Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan graphene sports insole ODM factory

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Insole ODM production factory in Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Flexible manufacturing OEM & ODM factory Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Ergonomic insole ODM production factory Taiwan

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan custom insole OEM factory

A team from the University of California, Riverside has made significant progress in understanding the SARS-CoV-2 virus by studying the M protein. Their research revealed how this protein helps the virus achieve its spherical shape, offering potential new avenues for viral intervention. Credit: SciTechDaily.com Researchers have uncovered how the M protein is key to the spherical structure of the SARS-CoV-2 virus, opening new paths for combating other pathogenic coronavirus outbreaks. For centuries, coronaviruses have triggered health crises and economic challenges, with SARS-CoV-2, the coronavirus that spreads COVID-19, being a recent example. One small protein in SARS-CoV-2, the Membrane protein, or M protein, is the most abundant and plays a crucial role in how the virus acquires its spherical structure. Nonetheless, this protein’s properties are not well understood. Innovative Research on M Protein A research team led by a physicist at the University of California, Riverside, has devised a new method to make large quantities of M protein, and has characterized the protein’s physical interactions with the membrane — the envelope, or “skin,” — of the virus. The team’s theoretical modeling and simulations show how these interactions are likely contributing to the virus assembling itself. The researchers report in their paper published today in Science Advances that when the M protein, which is adjacent to the spike protein on SARS-CoV-2, gets lodged in the membrane, it coaxes the membrane to curve by locally reducing the membrane thickness. This induction of curvature leads to SARS-CoV-2’s spherical shape. From L to R: Roya Zandi, Thomas Kuhlman, and Umar Mohideen. Credit: Kuhlman lab, UC Riverside “If we can better understand how the virus assembles itself, then, in principle, we can come up with ways to stop that process and control the virus’ spread,” said Thomas E. Kuhlman, an assistant professor of physics and astronomy, who led the research project. “M protein has previously resisted any kind of characterization because it is so hard to make.” Kuhlman and his colleagues overcame this difficulty by using Escherichia coli bacteria as a “factory” to make the M protein in large numbers. Kuhlman explained that although E. coli can make copious amounts of M proteins, the proteins tend to clump together in the E. coli cells, eventually killing them. To circumvent this challenge, the researchers induced the E. coli cells to produce the protein Small Ubiquitin-related Modifier, or SUMO, along with the M protein. Groundbreaking Techniques “In our experiments, when E. coli makes M protein, it makes SUMO at the same time,” Kuhlman said. “The M protein fuses with the SUMO protein, which prevents the M proteins from sticking to one another. The SUMO protein is relatively easy to remove via another protein that simply cuts it off. The M protein is thus purified and separated from SUMO.” The work provides fundamental insights into the mechanisms driving SARS-CoV-2 viral assembly. “As M proteins are an integral component of other coronaviruses as well, our findings provide useful insights that can enhance our understanding and potentially enable interventions in viral formation not only in SARS-CoV-2 but also in other pathogenic coronaviruses,” Kuhlman said. Future Directions Next, the researchers plan to study the interactions of the M protein with other SARS-CoV-2 proteins to potentially disrupt these interactions with drugs. Kuhlman was joined in the research by fellow-UCR physicists Roya Zandi and Umar Mohideen. Kuhlman was charged with making the M proteins. Mohideen, a distinguished professor of physics and astronomy, used atomic force microscopy and cryogenic electron microscopy to measure how the M protein interacts with the membrane. Zandi, an expert on virus assembly and a professor of physics and astronomy, developed simulations of how the M proteins interact with each other and with the membrane. Other coauthors on the paper are Yuanzhong Zhang, Siyu Li, Michael Worcester, Sara Anbir, Pratyasha Mishra of UCR; and Joseph McTiernan, Michael E. Colvin and Ajay Gopinathan of UC Merced. Co-first authors Zhang and Anbir contributed equally to the work. The research was supported by a grant from the University of California Office of the President to investigate how the COVID-19 virus assembles itself. The research paper is titled “Synthesis, Insertion, and Characterization of SARS-CoV-2 Membrane Protein Within Lipid Bilayers.” Reference: “Synthesis, insertion, and characterization of SARS-CoV-2 membrane protein within lipid bilayers” by Yuanzhong Zhang, Sara Anbir, Joseph McTiernan, Siyu Li, Michael Worcester, Pratyasha Mishra, Michael E. Colvin, Ajay Gopinathan, Umar Mohideen, Roya Zandi and Thomas E. Kuhlman, 28 February 2024, Science Advances. DOI: 10.1126/sciadv.adm7030

Researchers have uncovered the specific pheromone blend used by male moths in courtship, highlighting the importance of methyl salicylate, a plant-derived substance, in attracting females. This discovery marks a significant advancement in understanding the chemical communication essential for moth mating rituals, revealing evolutionary adaptations and the role of diet in pheromone composition. Credit: SciTechDaily.com Research identifies methyl salicylate as a key component in male moth pheromones, sourced from plants and crucial for attracting mates, underscoring the interplay between diet, evolutionary adaptation, and mating strategies in moths. Researchers from the University of Amsterdam and North Carolina State University have identified the specific mixture of pheromone chemicals that male moths use during courtship. The findings provide more detail about the complex blend of chemicals that males and females of this group of moths use in fundamental short-range communication. The research was published in the scientific journal Current Biology. Scent compounds are essential for male moths to entice female conspecifics to mate. Both partners need to find and recognize each other in the dark. This is done by sex pheromones secreted by the female. Then it is up to the male to convince the female that he is a good match. Aphrodisiac from plants The study shows that male Chloridea virescens moths get one key ingredient of their aphrodisiac from plants: when they eat from a plant, it secretes the signaling substance methyl salicylate, for healing and as a cry for help to the moths’ enemies. Male moths appear to be able to incorporate this substance into their pheromone mixture, as caterpillars when eating plants or as adults when drinking nectar. “It is a new discovery that the courtship pheromone of this moth contains substances from plants,” says Astrid Groot, researcher at the Institute for Biodiversity and Ecosystem Dynamics (IBED) at the University of Amsterdam. “Until now, we thought that this and related moths produce their sex pheromone substances de novo.” And whether it is because the substance proves to a female that the male is capable of ingesting the plant’s defense substance, or that he has a good foraging ability as an adult, in any case, the ingestion increases the mating chances of males. Groot: “It was surprising to find methyl salicylate in the pheromone cocktails of male moths. Perhaps males could have developed this sexual signal through evolution because females could already perceive the substance.” Specific receptors in females The composition of the sex pheromone of male moths was first characterized almost 35 years ago. As chemical analysis techniques have become much more sensitive in recent decades, the scientists now studied the male pheromone using the technique of gas chromatography. In the process, they discovered some chemical compounds that were not found before. Including methyl salicylate, whose importance was further investigated via lab experiments. By measuring changes in electropotential charge on the antennae of female moths, the researchers could see that methyl salicylate, which was barely detectable in gas chromatography studies, elicits a large response in females. Female moth antennae have two smell receptors specifically tuned to methyl salicylate, allowing them to recognize the chemical in the mixture emitted by males. The researchers were also able to reduce the amount of methyl salicylate secreted by males and they showed that mating success suffered as a result. When the males were administered methyl salicylate, their mating success returned to normal: evidence of the chemical’s aphrodisiac-like quality. Storage in the hair pencils The researchers additionally compared wild moths with specimens from the lab. Male moths caught in soybean fields in North Carolina had large amounts of methyl salicylate in their hair pencils — the male organs that secrete the pheromone mixture. The researchers reduced the amounts of methyl salicylate in moths fed an artificial diet in the laboratory. When the substance was added to the diet of these male lab moths via nectar-like sugar water, they stored it in their hair pencils. After they were encouraged to court females, methyl salicylate disappeared from the hair pencils again as males used it in their pheromone cocktail. For more on this research, see Unlocking the Secret Aphrodisiac of Moths. Reference: “A mosaic of endogenous and plant-derived courtship signals in moths” by Yang Liu, Jeremy J. Heath, Sai Zhang, Michiel van Wijk, Guirong Wang, Jan Buellesbach, Ayako Wada-Katsumata, Astrid T. Groot and Coby Schal, 1 August 2023, Current Biology. DOI: 10.1016/j.cub.2023.07.010

MIT researchers have devised a way to program memories into bacterial cells by rewriting their DNA more efficiently. Credit: MIT News, iStockphoto Technique for editing bacterial genomes can record interactions between cells, may offer a way to edit genes in the human microbiome. Biological engineers at MIT have devised a new way to efficiently edit bacterial genomes and program memories into bacterial cells by rewriting their DNA. Using this approach, various forms of spatial and temporal information can be permanently stored for generations and retrieved by sequencing the cells’ DNA. The new DNA writing technique, which the researchers call HiSCRIBE, is much more efficient than previously developed systems for editing DNA in bacteria, which had a success rate of only about 1 in 10,000 cells per generation. In a new study, the researchers demonstrated that this approach could be used for storing memory of cellular interactions or spatial location. This technique could also make it possible to selectively edit, activate, or silence genes in certain species of bacteria living in a natural community such as the human microbiome, the researchers say. “With this new DNA writing system, we can precisely and efficiently edit bacterial genomes without the need for any form of selection, within complex bacterial ecosystems,” says Fahim Farzadfard, a former MIT postdoc and the lead author of the paper. “This enables us to perform genome editing and DNA writing outside of laboratory settings, whether to engineer bacteria, optimize traits of interest in situ, or study evolutionary dynamics and interactions in the bacterial populations.” Timothy Lu, an MIT associate professor of electrical engineering and computer science and of biological engineering, is the senior author of the study, which was published on August 5, 2021, in Cell Systems. Nava Gharaei, a former graduate student at Harvard University, and Robert Citorik, a former MIT graduate student, are also authors of the study. Genome writing and recording memories For several years, Lu’s lab has been working on ways to use DNA to store information such as memory of cellular events. In 2014, he and Farzadfard developed a way to employ bacteria as a “genomic tape recorder,” engineering E. coli to store long-term memories of events such as a chemical exposure. To achieve that, the researchers engineered the cells to produce a reverse transcriptase enzyme called retron, which produces a single-stranded DNA (ssDNA) when expressed in the cells, and a recombinase enzyme, which can insert (“write”) a specific sequence of single-stranded DNA into a targeted site in the genome. This DNA is produced only when activated by the presence of a predetermined molecule or another type of input, such as light. After the DNA is produced, the recombinase inserts the DNA into a preprogrammed site, which can be anywhere in the genome. That technique, which the researchers called SCRIBE, had a relatively low writing efficiency. In each generation, out of 10,000 E. coli cells, only one would acquire the new DNA that the researchers tried to incorporate into the cells. This is in part because the E. coli have cellular mechanisms that prevent single-stranded DNA from being accumulated and integrated into their genomes. In the new study, the researchers tried to boost the efficiency of the process by eliminating some of E. coli’s defense mechanisms against single-stranded DNA. First, they disabled enzymes called exonucleases, which break down single-stranded DNA. They also knocked out genes involved in a system called mismatch repair, which normally prevents integration of single-stranded DNA into the genome. With those modifications, the researchers were able to achieve near-universal incorporation of the genetic changes that they tried to introduce, creating an unparalleled and efficient way for editing bacterial genomes without the need for selection. “Because of that improvement, we were able to do some applications that we were not able to do with the previous generation of SCRIBE or with other DNA writing technologies,” Farzadfard says. Cellular interactions In their 2014 study, the researchers showed that they could use SCRIBE to record the duration and intensity of exposure to a specific molecule. With their new HiSCRIBE system, they can trace those kinds of exposures as well as additional types of events, such as interactions between cells. As one example, the researchers showed that they could track a process called bacterial conjugation, during which bacteria exchange pieces of DNA. By integrating a DNA “barcode” into each cell’s genome, which can then be exchanged with other cells, the researchers can determine which cells have interacted with each other by sequencing their DNA to see which barcodes they carry. This kind of mapping could help researchers study how bacteria communicate with each other within aggregates such as biofilms. If a similar approach could be deployed in mammalian cells, it could someday be used to map interactions between other types of cells such as neurons, Farzadfard says. Viruses that can cross neural synapses could be programmed to carry DNA barcodes that researchers could use to trace connections between neurons, offering a new way to help map the brain’s connectome. “We are using DNA as the mechanism to record spatial information about the interaction of bacterial cells, and maybe in the future, neurons that have been tagged,” Farzadfard says. The researchers also showed that they could use this technique to specifically edit the genome of one species of bacteria within a community of many species. In this case, they introduced the gene for an enzyme that breaks down galactose into E. coli cells growing in culture with several other species of bacteria. This kind of species-selective editing could offer a novel way to make antibiotic-resistant bacteria more susceptible to existing drugs by silencing their resistance genes, the researchers say. However, such treatments would likely require several years more years of research to develop, they say. The researchers also showed that they could use this technique to engineer a synthetic ecosystem made of bacteria and bacteriophages that can continuously rewrite certain segments of their genome and evolve autonomously with a rate higher than would be possible by natural evolution. In this case, they were able to optimize the cells’ ability to consume lactose consumption. “This approach could be used for evolutionary engineering of cellular traits, or in experimental evolution studies by allowing you to replay the tape of evolution over and over,” Farzadfard says. Reference: “Efficient retroelement-mediated DNA writing in bacteria” by Fahim Farzadfard, Nava Gharaei, Robert J. Citorik and Timothy K. Lu, 5 August 2021, Cell Systems. DOI: 10.1016/j.cels.2021.07.001 The research was funded by the National Institutes of Health, the Office of Naval Research, the National Science Foundation, the Defense Advanced Research Projects Agency, the MIT Center for Microbiome Informatics and Therapeutics, the NSF Expeditions in Computing Program Award, and the Schmidt Science Fellows Program.

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