Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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China OEM factory for footwear and bedding

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Custom graphene foam processing Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Orthopedic pillow OEM solutions Thailand

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Graphene sheet OEM supplier China

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan insole OEM manufacturer

A research team has discovered a wasp that parasitizes adult flies, offering new insights into parasitic biology. Their work highlights previously hidden biological phenomena. Credit: Matthew Ballinger A Mississippi State biologist has discovered a new parasitic wasp species that uniquely targets adult flies, a scientific first. Creating a buzz in Nature, a Mississippi State biologist’s research led to the discovery of a new parasitic wasp species with unusual biology in the Eastern U.S., opening doors for future research in fundamental biological processes. Associate Professor Matthew Ballinger’s article “Drosophila are hosts to the first described parasitoid wasp of adult flies” in the world’s leading science journal highlights the discovery of a new wasp from backyard fly traps, revealing a “spectacular example of undescribed biology hidden in plain sight.” Unprecedented Behavior in Parasitic Wasps “All known parasitoid wasps of flies attack and develop inside immature life stages,” he said, “and despite 200 years of research on parasitoid wasps of Drosophila and other flies, we have never come across a species that attacks the adult stage, until now.” Emergence of an S. perlmani larva from D. affinis. Around the eighteenth day post oviposition, the S. erlmani larva emerges from the lateral or dorsolateral (shown) abdomen of the host. Credit: Matthew Ballinger Logan Moore, Ballinger’s Ph.D. student who was the Nature article’s lead author, began the project by collecting infected fruit flies from his backyard in Starkville. The team then used a combination of field collections and public data to show the new species lives across the Eastern U.S. and infects one of the most studied animals in biology, the fruit fly Drosophila melanogaster. Matthew Ballinger. Credit: Matthew Ballinger Potential for Future Biological Research “Studying how parasites and pathogens influence Drosophila biology and behavior has helped researchers learn more about fundamental biological processes like immunity and reproduction,” Ballinger said. Ballinger’s team collaborated with Scott Shaw, an entomologist and parasitoid wasp expert at the University of Wyoming, to formally describe the new species. Researchers also documented the wasp’s complete life cycle and provided instructions for others to raise adult wasps in the laboratory. “We’re excited to learn more about the new species, and we hope other researchers will begin their own projects to better understand its infection biology, ecology and evolution in the coming years,” Ballinger said, emphasizing the need for ongoing research investment in insect biodiversity and systematics. This work is part of Ballinger’s 2022 $805,682 five-year CAREER grant to study Spiroplasma, the beneficial bacterium that protects its fruit fly hosts against infection by parasites. Reference: “Drosophila are hosts to the first described parasitoid wasp of adult flies” by Logan D. Moore, Toluwanimi Chris Amuwa, Scott Richard Shaw and Matthew J. Ballinger, 11 September 2024, Nature. DOI: 10.1038/s41586-024-07919-7 The study was funded by the U.S. National Science Foundation and McIntire-Stennis.

A microscopic image of a normal mouse small intestine. Cells stained red express normal amounts of cell-surface tags (MHC-II) needed by immune cells to find threats like infections or cancer. High-fat diets reduce the levels of MHC-II tags in intestinal cells, and so the immune system has a harder time recognizing intestinal tumors. Credit: Beyaz lab/CSHL, 2021 The immune system relies on cell surface tags to recognize cancer cells. CSHL researchers discovered mice who ate high-fat diets produced less of these tags on their intestinal cells, suppressing the ability of immune cells to identify and eliminate intestinal tumors. The high-fat diet also reduced the presence of certain bacteria in the mice’s gut, which normally helps maintain the production of these tags. A high-fat diet increases the incidence of colorectal cancer. Cold Spring Harbor Laboratory Fellow Semir Beyaz and collaborators from Harvard Medical School and Massachusetts Institute of Technology have discovered that in mice, fat disrupts the relationship between intestinal cells and the immune cells that patrol them looking for emerging tumors. Reconfiguring the gut microbiome may be a way to heal the relationship. The immune system patrols tissues looking for and eliminating threats. Certain immune cells look for tags that distinguish between normal and abnormal cells. One tag, called MHC-II, helps target cells for destruction. Cell-surface MHC-II activates the immune system to destroy that cell, whether it is just worn out or about to become cancerous. Beyaz and his colleagues found that when mice ate diets high in fat, MHC-II levels were suppressed in intestinal cells. Cells with reduced levels of these tags were not recognized as abnormal and thus could grow into tumors. Charlie Chung, a Stony Brook University graduate student-in-residence in Beyaz’s lab, says, “If we alter the level of these immune recognition molecules in a positive way, then the tumor will more likely be recognized by the immune cell. We hope this can be coupled with the existing strategies, such as immunotherapy, to eradicate tumors.” Intestinal cells of a mouse that were fed a high-fat diet. The intestinal cells express less of the MHC-II tag than found in a gut from mice fed a normal diet. Credit: Beyaz lab/CSHL, 2021 The researchers found that a high-fat diet changed the mouse’s intestinal microbiome (the mixture of microbes in the gut). Several bacteria, including ones called Helicobacter, increase MHC-II, which may help immune cells locate abnormal cells. The team did a “dirty roommate” experiment where mice without these bacteria were housed with ones that had it. The “clean” mice became infected with the Helicobacter bacteria and produced more of the MHC-II tag. The scientists’ findings suggest a new way to boost current immunotherapy treatments against cancer. Increasing the production of this MHC-II tag, either by diet, drugs, or changing the microbes in the body, can help the immune system recognize and eliminate cancer cells. Beyaz says: “This interaction between diet, microbes, and immune recognition has the potential to help us explain how lifestyle factors can contribute to tumor initiation, progression, or response to therapy.” Cancer cells use many tricks to avoid being recognized as abnormal by the immune system, but Beyaz hopes he’s found several ways to outwit them. Reference: “Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis” by Semir Beyaz, Charlie Chung, Haiwei Mou, Khristian E. Bauer-Rowe, Michael E. Xifaras, Ilgin Ergin, Lenka Dohnalova, Moshe Biton, Karthik Shekhar, Onur Eskiocak, Katherine Papciak, Kadir Ozler, Mohammad Almeqdadi, Brian Yueh, Miriam Fein, Damodaran Annamalai, Eider Valle-Encinas, Aysegul Erdemir, Karoline Dogum, Vyom Shah, Aybuke Alici-Garipcan, Hannah V. Meyer, Deniz M.Özata, Eran Elinav, Alper Kucukural, Pawan Kumar, Jeremy P. Mc Aleer, James G. Fox, Christoph A. Thaiss, Aviv Regev, Jatin Roper, Stuart H. Orkin and Ömer H. Yilmaz, 15 September 2021, Cell Stem Cell. DOI: 10.1016/j.stem.2021.08.007 Funding: National Cancer Institute, Oliver S. and Jennie R. Donaldson Charitable Trust, Mathers Foundation, STARR Cancer Consortium, Mark Foundation For Cancer Research, National Institutes of Health, Massachusetts Institute of Technology Stem Cell Initiative, Pew Foundation, Howard Hughes Medical Institute, American Association of Immunologists Career Reentry Fellowship

The helper protein UNC45 ensures muscle health by managing the quality of myosin proteins. It removes defective ones and organizes functional ones, helping muscles work efficiently and preventing disease. Credit: SciTechDaily.com New research has detailed how UNC45, a protein chaperone, distinguishes between healthy and faulty myosin in muscle cells, guiding them to either proper assembly or degradation. Chaperones are molecular machines that help proteins in the cell fold into their proper shape. Among them, UNC45 plays a critical role in muscle health by ensuring the proper function of myosin, a key protein essential for muscle movement. UNC45 manages this by directing damaged myosin to degradation pathways while guiding correctly folded myosin toward assembly. Researchers from Tim Clausen’s lab at the IMP have uncovered the mechanisms behind this process, providing new insights into how disruptions in myosin quality control can lead to serious muscle disorders. Their findings have been published in Nature Communications. Understanding Muscle Protein Dynamics Muscle movement relies on the interaction between two key proteins: actin and myosin. These proteins slide past each other to generate the force needed for movement. For this process to work efficiently, actin and myosin must be precisely organized within the sarcomere, the basic structural and functional unit of muscle cells. This arrangement is crucial for maintaining muscle health, particularly during exercise, periods of stress, and as the body ages. 3D structure of myosin. The protein requires a set of molecular helpers–known as chaperones–to achieve its proper shape, such as the essential factor UNC45. Credit: Research Institute of Molecular Pathology Role of Chaperones in Muscle Function To ensure proteins achieve their correct shape, cells use specialized molecular assistants called chaperones. These chaperones act as caretakers, helping proteins fold and assemble correctly. For myosin, which makes up about 16% of the total protein in muscle cells, proper structure is especially important. One critical chaperone for this task is UNC45, found in all eukaryotic organisms. Identified through genetic studies, UNC45 plays a vital role in shaping myosin and preserving the integrity of the sarcomere. The importance of UNC45 is evident in severe muscle disorders, known as myopathies, which can result from mutations in the UNC45 gene. Beyond its role in helping myosin fold correctly, UNC45 also helps tag and remove faulty proteins, ensuring that only optimal myosin remains in muscle cells. However, the precise molecular mechanism by which UNC45 fulfills its dual role in keeping muscle cells healthy has remained unknown. New Insights into Muscle Health Mechanisms Researchers from Tim Clausen’s lab at the IMP have revealed the molecular details of how UNC45 mediates both processes. The scientists discovered that the chaperone can differentiate between healthy and damaged myosin, and direct it into appropriate assembly or degradation pathways depending on its folding state. The findings also directly link myosin quality control to myosin-related muscle diseases, revealing a previously unexplored connection. The scientists now published their study in the journal Nature Communications. To degrade or not to degrade, that is the question: how a molecular helper holds the key to muscle health Incorrectly shaped proteins–myosin included–are identified and targeted for degradation through a process called ubiquitination, where a small molecule called ubiquitin is attached to them. This tagging marks proteins for breakdown, ensuring that only fit ones are preserved. Such a quality control mechanism is also crucial for keeping muscle cells healthy and functioning properly. During this process, UNC45 interacts with a protein evaluator–that of the class of E3 ubiquitin ligases–enabling it to selectively channel faulty myosin molecules to their breakdown. Advanced Techniques Uncover Protein Interactions To understand how UNC45 distinguishes between healthy and faulty myosin, researchers recreated their interaction using proteins from the model organism C. elegans, a nematode worm. They employed advanced techniques, including crosslinking mass spectrometry, to identify the exact contact points between the chaperone and myosin. This method chemically links interacting proteins, allowing scientists to see where and how they connect. “The chaperone UNC45 can interact with both properly folded and incorrectly shaped myosin, resulting in different functional complexes,” explains Antonia Vogel, former student in the Vienna BioCenter PhD Program at the Clausen lab. These connections determine whether the myosin is structurally sound. One complex will be prone to ubiquitination and degradation, while the other will not, with the myosin’s folding state determining its own fate. “We found how different elements of the protein quality control system in muscle cells work together and compete to decide whether a protein gets folded correctly or is tagged for removal,” concludes Vogel. To understand how myosin interacts with UNC45 at a structural level, researchers used X-ray crystallography, a technique that achieves detailed atomic resolution of proteins. Purified proteins are first turned into a crystal, then irradiated with high-energy beams. The resulting radiation patterns provide clues on the structure of the protein. “We discovered that one specific part of myosin, the FX3HY motif, plays a crucial role in recruiting and connecting to UNC45,” says Renato Arnese, Research Assistant in the Clausen lab. “This motif acts as a recognition signal that is consistently found across different organisms.” Link Between Myosin Quality Control and Myopathies Other than being essential for this chaperone-substrate interaction, it is also involved in human pathology. “Several site-specific mutations in this region prevent UNC45 from connecting with myosin, causing the protein to never reach its proper shape,” explains Arnese. Additionally, a single point mutation in the FX3HY motif is linked to a severe developmental myopathy, the Freeman Sheldon Syndrome (FSS). “Our findings establish the first direct connection between defects in myosin quality control and the onset of myopathies,” says Tim Clausen. “The fact that mutations in myosin and UNC-45 that cause disease in humans are also replicated in C. elegans makes this model system highly valuable for studying such conditions.” The study paves the way to better understand how other client-specific chaperones work, and to investigate whether other muscle diseases could stem from issues with myosin quality control. Reference: “UNC-45 assisted myosin folding depends on a conserved FX3HY motif implicated in Freeman Sheldon Syndrome” by Antonia Vogel, Renato Arnese, Ricardo M. Gudino Carrillo, Daria Sehr, Luiza Deszcz, Andrzej Bylicki, Anton Meinhart and Tim Clausen, 25 July 2024, Nature Communications. DOI: 10.1038/s41467-024-50442-6

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