Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Vietnam OEM/ODM hybrid insole services

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Orthopedic pillow OEM solutions Thailand

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Soft-touch pillow OEM service in Vietnam

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Thailand eco-friendly graphene material processing

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene insole OEM factory Indonesia

Researchers have identified a biological mechanism involving the molecule KIBRA that explains the long-term stability of memories, shedding light on potential treatments for memory-related disorders. Pioneering study reveals a “molecular glue” critical for memory formation and stabilization. New research identifies the molecule KIBRA as a critical “glue” in stabilizing long-term memories by maintaining synaptic strength, offering insights into memory persistence despite ongoing cellular changes. Whether it’s a first-time visit to a zoo or when we learned to ride a bicycle, we have memories from our childhoods kept well into adult years. But what explains how these memories last nearly an entire lifetime? A new study in the journal Science Advances, conducted by a team of international researchers, has uncovered a biological explanation for long-term memories. It centers on the discovery of the role of a molecule, KIBRA, that serves as a “glue” to other molecules, thereby solidifying memory formation. “Previous efforts to understand how molecules store long-term memory focused on the individual actions of single molecules,” explains André Fenton, a professor of neural science at New York University and one of the study’s principal investigators. “Our study shows how they work together to ensure perpetual memory storage.” “A firmer understanding of how we keep our memories will help guide efforts to illuminate and address memory-related afflictions in the future,” adds Todd Sacktor, a professor at SUNY Downstate Health Sciences University and one of the study’s principal investigators. The Challenge of Synaptic Stability It’s been long-established that neurons store information in memory as the pattern of strong synapses and weak synapses, which determines the connectivity and function of neural networks. However, the molecules in synapses are unstable, continually moving around in the neurons, and wearing out and being replaced in hours to days, thereby raising the question: How, then, can memories be stable for years to decades? Memories are stored by the interaction of two proteins: a structural protein, KIBRA (green), that acts as a persistent synaptic tag, and a synapse-strengthening enzyme, protein kinase Mzeta (red). Drugs that disrupt the memory-perpetuating interaction (other colors) erase pre-established long-term and remote memories. Credit: Changchi Hsieh, Ph.D. In a study using laboratory mice, the scientists focused on the role of KIBRA, or kidney and brain expressed protein, the human genetic variants of which are associated with both good and poor memory. They focused on KIBRA’s interactions with other molecules crucial to memory formation—in this case, protein kinase Mzeta (PKMzeta). This enzyme is the most crucial molecule for strengthening normal mammalian synapses that is known, but it degrades after a few days. Their experiments reveal that KIBRA is the “missing link” in long-term memories, serving as a “persistent synaptic tag,” or glue, that sticks to strong synapses and to PKMzeta while also avoiding weak synapses. Mechanisms of Memory Retention “During memory formation the synapses involved in the formation are activated—and KIBRA is selectively positioned in these synapses,” explains Sacktor, a professor of physiology, pharmacology, anesthesiology, and neurology at SUNY Downstate. “PKMzeta then attaches to the KIBRA-synaptic-tag and keeps those synapses strong. This allows the synapses to stick to newly made KIBRA, attracting more newly made PKMzeta.” More specifically, their experiments in the Science Advances paper show that breaking the KIBRA-PKMzeta bond erases old memory. Previous work had shown that randomly increasing PKMzeta in the brain enhances weak or faded memories, which was mysterious because it should have done the opposite by acting at random locations, but the persistent synaptic tagging by KIBRA explains why the additional PKMzeta was memory enhancing, by only acting at the KIBRA tagged sites. “The persistent synaptic tagging mechanism for the first time explains these results that are clinically relevant to neurological and psychiatric disorders of memory,” observes Fenton, who is also on the faculty at NYU Langone Medical Center’s Neuroscience Institute. The paper’s authors note that the research affirms a concept introduced in 1984 by Francis Crick. Sacktor and Fenton point out that his proposed hypothesis to explain the brain’s role in memory storage despite constant cellular and molecular changes is a Theseus’s Ship mechanism—borrowed from a philosophical argument stemming from Greek mythology in which new planks replace old ones to maintain Theseus’s Ship for years. “The persistent synaptic tagging mechanism we found is analogous to how new planks replace old planks to maintain Theseus’s Ship for generations, and allows memories to last for years even as the proteins maintaining the memory are replaced,” says Sacktor. “Francis Crick intuited this Theseus’s Ship mechanism, even predicting the role for a protein kinase. But it took 40 years to discover that the components are KIBRA and PKMzeta and to work out the mechanism of their interaction.” Reference: “KIBRA anchoring the action of PKM? maintains the persistence of memory” by Panayiotis Tsokas, Changchi Hsieh, Rafael E. Flores-Obando, Matteo Bernabo, Andrew Tcherepanov, A. Iván Hernández, Christian Thomas, Peter J. Bergold, James E. Cottrell, Joachim Kremerskothen, Harel Z. Shouval, Karim Nader, André A. Fenton and Todd C. Sacktor, 26 June 2024, Science Advances. DOI: 10.1126/sciadv.adl0030 The study also included researchers from Canada’s McGill University, Germany’s University Hospital of Münster, and the University of Texas Medical School at Houston. This work was supported by grants from the National Institutes of Health (R37 MH057068, R01 MH115304, R01 NS105472, R01 MH132204, R01 NS108190), the Natural Sciences and Engineering Research Council of Canada Discovery (203523), and the Garry and Sarah S. Sklar Fund.

Corals display glowing colors (fluorescence). Credit: Tel Aviv University Researchers have proved for the first time that corals’ fluorescent colors are intended to attract prey. For the first time, a recent study from Tel Aviv University, in association with the Steinhardt Museum of Natural History and the Interuniversity Institute for Marine Sciences in Eilat, has established that the magical phenomenon in deep reefs where corals exhibit glowing colors (fluorescence) is intended to serve as a mechanism for luring prey. The research demonstrates that the marine creatures that corals feed on are drawn to fluorescent colors. Professor Yossi Loya from the School of Zoology and the Steinhardt Museum of Natural History at Tel Aviv University supervised the research, which was led by Dr. Or Ben-Zvi, Yoav Lindemann, and Dr. Gal Eyal. Fluorescence as a Prey-Attracting Strategy According to the researchers, the ability of aquatic organisms to glow has long attracted both scientists and those who love nature. The biological role of the phenomena, which occurs often in corals that produce reefs, has been fiercely disputed. A variety of possibilities have been explored over the years, including: Does this phenomenon defend against radiation? improve photosynthesis? an antioxidant activity? According to the most recent research, coral fluorescence actually serves as a lure for prey. In the study, the researchers put their hypothesis to the test; to this end, they first sought to determine whether plankton (small organisms that drift in the sea along with the current) are attracted to fluorescence, both in the laboratory and at sea. Then, in the lab, the researchers quantified the predatory capabilities of mesophotic corals (corals that live between the shallow coral reef area and the deep, completely dark zone of ​​the ocean), which exhibit different fluorescent appearances. Plankton Attraction In order to test the planktons’ potential attraction to fluorescence, the researchers used, inter alia, the crustacean Artemia salina, which is used in many experiments as well as for food for corals. The researchers noted that when the crustaceans were given a choice between a green or orange fluorescent target versus a clear “control” target, they showed a significant preference for the fluorescent target. Moreover, when the crustaceans were given a choice between two clear targets, their choices were observed to be randomly distributed in the experimental setup. In all of the laboratory experiments, the crustaceans vastly exhibited a preferred attraction toward a fluorescent signal. Similar results were presented when using a native crustacean from the Red Sea. However, unlike the crustaceans, fish that are not considered coral prey did not exhibit these trends, and rather avoided the fluorescent targets in general and the orange targets in particular. A scientist obtaining data for the study. Credit: Tel Aviv University In the second phase of the study, the experiment was carried out in the corals’ natural habitat, about 40 meters deep in the sea, where the fluorescent traps (both green and orange) attracted twice as many plankton as the clear trap. Dr. Or Ben-Zvi says, “We conducted an experiment in the depths of the sea in order to examine the possible attraction of diverse and natural collections of plankton to fluorescence, under the natural currents and light conditions that exist in deep water. Since fluorescence is ‘activated’ principally by blue light (the light of the depths of the sea), at these depths the fluorescence is naturally illuminated, and the data that emerged from the experiment were unequivocal, similar to the laboratory experiment.” Predation Rates Linked to Fluorescent Coloration in Corals In the last part of the study, the researchers examined the predation rates of mesophotic corals that were collected at 45-meter (148-foot) depth in the Gulf of Eilat and found that corals that displayed green fluorescence enjoyed predation rates that were 25 percent higher than corals exhibiting yellow fluorescence. Professor Loya: “Many corals display a fluorescent color pattern that highlights their mouths or tentacle tips, a fact that supports the idea that fluorescence, like bioluminescence (the production of light by a chemical reaction), acts as a mechanism to attract prey. The study proves that the glowing and colorful appearance of corals can act as a lure to attract swimming plankton to ground-dwelling predators, such as corals, and especially in habitats where corals require other energy sources in addition or as a substitute for photosynthesis (sugar production by symbiotic algae inside the coral tissue using light energy).” Dr. Ben-Zvi concludes: “Despite the gaps in the existing knowledge regarding the visual perception of fluorescence signals by plankton, the current study presents experimental evidence for the prey-luring role of fluorescence in corals. We suggest that this hypothesis, which we term the ‘light trap hypothesis’, may also apply to other fluorescent organisms in the sea, and that this phenomenon may play a greater role in marine ecosystems than previously thought.” Reference: “Coral fluorescence: a prey-lure in deep habitats” by Or Ben-Zvi, Yoav Lindemann, Gal Eyal, and Yossi Loya, 2 June 2022, Communications Biology. DOI: 10.1038/s42003-022-03460-3

Researchers discovered key differences in gene regulation between human and non-human primate hearts, revealing evolutionary adaptations and potential new targets for heart disease therapy. The study also warns against relying on animal models for human heart research. Researchers at the Max Delbrück Center have uncovered genetic distinctions between human hearts and those of other primates. This study highlights evolutionary changes specific to humans and offers fresh perspectives on heart disease. Researchers from the Hübner and Diecke Labs at the Max Delbrück Center have uncovered genetic differences between human and non-human primate hearts. Published in Nature Cardiovascular Research, their study highlights evolutionary changes in human hearts and offers fresh perspectives on heart disease. Humans are 98-99% genetically similar to chimpanzees. What then accounts for our differences? Over the years, researchers have shown that the regulation of gene expression – when, where, and by how much genes are switched on – is in large part responsible for our divergent evolutionary trajectories. Now, researchers in the Cardiovascular and Metabolic Sciences Lab of Professor Norbert Hübner and the Pluripotent Stem Cells Platform of Dr. Sebastian Diecke at the Max Delbrück Center have unveiled surprising differences in gene expression in the hearts of humans and non-human primates. The research, led by Dr. Jorge Ruiz-Orera and published in the journal Nature Cardiovascular Research, points to adaptations in the way genes are regulated that distinguish our hearts from those of our closest evolutionary relatives. It also serves as a warning against extrapolating research from animal hearts to human hearts. “One of the most surprising findings was how gene regulation in the human heart differs so much from other primates,” says Ruiz-Orera. In terms of anatomy, most mammalian hearts are similar. “But we have many unique evolutionary innovations in terms of gene regulation or translation of proteins,” he adds. The researchers found hundreds of genes and microproteins – tiny proteins that have been previously identified in human organs but whose function has mostly been a mystery – present in human hearts but not in the hearts of other primates, rats, or mice. “Many of these human genes and microproteins are also abnormally expressed in heart failure, which suggests they could play important roles in cardiac function and disease and may present new targets for therapy,” says Ruiz-Orera. Comparing gene transcription and translation The team analyzed heart tissue from chimpanzees and macaques obtained from the biobank of Dr. Ivanela Kondova in the Biomedical Primate Research Centre in Rijswijk, Netherlands, as well as stored heart tissue from humans, rats, and mice that has been used in the lab’s previous research. Using RNA sequencing, the researchers first mapped and quantified RNA molecules from heart tissues, which provided a comprehensive view of gene expression across different species. To focus specifically on the RNA regions being translated into proteins, the researchers used Ribo-seq to sequence RNA fragments that were actively being translated in each cell. This gave insight into which genes produce functional proteins. By integrating data from these technologies, the team created the most comprehensive resource to date on gene and protein activity in human and non-human primate hearts. In addition, the researchers used induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) cell cultures as a model to study how genes are expressed during heart development in humans and other primates. iPSC-CMs are a useful model because they can be grown from adult primate skin cells that have been reprogrammed to an embryonic-like state. These cells turn into cardiomyocytes, the basic cell unit of the heart, enabling researchers to study them during different stages of development. The discovery that specific microproteins – which are encoded in the genome by snippets of DNA called small open reading frames (ORFs) – are uniquely expressed or translated in human heart cells at different developmental stages suggests that some of these genetic elements may have evolved specifically to meet the demands of the human heart, says Ruiz-Orera. (ORFs lack the classic hallmarks of protein-coding genes and are therefore not classified as genes.) “Our hearts have different energy demands compared to those of smaller primates like macaques, who have much faster heart rates,” he explains. “This difference seems to be reflected in the regulation of genes related to energy production in the heart. These evolutionary adaptations may also be linked to our bipedalism, lifestyle, and diet.” In all, the team identified over 1,000 species-specific genomic adaptations, including 551 genes and 504 microprotein coding regions that are only found in human hearts. Among these, they found 76 genes that were common to both humans and other primates and mammals, but only in the human species did they evolve to be expressed in the heart. Implications for heart disease and use of animals The researchers showed that some of the genes and microproteins that are specific to humans are dysregulated in conditions like dilated cardiomyopathy, highlighting a potential role in the development of cardiac diseases and suggesting a new target for therapy. The study also raises important issues about using animals such as mice to study the genetics of human cardiac disease. “Our findings suggest that the differences between species could sometimes result in misleading results,” says Ruiz-Orera. “There are many genes expressed in the human heart that simply aren’t expressed in the hearts of other species.” In humans, for example, the gene SGLT1 is expressed in the heart. But in non-human primates, rats, and mice, it is expressed only in the kidneys. Dual inhibitors of SGLT1 and SGLT2 have been shown to reduce heart failure, even though their exact role in the heart remains a mystery, says Ruiz-Orera. But since it isn’t expressed in the hearts of other animals, researchers will not be able to learn much by testing such therapies in these models. “It highlights the importance of considering evolutionary context in medical research,” he adds. Reference: “Evolution of translational control and the emergence of genes and open reading frames in human and non-human primate hearts” by Jorge Ruiz-Orera, Duncan C. Miller, Johannes Greiner, Carolin Genehr, Aliki Grammatikaki, Susanne Blachut, Jeanne Mbebi, Giannino Patone, Anna Myronova, Eleonora Adami, Nikita Dewani, Ning Liang, Oliver Hummel, Michael B. Muecke, Thomas B. Hildebrandt, Guido Fritsch, Lisa Schrade, Wolfram H. Zimmermann, Ivanela Kondova, Sebastian Diecke, Sebastiaan van Heesch and Norbert Hübner, 24 September 2024, Nature Cardiovascular Research. DOI: 10.1038/s44161-024-00544-7

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