Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Graphene-infused pillow ODM Indonesia

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Vietnam ergonomic pillow OEM supplier

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Taiwan orthopedic insole OEM manufacturing site

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.ODM pillow factory in Taiwan

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene insole manufacturer in Indonesia

Researchers have identified a set of neurons that drive mice to consume fatty or sugary foods even when they are not hungry. A new study reveals that a region of the brain called the amygdala may be responsible for overeating.  The amygdala, a region of the brain, is responsible for strong emotions such as fear. Researchers have recently shown that the amygdala may also be to blame for overeating. Professor Bo Li of Cold Spring Harbor Laboratory (CSHL) has identified a section of neurons in the amygdala that causes mice to eat fatty or sugary foods even when they are not hungry. Therapeutics targeting these neurons might lead to new obesity treatments with few side effects. Neurons That Drive Hedonic Eating Mice, like the majority of humans, like foods that are high in fat and sugar. Instead of eating these foods to survive, they may do so for enjoyment. They may indulge in these treats for pleasure, rather than for survival. The neurons Li and his colleagues studied trigger this behavior, called hedonic eating. Li notes: “Even if the animal is supposed to stop eating because they are already full, if those neurons are still active, it can still drive those animals to eat more.” When the neurons Li studied were inactivated, it protected mice against long-term weight gain. The left image shows lipid droplets (red) in the liver of a mouse that had those neurons turned off. In contrast, the right image shows many more lipid droplets in mice that did not have the neurons turned off. Credit: Bo Li Lab/CSHL/2022 According to Li, almost no one succeeds in long-term weight management while treating obesity. Metabolic processes in the body often undo any progress made. Therapeutics may improve the chances of successful treatment, yet many drugs have undesirable side effects. “The medications currently available to aid weight management can cause significant side effects. So, a more targeted approach is needed,” Li says. “Identifying the brain circuitry that controls eating is important for developing better treatment options for people who struggle to control their weight.” Shutting Off Overeating Neurons When the team switched off the specific neurons, mice weren’t drawn to the fatty, sugary foods that had tempted them before. “They just happily ate and stayed healthy,” Li says. “They not only stopped gaining weight but also seemed to be much healthier overall.” Switching these neurons off reduced overeating and protected against obesity. It also boosted the animals’ physical activity, leading to weight loss and better metabolic health. Li and his team are exploring ways to manipulate the neurons that trigger hedonic eating. The next step, he says, is to map out how these neurons respond to different types of food and see what makes them so sensitive. He hopes this collaboration will lead to new strategies for effective anti-obesity therapeutics. For this study, Li and CSHL Associate Professor Stephen Shea combined their neuroscience expertise with CSHL Professor Tobias Janowitz’s expertise in metabolism and endocrinology. They also collaborated with CSHL Assistant Professor Semir Beyaz, an expert in gut and nutrition research. It’s part of an ongoing, multidisciplinary initiative at CSHL to research the connections between the brain and the body. Reference: “Neurotensin neurons in the extended amygdala control dietary choice and energy homeostasis” by Alessandro Furlan, Alberto Corona, Sara Boyle, Radhashree Sharma, Rachel Rubino, Jill Habel, Eva Carlotta Gablenz, Jacqueline Giovanniello, Semir Beyaz, Tobias Janowitz, Stephen David Shea and Bo Li, 20 October 2022, Nature Neuroscience. DOI: 10.1038/s41593-022-01178-3 The study was funded by the European Molecular Biology Organization, the Swedish Research Council, the Charles H. Revson Foundation, the National Institutes of Health, the Feil Family Neuroscience Endowment, Cold Spring Harbor Laboratory and Northwell Health Affiliation, and the German Academic Scholarship Foundation.

Scientists have found a new way cells degrade unneeded proteins, which influence vital neural, immune, and developmental genes. This discovery may lead to treatments for conditions caused by protein imbalances in cells. The Mechanism Degrades Short-Lived Proteins That Support Brain and Immune Functions Short-lived proteins control gene expression in cells and execute critical roles ranging from assisting brain connectivity to fortifying the body’s immune response. Originating in the nucleus, these proteins are swiftly degraded after fulfilling their purpose. For decades, the mechanism behind the degradation and removal of these essential proteins from cells remained a mystery to researchers — until now. In a cross-departmental collaboration, researchers from Harvard Medical School identified a protein called midnolin that plays a key role in degrading many short-lived nuclear proteins. The study shows that midnolin does so by directly grabbing the proteins and pulling them into the cellular waste-disposal system, called the proteasome, where they are destroyed. The findings were recently published in the journal Science. “These particular short-lived proteins have been known for over 40 years, but no one has established how they are actually degraded,” said co-lead author Xin Gu, a research fellow in neurobiology at HMS. Because the proteins broken down by this process modulate genes with important functions related to the brain, the immune system, and development, scientists may eventually be able to target the process as a way of controlling protein levels to alter these functions and correct any dysfunction. “The mechanism we found is very simple and quite elegant,” added co-lead author Christopher Nardone, a PhD candidate in genetics at HMS. “It is a basic science discovery, but there are many implications for the future.” A Molecular Mystery It is well-established that cells can break down proteins by tagging them with a small molecule called ubiquitin. The tag tells the proteasome that the proteins are no longer needed, and it destroys them. Much of the pioneering research on this process was done by the late Fred Goldberg at HMS. However, sometimes the proteasome breaks down proteins without the help of ubiquitin tags, leading researchers to suspect that there was another, ubiquitin-independent mechanism of protein degradation. “There has been sporadic evidence in the literature that somehow the proteasome can directly degrade unmarked proteins, but no one understood how that can happen,” Nardone said. One group of proteins that seemed to be degraded by an alternative mechanism are stimuli-induced transcription factors: Proteins rapidly made in response to cellular stimuli that travel to the nucleus of a cell to turn on genes, after which they are rapidly destroyed. “What struck me, in the beginning, is that these proteins are extremely unstable and they have a very short half-life — once they are produced, they carry out their function, and they are quickly degraded afterward,” Gu said. These transcription factors support a range of important biological processes in the body, yet even after decades of research, “the mechanism of their turnover was largely unknown,” said Michael Greenberg, the Nathan Marsh Pusey Professor of Neurobiology in the Blavatnik Institute at HMS and a co-senior author on the paper with Stephen Elledge, the Gregor Mendel Professor of Genetics and of Medicine at HMS and Brigham and Women’s Hospital. From a Handful to Hundreds To investigate this mechanism, the team began with two familiar transcription factors: Fos, studied extensively by the Greenberg lab for its role in learning and memory, and EGR1, which is involved in cell division and survival. Using sophisticated protein and genetic analyses developed in the Elledge lab, the researchers homed in on midnolin as a protein that helps break down both transcription factors. Follow-up experiments revealed that in addition to Fos and EGR1, midnolin may also be involved in breaking down hundreds of other transcription factors in the nucleus. Gu and Nardone recall being shocked and skeptical about their results. To confirm their findings, they decided they needed to figure out exactly how midnolin targets and degrades so many different proteins. “Once we identified all these proteins, there were many puzzling questions about how the midnolin mechanism actually works,” Nardone said. With the aid of a machine learning tool called AlphaFold that predicts protein structures, plus results from a series of lab experiments, the team was able to flesh out the details of the mechanism. They established that midnolin has a “Catch domain” — a region of the protein that grabs other proteins and feeds them directly into the proteasome, where they are broken down. This Catch domain is composed of two separate regions linked by amino acids (think mittens on a string) that grab a relatively unstructured region of a protein, thus allowing midnolin to capture many different types of proteins. Of note are proteins like Fos that are responsible for turning on genes that prompt neurons in the brain to wire and rewire themselves in response to stimuli. Other proteins like IRF4 activate genes that support the immune system by ensuring that cells can make functional B and T cells. “The most exciting aspect of this study is that we now understand a new general, ubiquitination-independent mechanism that degrades proteins,” Elledge said. Tantalizing Translational Potential In the short term, the researchers want to delve deeper into the mechanism they discovered. They are planning structural studies to better understand the fine-scale details of how midnolin captures and degrades proteins. They are also making mice that lack midnolin to understand the protein’s role in different cells and stages of development. The scientists say their finding has tantalizing translational potential. It may offer a pathway that researchers can harness to control levels of transcription factors, thus modulating gene expression, and in turn, associated processes in the body. “Protein degradation is a critical process and its deregulation underlies many disorders and diseases,” including certain neurological and psychiatric conditions, as well as some cancers, Greenberg said. For example, when cells have too much or too little of transcription factors such as Fos, problems with learning and memory may arise. In multiple myeloma, cancer cells become addicted to the immune protein IRF4, so its presence can fuel the disease. The researchers are especially interested in identifying diseases that may be good candidates for the development of therapies that work through the mindolin-proteasome pathway. “One of the areas we are actively exploring is how to tune the specificity of the mechanism so it can specifically degrade proteins of interest,” Gu said. Reference: “The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation” by Xin Gu, Christopher Nardone, Nolan Kamitaki, Aoyue Mao, Stephen J. Elledge and Michael E. Greenberg, 25 August 2023, Science. DOI: 10.1126/science.adh5021 Funding was provided by a National Mah Jongg League Fellowship from the Damon Runyon Cancer Research Foundation, a National Science Foundation Graduate Research Fellowship, and the National Institutes of Health (T32 HG002295; R01 NS115965; AG11085).

Nests of icefish. Researchers on the Polarstern vessel identified a significant icefish breeding colony in the Antarctic Weddell Sea, covering an area as large as Malta with around 60 million nests. Credit: AWI OFOBS Team Researchers detect around 60 million nests of Antarctic icefish over a 240 square kilometers area in the Weddell Sea. Near the Filchner Ice Shelf in the south of the Antarctic Weddell Sea, a research team has found the world’s largest fish breeding area known to date. A towed camera system photographed and filmed thousands of nests of icefish of the species Neopagetopsis ionah on the seabed. The density of the nests and the size of the entire breeding area suggest a total number of about 60 million icefish breeding at the time of observation. These findings provide support for the establishment of a Marine Protected Area in the Atlantic sector of the Southern Ocean. A team led by Autun Purser from the Alfred Wegener Institute publish their results in the current issue of the scientific journal Current Biology. World’s Largest Fish Breeding Area Discovered in Antarctica The joy was great when, in February 2021, researchers viewed numerous fish nests on the monitors aboard the German research vessel Polarstern, which their towed camera system transmitted live to the vessel from the seabed, 535 to 420 meters (1,755 to 1,378 feet) below the ship, from the seafloor of the Antarctic Weddell Sea. The longer the mission lasted, the more the excitement grew, finally ending in disbelief: nest followed nest, with later precise evaluation showing that there were on average one breeding site per three square meters (32 square feet), with the team even finding a maximum of one to two active nests per square meter. Eastern break-off edge of the iceberg. Credit: Alfred-Wegener-Institut / Ralph Timmermann The mapping of the area suggests a total extent of 240 square kilometers (93 square miles), which is roughly the size of the island of Malta. Extrapolated to this area size, the total number of fish nests was estimated to be about 60 million. “The idea that such a huge breeding area of icefish in the Weddell Sea was previously undiscovered is totally fascinating,” says Autun Purser, deep-sea biologist at the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI) and lead author of the current publication. After all, the Alfred Wegener Institute has been exploring the area with its icebreaker Polarstern since the early 1980s. So far, only individual Neopagetopsis ionah or small clusters of nests have been detected here. Advanced Survey Technology Enhances Deep-Sea Research The unique observations are made with a so-called OFOBS, the Ocean Floor Observation, and Bathymetry System. It is a camera sledge built to survey the seafloor of extreme environments, like ice-covered seas. It is towed on a special fiber-optic and power cable normally at a speed of about one half to one knot, about one and half meters above the seafloor. “After the spectacular discovery of the many fish nests, we thought about a strategy on board to find out how large the breeding area was — there was literally no end in sight. The nests are three quarters of a meter (2.5 feet) in diameter — so they are much larger than the structures and creatures, some of which are only centimeters in size, that we normally detect with the OFOBS system,” Autun Purser reports. “So, we were able to increase the height above ground to about three meters (10 feet) and the towing speed to a maximum of three knots, thus multiplying the area investigated. We covered an area of 45,600 square meters (4.9 million square feet) and counted an incredible 16,160 fish nests on the photo and video footage,” says the AWI expert. Fish nests in Weddell Sea. Credit: PS124, AWI OFOBS team Based on the images, the team was able to clearly identify the round fish nests, about 15 centimeters (6 inches) deep and 75 centimeters (2.5 feet) in diameter, which were made distinct from the otherwise muddy seabed by a round central area of small stones. Several types of fish nests were distinguished: “Active” nests, containing between 1,500 and 2,500 eggs and guarded in three-quarters of the cases by an adult icefish of the species Neopagetopsis ionah, or nests which contained only eggs; there were also unused nests, in the vicinity of which either only a fish without eggs could be seen, or a dead fish. The researchers mapped the distribution and density of the nests using OFOBS’s longer-range but lower-resolution side scan sonars, which recorded over 100,000 nests. Ecological Significance of the Icefish Breeding Area The scientists combined their results with oceanographic and biological data. The result: the breeding area corresponds spatially with the inflow of warmer deep water from the Weddell Sea onto the higher shelf. With the help of transmitter equipped seals, the multidisciplinary team was also able to prove that the region is also a popular destination for Weddell seals. 90 percent of the seals’ diving activities took place within the region of active fish nests, where they presumably go in search of food. No wonder, the researchers calculate the biomass of the ice fish colony there at 60 thousand tonnes. Icefish Nest in Weddell Sea. Credit: PS124, AWI OFOBS team With its biomass, this huge breeding area is an extremely important ecosystem for the Weddell Sea and, according to current research, likely to be the most spatially extensive contiguous fish breeding colony discovered worldwide to date, the experts report in the publication in Current Biology. Political and Scientific Reactions to the Discovery German Federal Research Minister Bettina Stark-Watzinger said: “My congratulations to the researchers involved on their fascinating discovery. After the MOSAiC expedition, German marine and polar research has once more reaffirmed its outstanding position. German research vessels are floating environmental research laboratories. They continue to sail the polar seas and our oceans almost non-stop, serving as platforms for science aimed at generating important findings to support climate and environmental protection. Funding by the Federal Ministry of Education and Research (BMBF) provides German marine and polar research with one of the most state-of-the-art research vessel fleets worldwide. This discovery can make an important contribution towards protecting the Antarctic environment. The BMBF will continue to work towards this goal under the umbrella of the United Nations Decade of Ocean Science for Sustainable Development that runs until 2030.” For AWI Director and deep-sea biologist Prof. Antje Boetius, the current study is a sign of how urgent it is to establish marine protected areas in Antarctica. “This great discovery was enabled by a specific under-ice survey technology we developed during my ERC Grant. It shows how important it is to be able to investigate unknown ecosystems before we disturb them. Considering how little known the Antarctic Weddell Sea is, this underlines all the more the need of international efforts to establish a Marine Protected Area (MPA),” Antje Boetius classifies the results of the study, in which she was not directly involved. A proposal for such an MPA has been prepared under the lead of the Alfred Wegener Institute and is defended since 2016 by the European Union and its member states as well as other supporting countries in the International Commission for the Conservation of Antarctic Marine Living Resources (CCAMLR). Antje Boetius adds: “Unfortunately, the Weddell Sea MPA has still not yet been adopted unanimously by CCAMLR. But now that the location of this extraordinary breeding colony is known, Germany and other CCAMLR members should ensure that no fishing and only non-invasive research takes place there in future. So far, the remoteness and difficult sea ice conditions of this southernmost area of the Weddell Sea have protected the area, but with the increasing pressures on the ocean and polar regions, we should be much more ambitious with marine conservation.” For more on this discovery, see Massive Icefish Breeding Colony With 60 Million Active Nests Found in Antarctica. Reference: “A vast icefish breeding colony discovered in the Antarctic” by Autun Purser, Laura Hehemann, Lilian Boehringer, Sandra Tippenhauer, Mia Wege, Horst Bornemann, Santiago E.A. Pineda-Metz, Clara M. Flintrop, Florian Koch, Hartmut H. Hellmer, Patricia Burkhardt-Holm, Markus Janout, Ellen Werner, Barbara Glemser, Jenna Balaguer, Andreas Rogge, Moritz Holtappels and Frank Wenzhoefer, 13 January 2022, Current Biology. DOI: 10.1016/j.cub.2021.12.022

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