Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Vietnam anti-bacterial pillow ODM design

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Vietnam ergonomic pillow OEM supplier

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.China graphene product OEM service

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Pillow OEM for wellness brands Indonesia

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.China OEM/ODM hybrid insole services

Stock photo of a beached pilot whale carcass. A new study published by the open access publisher Frontiers shows the usefulness of opportunistically collected specimens, such as stranded carcasses, to study elusive species. The researchers used stable isotope analysis of skin, muscle, and bone tissue of Sowerby’s beaked whales to study their spatial ecology. They found that the species exhibits both short- and long-term habitat fidelity. The results are published in Frontiers in Conservation Science and show the importance of such studies for marine wildlife conservation. A mysterious whale species Beaked whales, a species of toothed whales, make up more than 25% of extant cetaceans (dolphins, porpoises, and whales), but are elusive and notoriously difficult to study. They live in deep waters and stay away from shores. Due to a lack of observations from the wild, little is known about their ecology and biology. Because of this, they are considered ‘data deficient’ by the IUCN Red List and developing conservation plans is challenging. Some species of beaked whales have never been observed alive and are only known from stranded carcasses. “Beaked whales are really cool, but most people haven’t heard of them because they are so enigmatic. Whales are generally large and charismatic — we can go on whale watching trips and see them in the wild, yet there are entire groups of whale species we know almost nothing about,” says Dr. Kerri Smith, of the University of Texas El Paso and the Smithsonian National Museum of Natural History, United States. Sowerby’s beaked whales (Mesoplodon bidens) were first described more than 200 years ago, yet little is known about this species. The species’ geographic range is thought to cover much of the North Atlantic Ocean. Stranded animals have been collected from both North American and European waters, but it is unknown if the species is structured into spatially separate subpopulations or if there is one continuous and highly mobile population. Stable isotope analysis to study elusive animals Stable isotopes get incorporated into different tissue types through diet. The rate at which stable isotopes get incorporated into a tissue depends on the tissue’s growth and replacement rates. For example, skin turnover rates are faster than those of muscle, which in turn are faster than the turnover of bone. Stable isotope analysis is an efficient tool that can be used when traditional techniques, such as GPS tracking and camera recording from field observations, can’t be applied. It can be used to answer ecological and biological questions about a species’ diet or spatial origin across time. To better understand the species’ spatial range, the researchers measured the carbon isotope (δ13C) and nitrogen isotope (δ15N) composition of skin, muscle, and bone tissue of Sowerby’s beaked whales from the east and west Atlantic. The 102 samples were collected from museum specimens, stranded carcasses, and bycaught animals, and included females and males from all ages. A treasure trove of data When researchers work with specimens of opportunity, there is little control over how samples were collected. “In our study, the majority of our specimens came from strandings and fisheries bycatch; since these specimens represent only a small portion of all Sowerby’s beaked whales, we only have a few pieces of a large, complex puzzle. Those pieces can tell us a lot, however, and the more we study these whales, the more we will learn about their distributions, behavior, and lives.” The results show that there are at least two subpopulations of Sowerby’s beaked whales, one each in the eastern and western Atlantic. “Our study has two major results. First, it demonstrates the power of specimens of opportunity to answer fundamental ecological questions — these specimens are treasure troves of data waiting for someone to query them,” says Smith. “Second, it provides some of the first data about Sowerby’s beaked whale long-term distribution and population structure, something that would be nearly impossible to learn by studying living whales in their habitat. We can learn a lot about beaked whale ecology from specimens of opportunity.” The researchers suggest genetic analysis to explore possible genetic differentiation between the two populations. The findings have implications for marine wildlife conservation. The two populations found here likely have different conservation needs. Smith concludes: “A key action to take going forward is generating more fundamental data through studies like this one — successful conservation action requires a strong foundation of reliable data, and there is still so much we do not know about beaked whales and many other marine species. As we learn more about them and their habitats, we may need to set aside important habitats as marine protected areas. Additional research to identify the potential influence of fishing activities and naval sonar on critical beaked whale habitats is also needed.” Reference: “Stable Isotope Analysis of Specimens of Opportunity Reveals Ocean-Scale Site Fidelity in an Elusive Whale Species” by Kerri J. Smith, Clive N. Trueman, Christine A. M. France, Jed P. Sparks, Andrew C. Brownlow, Michael Dähne, Nicholas J. Davison, Guðmundur Guðmundsson, Kamal Khidas, Andrew C. Kitchener, Bram W. Langeveld, Véronique Lesage, Hanneke J. M. Meijer, John J. Ososky, Richard C. Sabin, Zena L. Timmons, Gísli A. Víkingsson, Frederick W. Wenzel and Markus J. Peterson, 28 May 2021, Frontiers in Conservation Science. DOI: 10.3389/fcosc.2021.653766

Organization of mitotic chromosomes (magenta) and spindle microtubules (green) at an early phase of cell division. Shortly after what’s shown in the image, the microtubules will invade the nuclear space. However, chromatin compaction regulated by histone acetylation will prevent the perforation of the chromosomes by microtubules. Credit: ©Gerlich/IMBA How the genome is packed into chromosomes that can be faithfully moved during cell division. Scientists discovered a molecular mechanism that confers special physical properties to chromosomes in dividing human cells to enable their faithful transport to the progeny. The research team showed how a chemical modification establishes a sharp surface boundary on chromosomes, thus allowing them to resist perforation by microtubules of the spindle apparatus. The researchers are from the Gerlich Group at IMBA – Institute of Molecular Biotechnology of the Austrian Academy of Sciences, and their findings are published today (August 3, 2022) in the journal Nature. Exactly one genome copy must be transported to each of the two daughter cells during cell division. Faithful genome segregation requires the packaging of extremely long chromosomal DNA molecules into discrete bodies. This allows them to be efficiently moved by the mitotic spindle, a filament system composed of thousands of microtubules. The new findings by the Gerlich Research Group at IMBA – Institute of Molecular Biotechnology of the Austrian Academy of Sciences – shed light on how mitotic chromosomes resist the constant pushing and pulling forces generated by the microtubules. “Amidst this complex system, the distinct physical properties are conferred to the chromosomes by changing the levels of histone acetylation, a chemical modification within the chromatin fiber,” says IMBA Group Leader Daniel Gerlich. Prior research had demonstrated that, in dividing cells, the chromatin fibers are folded into loops by a large protein complex called condensin. However, the role of condensin alone could not explain why chromosomes appear as dense bodies with a sharp surface rather than a loose structure resembling a bottlebrush. Some studies had suggested a role of histone acetylation in regulating the level of compaction during cell division, but the interplay of histone acetylation with condensin and its functional relevance remained unclear. “With our work, we are now able to conceptually disentangle the two mechanisms,” states Gerlich. Disentangling the Effects of Condensin and Histone Acetylation The scientists varied the levels of condensin and histone acetylation to study their precise effects. Removing condensin disrupted the elongated shape of chromosomes in dividing cells and lowered their resistance to pulling forces but did not affect their level of compaction. Combining condensin depletion with a treatment that increases the levels of histone acetylation caused massive chromatin decompaction in dividing cells, and perforation of chromosomes by microtubules. The team hypothesized that chromatin is organized as a swollen gel throughout most of the cell cycle (when it is relatively highly acetylated) and that this gel compacts to an insoluble form during cell division when the acetylation levels globally decrease. They then developed an assay to probe the solubility of chromatin by fragmenting mitotic chromosomes into small pieces. The fragments of mitotic chromosomes formed droplets of liquid chromatin, but when the acetylation level was increased, the chromatin fragments dissolved in the cytoplasm. These observations support a model where a global reduction of chromatin acetylation during mitosis establishes an immiscible chromatin gel with a sharp phase boundary, providing a physical basis for resistance against microtubule perforation. With further experiments involving pure chromatin that was reconstituted in vitro, and by probing chromatin access by various soluble macromolecules, the researchers discovered that immiscible chromatin forms a structure dense in negative charge that excludes negatively charged macromolecules and microtubules. Cooperation Between Condensin and Chromatin Phase Separation “Our study shows how DNA looping by the condensin complex cooperates with a chromatin phase separation process to build mitotic chromosomes that resist both pulling and pushing forces exerted by the spindle. The deacetylation of histones during cell division hence confers unique physical properties to chromosomes that are required for their faithful segregation,” concludes Daniel Gerlich. Reference: “A mitotic chromatin phase transition prevents perforation by microtubules” by Maximilian W. G. Schneider, Bryan A. Gibson, Shotaro Otsuka, Maximilian F. D. Spicer, Mina Petrovic, Claudia Blaukopf, Christoph C. H. Langer, Paul Batty, Thejaswi Nagaraju, Lynda K. Doolittle, Michael K. Rosen and Daniel W. Gerlich, 3 August 2022, Nature. DOI: 10.1038/s41586-022-05027-y Funding: Austrian Science Fund, Vienna Science and Technology Fund, Vienna Science and Technology Fund, Howard Hughes Medical Institute, NIH/National Institutes of Health, Welch Foundation, Boehringer Ingelheim Fonds

A study by the MRC Laboratory of Medical Sciences reveals that cells in different organs selectively express maternal or paternal X chromosomes. This variation, shown in both human data and mouse models, is driven by cellular competition, affecting organ development in biological females. Credit: SciTechDaily.com Research reveals that selective expression of maternal or paternal X chromosomes varies by organ, driven by cellular competition. A new study published today (July 26) in Nature Genetics by the Lymphoid Development Group at the MRC Laboratory of Medical Sciences has revealed that the contribution of cells expressing maternal or paternal X chromosomes can be selectively skewed in different parts of the body. The study leverages human data from the 1000 Genomes Project combined with mouse models of human X chromosome-linked DNA sequence variation to advance our fundamental understanding of development in biologically female individuals who have two X chromosomes. Mechanisms Behind X Chromosome Selection Until now, it was thought that the usage of maternal and paternal X-chromosomes was similar throughout the body. The new work shows that this is not always true, and that different organs may be skewed towards using either maternal or paternal X-chromosomes. The work also reveals the process driving this skew: competition between cells expressing either one or the other X-chromosome. In some individuals, cells in organs such as the heart mostly use the X chromosome from one parent, whereas immune cells almost exclusively utilize the X chromosome from the other parent. This provides an important step forward in understanding the underlying principles and mechanisms of development in XX individuals. Implications of X Chromosome Selection Biological females inherit two X chromosomes – one from each parent – along with all the other genetic material that builds and sustains the body. But despite the presence of both parental X chromosomes, only one X chromosome is actively expressed in any given cell. Since the DNA sequence of each X chromosome has genetic variations, each cell effectively chooses to express a set of unique characteristics derived from either one or the other parent. “We realized that when cells chose one of their two X chromosomes over the other, they also chose which set of genetic variants to express,” said Matthias Merkenschlager, who leads the Lymphocyte Development Research Group. “As a result, individual cells express distinct genetic variants. We are now working to find out more about how X-linked genetic variants shape organismal development, and whether selective X chromosome usage in specific tissues may affect the likelihood of certain conditions later in life.” Research Focus on the STAG2 Gene The researchers focussed on a specific gene on the X chromosome, called STAG2. They found that cells with a genetic variant of STAG2 failed to develop into immune cells called lymphocytes in females that carried variant STAG2 on one X chromosome, and the common (‘reference’) version of STAG2 on the other X chromosome. By contrast, cells with the same variant of STAG2 were fully competent to form lymphocytes in XY males (with a single copy of the X chromosome), or females in which both X chromosomes carried the variant. The researchers concluded that what prevents variant cells from forming lymphocytes is not the variant as such, but the presence of cells expressing the reference version of STAG2. This shows that cells compete for ‘permission’ to form specific cell types within the body. The findings reveal a new aspect of X-linked diversity not previously appreciated: that interactions between cells can shape the contribution of X-linked diversity to specific cell types and tissues. Even if cells expressing reference STAG2 outcompete to form the blood, cells expressing the variant may predominate in other parts of the body. For the study’s lead author Teresa Buenaventura, this sparked a personal curiosity: “’Working on this project has been particularly exciting for me since it has made me curious about the contribution of each of the X chromosomes to my different tissues,” she said. These findings reveal a previously underappreciated aspect of X-linked diversity, where interactions between epigenetically diverse clones can shape the contribution of X-linked genetic diversity to specific cell types and tissues. Reference: “Competition shapes the landscape of X-chromosome-linked genetic diversity” by Teresa Buenaventura, Hakan Bagci, Ilinca Patrascan, Joshua J. Graham, Kelsey D. Hipwell, Roel Oldenkamp, James W. D. King, Jesus Urtasun, George Young, Daniel Mouzo, David Gomez-Cabrero, Benjamin D. Rowland, Daniel Panne, Amanda G. Fisher and Matthias Merkenschlager, 26 July 2024, Nature Genetics. DOI: 10.1038/s41588-024-01840-5

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