Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan athletic insole OEM supplier

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Vietnam insole ODM for global brands

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Taiwan insole ODM design and production

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Eco-friendly pillow OEM manufacturer Vietnam

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Private label insole and pillow OEM Indonesia

A subadult male elephant seal can be seen near sea lions in October 2024. Subadult elephant seals and sea lions frequently intermingle at rookeries along Península Valdés in Argentina. Close contact between pinniped species may have facilitated the spread of HPAI in 2023. Credit: Ralph Vanstreels, UC Davis Elephant seal numbers in Argentina remain low after a deadly H5N1 outbreak, highlighting the virus’s dangerous adaptability. The sound of barking elephant seals can be heard once again along the breeding grounds of Península Valdés, Argentina—but it’s quieter. Last year, a massive outbreak of H5N1 avian influenza killed over 17,000 elephant seals, including about 97% of their pups, and scientists estimate that only about a third of the usual number of elephant seals have returned. “It’s beautiful to walk the beaches now and hear elephant seals again,” said Marcela Uhart, director of the Latin America Program at the UC Davis Karen C. Drayer Wildlife Health Center within the UC Davis School of Veterinary Medicine. “At the same time, we’re walking among piles of carcasses and bones, and seeing very few elephant seal harems, so it’s still disturbing.” On occasion, elephant seals breed among sea lions. Here, an adult male elephant seal and a female with her black-coated pup in the background, are surrounded by sea lions in October 2024. Dynamics of contact and beach sharing between these species was disrupted in 2023 during the massive HPAI outbreak in Península Valdés, Argentina. Credit: Ralph Vanstreels, UC Davis A new study published in Nature Communications and co-led by UC Davis and the National Institute of Agricultural Technology (INTA) in Argentina provides evidence of mammal-to-mammal transmission during the 2023 outbreak. It found that H5N1 spread efficiently among marine mammals. The outbreak in elephant seals was a stepping stone amid the first transnational spread of the virus in these species, extending across five countries in southern South America. The study’s genomic analysis further found that, upon entering South America, the virus evolved into separate avian and marine mammal clades, which is unprecedented. An elephant seal harem at dusk on a sandy beach in PenínsulaValdés in October 2024. Following the massive outbreak of HPAI in 2023, only about a third ofthe reproductive females returned to the colony in 2024. Harems were significantly smaller thanexpected. Credit: Marcela Uhart, UC Davis “We’re showing the evolution of H5N1 viruses that belong to genotype B3.2 over time since their introduction in South America in late 2022,” said virologist and co-leading author Agustina Rimondi of INTA and currently also with Robert Koch Institute. “This virus is capable of adapting to marine mammal species, as we can see from the mutations that are consistently found in the viruses belonging to this clade. Very importantly, our study also shows that H5 marine mammal viruses are able to jump back to birds, highlighting the need for increased surveillance and research cooperation in the region.” This video compilation shows elephant seals infected with HPAI. The videos were shot in 2023 primarily for scientific documentation and outreach, and to help other wildlife care specialists recognize the clinical signs of HPAI. Credit: Ralph Vanstreels, UC Davis Elephant Seal Census The Wildlife Conservation Society in Argentina (WCS Argentina) estimated the population of returning elephant seals as part of a decades-long monitoring project. “We were totally appalled by the dramatic impact of the epidemic of avian influenza on this population,” said co-author Valeria Falabella, WCS Argentina director of coastal and marine conservation. “It is likely that more than half of the reproductive population died due to the virus. It will take decades before the numbers are back to the 2022 population size.” Falabella said the epidemic reversed decades of conservation efforts for the species, adding that most of the adult males and many of the most experienced and fertile females have not returned. Scientists survey a seabird colony for signs of HPAI outbreak in early October 2024. This colony was heavily affected in 2023, particularly the terns. Staying vigilant to detect signs of disease is critical for early detection of HPAI cases in wildlife. Credit: Marcela Uhart, UC Davis Tracking and monitoring the virus among elephant seals is a collaborative effort. As WCS Argentina conducts its census, Uhart and colleagues from UC Davis document and sample every animal that dies for signs of H5N1, and Rimondi and colleagues test and sequence them at the Institute of Virology, INTA. So far, no elephant seals have tested positive this breeding season. Yet lingering questions remain from last year’s outbreak. For instance, scientists do not know if the virus was transmitted by aerosol, saliva, feces, or other means, or if surviving animals have built resistance via protective antibodies. Such questions remain highly relevant. Over the past year, the virus has been widespread in wild birds and has caused outbreaks in poultry and U.S. dairy cows, with recent cases reported among dairy and poultry workers. The U.S. Department of Agriculture reported the first H5N1 case in swine in the United States on October 30. There is no known human-to-human spread of H5N1. Elephant seal carcasses line the beach at Punta Delgada in Argentina on October 10, 2023 following an outbreak of HPAI avian influenza that killed about 97% of all pups born that year. Credit: Ralph Vanstreels, UC Davis A Virus’ Journey The current variant of H5N1 clade 2.3.4.4b began to cause problems at a global scale in 2020. While humans confronted the COVID-19 pandemic, H5N1 began killing tens of thousands of seabirds in Europe before moving to South Africa. In 2021, it entered the United States and Canada, threatening poultry and wild birds, and spread to South America in late 2022. By February 2023, highly pathogenic avian influenza was detected in Argentina for the first time, affecting poultry primarily in inland central Argentina for five months. By August 2023, after two months of no outbreaks in poultry, the virus appeared in sea lions at the tip of South America off the Atlantic coastline of Tierra del Fuego island. From there, it moved swiftly northward, with deadly results, first for marine mammals and later for seabirds. An elephant seal weaned pup rests on the beach for several weeks asit matures for its life at sea (photo October 2024). A record low number of pups survived in2023 due to HPAI. The 2024 season looks more promising even if overall numbers of sealsreturning are significantly lower than expected. Credit: Marcela Uhart, UC Davis In October 2023, following outbreaks in sea lions, the study authors surveyed the breeding colony of elephant seals at Punta Delgada along the coast of Península Valdés, recording unprecedented mass mortality. Test results confirmed that HPAI H5N1 was present in the seals, as well as in several terns that died at the same time. The authors said continued monitoring and investigation is critically important to better understand the virus’ evolution. Its increased flexibility to adapt to new hosts could have global consequences for human health, wildlife conservation, and ecosystems. Reference: “Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission” by Marcela M. Uhart, Ralph E. T. Vanstreels, Martha I. Nelson, Valeria Olivera, Julieta Campagna, Victoria Zavattieri, Philippe Lemey, Claudio Campagna, Valeria Falabella and Agustina Rimondi, 11 November 2024, Nature Communications. DOI: 10.1038/s41467-024-53766-5 The study was funded by the WCS Argentina, UC Davis, and the National Institute of Agricultural Technology.

A new study in the journal Nature Aging describes a new anatomical structure in the brain called SLYM, an abbreviation of Subarachnoidal LYmphatic-like Membrane, that acts as a barrier and a platform from which immune cells can monitor the brain. Credit: University of Copenhagen Researchers discovered the SLYM, a thin brain membrane that regulates CSF flow, supports immune defense, and impacts waste removal. From the complexity of neural networks to basic biological functions and structures, the human brain only reluctantly reveals its secrets. Advances in neuro-imaging and molecular biology have only recently enabled scientists to study the living brain at level of detail not previously achievable, unlocking many of its mysteries. The latest discovery, described on January 5 in the journal Science, is a previously unknown component of brain anatomy that acts as both a protective barrier and platform from which immune cells monitor the brain for infection and inflammation. A Barrier and Immune Platform The new study comes from the labs of Maiken Nedergaard, co-director of the Center for Translational Neuromedicine at the University of Rochester and the University of Copenhagen and Kjeld Møllgård, M.D., a professor of neuroanatomy at the University of Copenhagen. Nedergaard and her colleagues have transformed our understanding of the fundamental mechanics of the human brain and made significant findings to the field of neuroscience, including detailing the many critical functions of previously overlooked cells in the brain called glia and the brain’s unique process of waste removal, which the lab named the glymphatic system. “The discovery of a new anatomic structure that segregates and helps control the flow of cerebrospinal fluid (CSF) in and around the brain now provides us much greater appreciation of the sophisticated role that CSF plays not only in transporting and removing waste from the brain, but also in supporting its immune defenses,” said Nedergaard. Structure and Role of the SLYM The study focuses on the membranes that encase the brain, which create a barrier from the rest of the body, and keep it bathed in CSF. The traditional understanding of what is collectively called the meningeal layer, a barrier comprised of individual layers known as the dura, arachnoid, and pia matter. The new layer discovered by the U.S. and Denmark-based research team further divides the space below the arachnoid layer, the subarachnoid space, into two compartments, separated by the newly described layer, which the researchers name the SLYM, an abbreviation of Subarachnoidal LYmphatic-like Membrane. While much of the research in the paper describes the function of SLYM in mice, they also report its actual presence in the adult human brain as well. The SLYM is a type of membrane called mesothelium, which is known to line other organs in the body, including the lungs and heart. Mesothelia typically surround and protect organs, and harbor immune cells. The idea that a similar membrane might exist in the central nervous system was a question first posed by Møllgård, the first author of the study. His research focuses on developmental neurobiology, and on the systems of barriers that protect the brain. The new membrane is very thin and delicate, and consists of only one or a few cells in thickness. Yet the SLYM is a tight barrier, and allows only very small molecules to transit; it seems to separate “clean” and “dirty” CSF. This last observation hints at the likely role played by SLYM in the glymphatic system, which requires a controlled flow and exchange of CSF, allowing the influx of fresh CSF while flushing the toxic proteins associated with Alzheimer’s and other neurological diseases from the central nervous system. This discovery will help researchers more precisely understand the mechanics of the glymphatic system, which was the subject of a recent $13 million grant from the National Institutes of Health’s BRAIN Initiative to the Center for Translational Neuromedicine at the University of Rochester. Immune Functions of the SLYM The SLYM also appears important to the brain’s defenses. The central nervous system maintains its own native population of immune cells, and the membrane’s integrity prevents outside immune cells from entering. In addition, the SLYM appears to host its own population of central nervous system immune cells that use the SLYM for surveillance at the surface of brain, allowing them to scan passing CSF for signs of infection. Discovery of the SLYM opens the door for further study of its role in brain disease. For example, the researchers note that larger and more diverse concentrations of immune cells congregate on the membrane during inflammation and aging. When the membrane was ruptured during traumatic brain injury, the resulting disruption in the flow of CSF impaired the glymphatic system and allowed non-central nervous system immune cells to enter the brain. These and similar observations suggest that diseases as diverse as multiple sclerosis, central nervous system infections, and Alzheimer’s might be triggered or worsened by abnormalities in SLYM function. They also suggest that the delivery of drugs and gene therapeutics to the brain may be impacted by SLYM function, which will need to be considered as new generations of biologic therapies are being developed. Reference: “A mesothelium divides the subarachnoid space into functional compartments” by Kjeld Møllgård, Felix R. M. Beinlich, Peter Kusk, Leo M. Miyakoshi, Christine Delle, Virginia Plá, Natalie L. Hauglund, Tina Esmail, Martin K. Rasmussen, Ryszard S. Gomolka, Yuki Mori and Maiken Nedergaard, 5 January 2023, Science. DOI: 10.1126/science.adc8810 Additional co-authors include Felix Beinlich, Peter Kusk, Leo Miyakoshi, Christine Delle, Virginia Pla, Natalie Hauglund, Tina Esmail, Martin Rasmussen, Ryszard Gomolka, and Yuki Mori with Center for Translational Neuromedicine at the University of Copenhagen. The study was supported with funding from the Lundbeck Foundation, Novo Nordisk Foundation, the National Institute of Neurological Disorders and Stroke, the U.S. Army Research Office, the Human Frontier Science Program, the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation and the Simons Foundation.

The value of natural history collections and the information that can be gleaned from them have increased over time as digitization efforts makes them more widely available for study. Credit: Illustration by Emile-Allain Séguy Extreme weather events are altering insect lifespans, impacting ecosystems and disease transmission. Scientists warn of long-term adaptation limits. With greenhouse gas emissions causing Earth’s climate to steadily heat up, we’re seeing an increasing number of extreme and anomalous weather events. But predicting and analyzing the effects of what is, by definition, an anomaly can be tricky. According to scientists, museum samples could provide some answers. In a first study of its kind, a team from the University of Florida utilized specimens from natural history to demonstrate that abnormal hot and cold days can extend the activity span of butterflies and moths by almost a month. “The results are not at all what we expected,” said lead author Robert Guralnick, curator of biodiversity informatics at the Florida Museum of Natural History. Most studies view climate change and its consequences through a periscope of average temperature increases. As the temperature goes up over time, the plants and animals in a particular region become active earlier in the spring, delay dormancy until later in the fall, and slowly shift their ranges to align with the climate in which they’re best suited to survive. Erratic weather adds a layer of complexity to these patterns, with unknown consequences that erect an opaque screen ahead of scientists attempting to predict the future of global ecosystems. “There had been hints in the scientific literature that weather anomalies can have cumulative effects on ecosystems, but there wasn’t anything that directly addressed this question at a broad scale,” Guralnick said. This omission, he explained, was due primarily to a lack of sufficient data. While climate data has been reliably collected in many areas of the world for more than a century, records documenting the location and activity of organisms are harder to come by. Natural History Museums: A Hidden Data Source Natural history museums have been increasingly regarded as a potential solution. The oldest museums have accumulated specimens for hundreds of years, and recent efforts to digitize collections have made their contents widely available. But digital museum records come with their own unique pitfalls and drawbacks. In the first study of its kind, researchers at the University of Florida used natural history specimens to show that unseasonably warm and cold days can prolong the active period of moths and butterflies by nearly a month. Credit: Illustrations by Emile-Allain Séguy In 2022, study co-author Michael Belitz constructed a dataset of moths and butterflies from museum collections to chart a course for other researchers hoping to use similar data. The result was a comprehensive instruction manual for how to gather, organize and analyze information from natural history specimens. With this robust resource at their disposal, Belitz and his colleagues wanted to see if they could detect a signal from aberrant weather patterns. Restricting their analyses to the eastern United States, the authors used records for 139 moth and butterfly species collected from the 1940s through the 2010s. Weather Anomalies Shape Insect Behavior Their results were unequivocal: Unusually warm and cold weather has significantly altered insect activity to a greater extent than the average increase in global temperature for the last several decades. The location and timing of extreme weather events influenced how insects responded. In higher latitudes, warm days in winter meant moths and butterflies became active earlier in the spring. Unusually cold days kept insects at all latitudes active longer, and the combination of exceptionally high and low temperatures had the strongest effect. “If you have a succession of abnormally cold and warm days, it limits the ability of insects to function at peak performance,” Guralnick said. “If the cold doesn’t kill you, it slows you down, and it might force insects into a torpor. Insects can recover from the cold snaps pretty quickly and go on to have longer lifespans as a direct result of sudden temperature declines.” Insects being active for longer periods of time might initially seem like a good thing. But rather than a counterweight to the negative repercussions of climate change, co-author Lindsay Campbell — who studies mosquitos — points out that longer or altered insect lifespans may also mean more opportunities for pathogen transmission. “There’s a correlation between El Niño and rift valley fever outbreaks in East Africa, and there are anecdotal observations that show unusually warm or hot and dry springs, followed by a heavy precipitation event, are also linked with increased outbreaks,” said Campbell, an assistant professor at the University of Florida. The Fragile Balance of Ecosystems Long-term ecosystem stability is also entirely dependent on the synchronized activity of its constituent parts, and plants may not respond to extreme weather in the same way as insects. If moths and butterflies take flight too early, they risk encountering plants that haven’t yet produced leaves or flowers, expending their energy in a vain search for food. And with a constantly shifting baseline for what constitutes ‘extreme,’ it’s unclear if insects will be able to keep pace with the changes. “As average temperature and climate variability increases, an organism’s resilience is going to drop precipitously,” Guralnick said. “The extreme events of today are going to become much more extreme in the future, and at some point, the capacity to buffer against these changes is going to reach its limit.” Reference: “Weather anomalies more important than climate means in driving insect phenology” by R. P. Guralnick, L. P. Campbell, and M. W. Belitz, 5 May 2023, Communications Biology. DOI: 10.1038/s42003-023-04873-4 The study was funded by the National Science Foundation and the National Institute of Food and Agriculture.

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