Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Innovative pillow ODM production solution in Taiwan

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.China ergonomic pillow OEM supplier

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Ergonomic insole ODM support Vietnam

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Memory foam pillow OEM factory China

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Vietnam insole ODM for global brands

Xenopus laevis. African clawed frogs are bred in the Aquatics Facility at ISTA’s Scientific Service Units. Credit: © Peter Rigaud / ISTA Researchers have developed a method using viruses to track neuronal development in frogs, shedding light on the evolution of vertebrate nervous systems and offering comparative insights with mammals. Although viruses are typically associated with illnesses, not all viruses are harmful or cause disease. Some are instrumental in therapeutic treatments and vaccinations. In scientific research, viruses are often used to infect certain cells, genetically modify them, or visualize neurons in the organism’s central nervous system (CNS)—the command center made up of the brain, spinal cord, and nerves. The highlighting process has now been successfully applied to amphibians, which are crucial for understanding the brain and spinal cord of tetrapods—four-limbed animals, including humans. This has been shown in a new study by an international EDGE consortium jointly led by the Sweeney Lab at the Institute of Science and Technology Austria (ISTA) and the Tosches Lab at Columbia University. The researchers developed a new method that uses adeno-associated viruses (AAVs) to track a frog’s nervous system throughout its metamorphosis—a developmental transition from the early tadpole stages to its adult form. This groundbreaking research, recently published in Developmental Cell, can help usher amphibian neurobiology into a new era. A coronal section of the frog forebrain showing AAV-mediated labeling of neurons. AAV-infected cells, green; cell nuclei, blue. Scale bares, 400 µm. Credit: © Developmental Cell / Jaeger, Vijatovic, Deryckere, et al. From Swimming to Walking: Studying Metamorphosis David Vijatovic and Lora Sweeney enter a laboratory full of water tanks. Vijatovic taps on one of them. Inside, a small mottled greenish-brown African clawed frog (Xenopus laevis) appears. Its limbs are prominent, gracefully maneuvering and gripping its surroundings. In another tank, tadpoles are swirling around using simple swimming motions. It is remarkable to think that one transforms into the other. “Frogs undergo metamorphosis,” Sweeney says, “making them a great model organism for studying the transition between two movement modes—swimming and walking.” A frog’s development spans over 12 to 16 weeks, giving scientists time to study each stage. During these weeks, a frog embryo develops into a young tadpole, a tadpole with two legs, and a young froglet with four legs before reaching the adult stage. “By looking at the several stages of development, we can investigate these locomotive behaviors and the underlying changes in the nervous system,” Vijatovic adds. Decoding Frog Neural Circuits An organism’s nervous system is called the neural circuit because it resembles an electrical circuit. “Nerve cells (neurons) are connected to other neurons, transmitting electrical information. How we behave, what we sense, and how we interact with the world are the product of the way our neurons communicate with each other within these circuits,” explains Sweeney. The critical piece is how the circuit is wired. We know that neurons are connected, but which neuron connects to which? Which other cells does a single cell talk to, and what messages does it convey? Study authors from the Sweeney group at the Institute of Science and Technology Austria (ISTA). From left to right: Georgiy Ivanian, David Vijatovic, and Lora Sweeney. Credit: © ISTA To know more about this wiring, researchers have been using viruses, which have proven to be a powerful tool. Adeno-associated viruses (AAVs) are ideal in that regard. They are non-pathogenic and can infect a wide range of cell types, including neurons. AAVs can be modified to glow in bright green fluorescent colors under the microscope as they travel along neurons, whether in retrograde (backward, from the synapse toward the cell body) or anterograde (forward, from the cell body toward the synapse). In other words, AAVs can be used to illuminate the neural circuit from the broadcasting end to the receiving end or vice-versa. “This is a common technique used in neuroscience, especially in well-studied organisms like mice. For amphibians, it was thought that it could not be done,” says Vijatovic. That was the general belief until now. Overcoming Barriers With Collaboration To make AAV labeling work in amphibians, Sweeney and Vijatovic joined forces with an international team of scientists from Maria Tosches’ group at Columbia University, where the study’s other two co-first authors, Eliza Jaeger and Astrid Deryckere, are based. The consortium also included researchers from Tel Aviv University, the University of Utah, the Scripps Research Institute, and the California Institute of Technology. The researchers put their heads together, drew expertise from each other, visited conferences, had countless Zoom calls, and came up with different perspectives and ideas. “When you start researching an organism that is not yet well understood, it is great to have a community where you can share information,” says Sweeney. Developing neurons. A coronal section of the frog midbrain showing that AAV labeling also captures the cohorts of neurons developing at the time of injection. AAV-infected cells, green; birthdated cells, magenta; cell nuclei, blue. Scale bars, 400 µm. Credit: © Developmental Cell / Jaeger, Vijatovic, Deryckere, et al. They screened existing AAVs to find what was suitable for amphibians and optimized the infecting strategy, eventually developing a “how-to guide” for frogs and newts. Vijatovic summarizes his PhD journey, “We started with young tadpoles, made our way to older tadpoles, and finally moved to juvenile and then adult frogs as well as adult newts. We tailored the tool to each life stage.” Insights into Human Neuroscience From Amphibians With this new technique, the scientists managed to apply AAVs to trace neuron connections in amphibians. This will help them find out more about how the amphibian brain compares to that of mammals. Besides that, the new approach also opens doors to further analyzing neuronal development. With some of the screened AAV variants, the researchers can label progenitor cells at a specific point in time during the circuit’s development and follow them to see what neurons they become. “This way, we can resolve the whole circuit by its development, see how it changes over time, and how the whole nervous system is built,” Sweeney says. Although amphibians and mammals last shared a common ancestor about 360 million years ago, they share common traits. “By comparing the details of a frog’s nervous system to a human’s, we can see what we don’t have and what we have,” Sweeney continues. This knowledge can help us understand how the human nervous system became specialized over time. “The better we understand the basic building blocks of the nervous system, the more we understand how we can replace them during disease and injury.” Reference: “Adeno-associated viral tools to trace neural development and connectivity across amphibians” by Eliza C.B. Jaeger, David Vijatovic, Astrid Deryckere, Nikol Zorin, Akemi L. Nguyen, Georgiy Ivanian, Jamie Woych, Rebecca C. Arnold, Alonso Ortega Gurrola, Arik Shvartsman, Francesca Barbieri, Florina A. Toma, Hollis T. Cline, Timothy F. Shay, Darcy B. Kelley, Ayako Yamaguchi, Mark Shein-Idelson, Maria Antonietta Tosches and Lora B. Sweeney, 26 November 2024, Developmental Cell. DOI: 10.1016/j.devcel.2024.10.025

A species of oval squid from Okinawa, locally known as Shiro-ika, is being cultured at OIST’s Marine Science Station. This animal exhibited amazing camouflaging abilities never before recorded in squid. Credit: Ryuta Nakajima / OIST Scientists have discovered that squid can camouflage to match their surroundings, challenging previous assumptions about cephalopod behavior. While octopus and cuttlefish are famous for their use of camouflage to match the color of the substrate, a third type of cephalopod—the squid—has never been reported displaying this ability. In a new study, scientists have shown that squid can and will camouflage by matching the color of a substrate to avoid predators. To determine this, the scientists performed a laboratory-based experiment to record the squid’s camouflaging abilities. When the squid were in a clean side of a tank, they were light in color, but when they were above algae, they promptly became darker. The researchers highlighted that as well as opening up exciting avenues for exploring the visual capabilities of the animal, the study shows that substrate is clearly useful for these squid to survive. Discovery of Squid Camouflage Ability While octopus and cuttlefish are famous for their use of camouflage to match the color of the substrate, a third type of cephalopod—the squid—has never been reported displaying this ability. Now, in a study published in Scientific Reports, scientists from the Physics and Biology Unit at the Okinawa Institute of Science and Technology Graduate University (OIST) have shown that squid can and will camouflage to match a substrate as a way of avoiding predators. This work opens up research avenues on how squid see and perceive the world around them. Furthermore, it sheds light on their behavior, and thus could go on to inform conservation initiatives. “Squid usually hover in the open ocean but we wanted to find out what happens when they move a bit closer to a coral reef or if they’re chased by a predator to the ocean floor,” explained one of the three first authors, Dr. Ryuta Nakajima, OIST visiting researcher. “If substrate is important for squid to avoid predation than that indicates that increases or decreases in squid populations are even more tied to the health of coral reef than we thought.” Previous studies on cephalopod camouflage have mostly been conducted on cuttlefish and octopus. Squid, as an animal that tends to live in the open ocean, are notoriously hard to keep in captivity and so have been rather avoided for this kind of research. But, since 2017, the scientists in the OIST’s Physics and Biology Unit have been culturing a species of oval squid in captivity. This squid, locally known as Shiro-ika, is one of three oval squids found in Okinawa. When in the open ocean, they are light in color, meaning that they blend into the ocean surface and flickering sunlight above. But the researchers suspected that when they moved closer to the ocean floor, it would be a different story entirely. Footage captured at OIST’s Marine Science Station shows that squid have an amazing ability to color-match the substrate in order to avoid predation. Credit: Ryuta Nakajima / OIST At OIST’s Marine Science Station, the oval squid were, almost accidentally, observed camouflaging to the substrate for the first time. The researchers were cleaning their tank to remove the algal growth. They noticed that the animals were changing color depending on whether they were over the cleaned surface or the algae. Following this observation, the researchers performed a controlled experiment. They kept several squid in a tank and cleaned half of the tank, leaving the other half covered in algae. They placed an underwater camera inside the water and suspended a regular camera above, so they could capture and run statistical tests on any color changes. The results were clear. When the squid were in the clean side of the tank, they were the light color. But when they were above the algae, they promptly became darker. The experiment uncovered an ability that had never previously been reported in squid. The researchers highlighted that as well as opening up exciting avenues for exploring the visual capabilities of the animal, the study also showed that substrate is clearly useful for these squid to survive. “This effect really is striking. I am still surprised that nobody has noticed this ability before us,” said another first author, Dr. Zdenek Lajbner. “It shows just how little we know about these wonderful animals.” Cultural and Economic Importance of Oval Squid in Okinawa Dr. Nakajima stated that this particular squid is important for Okinawa for economic and cultural reasons. “It was actually the local fishermen who were the first ones distinguishing three species of oval squids in Okinawa, long before the scientists,” said Dr. Nakajima. “We look forward to continuing to explore the camouflage capabilities of this species and cephalopods more generally,” said Prof. Jonathan Miller, Principal Investigator of OIST’s Physics and Biology Unit and the senior author of the research article. Reference: “Squid adjust their body color according to substrate” by Ryuta Nakajima, Zdeněk Lajbner, Michael J. Kuba, Tamar Gutnick, Teresa L. Iglesias, Keishu Asada, Takahiro Nishibayashi and Jonathan Miller, 28 March 2022, Scientific Reports. DOI: 10.1038/s41598-022-09209-6

Researchers have uncovered a nanoparticle released from cells, termed a “supermere,” containing enzymes, proteins, and RNA linked to various conditions such as cancer, cardiovascular disease, Alzheimer’s disease, and even COVID-19. Researchers at Vanderbilt University Medical Center have discovered a nanoparticle released from cells, called a “supermere,” which contains enzymes, proteins, and RNA associated with multiple cancers, cardiovascular disease, Alzheimer’s disease, and even COVID-19. The discovery, reported on December 9, 2021, in Nature Cell Biology, is a significant advance in understanding the role extracellular vesicles and nanoparticles play in shuttling important chemical “messages” between cells, both in health and disease. “We’ve identified a number of biomarkers and therapeutic targets in cancer and potentially in a number of other disease states that are cargo in these supermeres,” said the paper’s senior author, Robert Coffey, MD. “What is left to do now is to figure out how these things get released.” Coffey, Ingram Professor of Cancer Research and professor of Medicine and Cell & Developmental Biology, is internationally known for his studies of colorectal cancer. His team is currently exploring whether the detection and targeting of cancer-specific nanoparticles in the bloodstream could lead to earlier diagnoses and more effective treatment. Cutline: Members of the supermere discovery team include (front row from left) Qi Liu, PhD, Robert Coffey, MD, Qin Zhang, PhD, and (back row from left) James Higginbotham, PhD; Dennis Jeppesen, PhD; and Jeffrey Franklin, PhD. (Photo by Erin O. Smith). Credit: Vanderbilt University Medical Center In 2019 Dennis Jeppesen, PhD, a former research fellow in Coffey’s lab who is now a research instructor in Medicine, used advanced techniques to isolate and analyze small membrane-enclosed extracellular vesicles called “exosomes.” That year, using high-speed ultracentrifugation, another of Coffey’s colleagues, Qin Zhang, PhD, research assistant professor of Medicine, devised a simple method to isolate a nanoparticle called an “exomere” that lacks a surface coat. In the current study, Zhang took the “supernatant,” or fluid that remains after the exomeres have been spun into a “pellet,” and spun the fluid faster and longer. The result was a pellet of nanoparticles isolated from the supernatant of the exomere spin—which the researchers named supermeres. “They’re also super-interesting,” Coffey quipped, “because they contain many cargo previously thought to be in exosomes.” For one thing, supermeres carry most of the extracellular RNA released by cells and which is found in the bloodstream. Among other functional properties, cancer-derived supermeres can “transfer” drug resistance to tumor cells, perhaps via the RNA cargo they deliver, the researchers reported. Supermeres are important carriers of TGFBI, a protein that in established tumors promotes tumor progression. TGFBI thus may be a useful marker in liquid biopsies for patients with colorectal cancer, the researchers noted. They also carry ACE2, a cell-surface receptor that plays a role in cardiovascular disease and is the target of the COVID-19 virus. This raises the possibility that ACE2 carried by supermeres could serve as a “decoy” to bind the virus and prevent infection. Another potentially important cargo is APP, the amyloid-beta precursor protein implicated in the development of Alzheimer’s disease. Supermeres can cross the blood-brain barrier, suggesting that their analysis could improve early diagnosis or possibly even targeted treatment of the disease. “The identification of this rich plethora of bioactive molecules … raises interesting questions about the function of supermeres, and heightens interest in the potential of these particles as biomarkers for diseases,” researchers at the University of Notre Dame noted in a review published with the paper. Reference: “Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets” by Qin Zhang, Dennis K. Jeppesen, James N. Higginbotham, Ramona Graves-Deal, Vincent Q. Trinh, Marisol A. Ramirez, Yoojin Sohn, Abigail C. Neininger, Nilay Taneja, Eliot T. McKinley, Hiroaki Niitsu, Zheng Cao, Rachel Evans, Sarah E. Glass, Kevin C. Ray, William H. Fissell, Salisha Hill, Kristie Lindsey Rose, Won Jae Huh, Mary Kay Washington, Gregory Daniel Ayers, Dylan T. Burnette, Shivani Sharma, Leonard H. Rome, Jeffrey L. Franklin, Youngmin A. Lee, Qi Liu and Robert J. Coffey, 9 December 2021, Nature Cell Biology. DOI: 10.1038/s41556-021-00805-8 Zhang, Jeppesen and James Higginbotham, PhD, research instructor in Medicine, are the paper’s first authors. Other VUMC co-authors: Ramona Graves-Deal, Vincent Q. Trinh, MD, Marisol Ramirez, MS, Yoojin Sohn, Abigail Neininger, Nilay Taneja, PhD, Eliot McKinley, PhD, Hiroaki Niitsu, MD, PhD, Zheng Cao, MD, PhD, Rachel Evans, Sarah E. Glass, Kevin Ray, William Fissell, MD, Salisha Hill, MS, Kristie Rose, PhD, Mary Kay Washington, MD, PhD, Gregory Ayers, MS, Dylan Burnette, PhD, Jeffrey Franklin, PhD, Youngmin Lee, MD, PhD, and Qi Liu, PhD. Research support included National Institutes of Health grants GM125028, CA218386, CA211015, CA197570, CA236733, CA241685 and CA229123, the Nicholas Tierney GI Cancer Memorial Fund, and an American Heart Association Postdoctoral Fellowship.

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