Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Custom graphene foam processing factory Taiwan

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Thailand pillow ODM development service

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Taiwan flexible graphene product manufacturing factory

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Customized sports insole ODM Indonesia

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Arch support insole OEM from Thailand

Digital reconstructions of human neurons overlaid on a slice of brain tissue donated by a brain surgery patient. Allen Institute researchers are able to capture electrical information from these live human neurons, as well as their 3D shape and gene expression, through a technique known as Patch-seq. This image shows several different types of human neurons in the medial temporal gyrus of the neocortex, the outermost shell of the mammalian brain. Credit: Allen Institute Hundreds of neuroscientists built a ‘parts list’ of the motor cortex, laying groundwork to map the whole brain and better understand brain diseases. Before you read any further, bring your hand to your forehead. It probably didn’t feel like much, but that simple kind of motion required the concerted effort of millions of different neurons in several regions of your brain, followed by signals sent at 200 mph (320 kph) from your brain to your spinal cord and then to the muscles that contracted to move your arm. At the cellular level, that quick motion is a highly complicated process and, like most things that involve the human brain, scientists don’t fully understand how it all comes together. Now, for the first time, the neurons and other cells involved in a region of the human, mouse, and monkey brains that control movement have been mapped in exquisite detail. Its creators, a large consortium of neuroscientists brought together by the National Institutes of Health’s Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiative, say this brain atlas will pave the way for mapping the entire mammalian brain as well as a better understanding of mysterious brain diseases — including those that attack the neurons that control movement, like amyotrophic lateral sclerosis, or ALS. The atlas is described in a special package of 17 articles published today (October 6, 2021) in the journal Nature, including a single flagship paper that describes the entire atlas. Complete, brain-wide reconstructions of several different types of mouse neurons in 3D. A new study led by researchers at the Allen Institute and Southeast University in Nanjing, China, captured the detailed 3D shapes of more than 1,700 individual neurons in the mouse brain, the largest dataset of its kind to date. Studies like this will help neuroscientists piece together detailed views of neural circuits. Each color represents a different individual neuron. Credit: Allen Institute “In a human brain, there are more than 160 billion cells. Our brain has more than 20 times more cells than there are people in this world,” said Hongkui Zeng, Ph.D., Executive Vice President and Director of the Allen Institute for Brain Science, a division of the Allen Institute, and lead investigator on several BRAIN Initiative-funded studies. “To understand how a system works, you need to first build a parts list. Then you have to understand what each part is doing and put the pieces together to understand how the whole system works. That’s what we’re doing with the brain.” The massive BRAIN Initiative-funded collaboration involved dozens of research teams around the country who worked together to complete a cell-by-cell atlas of the primary motor cortex, a part of the mammalian brain that controls movement. Combining more than a dozen different techniques to define brain “cell types” across three different species of mammals, the resulting open-access data collection is by far the most comprehensive and detailed map of any part of the mammalian brain ever released. The researchers classified the millions of neurons and other kinds of brain cells present in the motor cortex into many different cell-type categories — the actual number of different brain cell types in this region depends on how they are being measured, but ranges from several dozen to more than 100. Scientists at the Allen Institute are studying human neurons that appear to be highly specialized as compared to their rodent counterparts. One of these newly described neuron types, the CARM1P1 neuron, sends long-range connections in the brain and may be selectively vulnerable in Alzheimer’s disease. Credit: Allen Institute The researchers picked the primary motor cortex in part because it’s similar across all mammalian species — while humans, monkeys and mice have many differences between our brains, the way we control movement is very similar — and because it’s representative of the neocortex, the outermost shell of the mammalian brain that not only integrates sensory and motor information but also gives rise to our complex cognitive functions. This completed atlas is one large step in the effort to create a catalog or census of all brain cell types through the BRAIN Initiative Cell Census Network, or BICCN. The NIH launched the BICCN in 2017, awarding nine collaborative network grants, three of which are led by Allen Institute for Brain Science researchers. Like a population census, the cell census aims to catalog all different types of brain cells, their properties, their relative proportions, and their physical addresses to get a picture of the cell populations that together form our brains. Knowing the “normal” brain’s cellular makeup is a key step to understanding what goes wrong in disease. “If we really want to understand how the brain works, we have to get down to its fundamental unit. And that is the cell,” said Ed Lein, Ph.D., Senior Investigator at the Allen Institute for Brain Science and lead investigator on several BRAIN Initiative studies focused on the human brain. “This is also clinically important because cells are the locus of disease. By understanding which cells are vulnerable in different brain diseases, we can better understand and ultimately treat the diseases themselves. The hope with these studies is that by making this fundamental classification of cell types, we can lay the groundwork for understanding the cellular basis of disease.” The atlas’s creators used several different methods to measure a variety of cellular properties to define a cell type by correlating and integrating these properties, which include the complete set of genes a cell switches on; a cell’s “epigenetic” landscape, which defines how genes are regulated; cells’ 3D shapes; their electrical properties; and how they connect to other cells. The single-cell gene expression and epigenetic data were especially important as the researchers were able to use these data to integrate all the other kinds of cell-type data, creating a common framework to classify cell types and compare them within and between species. The studies required not only collaboration among researchers to design and execute the experiments, but also coordination and public sharing of the data that resulted from the atlas project and other projects under the BICCN. The Brain Cell Data Center, or BCDC, is headquartered at the Allen Institute. The data center, led by Allen Institute for Brain Science Investigator Michael Hawrylycz, Ph.D., helps to organize the BICCN consortium and provides a single point of access to the study’s data-archiving centers across the country. “One of our many limitations in developing effective therapies for human brain disorders is that we just don’t know enough about which cells and connections are being affected by a particular disease, and therefore can’t pinpoint with precision what and where we need to target,” said John Ngai, Ph.D., Director of the NIH BRAIN Initiative. “The Allen Institute has played an important role in coordinating the large amounts of data produced by the BRAIN cell census project that provide detailed information about the types of cells that make up the brain and their properties. This information will ultimately enable the development of new therapies for neurologic and neuropsychiatric diseases.” Scientists at the Allen Institute for Brain Science played a role in nine of the 17 published studies and led or co-led six of them. The four primary Allen Institute-led studies explored: How cell types in the primary motor cortex compare across mice, humans, and marmoset monkeys. The research team found that most motor cortex brain cell types have similar counterparts across all three species, with species-specific differences at the level of proportions of cells, their shapes and electrical properties, and individual genes that are switched on and off. For example, humans have about twice as many excitatory neurons as inhibitory neurons in this region of the brain, while mice have five times as many. The researchers also delved into the famous Betz cells, enormous neurons that project to the spinal cord that exist in us, monkeys and many other larger mammals, and captured the first known electrical recordings from human Betz cells, which degenerate in ALS. Mice have evolutionarily related neurons based on shared genetic programs, but their shapes and electrical properties are very different from those in humans. A broader analysis of brain cell types in the human brain, looking at the second and third layers of the 6-layered neocortex. These layers, and the neocortex overall, are much larger and contain a larger diversity of cells in humans and other primates as compared to rodents. Allen Institute researchers used a three-prong technique known as Patch-seq to measure the electrical properties, genes and the 3D shapes of several kinds of neurons in these layers in tissue samples donated by brain surgery patients. The study characterizes these neurons in living human tissues and demonstrates an increased diversity of the types of neurons specialized to communicate between different regions of the human cortex, including delving into a specialized type of human neuron that is especially vulnerable in Alzheimer’s disease. The largest collection to date of complete brain-wide reconstructions of more than 1,700 different neurons in the mouse brain. This form of 3D neuron-tracing is extensive and complicated due to the cells’ lengthy and delicate axons and dendrites, but it yields important information about the long-distance connections different neuron types make through their axon arbors reaching faraway brain regions. Allen Institute researchers find that these neurons’ axon arbors show extremely diverse patterns, some with just a few focused branches while others spread across large areas. For example, some neurons in the structure known as the claustrum send axon arbors in a crown-like fashion around the entire circumference of the neocortex. Characteristic connection patterns like these are a critical attribute used to help classify a brain cell type. The cellular makeup of the mouse primary motor cortex, sorting approximately 500,000 neurons and other brain cells into cell-type categories based on the suite of genes each cell switches on (the “transcriptome”) as well as the gene-regulatory modifications on a cell’s chromosomes (the “epigenome”). Using a range of techniques, Allen Institute researchers and their collaborators generated seven types of transcriptomic and two types of epigenomic datasets, then developed computational and statistical methods to integrate these datasets into shared “evolutionary tree” of cell types. The study led to the discovery of thousands of marker genes and other DNA sequences specific for each of these cell types. Reference: “A multimodal cell census and atlas of the mammalian primary motor cortex BRAIN Initiative Cell Census Network (BICCN)” by BRAIN Initiative Cell Census Network (BICCN), 6 October 2021, Nature. DOI: 10.1038/s41586-021-03950-0 This research was supported by several awards from the National Institutes of Health, including award numbers U19MH114830, U01MH114812, U01MH105982, R01EY023173, and U24MH114827 to Allen Institute for Brain Science researchers. The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH and its subsidiary institutes.

Study finds caffeine boosts Argentine ants’ efficiency in locating baits, offering potential improvements in pest control strategies. Caffeine increases the navigational efficiency of Argentine ants towards sugary baits, suggesting a new method to enhance the effectiveness of pest control efforts. Research on Argentine ants has shown that caffeine can significantly enhance their navigational efficiency towards baited traps. By adding caffeine to sugary baits, the ants follow more direct paths to the reward, potentially making these baits more effective. This improvement in learning and navigation could help in controlling this invasive species, which has proven resistant to traditional baits due to poor uptake and bait abandonment. Potential Benefits of Caffeine in Pest Control “The idea with this project was to find some cognitive way of getting the ants to consume more of the poisonous baits we put in the field,” says Henrique Galante, the study’s first author and a computational biologist at the University of Regensburg. “We found that intermediate doses of caffeine actually boost learning—when you give them a bit of, it pushes them into having straighter paths and being able to reach the reward faster.” Argentine ants are a significant ecological and economic threat worldwide. Traditional control methods, primarily poisonous baits, often fail, likely due to low bait uptake and bait abandonment. By adding caffeine, known to enhance learning in other insects like honeybees and bumblebees, researchers hope to improve the ants’ ability to memorize bait locations and lead their nestmates back. This image shows L. humile before and after drinking caffeine. Credit: Laure-Anne Poissonnier “We’re trying to make them better at finding these baits, because the faster they go and come back to them, the more pheromone trails they lay, the more ants will come, and, therefore, the faster they will spread the poison in the colony before they realize it’s poison,” says Galante. Research Methodology In the laboratory, the research team experimented with various caffeine concentrations to observe any effects on the ants’ ability to locate and revisit a sugar solution. They set up a testing environment using a LEGO bridge and an A4 sheet of paper over an acrylic surface, where they placed drops of sucrose solution mixed with varying amounts of caffeine. “The lowest dose we used is what you find in natural plants, the intermediate dose is similar to what you would find in some energy drinks, and the highest amount is set to be the LD50 of bees—where half the bees fed this dose die—so it’s likely to be quite toxic for them,” says Galante. This image shows an L. humile nest. Credit: Laure-Anne Poissonnier Using an automated tracking system, researchers monitored the ants’ speed and the directness of their paths to and from the sugar reward. The study involved 142 ants, each tested four times. The ants were allowed to deposit the food they had gathered between trials, and researchers also removed and replaced the piece of paper so that the ants would not be able to follow their own pheromone trail back to the reward location. Results and Observations Without caffeine, the ants did not learn to navigate to the reward location more quickly on subsequent foraging trips, suggesting that they had not successfully committed its location to memory. However, ants exposed to low and intermediate levels of caffeine showed a marked increase in their foraging efficiency, with time reductions of 28% and 38% per visit respectively. Notably, the highest caffeine dose did not produce the same effect. This video shows how an ant was tracked. Credit: Henrique Galante The researchers showed that caffeine lowered the ants’ foraging times by making them more efficient, not by making them speedier. There was no effect of caffeine on the ants’ pace at any dosage, but ants that received low to intermediate doses of caffeine trips traveled by less tortuous paths. “What we see is that they’re not moving faster, they’re just being more focused on where they’re going,” says Galante. “This suggests that they know where they want to go, therefore, they have learned the locations of the reward.” Caffeine had no impact on the ants’ homing ability (how efficiently they traveled back to the nest), though their paths home became less winding with each trip regardless of caffeine. Implications and Future Research The promising results indicate the potential for using caffeine to improve bait uptake in efforts to control invasive Argentine ant populations. Further research is underway, with field tests in Spain and studies to examine possible interactions between caffeine and bait poisons. This research, which was recently published in the journal iScience, could pave the way for more effective strategies for managing invasive species through behavior modification. Reference: “Acute exposure to caffeine improves foraging in an invasive ant” by Henrique Galante, Massimo De Agrò, Alexandra Koch, Stefanie Kau and Tomer J. Czaczkes, 23 May 2024, iScience. DOI: 10.1016/j.isci.2024.109935 This research was supported by the European Research Council, the Deutsche Forschungsgemeinschaft, and the University of Regensburg.

The default mode network (DMN) activates during the brain’s resting state and has been linked to daydreaming, planning, and imagining the future. The study found the DMN is divided into separate subsystems for constructing and evaluating imagined scenarios. One subnetwork constructs imagined scenarios, while the other evaluates them. Two components of imagination — constructing and evaluating imagined scenarios — rely on separate subnetworks in the default mode network, according to research recently published in JNeurosci. Even when you aren’t doing anything, your brain is hard at work. The default mode network (DMN) activates during the brain’s resting state and has been linked to daydreaming, planning, and imagining the future. In previous studies, scientists noticed the DMN could be divided into two subnetworks, ventral and dorsal, but their different roles were debated. Whole-brain analysis of vividness and valence. Top panel shows the main effect of valence and vividness as well as their difference contrasts for the entire 12-second imagination period. The bottom two panels show the four effects for the early (first 4 s) and middle (middle 4 s) parts of the imagination period. There were no significant effects for the late (last 4 s) part of the imagination period. Credit: Lee et al., JNeurosci 2021 Lee et al. used fMRI to measure participants’ brain activity while they imagined scenarios listed on prompts, like “Imagine you win the lottery.” The scenarios varied in vividness and valence — some were positive, others negative. Only the vividness of a scenario influenced the activity of the ventral default mode network. Conversely, only the positive or negative quality of the imagined scenario affected the activity of the dorsal default mode network. The results indicate the default mode network is divided into separate subsystems for constructing and evaluating imagined scenarios. Understanding this division allows for future, more detailed studies on the neural mechanisms underlying imagination. Reference: “The Ventral and Dorsal Default Mode Networks Are Dissociably Modulated by the Vividness and Valence of Imagined Events” by Sangil Lee, Trishala Parthasarathi and Joseph W. Kable, 17 May 2021, Journal of Neuroscience. DOI: 10.1523/JNEUROSCI.1273-20.2021 Funding: NIH/National Institute of Drug Abuse

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