate across long distances in the brain, spanning multiple regions. Studying the direction of their spatial travels, as well as their timing, could shed further light on how cognitive control is implemented. New Ideas Beget New Questions Beta rhythm bursts can differ not only in their frequency, but also their duration, amplitude, origin and other characteristics. This variety speaks to their versatility, the authors write, but also obliges neuroscientists to study and understand these many different forms of the phenomenon and what they represent to harness more information from these neural signals. “It quickly becomes very complicated, but I think the most important aspect of beta bursts is the very simple and basic premise that they shed light on the transient nature of oscillations and neural processes associated with cognition,” Lundqvist said.“This changes our models of cognition and will impact everything we do. For a long time we implicitly or explicitly assumed oscillations are ongoing which has colored experiments and analyses. Now we see a first wave of studies based on this new thinking, with new hypothesis and ways to analyze data, and it should only pick up in years to come.” The authors acknowledge another major issue that must be resolved by further research—How do beta bursts emerge in the first place to perform their apparent role in cognitive control? “It is unknown how beta bursts arise as a mediator of an executive command that cascades to other regions of the brain,” the authors write. The authors don’t claim to have all the answers. Instead, they write, because beta rhythms appear to have an integral role in controlling cognition, the as yet unanswered questions are worth asking. “We propose that beta bursts provide both experimental and computational studies with a window through which to explore the real-time organization and execution of cognitive functions,” they conclude. “To fully leverage this potential there is a need to address the outstanding questions with new experimental paradigms, analytical methods and modeling approaches.” Reference: “Beta: bursts of cognition” by Mikael Lundqvist, Earl K. Miller, Jonatan Nordmark, Johan Liljefors and Pawel Herman, 23 April 2024, Trends in Cognitive Sciences. DOI: 10.1016/j.tics.2024.03.010

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