Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Indonesia OEM factory for footwear and bedding

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Graphene insole manufacturer in Thailand

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.ESG-compliant OEM manufacturer in Indonesia

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Vietnam flexible graphene product manufacturing

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Indonesia high-end foam product OEM/ODM

The research reveals that synaptotagmin-3 plays a role in high-frequency synaptic transmission. Researchers at Oregon Health & Science University have discovered a key molecule that contributes to understanding and treating neurological diseases like epilepsy and autism. Researchers at Oregon Health & Science University have discovered a long-sought gene-encoded protein that allows the brain to communicate a number of signals across synapses, or gaps between neurons. The discovery was recently published in the journal Nature.  The protein, known as synaptotagmin-3 (SYT3), aids in replenishing the supply of chemical neurotransmitters that transmit signals between neurons. “When brain cells are active, they release neurotransmitters to communicate with their neighbors,” said senior author Skyler Jackman, Ph.D., assistant scientist at the OHSU Vollum Institute. “If a cell is very active it can exhaust its supply of neurotransmitters, which can cause a breakdown of communication and brain dysfunction. It turns out that cells have a boost mode that replenishes their supply of neurotransmitters, but until now, we didn’t know the molecule that was responsible. We found that SYT3 is directly responsible for that neurotransmitter boost,” he said. “This gives us new insight about how brains can break down and fail to process information properly.” Skyler Jackman, Ph.D., assistant scientist at the OHSU Vollum Institute, is the senior author of a neurotransmitter discovery that is published in the journal Nature. He is sitting next to the scope used to view synaptic transmission. Credit: OHSU/Christine Torres Hicks Insights From SYT3 Gene “Knock-Out” Studies Scientists created “knock-out” mice that lacked the SYT3 gene. They discovered that in contrast to control mice that had the gene, those mice lacked the more robust level of synaptic transmission. Notably, SYT3 gene mutations have been linked to human instances of autism spectrum disorder and epilepsy. According to Jackman, recent research raises the prospect of developing gene therapies or pharmaceutical approaches that target SYT3. “Imbalances in neurotransmitter release are the underlying causes for many neurological disorders,” said lead author Dennis Weingarten, Ph.D., a postdoctoral researcher in the Jackman lab. In the future, he said, “understanding these molecular switches — such as SYT3 — is a crucial step for us to combat these diseases.” Jackman’s lab specializes in the study of synaptic transmission. The human brain contains hundreds of trillions of synapses. Discovering the molecules that endow these specialized structures with their unique properties is essential for understanding brain function and neurological disorders. Synaptic Transmission: A Window to Understanding the Brain “Synaptic transmission is fundamental for sensing our surroundings, making decisions, and nearly every other feature of our inner world,” Jackman said. Reference: “Fast resupply of synaptic vesicles requires synaptotagmin-3” by Dennis J. Weingarten, Amita Shrestha, Kessa Juda-Nelson, Sarah A. Kissiwaa, Evan Spruston and Skyler L. Jackman, 19 October 2022, Nature. DOI: 10.1038/s41586-022-05337-1 The study was funded by the Whitehall Foundation, the Medical Research Foundation, and the National Institutes of Health Imaging Core Facility.

A study conducted by researchers from Florida Atlantic University and various international institutions has revealed that Vibrio bacteria, which can cause deadly human diseases, can quickly stick to and potentially adapt to plastic marine debris and Sargassum, a rapidly expanding type of seaweed found in the Sargasso Sea and beyond. This study, the first to assemble a Vibrio spp. genome from plastic debris, emphasizes the potential health risks associated with increased human interaction with Sargassum and plastic marine debris, and the researchers urge caution regarding the harvest and processing of Sargassum biomass until the risks are thoroughly investigated. Genomics study in the Caribbean and Sargasso Seas signifies the first assembly of vibrio bacteria sourced from plastic waste. Recent research has unveiled how the interaction among Sargassum species, plastic marine waste, and Vibrio bacteria creates the perfect “pathogen” that poses threats to marine biodiversity and public health. Vibrio bacteria, commonly found in global waters, are the leading cause of marine-related human fatalities. For instance, Vibrio vulnificus, often known as the flesh-eating bacteria, can cause severe foodborne illnesses from consuming seafood and can lead to infections and death from open wounds. From 2011 onwards, there’s been a notable increase in the presence of Sargassum, a type of free-living brown macroalgae, in the Sargasso Sea and other open ocean areas like the Great Atlantic Sargassum Belt, with regular and unusual seaweed accumulation events occurring on beaches. Additionally, plastic marine waste, initially discovered in the surface waters of the Sargasso Sea, has emerged as a global concern due to its longevity, persisting for decades longer than natural substrates in the marine ecosystem. Currently, little is known about the ecological relationship of vibrios with Sargassum. Moreover, genomic and metagenomic evidence has been lacking as to whether vibrios colonizing plastic marine debris and Sargassum could potentially infect humans. As summer kicks into high gear and efforts are underway to find innovative solutions to repurpose Sargassum, could these substrates pose a triple threat to public health? (Blood agar test on the left; β hemolysis phenotype on the right): More than 40 percent of plastic derived Vibrio isolates displayed hemolytic activity, consistent with pathogenic potential. Credit: Tracy Mincer, Florida Atlantic University Vibrio Pathogens: Aggressive Adapters Researchers from Florida Atlantic University and collaborators fully sequenced the genomes of 16 Vibrio cultivars isolated from eel larvae, plastic marine debris, Sargassum, and seawater samples collected from the Caribbean and Sargasso seas of the North Atlantic Ocean. What they discovered is Vibrio pathogens have the unique ability to “stick” to microplastics and that these microbes might just be adapting to plastic. “Plastic is a new element that’s been introduced into marine environments and has only been around for about 50 years,” said Tracy Mincer, Ph.D., corresponding lead author and an assistant professor of biology at FAU’s Harbor Branch Oceanographic Institute and Harriet L. Wilkes Honors College. “Our lab work showed that these Vibrio are extremely aggressive and can seek out and stick to plastic within minutes. We also found that there are attachment factors that microbes use to stick to plastics, and it is the same kind of mechanism that pathogens use.” The study, published in the journal Water Research, illustrates that open ocean vibrios represent an up-to-now undescribed group of microbes, some representing potential new species, possessing a blend of pathogenic and low nutrient acquisition genes, reflecting their pelagic habitat and the substrates and hosts they colonize. Utilizing metagenome-assembled genome (MAG), this study represents the first Vibrio spp. genome assembled from plastic debris. Some cultivation-based data show beached Sargassum appear to harbor high amounts of Vibrio bacteria. Credit: Brian Lapointe, FAU Harbor Branch Pathogenic Genes and Biofilm Formation The study highlighted vertebrate pathogen genes closely related to cholera and non-cholera bacterial strains. Phenotype testing of cultivars confirmed rapid biofilm formation, hemolytic and lipophospholytic activities, consistent with pathogenic potential. Researchers also discovered that zonula occludens toxin or “zot” genes, first described in Vibrio cholerae, which is a secreted toxin that increases intestinal permeability, were some of the most highly retained and selected genes in the vibrios they found. These vibrios appear to be getting in through the gut, getting stuck in the intestines, and infecting that way. “Another interesting thing we discovered is a set of genes called ‘zot’ genes, which causes leaky gut syndrome,” said Mincer. “For instance, if a fish eats a piece of plastic and gets infected by this Vibrio, which then results in a leaky gut and diarrhea, it’s going to release waste nutrients such nitrogen and phosphate that could stimulate Sargassum growth and other surrounding organisms.” Findings show some Vibrio spp. in this environment have an ‘omnivorous’ lifestyle targeting both plant and animal hosts in combination with an ability to persist in oligotrophic conditions. With increased human-Sargassum-plastic marine debris interactions, associated microbial flora of these substrates could harbor potent opportunistic pathogens. Importantly, some cultivation-based data show beached Sargassum appear to harbor high amounts of Vibrio bacteria. “I don’t think at this point, anyone has really considered these microbes and their capability to cause infections,” said Mincer. “We really want to make the public aware of these associated risks. In particular, caution should be exercised regarding the harvest and processing of Sargassum biomass until the risks are explored more thoroughly.” Reference: “Sargasso Sea Vibrio bacteria: underexplored potential pathovars in a perturbed habitat” by Tracy J. Mincer, Ryan P. Bos, Erik R. Zettler, Shiye Zhao, Alejandro A. Asbun, William D. Orsi, Vincent S. Guzzetta and Linda A. Amaral-Zettler, 3 May 2023, Water Research. DOI: 10.1016/j.watres.2023.120033 Study co-authors represent the NIOZ Royal Netherlands Institute for Sea Research, the Japan Agency for Marine-Earth Science and Technology, the Ludwig Maximilian University of Munich, Germany, Emory University, the University of Amsterdam and the Marine Biological Laboratory. This research was supported by the National Science Foundation (NSF) (grant OCE-1155671 awarded to Mincer), FAU World Class Faculty and Scholar Program (awarded to Mincer), NSF (grant OCE-1155571 awarded to Linda A. Amaral-Zettler, Ph.D., corresponding author, NIOZ), NSF (grant OCE-1155379 awarded to Erik R. Zettler, Ph.D., co-author, NIOZ), NSF TUES grant (DUE-1043468 awarded to Linda Zettler and Erik Zettler).

A groundbreaking study combines protein structure with genetic data to trace ancient evolutionary paths, offering a more reliable method to understand the lineage of life. This method could significantly influence drug development and our grasp of disease evolution. Credit: SciTechDaily.com Researchers have innovatively merged protein structural data with genetic sequences to construct evolutionary trees, revealing deep-rooted relationships among species with enhanced accuracy. This novel approach leverages both experimentally determined and predicted protein structures, potentially revolutionizing our understanding of life’s history and advancing health sciences by refining targets for cancer therapies and more. Protein Structures in Evolutionary Studies The three-dimensional shape of proteins is unlocking ancient evolutionary connections in the tree of life, according to a study published today (January 15) in Nature Communications. For the first time, researchers have combined protein shape data with genomic sequences to build more reliable evolutionary trees. These trees are vital tools for scientists, helping them explore the history of life, track the spread of pathogens, and develop new treatments for diseases. Artistic concept of protein structures solving saturation. Credit: Queralt Tolosa/Centro de Regulación Genómica Overcoming Data Saturation with Protein Structures Notably, this method works even with predicted protein structures that haven’t been experimentally verified. With tools like AlphaFold 2 generating vast amounts of structural data, this approach could provide new insights into the deep history of life on Earth. There are 210 thousand experimentally determined protein structures but 250 million known protein sequences. Initiatives like the EarthBioGenome project could generate billions more protein sequences in the next few years. The abundance of data opens the door to applying the approach on an unprecedented scale. Traditional vs. Structural Phylogenetic Approaches For many decades, biologists have been reconstructing evolution by tracing how species and genes diverge from common ancestors. These phylogenetic or evolutionary trees are traditionally built by comparing DNA or protein sequences and counting the similarities and differences to infer relationships. However, researchers face a significant hurdle – a problem known as saturation. Over vast timescales, genomic sequences can change so much that they no longer resemble their ancestral forms, erasing signals of shared heritage. “The issue of saturation dominates phylogeny and represents the main obstacle for the reconstruction of ancient relationships,” says Dr. Cedric Notredame, researcher at the Centre for Genomic Regulation (CRG) and lead author of the study. “It’s like the erosion of an ancient text. The letters become indistinct, and the message is lost.” Advantages of Using Structural Data in Phylogenetics To overcome this challenge, the research team turned to the physical structures of proteins. Proteins fold into complex shapes that determine a cell’s function. These shapes are more conserved over evolutionary time than the sequences themselves, meaning they change more slowly and retain ancestral features for longer. The shape of a protein is dictated by its amino acid sequence. While sequences may mutate, the overall structure often remains similar to preserve function. The researchers hypothesized they could gauge how much the structures diverge over time by measuring the distance between pairs of amino acids within a protein, also known as intra-molecular distances (IMDs). Methodology and Impact of Structural Phylogenetics The study compiled a massive dataset of proteins with known structures, covering a wide range of species. They calculated the IMDs for each protein and used these measurements to construct phylogenetic trees. They found that trees built from structural data closely matched those derived from genetic sequences, but with a crucial advantage: the structural trees were less affected by saturation. This means they retained reliable signals even when genetic sequences had diverged significantly. Practical Implications and Future Applications Recognizing that both sequences and structures offer valuable insights, the team developed a combined approach which not only improved the reliability of the tree branches but also helped distinguish between correct and incorrect relationships. “It’s akin to having two witnesses describe an event from different angles,” explains Dr. Leila Mansouri, coauthor of the study. “Each provides unique details, but together they give a fuller, more accurate account.” One practical example where the combined approach could make a significant impact is in understanding the relationships among kinases in the human genome. Kinases are proteins involved in many different important cellular functions. “The genome of most mammals, including humans, contains about 500 protein kinases that regulate most aspects of our biology,” says Dr. Notredame. “These kinases are major targets for cancer therapy, for example drugs like imatinib for humans or toceranib for dogs.” Human kinases have arisen through duplications occurring over the last billion years. “Within the human genome, the most distantly related kinases are about a billion years apart,” says Dr. Notredame. “They duplicated in the common ancestor of the common ancestor of our common ancestor.” This vast timescale makes it incredibly difficult to build accurate gene trees that show how all these kinases are related. “Yet, as imperfect as it may be, the kinase evolutionary tree is widely used to understand how it interacts with other drugs. Improving this tree, or improving trees of other important protein families, would be an important advance for human health,” adds Dr. Notredame. Expanding the Utility of Evolutionary Trees The potential applications of the work go beyond cancer. Using the approach to create more accurate evolutionary trees could also improve our understanding of how diseases evolve more generally, aiding in the development of vaccines and treatments. They can also help shed light on the origins of complex traits, guide the discovery of new enzymes for biotechnology, and even help trace the spread of species in response to climate change. Reference: “multistrap: boosting phylogenetic analyses with structural information” by Athanasios Baltzis, Luisa Santus, Björn E. Langer, Cedrik Magis, Damien M. de Vienne, Olivier Gascuel, Leila Mansouri and Cedric Notredame, 15 January 2025, Nature Communications. DOI: 10.1038/s41467-024-55264-0

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