Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Customized sports insole ODM Taiwan

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Graphene insole manufacturing factory in Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Flexible manufacturing OEM & ODM Vietnam

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.ODM pillow for sleep brands Vietnam

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Vietnam OEM insole and pillow supplier

A recent study identified Interleukin-18 as a trigger for Eosinophilic esophagitis, a chronic immune disease affecting children. The research suggests that inhibiting the protein’s release could prevent the disease and proposes an existing drug, VX-765, as a potential treatment. Eosiniphilic esophagitis was not identified as a disease until the 1990s. Decades later, a treatment may have been discovered. A new study from Tulane University has identified a new treatment for a chronic immune system disease that can prevent children from eating. Eosinophilic esophagitis (EoE) is triggered by food allergies or airborne allergens which causes a type of white blood cell, eosinophils, to build up in the lining of the esophagus. This causes the esophagus to shorten and the esophageal wall to thicken, making swallowing difficult and causing food to get stuck in the throat. Disease Prevalence and Newly Identified Cause The disease occurs in an estimated 1 in 2,000 adults but more frequently affects children (1 in 1,500) where symptoms can be harder to diagnose and pose greater risks as difficulty feeding can lead to malnutrition, weight loss, and poor growth. The new study, published today (July 31)  in Nature’s Communications Biology journal, found that the disease is caused by Interleukin-18 (IL-18), a protein involved in the innate immune response that can cause inflammation if produced in excess. When a food allergen enters the body, it activates a pathway responsible for regulating the innate immune system, resulting in the release of proinflammatory proteins like IL-18. This produces the eosinophils which damage the esophagus. Discovering Potential Treatment The study found that successfully inhibiting this pathway, called the NLRP3 pathway, and the release of IL-18 prevented the development of EoE from both food and airborne allergens. “Parents and doctors may not be aware of this, but this is a very prominent and serious disease in the pediatric population, and it is increasing in number because it is directly related to food allergens, which are also on the rise,” said lead author Dr. Anil Mishra, director of the Eosinophilic Disorder Center at the Tulane University School of Medicine. “In this study, we show that after treating the disease in animals, the disease is gone and completely in remission.” The Study’s Impact The findings are crucial for a disease that was not identified until the 1990s. For many years, EoE was misdiagnosed as gastrointestinal reflux disease (GERD), despite GERD medication being ineffective for treating EoE. Additionally, this study’s findings replace decades of thinking that Th2 cells play a major role in triggering EoE. “Given the paucity of mechanistic information and treatment strategies for EoE, we feel the proposed studies are highly relevant and are poised to have a major impact on establishing the significance of NLRP3-IL-18 pathway in the initiation of EoE pathogenesis,” Mishra said. The Next Steps The study identified one existing drug, VX-765, as an inhibitor that may work as a treatment for humans. Importantly, this inhibitor would only deplete pathogenic eosinophils generated and transformed by IL-18 and not affect white blood cells created by IL-5, a protein important for maintaining innate immunity. Mishra said a clinical trial would be the next step to determining the treatment’s effectiveness. Reference: “Allergen-induced NLRP3/caspase1/IL-18 signaling initiate eosinophilic esophagitis and respective inhibitors protect disease pathogenesis” by Chandra Sekhar Yadavalli, Sathisha Upparahalli Venkateshaiah, Sandeep Kumar, Hemanth Kumar Kandikattu, Lokanatha Oruganti, Chandra Sekhar Kathera and Anil Mishra, 31 July 2023, Communications Biology. DOI: 10.1038/s42003-023-05130-4

Bats map the world in units of time A new Tel Aviv University study has revealed, for the first time, that bats know the speed of sound from birth. In order to prove this, the researchers raised bats from the time of their birth in a helium-enriched environment in which the speed of sound is higher than normal. They found that unlike humans, who map the world in units of distance, bats map the world in units of time. What this means is that the bat perceives an insect as being at a distance of nine milliseconds, and not one and a half meters, as was thought until now. Prof. Yossi Yovel. Credit: Tel Aviv University The study was published in PNAS. In order to determine where things are in a space, bats use sonar — they produce sound waves that hit objects and are reflected back to the bat. Bats can estimate the position of the object based on the time that elapses between the moment the sound wave is produced and the moment it is returned to the bat. This calculation depends on the speed of sound, which can vary in different environmental conditions, such as air composition or temperature. For example, there could be a difference of almost 10% between the speed of sound at the height of the summer, when the air is hot and the sound waves spread faster, and the winter season. Since the discovery of sonar in bats 80 years ago, researchers have been trying to figure out whether bats acquire the ability to measure the speed of sound over the course of their lifetime or are born with this innate, constant sense. Now, researchers led by Prof. Yossi Yovel, head of the Sagol School of Neuroscience and a faculty member of the School of Zoology in the Faculty of Life Sciences and his former doctoral student Dr. Eran Amichai (currently studying at Dartmouth College) have succeeded in answering this question. Prof. Yossi Yovel. Credit: Tel Aviv University The researchers conducted an experiment in which they were able to manipulate the speed of sound. They enriched the air composition with helium to increase the speed of sound, and under these conditions raised bat pups from the time of their birth, as well as adult bats. Neither the adult bats nor the bat pups were able to adjust to the new speed of sound and consistently landed in front of the target, indicating that they perceived the target as being closer — that is, they did not adjust their behavior to the higher speed of sound. Because this occurred both in the adult bats that had learned to fly in normal environmental conditions and in the pups that learned to fly in an environment with a higher-than-normal speed of sound, the researchers concluded that the rate of the speed of sound in bats is innate — they have a constant sense of it. “Because bats need to learn to fly within a short time of their birth,” explains Prof. Yovel, “we hypothesize that an evolutionary ‘choice’ was made to be born with this knowledge in order to save time during the sensitive development period.” Another interesting conclusion of the study is that bats do not actually calculate the distance to the target according to the speed of sound. Because they do not adjust the speed of sound encoded in their brains, it seems that they also do not translate the time it takes for the sound waves to return into units of distance. Therefore, their spatial perception is actually based on measurements of time and not distance. Prof. Yossi Yovel: “What most excited me about this study is that we were able to answer a very basic question — we found that in fact bats do not measure distance, but rather time, to orient themselves in space. This may sound like a semantic difference, but I think that it means that their spatial perception is fundamentally different than that of humans and other visual creatures, at least when they rely on sonar. It’s fascinating to see how diverse evolution is in the brain-computing strategies it produces.” Reference: “Echolocating bats rely on an innate speed-of-sound reference” by Eran Amichai and Yossi Yovel, 5 May 2021, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2024352118

Researchers at the Center for Genomic Regulation (CRG) have uncovered that chromatin, the coiled genetic structure in eukaryotes, originated in ancient microbes between one and two billion years ago. Analysis of the genome and proteome shows that eukaryotic evolution gave rise to the regulatory function of chromatin. Two meters of DNA must fit into a nucleus that is just 8 millionths of a meter wide in practically every human cell. DNA must wrap around structural proteins called histones in order to solve the extreme space challenge, much like wool around a spool. This coiled genetic architecture, known as chromatin, shields DNA from harm and plays an important role in gene regulation. Histones are found in both eukaryotes, living organisms with specialized cellular machinery like nuclei and microtubules, and archaea, a branch of the tree of life made up of single-celled microbes that are prokaryotic, which means they lack a nucleus. Enzymes alter histones in eukaryotic cells, continually reshaping the genomic landscape to regulate gene expression and other genomic processes. Despite playing this crucial role, the precise origin of chromatin has remained a mystery. Discovery of Chromatin’s Ancient Origins Researchers at the Center for Genomic Regulation (CRG) now reveal that nature’s storage solution first evolved in ancient microbes living on Earth between one and two billion years ago. The research was recently published in Nature Ecology and Evolution. To go back in time, the researchers exploited information encoded in current organisms’ genomes, grouping living forms based on the evolution of genes and proteins connected to chromatin. They looked at thirty distinct species found in water samples from Canada and France. The bacteria were identified using contemporary gene-sequencing technology, which enables species identification by filtering DNA. They were then grown in the laboratory for proteomic and genomic sequencing. Prokaryotes vs Eukaryotes: Different Roles for Histones The researchers discovered that prokaryotes lack the machinery required to alter histones, implying that archaeal chromatin had a basic structural function but did not regulate the genome at the time. In contrast, researchers found ample evidence of proteins that read, write and erase histone modifications in early diverging eukaryotic lineages such as the malawimonad Gefionella okellyi, the ancyromonad Fabomonas tropica, or the discoban Naegleria gruberi, microbes that had not been sampled until now. “Our results underscore that the structural and regulatory roles of chromatin are as old as eukaryotes themselves. These functions are essential for eukaryotic life — since chromatin first appeared, it’s never been lost again in any life form,” says Dr. Xavier Grau-Bové, a post-doctoral researcher at the CRG and first author of the study. “We are now a bit closer to understanding its origin, thanks to the power of comparative analyses to uncover evolutionary events that occurred billions of years ago.” Using the sequence data, the researchers reconstructed the repertoire of genes held by the Last Eukaryotic Common Ancestor, the cell that gave rise to all eukaryotes. This living organism had dozens of histone-modifying genes and lived between one and two billion years ago on Earth, which is itself estimated to be 4.5 billion years old. The authors of the study hypothesize that chromatin evolved in this microbe as a result of selective pressures in the primordial environment of Earth. Viruses and Genome Parasites: Evolutionary Pressure to Develop Chromatin Dr. Arnau Sebe-Pedrós, a researcher at the CRG and senior author of the study, points out that “viruses and transposable elements are genome parasites that regularly attack DNA of single-celled organisms. This could have led to an evolutionary arms race to protect the genome, resulting in the development of chromatin as a defensive mechanism in the cell that gave rise to all known eukaryotic life on Earth. Later on, these mechanisms were co-opted into elaborate gene regulation, as we observe in modern eukaryotes, particularly multicellular organisms.” According to the authors of the study, future research could look at the evolution of histone-modifying enzymes in Asgardian archaea, microbes named after a mythological region inhabited by Norse gods that are often described as an evolutionary stepping stone between archaea and eukaryotes. The researchers found evidence that some species of Asgardian microbes, such as Lokiarchaeota, have histones with eukaryotic-like features, and could be the result of convergent evolution. Reference: “A phylogenetic and proteomic reconstruction of eukaryotic chromatin evolution” by Xavier Grau-Bové, Cristina Navarrete, Cristina Chiva, Thomas Pribasnig, Meritxell Antó, Guifré Torruella, Luis Javier Galindo, Bernd Franz Lang, David Moreira, Purificación López-Garcia, Iñaki Ruiz-Trillo, Christa Schleper, Eduard Sabidó and Arnau Sebé-Pedrós, 9 June 2022, Nature Ecology & Evolution. DOI: 10.1038/s41559-022-01771-6 The study is the result of a research project that started eight years ago. Led by researchers at the CRG, the work counts on the collaboration of the CRG-UPF Proteomics Unit, the Institut de Biologia Evolutiva (CSIC-UPF), Université Paris-Saclay, Université de Montreal, and the University of Vienna. The study was funded the European Research Council, the Ministerio de Ciencia e Innovación, the Centro de Excelencia Severo Ochoa, and the Agencia Estatal de Investigación.

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