Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Innovative pillow ODM solution in Thailand

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Customized sports insole ODM factory Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Eco-friendly pillow OEM manufacturer Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Graphene cushion OEM factory in Thailand

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.China orthopedic insole OEM manufacturer

Researchers have reconstructed the ancestral sequence of the great ape Y chromosome by comparing three existing (gorilla, human, and chimpanzee) and two newly generated (orangutan and bonobo) Y chromosome assemblies. The new research shows that many gene families and multi-copy sequences were already present in the great ape Y common ancestor and that the chimpanzee and bonobo lineages experienced accelerated gene death and nucleotide substitution rates after their divergence from the human lineage. Credit: Dani Zemba and Monika Cechova, Penn State Researchers reconstruct the ancestral great ape Y and show its rapid evolution in bonobo and chimpanzee. New analysis of the DNA sequence of the male-specific Y chromosomes from all living species of the great ape family helps to clarify our understanding of how this enigmatic chromosome evolved. A clearer picture of the evolution of the Y chromosome is important for studying male fertility in humans as well as our understanding of reproduction patterns and the ability to track male lineages in the great apes, which can help with conservation efforts for these endangered species. A team of biologists and computer scientists at Penn State sequenced and assembled the Y chromosome from orangutan and bonobo and compared those sequences to the existing human, chimpanzee, and gorilla Y sequences. From the comparison, the team was able to clarify patterns of evolution that seem to fit with behavioral differences between the species and reconstruct a model of what the Y chromosome might have looked like in the ancestor of all great apes. A paper describing the research was published in the journal Proceedings of the National Academy of Sciences. “The Y chromosome is important for male fertility and contains the genes critical for sperm production, but it is often neglected in genomic studies because it is so difficult to sequence and assemble,” said Monika Cechova, a graduate student at Penn State at the time of the research and co-first author of the paper. “The Y chromosome contains a lot of repetitive sequences, which are challenging for DNA sequencing, assembling sequences, and aligning sequences for comparison. There aren’t out-of-the-box software packages to deal with the Y chromosome, so we had to overcome these hurdles and optimize our experimental and computational protocols, which allowed us to address interesting biological questions.” Unusual Features of the Y Chromosome The Y chromosome is unusual. It contains relatively few genes, many of which are involved in male sex determination and sperm production; large sections of repetitive DNA, short sequences repeated over and over again; and large DNA palindromes, inverted repeats that can be many thousands of letters long and read the same forwards and backwards. Previous work by the team comparing human, chimpanzee, and gorilla sequences had revealed some unexpected patterns. Humans are more closely related to chimpanzees, but for some characteristics, the human Y was more similar to the gorilla Y. “If you just compare the sequence identity—comparing the As, Ts, Cs, and Gs of the chromosomes—humans are more similar to chimpanzees, as you would expect,” said Kateryna Makova, Pentz Professor of Biology at Penn State and one of the leaders of the research team. “But if you look at which genes are present, the types of repetitive sequences, and the shared palindromes, humans look more similar to gorillas. We needed the Y chromosome of more great ape species to tease out the details of what was going on.” The team, therefore, sequenced the Y chromosome of a bonobo, a close relative of the chimpanzee, and an orangutan, a more distantly related great ape. With these new sequences, the researchers could see that the bonobo and chimpanzee shared the unusual pattern of accelerated rates of DNA sequence change and gene loss, suggesting that this pattern emerged prior to the evolutionary split between the two species. The orangutan Y chromosome, on the other hand, which serves as an outgroup to ground the comparisons, looked about like what you expect based on its known relationship to the other great apes. Mating Behaviors May Drive Evolutionary Change “Our hypothesis is that the accelerated change that we see in chimpanzees and bonobos could be related to their mating habits,” said Rahulsimham Vegesna, a graduate student at Penn State and co-first author of the paper. “In chimpanzees and bonobos, one female mates with multiple males during a single cycle. This leads to what we call ‘sperm competition,’ the sperm from several males trying to fertilize a single egg. We think that this situation could provide the evolutionary pressure to accelerate change on the chimpanzee and bonobo Y chromosome, compared to other apes with different mating patterns, but this hypothesis, while consistent with our findings, needs to be evaluated in subsequent studies.” In addition to teasing out some of the details of how the Y chromosome evolved in individual species, the team used the set of great ape sequences to reconstruct what the Y chromosome might have looked like in the ancestor of modern great apes. “Having the ancestral great ape Y chromosome helps us to understand how the chromosome evolved,” said Vegesna. “For example, we can see that many of the repetitive regions and palindromes on the Y were already present on the ancestral chromosome. This, in turn, argues for the importance of these features for the Y chromosome in all great apes and allows us to explore how they evolved in each of the separate species.” The Y Chromosome and Self-Recombination The Y chromosome is also unusual because, unlike most chromosomes it doesn’t have a matching partner. We each get two copies of chromosomes 1 through 22, and then some of us (females) get two X chromosomes and some of us (males) get one X and one Y. Partner chromosomes can exchange sections in a process called ‘recombination,’ which is important to preserve the chromosomes evolutionarily. Because the Y doesn’t have a partner, it had been hypothesized that the long palindromic sequences on the Y might be able to recombine with themselves and thus still be able to preserve their genes, but the mechanism was not known. “We used the data from a technique called Hi-C, which captures the three-dimensional organization of the chromosome, to try to see how this ‘self-recombination’ is facilitated,” said Cechova. “What we found was that regions of the chromosome that recombine with each other are kept in close proximity to one another spatially by the structure of the chromosome.” “Working on the Y chromosome presents a lot of challenges,” said Paul Medvedev, associate professor of computer science and engineering and of biochemistry and molecular biology at Penn State and the other leader of the research team. “We had to develop specialized methods and computational analyses to account for the highly repetitive nature of the sequence of the Y. This project is truly cross-disciplinary and could not have happened without the combination of computational and biological scientists that we have on our team.” Reference: “Dynamic evolution of great ape Y chromosomes” by Monika Cechova, Rahulsimham Vegesna, Marta Tomaszkiewicz, Robert S. Harris, Di Chen, Samarth Rangavittal, Paul Medvedev and Kateryna D. Makova, 5 October 2020, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2001749117 In addition to Cechova, Makova, Vegesna, and Medvedev, the research team at Penn State included Marta Tomaszkiewicz, Robert S. Harris, Di Chen, and Samarth Rangavittal. The research was supported by the U.S. National Institutes of Health, the U.S. National Science Foundation, the Clinical and Translational Sciences Institute, the Institute of Computational and Data Sciences, the Huck Institutes of the Life Sciences, and the Eberly College of Science of the Pennsylvania State University, and by the CBIOS Predoctoral Training Program awarded to Penn State by the National Institutes of Health.

Picture of a bee. Credit: Emilie Ellis and Stuart Campbell New research from the University of Sheffield indicates that nocturnal pollinators like moths, could visit as many plants as bees, and also deserve considerable conservation and protection measures. The study discovered that compared to bees, moths may have lower resilience under the strain of urbanization, due to their intricate life cycle and more particular plant needs. However, despite facing these risks, moths make a significant contribution to the support of urban plant ecosystems. They are responsible for one-third of the pollination activity in flowering plants, crops, and trees. The researchers suggest that when planning or redeveloping urban areas, supporting the introduction of plant species that are beneficial for moths, as well as bees, will become increasingly important for the health of urban ecosystems. Picture of moth. Credit: Emilie Ellis and Stuart Campbell Dr. Emilie Ellis, lead author from the University of Sheffield’s Grantham Institute for Sustainable Futures, and now the Research Centre for Ecological Change (REC) at the University of Helsinki, said: “Our study found that in more urbanized areas the diversity of pollen being carried by moths and bees decreases, meaning that urban pollinators may have fewer flower resources available to them. “As moths and bees both rely on plants for survival, plant populations also rely on insects for pollination. Protecting urban green spaces and ensuring they are developed in such a way that moves beyond bee-only conservation but also supports a diverse array of wildlife, will ensure both bee and moth populations remain resilient and our towns and cities remain healthier, greener places.” Moths Pollinate More Than Previously Thought In the study, Dr. Ellis and her co-authors showed that bees and moths are visiting significantly different plant communities. Along with the usual pale and fragrant flower species moths are known to frequent, the study showed that moths were found to be carrying more pollen than previously thought, and visiting more types of tree and fruit crops than previously identified. In urbanized areas, there can sometimes be an overabundance of non-native plant species or just an overall reduction in the diversity of plant species; this may result in lower insect interactions for less attractive plant species, having negative effects on both plant and insect populations. Picture of moth. Credit: Emilie Ellis and Stuart Campbell Dr. Ellis says the research demonstrates just how crucial moths are at pollinating plants, including crops, and that the study has implications for wildlife-friendly gardening initiatives, urban planners, and policymakers responsible for developing urban green spaces for parks or urban horticulture. Dr Ellis said: “People don’t generally appreciate moths so they can often be overlooked compared to bees when talking about protection and conservation, but it’s becoming apparent that there needs to be a much more focused effort to raise awareness of the important role moths play in establishing healthy environments, especially as we know moth populations have drastically declined over the past 50 years. “When planning green spaces, consideration needs to be given to ensure planting is diverse and moth-friendly as well as bee-friendly, to ensure both our plants and insects remain resilient in the face of the climate crisis and further losses.” Using DNA to Uncover Moth Pollination Patterns Dr Stuart Campbell, from the University of Sheffield’s School of Biosciences, and a senior author on the study, said: “Most plants depend on insects for pollination, but knowing which insects do the pollinating is actually a really difficult question to answer. There are about 250 species of bee in the UK, and we know quite a bit about some of these species, but we also have over 2,500 species of moth which visit flowers mostly at night. So, as you might expect, we know a lot less about these. “What we were able to do in this study is use DNA sequencing to identify the pollen that gets stuck to night-flying moths when they visit flowers. We found that moths are probably pollinating a range of plant species, many of them wild, that are unlikely to be pollinated by bees – and vice versa. It’s clear from this study that pollination is achieved by complex networks of insects and plants, and these networks may be delicate, and sensitive to urbanization. We can also learn which plant species might be the best sources of food for different insects, including nocturnal ones like adult moths, and use that information to better provide for all our pollinators.” Reference: “Negative effects of urbanisation on diurnal and nocturnal pollen-transport networks” by Emilie E. Ellis, Jill L. Edmondson, Kathryn H. Maher, Helen Hipperson and Stuart A. Campbell, 5 June 2023, Ecology Letters. DOI: 10.1111/ele.14261

A spherical lipoprotein article with proteins on the surface is visible in the lower part of the image in this artist’s rendition that includes neurons (light-green cells), synapses (connections highlighted in yellow), and microglia (in purple). Credit: Mike Perkins | Pacific Northwest National Laboratory New research provides a fresh glimpse of APOE, scores of new molecular players in the central nervous system. Researchers have developed a technique to identify key fat-filled particles known as lipoproteins within the central nervous system, opening a new view into the workings of the brain. The study revealed that these particles, molecular cousins of the well-known HDL, or “good cholesterol” particles in our bloodstream, are much more diverse than previously thought. The team identified over 300 distinct proteins linked with these particles, a significant increase from the previously known 16, that fall into at least 10 different families. These particles are rich in proteins that affect wound healing, the immune response, and the creation and nurturing of brain cells called neurons which are important for cognitive function. The most common protein on the particles is apolipoprotein E, better known as APOE. Of the three commonly studied forms of APOE, the form known as APOE4 puts people at higher risk of Alzheimer’s disease. One copy of the APOE4 gene makes a person approximately four times as likely to develop dementia; a person with two copies is about 12 times more vulnerable. The results were recently published in the journal Science Advances. The leader of the study is John Melchior, a protein biochemist at the Department of Energy’s Pacific Northwest National Laboratory. Melchior is a leader in lipoprotein research—and a carrier of two copies of the APOE4 gene, adding a personal incentive to his work to understand the protein’s action in the nervous system. “We’ve known for a long time that in the nervous system, APOE is the primary protein on these particles calling the shots. But we don’t know much more beyond that. Our technology opens the door to learning more,” said Melchior. “What the heck is APOE4 doing? That’s the big question. Why does one form translate to less risk for dementia while a slightly different form confers significant risk? Our technology brings us one step toward more answers,” he added. APOE: Bringing Fats and Proteins Together Lipoproteins are best known for their work in the circulatory system, where they transport fat and cholesterol. It’s easy for scientists to detect HDL and LDL, known to many as “good cholesterol” and “bad cholesterol,” in the bloodstream because the molecules there are plentiful. However, lipoproteins in the nervous system are much scanter, present at less than 1 percent of the concentration in blood. Their actions, even their presence, in the nervous system have been a mystery. Scientists know that these balls of fat and protein wrapped together to travel in the bloodstream and carry out all sorts of important functions, like shuttling cholesterol and nutrients. On the particles in the central nervous system, APOE reigns supreme, serving as a scaffold to hold lipids and other proteins together. It also transports these nutrient-rich lipids and collections of molecular collaborators—groupings of proteins on its surface—throughout the nervous system to perform their tasks. The proteins are specialized tools that can do things like repair cells, turn genes on or off, or regulate amyloid-beta processing, a well-known molecule related to the development of dementia. The work suggests that APOE may bring these tools together on different particles to deliver them where needed. But something is more likely to go wrong in people with one or two copies of APOE4, leading to dementia. Scientists don’t know what. Scientists suspect APOE4 of playing a role in other neurologic conditions such as Parkinson’s and Huntington’s diseases, multiple sclerosis, amyotrophic lateral sclerosis, and even traumatic brain injury. Because lipoproteins are less common in the nervous system, researchers either need an impossibly large amount of the cerebrospinal fluid to study them—or scientists develop a new way to detect the rare molecules. That’s what Melchior’s team did, creating a new fluorescent technology to tag lipoproteins in spinal fluid. The team studied just one-third of a milliliter of spinal fluid—much less fluid than in a raindrop—and discovered 303 different proteins across the particle families using mass spectrometry. Most had never been detected on these particles in the nervous system before. A Solid Start and Next Steps: Lipoproteins and Neurological Diseases “Now comes the fun part,” said Melchior. “We want to open up our technology to clinicians to learn more about what’s happening in Alzheimer’s disease and possibly other conditions like multiple sclerosis and Parkinson’s disease. “There are existing cerebrospinal fluid samples sitting in freezers, and we have a new way to analyze them. We’d love to work together with other research teams to investigate them. The sooner we can start profiling lipoproteins in these conditions, the sooner we can understand more about their role in disease pathology and identify targets for treatments,” added Melchior, who holds joint appointments at Oregon Health & Science University and the University of Cincinnati. First author of the paper is PNNL scientist Nathaniel Merrill who did much of the computational analysis of the data. Merrill designed computational tools to help sort out extraordinarily complicated datasets. This includes which proteins are most likely to be found together on different particle populations and what processes those proteins control in the central nervous system. Reference: “Human cerebrospinal fluid contains diverse lipoprotein subspecies enriched in proteins implicated in central nervous system health” by Nathaniel J. Merrill, W. Sean Davidson, Yi He, Ivo Díaz Ludovico, Snigdha Sarkar, Madelyn R. Berger, Jason E. McDermott, Linda J. Van Eldik, Donna M. Wilcock, Matthew E. Monroe, Jennifer E. Kyle, Kimberley D. Bruce, Jay W. Heinecke, Tomas Vaisar, Jacob Raber, Joseph F. Quinn and John T. Melchior, 30 August 2023, Science Advances. DOI: 10.1126/sciadv.adi5571 The study brought together investigators from the University of Cincinnati, OHSU, University of Washington, University of Kentucky, University of Colorado, VA Portland Healthcare System as well as PNNL. In addition to Melchior and Merrill, PNNL authors include Ivo Díaz Ludovico, Snigdha Sarkar, Madelyn Berger, Jason McDermott, Matthew Monroe and Jennifer Kyle. The work was done as part of the Pacific Northwest Biomedical Innovation Co-Laboratory, or PMedIC, where PNNL and OHSU scientists and physicians work together to bring basic science and clinical experience together to explore disease and develop innovative therapies. The work was funded by the National Institutes of Health (1R03AG070480, P01HL128203, R01AG079217, P30AG066518) and by the OHSU School of Medicine. The early support for the project from NIH was crucial, said W. Sean Davidson of the University of Cincinnati, a coauthor and an expert on lipoproteins in the circulatory system. “We took advantage of the Notice of Special Interest program, which allows labs that are funded in other areas—in our case, cardiovascular disease—to translate new technologies toward Alzheimer’s disease. This made it possible to turn a crazy idea into an exciting new way to analyze lipoproteins in the brain,” said Davidson.

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