Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Latex pillow OEM production in China

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Pillow OEM factory for wellness brands

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Arch support insole OEM from Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.One-stop OEM/ODM manufacturing factory and solution provider

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.China insole ODM service provider

Newly produced neurons (red) in the dentate gyrus with cell nuclei (blue) and a marker for immature neurons (green). Credit: Knobloch Lab – UNIL A team of biologists has discovered how to awaken neural stem cells and reactivate them in adult mice. Some areas of the adult brain contain quiescent, or dormant, neural stem cells that can potentially be reactivated to form new neurons. However, the transition from quiescence to proliferation is still poorly understood. A team led by scientists from the Universities of Geneva (UNIGE) and Lausanne (UNIL) has discovered the importance of cell metabolism in this process and identified how to wake up these neural stem cells and reactivate them. Biologists succeeded in increasing the number of new neurons in the brain of adult and even elderly mice. These results, promising for the treatment of neurodegenerative diseases, are to be discovered in the journal Science Advances. Stem cells have the unique ability to continuously produce copies of themselves and give rise to differentiated cells with more specialized functions. Neural stem cells (NSCs) are responsible for building the brain during embryonic development, generating all the cells of the central nervous system, including neurons. Neurogenesis Capacity Decreases With Age Surprisingly, NSCs persist in certain brain regions even after the brain is fully formed and can make new neurons throughout life. This biological phenomenon, called adult neurogenesis, is important for specific functions such as learning and memory processes. However, in the adult brain, these stem cells become more silent or ‘‘dormant’’ and reduce their capacity for renewal and differentiation. As a result, neurogenesis decreases significantly with age. The laboratories of Jean-Claude Martinou, Emeritus Professor in the Department of Molecular and Cellular Biology at the UNIGE Faculty of Science, and Marlen Knobloch, Associate Professor in the Department of Biomedical Sciences at the UNIL Faculty of Biology and Medicine, have uncovered a metabolic mechanism by which adult NSCs can emerge from their dormant state and become active. ‘‘We found that mitochondria, the energy-producing organelles within cells, are involved in regulating the level of activation of adult NSCs,’’ explains Francesco Petrelli, research fellow at UNIL and co-first author of the study with Valentina Scandella. The mitochondrial pyruvate transporter (MPC), a protein complex discovered eleven years ago in Professor Martinou’s group, plays a particular role in this regulation. Its activity influences the metabolic options a cell can use. By knowing the metabolic pathways that distinguish active cells from dormant cells, scientists can wake up dormant cells by modifying their mitochondrial metabolism. New Perspectives Biologists have blocked MPC activity by using chemical inhibitors or by generating mutant mice for the Mpc1 gene. Using these pharmacological and genetic approaches, the scientists were able to activate dormant NSCs and thus generate new neurons in the brains of adult and even aged mice. ‘‘With this work, we show that redirection of metabolic pathways can directly influence the activity state of adult NSCs and consequently the number of new neurons generated,’’ summarizes Professor Knobloch, co-lead author of the study. ‘‘These results shed new light on the role of cell metabolism in the regulation of neurogenesis. In the long term, these results could lead to potential treatments for conditions such as depression or neurodegenerative diseases’’, concludes Jean-Claude Martinou, co-lead author of the study. Reference: “Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells” by Francesco Petrelli, Valentina Scandella, Sylvie Montessuit, Nicola Zamboni, Jean-Claude Martinou and Marlen Knobloch, 1 March 2023, Science Advances. DOI: 10.1126/sciadv.add5220

Understanding the origin of a viral outbreak is crucial for scientists to gather insights into viral lineages and implement preventive measures against future outbreaks. The theory that the COVID-19 pandemic was triggered by the Sars-CoV-2 virus being leaked from the Wuhan Institute of Virology in China was recently given new life following an explosive article in the Wall Street Journal (WSJ) in which the authors claimed “the most compelling reason to favor the lab leak hypothesis is firmly based in science.” But does the science really support the claim that the virus was engineered in a laboratory? Understanding the origin of a viral outbreak can provide scientists with important information about viral lineages and allow steps to be put in place to avoid similar outbreaks in the future. As such, the origin of Sars-CoV-2 has been debated from the beginning of the pandemic and remains an active topic of discussion among scientists. It has long been known that viruses similar to the original Sars-CoV that causes Sars are found in bats. These viruses are well studied in China, where the 2002 Sars outbreak originated. But related viruses have been found globally. Unsurprisingly, coronaviruses are again involved in a pandemic, the third such event in the 21st century – first Sars, then Mers, now COVID-19. While a natural origin seems likely – and many have long warned about the danger of wildlife circulating viruses – scientists shouldn’t jump to conclusions. An important way scientists can determine the origin of a virus is by looking at its genome. In the WSJ article, the authors, Prof Richard Muller, an astrophysicist, and Dr Steven Quay, physician and chief executive of Atossa Therapeutics, claim Sars-CoV-2 has “genetic fingerprints” of a lab-origin virus. They say that the presence of a particular genetic sequence (CGG-CGG) is a sign that the virus originated in a lab. To understand the claims being made, we must first understand the genetic code. When a virus infects a cell, it hijacks the cellular machinery, providing instructions (genome) to produce more copies of itself. This genome comprises a long series of molecules called nucleotides, each of which is represented by the letters A, C, G or U. A group of three nucleotides (known as a codon) provides the instruction for a cell to make an amino acid, the most basic molecular building block of living things. Most amino acids are encoded by several different codons. CGG is one of six possible codons that instruct the cell to add the amino acid arginine. The authors of the WSJ article argue that Sars-CoV-2 originated in a lab based on the presence of a “CGG-CGG” sequence. They claim this is a “readily available and convenient” codon pair that scientists prefer to use to produce the amino acid arginine. But to anyone with an understanding of the techniques required for genetic modification, this double-CGG is usually no more difficult or easy to produce than any other pair of codons that encode arginines. No reason CGG-CGG had to be made in lab The authors claim that the CGG codon appears less frequently than the other five possible codons in betacoronaviruses (the family of coronaviruses to which Sars-CoV-2 belongs). If we look at related coronaviruses, the CGG codon encodes about 5% of all arginines in Sars-CoV compared with about 3% of all arginines in Sars-CoV-2. Though CGG is less common than other codons, the authors’ argument fails to provide a reason that the double-CGG sequence could not exist naturally. The authors argue that recombination (when viruses that infect the same host share genetic material) was the most likely way in which Sars-CoV-2 was able to obtain the double-CGG sequence. They note that the double-CGG codon pair is not found in other members of this “class” of coronavirus, so natural recombination could not possibly generate a double-CGG. However, viruses do not just depend on preassembled segments of genetic material to evolve and expand their host range. The authors also claim that mutation (random copying errors) is unlikely to generate the double-CGG sequence. But viruses evolve at a rapid rate, so much so that the accumulation of mutations is a common inconvenience of virological studies. Recombination is one way in which viruses evolve, but the authors’ dismissal of mutation as a source of viral change is an inaccurate description of reality. The final claim that the first sequenced Sars-CoV-2 virus was ideally suited to the human host neglects evidence of viral circulation in local animal populations, animal-to-animal transmission, and the rapid evolution that is driving the increasing transmissibility of the newer variants. If the virus was ideally adapted to humans, why is so much further evolution evident? Disappointingly, many other media articles appear to have accepted and repeated the claims from the WSJ piece. The origin of Sars-CoV-2 may remain unresolved, but there is no evidence presented in the WSJ piece that scientifically supports the concept of a lab leak of a genetically engineered virus. Written by Keith Grehan – Postdoctoral Researcher, Molecular Biology, University of Leeds Natalie Kingston – Research Fellow, Virology, University of Leeds Adapted from an article originally published on The Conversation.

Using a new method, scientists have discovered that cells lose about 4% of their mass as they enter cell division. They are essentially taking out the trash to give their offspring a fresh start. Cells may use this strategy to clear out toxic byproducts and give their offspring a fresh start. MIT scientists have discovered that before cells start to divide, they do a little cleanup, throwing out molecules that they appear not to need anymore. Using a new method they developed for measuring the dry mass of cells, the researchers found that cells lose about 4 percent of their mass as they enter cell division. The researchers believe that this emptying of trash helps cells to give their offspring a “clean slate,” free of the parent cell’s accumulated junk. “Our hypothesis is that cells might be throwing out things that are building up, toxic components or just things that don’t function properly that you don’t want to have there. It could allow the newborn cells to be born with more functional contents,” says Teemu Miettinen, an MIT research scientist and the lead author of the new study. Scott Manalis, the David H. Koch Professor of Engineering in the departments of Biological Engineering and Mechanical Engineering, and a member of the Koch Institute for Integrative Cancer Research, is the senior author of the paper, which was published on May 10, 2022, in the journal eLife. MIT biological engineering undergraduates Kevin Ly and Alice Lam are also authors of the paper. Measuring Mass Measuring the dry mass of a cell — the weight of its contents not including the water — is commonly done using a microscopy technique called quantitative phase microscopy. This technique can measure cell growth, but it does not reveal information about the molecular content of the dry mass and it is difficult to use with cells that grow in suspension. Manalis’ lab has previously developed a technique for measuring the buoyant mass of cells, which is their mass as they float in a fluid such as water. This method measures buoyant mass by flowing cells through a channel embedded in a vibrating cantilever, which can be done repeatedly to track changes in a particular cell’s mass over many hours or days. MIT researchers have discovered that before cells start to divide, they toss waste products. In this image, the magenta represents DNA, and the green represents a lysosomal marker on the surface of the cells, which is an indicator of lysosomal exocytosis. Credit: Courtesy of the researchers For their new study, the researchers wanted to adapt the technique so that it could be used to calculate the dry mass of cells, as well as the density of the dry mass. About 10 years ago, they had discovered that they could calculate a cell’s dry mass if they first measured the cell in normal water and then in heavy water (which contains deuterium instead of ordinary hydrogen). These two measurements can be used to calculate the cell’s dry mass. However, heavy water is toxic to cells, so they were only able to obtain a single measurement per cell. Last year, Miettinen set out to see if he could design a system in which cells could be measured repeatedly with minimal exposure to heavy water. In the system he came up with, cells are exposed to heavy water very briefly as they flow through microfluidic channels. It takes only one second for a cell to completely exchange its water content, so the researchers could measure the cell’s mass when it was full of heavy water, compare it to the mass in normal water, and then calculate the dry mass. “Our idea was that if we minimize the cells’ exposure to the heavy water, we could engineer the system so that we could repeat this measurement over extended time periods without hurting the cell,” Miettinen says. “That enabled us for the first time to track not just the dry mass of a cell, which is what others do using microscopic methods, but also the density of the dry mass, which informs us of the cell’s biomolecular composition.” The researchers showed that their dry mass measurements qualitatively agreed with previous work using quantitative phase microscopy. And, in addition to providing density of the dry mass, the MIT team’s method enables higher temporal resolution, which proved to be useful for revealing dynamics during mitosis (cell division). Taking Out the Trash In cells undergoing mitosis, the researchers used their new technique to study what happens to cell mass and composition during that process. In a 2019 paper, Miettinen and Manalis found that buoyant mass increases slightly as mitosis begins. However, other studies that used quantitative phase microscopy suggested that cells might retain or lose dry mass early in cell division. In the new study, the MIT team measured three types of cancer cells, which are easier to study because they divide more frequently than healthy cells. To their surprise, the researchers found that the dry mass of cells actually decreases when they enter the cell division cycle. This mass is regained later on, before division is complete. Further experiments revealed that as cells enter mitosis, they ramp up activity of a process called lysosomal exocytosis. Lysosomes are cell organelles that break down or recycle cellular waste products, and exocytosis is the process they use to jettison any molecules that aren’t needed anymore. The researchers also found that the density of the dry mass increases as the cells lose dry mass, leading them to believe that the cells are losing low-density molecules such as lipids or lipoproteins. They hypothesize that cells use this process to clear out toxic molecules before dividing. “What we are seeing is that cells might be trying to throw out damaged components before dividing,” Miettinen says. The researchers speculate that their findings may help explain why neurons, which do not divide, are more likely to accumulate toxic proteins such as Tau or amyloid beta, which are linked to the development of Alzheimer’s disease. The findings could also be relevant to cancer: Cancer cells can expel some chemotherapy drugs using exocytosis, helping them to become resistant to the drugs. In theory, preventing exocytosis from occurring before cell division could help to make cancer cells more susceptible to such drugs. “There are diseases where we might want upregulate exocytosis, for example in neurodegenerative diseases, but then there are diseases like cancer where maybe we want to dial it down,” Miettinen says. “In the future, if we could better understand the molecular mechanism behind this, and find a way to trigger it outside of mitosis or prevent it during mitosis, we could really have a new toggle to use when treating disease.” Reference: “Single-cell monitoring of dry mass and dry mass density reveals exocytosis of cellular dry contents in mitosis” by Teemu P Miettinen, Kevin S Ly, Alice Lam, Scott R Manalis, 10 May 2022, eLife. DOI: 10.7554/eLife.76664 The research was funded by the MIT Center for Cancer Precision Medicine, the Virginia and D.K. Ludwig Fund for Cancer Research, the Cancer Systems Biology Consortium, and the Koch Institute Support (core) Grant from the National Cancer Institute.

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