Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Cushion insole OEM manufacturing facility Taiwan

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Vietnam insole OEM manufacturer

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Vietnam ODM expert for comfort products

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Graphene insole OEM factory Taiwan

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene insole manufacturer in Indonesia

Modern humans, Neanderthals, and their relatives evolved larger brains gradually over millions of years, not through sudden leaps between species, a groundbreaking study reveals. Researchers used a vast fossil dataset and advanced methods to show steady brain size growth driven by gradual adaptation within species. Humans and relatives evolved larger brains through gradual changes within species, not sudden leaps. This study challenges old ideas and reveals the complexity of brain evolution over millions of years. A new study on human brain evolution reveals that modern humans, Neanderthals, and other recent relatives in our evolutionary lineage developed larger brains at a significantly faster rate compared to earlier species. The study, published in the journal PNAS, overturns long-standing ideas about human brain evolution. Scientists from the University of Reading, the University of Oxford, and Durham University found that brain size increased gradually within each ancient human species rather than through sudden leaps between species. The team assembled the largest-ever dataset of ancient human fossils spanning 7 million years and used advanced computational and statistical methods to account for gaps in the fossil record. These innovative approaches provided the most comprehensive view yet of how brain size evolved over time. Incremental Growth in Brain Size Professor Chris Venditti, co-author of the study from the University of Reading, said: “This study completely changes our understanding of how human brains evolved. It was previously thought that brain size jumps dramatically between species, like new upgrades between the latest computer models. Our study instead shows a steady, incremental ‘software update’ happening within each species over millions of years.” The research challenges old ideas that some species, like Neanderthals, were unchanging and unable to adapt and instead highlights gradual and continuous change as the driving force behind brain size evolution. Dr Thomas Puschel, lead author now at Oxford University, said: “Big evolutionary changes don’t always need dramatic events. They can happen through small, gradual improvements over time, much like how we learn and adapt today.” Brains, bodies, and evolutionary scale The researchers also uncovered a striking pattern: while larger-bodied species generally had bigger brains, the variation observed within an individual species did not consistently correlate with body size. Brain size evolution across long evolutionary timescales extending millions of years is therefore shaped by different factors to those observed within individual species – highlighting the complexity of evolutionary pressures on brain size. Dr Joanna Baker, co-author from the University of Reading, said: “Why and how humans evolved large brains is a central question in human evolution. By studying brain and body size in various species over millions of years, we reveal that our hallmark large brains arose primarily from gradual changes within individual species.” Reference: “Hominin brain size increase has emerged from within-species encephalization” by Thomas A. Püschel, Samuel L. Nicholson, Joanna Baker, Robert A. Barton and Chris Venditti, 26 November 2024, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2409542121 The study was produced as part of a £1 million Research Leadership Awards grant from the Leverhulme Trust. The project was to better understand the evolution of human ancestors.

Animals’ reactions to respective excrements monitored by the research team. Top left: Japanese macaques/human-like. Top right: Adélie penguin/white-splash (parasites, pathogens). Bottom left: Red-eared slider/black-pellet. Bottom right: Slow loris/macaque-like but smaller. Credit: KyotoU/Jake Tobiyama Scientists Unveil Multiple Animal Species’ Disease Avoidance Strategies Life for all creatures, humans included, would be a lot more straightforward if diseases were as noticeable as flashing warning signs or loud alarm bells. However, in lieu of such overt warnings, humans have evolved to experience a feeling known as disgust as a protective measure. Does this sort of defensive strategy exist in other animals? Even though substantial focus has been directed toward fear and predator evasion in the field of animal behavior, the study of disease avoidance has notably received less attention in comparison. An international team of scientists has now set up a framework to test disgust and its associated disease-avoidance behaviors across various animal species, social systems, and habitats. “Over 30 species have been reported to exhibit disease avoidance strategies in the wild. We provide predictions for seven others that were previously overlooked and that could serve as new model species,” notes lead author Cécile Sarabian, a former JSPS postdoctoral fellow at Kyoto University. With these predictions, the team accounts for models of specific ecological niches, sensory environments, and social systems for a number of species including the native common octopus and the invasive red-eared slider, which are both relevant to Japan. The Relationship Between Social Systems and Disgust Behaviors “The various costs and benefits involved in experiencing disgust and avoiding illness depend on the social system and ecology of the species,” remarks co-author Andrew MacIntosh, Associate Professor at Kyoto University Wildlife Research Center. Disgust can be triggered by sensory cues associated with disease risk, such as the sight of diarrhea, which releases a set of behavioral or physiological responses that help animals avoid parasites, pathogens, and toxins. The levels of disgust behavior vary also from species to species depending on their social systems and ecological niches. Since solitary species have relatively fewer social interactions and resulting disease transmission, they are less adapted than group-living species in recognizing and evading such life-threatening risks. “Some species living in colonies, such as rabbits and penguins, go further in tolerating diseased mates since a community immunity strategy ensures the colony’s survival,” adds MacIntosh. Insights for Human Health and Conservation The implications to human health are significant since expected disgust-driven behaviors can be applied to the study of the Covid-19 pandemic. For example, a model of coronavirus infections that considers social distancing flattens the curve predicting the number of positive cases, in contrast to the exponential curve for cases without social distancing “Beyond fundamental research, it’s important to keep promoting the creation of a database that gathers disease-avoidance evidence in animals and its applications in relevant conservation and wildlife management strategies,” concludes Sarabian. Reference: “Disgust in animals and the application of disease avoidance to wildlife management and conservation” by Cécile Sarabian, Anna Wilkinson, Marie Sigaud, Fumihiro Kano, Jorge Tobajas, Anne-Sophie Darmaillacq, Gladys Kalema-Zikusoka, Joshua M. Plotnik and Andrew J. J. MacIntosh, 13 March 2023, Journal of Animal Ecology. DOI: 10.1111/1365-2656.13903

DNA damage can persist unrepaired for years, particularly in blood stem cells, increasing the risk of mutations and cancer. This discovery challenges traditional views on mutation processes and highlights the need for further research to understand and address the causes of such persistent damage. In a groundbreaking shift in our understanding of mutations, researchers have discovered types of DNA damage in healthy cells that can remain unrepaired for years. While most types of DNA damage are repaired by the body’s natural DNA repair mechanisms, some forms of damage can evade these processes and persist for years, according to new research. This prolonged presence increases the likelihood of generating harmful mutations, which may eventually lead to cancer. Scientists from the Wellcome Sanger Institute and their collaborators studied the family trees of hundreds of single cells from several individuals. By analyzing shared mutation patterns among cells, they reconstructed these family trees, identifying common ancestral origins. Their findings revealed surprising patterns of mutation inheritance, indicating that certain DNA damage remains unrepaired over extended periods. For example, in blood stem cells, some forms of damage can persist for two to three years. The research, published in Nature, changes the way we think about mutations, and has implications for understanding the development of various cancers. Throughout our life, all of the cells in our body accumulate genetic errors in the genome, known as somatic mutations. These can be caused by damaging environmental exposures, such as smoking, as well as the everyday chemistry occurring in our cells. Mutation Origins and Persistent Damage DNA damage is distinct from a mutation. While a mutation is one of the standard four DNA bases (A, G, T or C) in the wrong place, similar to a spelling mistake, DNA damage is chemical alteration of the DNA, like a smudged unrecognizable letter. DNA damage can result in the genetic sequence being misread and copied during cell division – known as DNA replication – and this introduces permanent mutations that can contribute to the development of cancers. However, the DNA damage itself is usually recognized and mended quickly by repair mechanisms in our cells. If researchers can better understand the causes and mechanisms of mutations, they may be able to intervene and slow or remove them. In a new study, Sanger Institute scientists and their collaborators analyzed data in the form of family trees of hundreds of single cells from individuals. The family trees are constructed from patterns of mutations across the genome that are shared between cells – for example, cells with many shared mutations have a recent common ancestor cell and are closely related. The researchers collated seven published sets of these family trees, known as somatic phylogenies. The data set included 103 phylogenies from 89 individuals, spanning blood stem cells, bronchial epithelial cells, and liver cells. The team found unexpected patterns of mutation inheritance in the family trees, revealing that some DNA damage can persist unrepaired through multiple rounds of cell division. This was particularly evident in blood stem cells, where between 15 to 20 percent of the mutations resulted from a specific type of DNA damage that persists for two to three years on average, and in some cases longer. Implications for Cancer Development This means that during cell division, each time the cell attempts to copy the damaged DNA it can make a different mistake, leading to multiple different mutations from a single source of DNA damage. Importantly, this creates multiple chances of harmful mutations that could contribute to cancer. Researchers suggest that although these types of DNA damage occur rarely, their persistence over years means they can cause as many mutations as more common DNA damage. Overall, these findings change the way researchers think about mutations, and have implications for the development of cancer. Dr Michael Spencer Chapman, first author from the Wellcome Sanger Institute and the Barts Cancer Institute, said: “With these family trees, we can link the relationships of hundreds of cells from one person right back to conception, meaning we can track back through the divisions each cell has gone through. It’s these large-scale, novel datasets that have led us to this unexpected finding that some forms of DNA damage can last for a long time without being repaired. This study is a prime example of exploratory science – you don’t always know what you’re going to find until you look; you have to stay curious.” Emily Mitchell, an author from the Wellcome Sanger Institute, Wellcome-MRC Cambridge Stem Cell Institute and University of Cambridge, said: “When exploring family trees of blood stem cells in particular, we found a specific type of DNA damage that results in around 15 to 20 percent of the mutations in these cells, and can last for several years. It is unclear why this process is only found in blood stem cells and not other healthy tissues. Knowing that the DNA damage is long-lasting gives new routes to investigate what the damage actually is. As we continue to better understand the causes of mutations, we may one day be able to intervene and remove them.” Dr Peter Campbell, lead author previously from the Wellcome Sanger Institute and now Chief Scientific Officer at Quotient Therapeutics, said: “We have identified forms of DNA damage that manage to escape our DNA repair mechanisms and persist in the genome for days, months, or sometimes years. These findings don’t fit with what scientists have previously thought about the fundamentals of how mutations are acquired. This paradigm shift brings a new dimension to the way we think about mutations, and is important for the research community when designing future studies.” Reference: “Prolonged persistence of mutagenic DNA lesions in somatic cells” by Michael Spencer Chapman, Emily Mitchell, Kenichi Yoshida, Nicholas Williams, Margarete A. Fabre, Anna Maria Ranzoni, Philip S. Robinson, Lori D. Kregar, Matthias Wilk, Steffen Boettcher, Krishnaa Mahbubani, Kourosh Saeb Parsy, Kate H. C. Gowers, Sam M. Janes, Stanley W. K. Ng, Matt Hoare, Anthony R. Green, George S. Vassiliou, Ana Cvejic, Markus G. Manz, Elisa Laurenti, Iñigo Martincorena, Michael R. Stratton, Jyoti Nangalia, Tim H. H. Coorens and Peter J. Campbell, 15 January 2025, Nature. DOI: 10.1038/s41586-024-08423-8

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