Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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High-performance graphene insole OEM Indonesia

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Pillow OEM for wellness brands Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.China ODM expert for comfort products

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.One-stop OEM/ODM solution provider Taiwan

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene sheet OEM supplier factory Taiwan

A study reveals that both sensory and motor signals are processed in the cortex, challenging previous understandings and indicating that these signals are intertwined in influencing decisions. Credit: SciTechDaily.com Groundbreaking research shows how the brain integrates sensory information and movement signals, influencing how we react to what we hear. You hear a phone ring or a dog bark. Is it yours or someone else’s? You hear footsteps in the night — is it your child, or an intruder? Friend or foe? The decision you make will determine what action you take next. Researchers at the Champalimaud Foundation have shed light on what might be going on in our brains during moments like these, and take us a step closer to unraveling the mystery of how the brain translates perceptions into actions. Understanding Brain Processes During Decision-Making Every day, we make countless decisions based on sounds without a second thought. But what exactly happens in the brain during such instances? A new study from the Renart Lab, published today (May 10) in Current Biology, takes a look under the hood. Their findings deepen our understanding of how sensory information and behavioral choices are intertwined within the cortex — the brain’s outer layer that shapes our conscious perception of the world. The cortex is divided into regions that handle different functions: sensory areas process information from our environment, while motor areas manage our actions. Surprisingly, signals related to future actions, which one might expect to find only in motor areas, also appear in sensory ones. What are movement-related signals doing in regions dedicated to sensory processing? When and where do these signals emerge? Exploring these questions could clarify the origin and role of these perplexing signals, and how they do — or don’t — drive decisions. Innovative Research Methods The researchers tackled these queries by devising a task for mice. Postdoc Raphael Steinfeld, the study’s lead author, picks up the story: “To unravel what signals related to future actions might be doing in sensory areas, we thought carefully about the task mice would have to perform. Previous studies often relied on “Go-NoGo” tasks, where animals report their choice by either making an action, or not moving, depending on the identity of the stimulus. This setup, however, mixes up signals linked to specific movements with those related to just moving in general. To isolate signals for specific actions, we trained mice to decide between one of two actions. They had to decide if a sound was high or low compared to a set threshold and report their decision by licking one of two spouts, left or right.” However, this wasn’t sufficient. “Mice quickly learn this task, often responding as soon as they hear the sound,” Steinfeld continues. “To separate brain activity related to the sound from that related to the response, we introduced a critical half-second delay. During this interval, the mice had to withhold their decision. Crucially, this delay allowed us to temporally separate brain activity linked to the stimulus from that linked to the choice, and track how movement-related neural signals unfolded over time from the initial sensory input.” “To dissect neural representations of stimulus and choice, it was also important to design an experiment challenging enough to allow the mice to make mistakes. A 100% success rate would blur the distinction between stimulus and choice, as each stimulus would always elicit the same response. By creating the potential for errors, we could tease apart the neural encoding of the sound from the decisions made.” For instance, in cases where the mice heard the same tone but made different decisions (correct or incorrect), they could examine whether a neuron’s activity varied between the two actions. If so, it would indicate that the neuron encoded information about the choice. Deepening Understanding of Neural Connections After six months of rigorous training, the researchers could finally begin recording neural activity in mice as they performed the task. They focused on the auditory cortex, the part of the cortex responsible for processing what we hear, which they had already shown was required for the task. “The cortex of mice and humans is composed of six layers, each with specialized functions and distinct connections to other brain regions,” explains Alfonso Renart, principal investigator and the study’s senior author. “Given that certain layers typically receive sensory information from brain regions, while others send input to motor centers, we simultaneously recorded activity across the layers of the auditory cortex—for the first time in a task like ours, in which sensory and motor signals could be cleanly separated.” “We found that sensory- and choice-related signals displayed distinct spatial and temporal patterns,” Renart continues. “Signals related to sound detection appeared quickly but faded fast, vanishing around 400 milliseconds after the sound was presented, and were distributed broadly across all cortical layers. In contrast, choice-related signals, which indicate the movement the mouse is about to make, emerged later, before the decision was executed, and were concentrated in the cortex’s deeper layers.” However, despite the temporal separation between stimulus and choice activity, further analysis revealed an intriguing connection: neurons that responded to a specific sound frequency also tended to be more active for the actions associated with those sounds. As Steinfeld explains, “For instance, a neuron that reacts to high frequencies might activate more for a rightward lick in one mouse and a leftward lick in another, depending on how each was trained, since we switched the sound-action contingency. This variability across different animals shows that the activity isn’t hardwired but adapts through experience. These neurons learn to increase their activity for whatever action is appropriate based on their preferred sound frequency.” Origin and Role of Choice Signals So, what might the origin of these choice signals in the auditory cortex be? “Interestingly,” notes Renart, “the early sensory signals in the auditory cortex don’t seem to predict the mice’s eventual choice, and the choice signals emerge significantly later. This suggests that the sensory signals in the auditory cortex don’t directly cause the mice’s actions, and that the choice signals we observe are likely computed elsewhere in higher brain regions involved in planning or executing movements, which then send their feedback to the auditory cortex.” But if these movement signals don’t dictate actions, what role could they play? Perhaps they serve mainly to integrate and relay information. For instance, these signals could adjust the brain’s perception to align with an unfolding decision, enhancing the stability of what we perceive. Alternatively, they could prime the brain for the expected sensory outcomes of actions, like the noise made by moving, ensuring our sensory experiences match our movements. Future Research and Implications Yet, these hypotheses remain to be verified. “One might wonder, if the sensory signals of the auditory cortex don’t directly inform choices, and the choice signals we observe there aren’t actually produced by it, then what exactly is the purpose of the auditory cortex?” Renart muses. “We could speculate that the auditory cortex is more concerned with constructing a conscious experience of sound than with sensory-motor transformation, but that’s a story for another day.” Still, a causal role cannot be ruled out, particularly since the deeper layers of the auditory cortex transmit information to the posterior striatum, part of the brain’s control center for habits and movements. Future studies will aim to pinpoint the precise origins of these movement signals and whether they are indeed causal to behavior. For now, we can add another piece to the puzzle of how brains convert perception to action, and the internal mechanisms at work when you next hear footsteps in the night. Reference: “Differential representation of sensory information and behavioral choice across layers of the mouse auditory cortex” by Raphael Steinfeld, André Tacão-Monteiro and Alfonso Renart, 10 May 2024, Current Biology. DOI: 10.1016/j.cub.2024.04.040

Fat droplets in the fat cell of a mouse: The membrane of the droplets was stained green, and the fat stored in them was stained red. Credit: Johanna Spandl / University of Bonn The Study Offers the First Precise Understanding of Crucial Remodeling Processes in Adipose Tissue Fat cells utilize fat molecules as a means of energy storage. These molecules are comprised of three fatty acids attached to a glycerol backbone, and are commonly referred to as triglycerides. It has been long believed that these molecules undergo constant change during storage, being regularly broken down and reconstructed – a process known as “triglyceride cycling.” But is this assumption true, and if so, what is the purpose of this process? “Until now, there has been no real answer to these questions,” explains Prof. Dr. Christoph Thiele of the LIMES Institute at the University of Bonn. “It’s true that there has been indirect evidence of this permanent reconstruction for the past 50 years. However, direct evidence of this has so far been lacking.” The problem: To prove that triglycerides are broken down, and fatty acids modified and reincorporated into new molecules, one would need to track their transformation as they travel through the body. Yet there are thousands of different forms of triglycerides in each cell. Keeping track of individual fatty acids is therefore extremely difficult. Label Makes Fatty Acids Unmistakable “However, we have developed a method that allows us to attach a special label to fatty acids, making them unmistakable,” says Thiele. His research group labeled various fatty acids in this way and added them in a nutrient medium to mouse fat cells. The mouse cells then incorporated the labeled molecules into triglycerides. “We were able to show that these triglycerides do not remain unchanged, but are continuously degraded and remodeled: Each fatty acid is split off about twice a day and reattached to another fat molecule,” the researcher explains. But why is that? After all, this conversion costs energy, which is released as waste heat – what does the cell get out of it? Until now, it was thought that the cell needed this process to balance energy storage and supply. Or perhaps it is simply a way for the body to generate heat. “Our results now point to a completely different explanation,” Thiele explains. “It’s possible that in the course of this process, the fats are converted to what the body needs.” Poorly utilizable fatty acids would consequently be refined into higher-quality variants and stored in this form until they are needed. Fatty acids consist largely of carbon atoms, which hang one behind the other like the carriages of a train. Their length can be very different: Some consist of only ten carbon atoms, others of 16 or even more. In their study, the researchers produced three different fatty acids and labeled them. One of them was eleven, the second 16, and the third 18 carbon atoms long. “These chain lengths are typically found in food as well,” Thiele explains. Short Fatty Acids Are Eliminated, Long Ones “Improved” Labeling allowed the researchers to track exactly what happens to the fatty acids of different lengths in the cell. This showed that the fatty acids consisting of eleven carbon atoms were initially incorporated into triglycerides. After a short time, however, they were split off again and channeled out of the cell. After two days, they were no longer detectable. “Such shorter fatty acids are poorly usable by cells and can even damage them,” says Thiele, who is also a member of the Cluster of Excellence ImmunoSensation2. “Therefore, they are disposed of quickly.” In contrast, the 16- and 18-atom fatty acids remained in the cell, although not in their original fat molecules. They were also gradually chemically modified, for example by additional carbon atoms being inserted. In the original fatty acids, the carbon atoms were moreover linked with single bonds – roughly like a human chain in which neighbors join hands. Over time, this sometimes developed into double bonds – as if revelers at a party were doing a conga. The fatty acids that are formed in this process are called unsaturated. They are better utilizable for the body. “Overall, in this way the cells produce fatty acids that are more beneficial to the organism than those that we had originally supplied with the nutrient solution,” Thiele emphasizes. In the long term, this results for instance in the formation of oleic acid, a component of high-quality olive oil, from palmitate, such as that contained in palm fat. However, the cell cannot change the fatty acids as long as they are inside the fat molecule. They must first be split off, then modified, and finally tacked back on. Thiele: “Without triglyceride cycling, there is also no fatty acid modification.” Adipose tissue can therefore improve triglycerides. If we eat and store food with unfavorable fatty acids, they do not have to be released in that state again when we are hungry. What we get back contains fewer “short” fatty acids, more oleic acid (instead of palmitate), and more of the important arachidonic acid (instead of linoleic acid). “Nevertheless, we should take care in our diet to consume high-quality dietary fats as much as possible,” the researcher stresses. Because the refinement never works 100 percent. In addition, some of the fatty acids are not stored but used directly in the body. In the next step, the researchers now want to test whether the same processes occur in human adipose tissue as in individual mouse fat cells in the test tube. They also want to find out which enzymes make cycling work. Reference: “Triglyceride cycling enables modification of stored fatty acids” by Klaus Wunderling, Jelena Zurkovic, Fabian Zink, Lars Kuerschner and Christoph Thiele, 3 April 2023, Nature Metabolism. DOI: 10.1038/s42255-023-00769-z The study was funded by the German Research Foundation (DFG).

Researchers at Northwestern University have developed a device, funded by DARPA, that produces oxygen to keep cells alive within an implantable “living pharmacy.” This pharmacy aims to autonomously produce therapeutics to regulate sleep/wake cycles. New Device Could Improve the Outcomes of Cell-Based Therapies Cell-based therapies show promise for drug delivery, replacing damaged tissues, harnessing the body’s own healing mechanisms, and more But keeping cells alive to produce therapies has remained a challenge Researchers used a smart, energy-efficient version of water splitting to produce oxygen for these cells New approach maintains cells in vitro and in vivo, showing promise for both acute and chronic applications Breakthrough in Biomedical Engineering In 2021, a Northwestern University-led research team received a Defense Advanced Research Projects Agency (DARPA) contract worth up to $33 million to develop an implantable “living pharmacy” to control the human body’s sleep/wake cycles. Now, the researchers have completed a major step toward achieving this goal. In new work, researchers have developed a novel device that produces oxygen at the site in order to keep cells alive inside the self-contained implant. Oxygen is a major ingredient for keeping cells alive — and thriving — for longer periods of time inside of the implantable pharmacy. Because the longer cells can stay alive and healthy, the longer they can autonomously produce therapeutics for the body. By using electricity to split water that the cells are already bathed in, the researchers were able to produce oxygen while avoiding the production of harmful byproducts such as chlorine or hydrogen peroxide. And by controlling the amount of electricity used, the researchers could change how much oxygen it produces. Advancements in Cell Viability and Device Operation In new experiments, the novel device (called the “electrocatalytic on-site oxygenator” or “ecO2”) kept cells (70-80%) alive for close to a month in low oxygen conditions in vitro or for weeks in vivo. Without ecO2, only about 20% of cells were alive after 10 days, but the researchers hypothesize that the cells would lose their ability to secrete drugs long before that. With advances in wireless power and communication, the researchers are confident that chronic operation over multiple months or more is within reach. The research will be published today (November 9) in the journal Nature Communications. A side-by-side comparison of cells supported by the oxygenation device (left) and cells without the device support (right). Living cells are shown in green; dead cells are in red. Credit: Jonathan Rivnay/Northwestern University Potential Impact on Cell-Based Therapies “Our device can be used to improve the outcomes of cell-based therapies, which use biological cells to treat diseases or injuries in the body,” said Northwestern’s Jonathan Rivnay, who co-led the study. “Cell-based therapies could be used for replacing damaged tissues, for drug delivery or augmenting the body’s own healing mechanisms, thus opening opportunities in wound healing and treatments for obesity, diabetes and cancer, for example. Generating oxygen on site is critical for many of these ‘biohybrid’ cell therapies. We need many cells to have sufficient production of therapeutics from those cells, thus there is a high metabolic demand. Our approach would integrate the ecO2 device to generate oxygen from the water itself.” Rivnay is a professor of biomedical engineering and materials science and engineering at Northwestern’s McCormick School of Engineering and principal investigator of the DARPA-funded NTRAIN (Normalizing Timing of Rhythms Across Internal Networks of Circadian Clocks) project. He co-led the new study with Tzahi Cohen-Karni, a professor of biomedical engineering and materials science and engineering at Carnegie Mellon University (CMU). The study’s co-first authors are Northwestern’s Abhijith Surendran and CMU’s Inkyu Lee. The Future of Implantable Drug Delivery Ultimately, the goal of the implantable “living pharmacy” strategy is to develop devices that never run out of drugs. Then, people will never have to worry about remembering to take their medicine or inject therapeutics. But, for this to work successfully, the implant needs to last for long periods of time without needing to be refilled. Combining synthetic biology with bioelectronics, Northwestern leads a collaboration with Rice University biomedical engineering professor Omid Veiseh to produce the therapeutics on site within the device. Keeping these engineered cells alive is a crucial step in the development of these potentially life-saving devices. Although previous research has explored strategies for delivering oxygen to cells, those methods used bulky equipment that is impractical for use inside the human body. “Some approaches introduce gaseous oxygen from outside the body to tackle this problem. This is akin to using a scuba tank while diving,” Surendran said. “It is bulky. You have to carry it around with you. The air can run out, and there is a high risk of gas embolism.” Innovative Water-Splitting Technique To bypass the need for impractical equipment, the researchers turned to water-splitting, a popular strategy for energy conversion and storage. For example, other researchers have explored splitting water into hydrogen and oxygen in order to use hydrogen as fuel. However, these technologies focus on water splitting at alkaline or acidic conditions. Rivnay’s team, on the other hand, is more interested in oxygen production at conditions comparable to those within the human body. The secret behind the team’s new ecO2 device is sputtered iridium oxide, a successful electrocatalyst that has also been used in biomedical applications. Inside the device, the cells are already living in a fluid of water, salts, and nutrients. Iridium oxide helps drive an electrochemical reaction at low voltage to deliver oxygen using the already-available water in biofluids. The electricity splits the water into hydrogen and oxygen. “It is as simple as a Chemistry 101 experiment we all did as kids,” Rivnay said. “You pass electricity through water and bubbles form at the metals, and the water splits into oxygen and hydrogen. We are doing this but in a smarter manner. Using unique materials allows more efficient and low energy production of oxygen. And in our device, we aren’t forming oxygen bubbles. We operate our devices under conditions where the oxygen generated is dissolved in water — without bubbles.” Experimentation and Applications In experiments, ecO2 generated enough oxygen to keep densely packed cells (60,000 cells per cubic millimeter) alive in hypoxic conditions. These results prove that ecO2 devices can be readily integrated into bioelectronic platforms, enabling high cell loadings in smaller devices with broad applicability. Without ecO2, control cells met a swift demise. “The cell density used in our study is about six times higher than the average cell density of pancreatic islets reported in the literature,” Surendran said. “Normal oxygen concentration in blood is not sufficient to sustain their viability for extended periods. After the first week, 70% of the cells in control devices lost functionality. The remaining 30% took about 10 more days to lose functionality.” Moving Toward Clinical Application Next, Rivnay and collaborators will focus on long-term deployment of ecO2. Specifically, they are working on highly stable materials that can operate inside the body for months at time — eventually using this approach to treat chronic disease conditions. “We believe this technology will enable smaller, more potent cell therapy and regulated cell-therapy devices,” Rivnay said. “Our goal is to translate this technology to clinic. We are currently exploring various disease models.” Reference: “Electrocatalytic on-site oxygenation for transplanted cell-based-therapies” by Inkyu Lee, Abhijith Surendran, Samantha Fleury, Ian Gimino, Alexander Curtiss, Cody Fell, Daniel J. Shiwarski, Omar Refy, Blaine Rothrock, Seonghan Jo, Tim Schwartzkopff, Abijeet Singh Mehta, Yingqiao Wang, Adam Sipe, Sharon John, Xudong Ji, Georgios Nikiforidis, Adam W. Feinberg, Josiah Hester, Douglas J. Weber, Omid Veiseh, Jonathan Rivnay and Tzahi Cohen-Karni, 9 November 2023, Nature Communications. DOI: 10.1038/s41467-023-42697-2 The study, “Electrocatalytic on-site oxygenation for transplanted cell-based therapies,” was supported by DARPA (agreement number FA8650-21-1-7119).

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