Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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PU insole OEM production factory in Taiwan

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan eco-friendly graphene material processing factory

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Taiwan graphene material ODM solution

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan anti-bacterial pillow ODM production factory

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Thailand graphene sports insole ODM

Left: Muscle actin cytoskeleton in young animals. Middle: Muscle actin cytoskeleton in old animals with destabilization of muscle cytoskeleton due to aging Right: Prevention of destabilization of muscle cytoskeleton in old animals by lowering the age-dysregulated high levels of EPS-8, a regulator of actin cytoskeleton. Credit: ©Vilchez Lab The attachment of the small protein ubiquitin to other proteins (ubiquitination) regulates numerous biological processes, including signal transduction and metabolism / Scientists at the University of Cologne discover the link to aging and longevity. Scientists have discovered that the protein ubiquitin plays an important role in the regulation of the aging process. Ubiquitin was previously known to control numerous processes, such as signal transduction and metabolism. Prof. Dr. David Vilchez and his colleagues at the CECAD Cluster of Excellence for Aging Research at the University of Cologne performed a comprehensive quantitative analysis of ubiquitin signatures during aging in the model organism Caenorhabditis elegans, a nematode worm which is broadly used for aging research. This method — called ubiquitin proteomics — measures all changes in ubiquitination of proteins in the cell. The resulting data provide site-specific information and define quantitative changes in ubiquitin changes across all proteins in a cell during aging. A comparison with the total protein content of a cell (proteome) showed which changes have functional consequences in protein turnover and actual protein content during aging. The scientists thus discovered new regulators of lifespan and provide a comprehensive data set that helps to understand aging and longevity. The article, ‘Rewiring of the ubiquitinated proteome determines aging in C. elegans,‘ has now been published in Nature. “Our study of ubiquitin changes led us to a number of exciting conclusions with important insights for understanding the aging process,” said Dr. Seda Koyuncu, lead author of the study. “We discovered that aging leads to changes in the ubiquitination of thousands of proteins in the cell, whereas longevity measures such as reduced food intake and reduced insulin signaling prevent these changes.” Specifically, the researchers found that aging causes a general loss of ubiquitination. This is caused by the enzymes that remove ubiquitin from proteins become more active during aging. Normally, ubiquitinated proteins are recognized and destroyed by the proteasome, the cell’s garbage truck. The scientists showed that the longevity of organisms is determined by age-related changes in the degradation of structural and regulatory proteins by the proteasome. “We studied animals with a defective proteasome to identify proteins that become less ubiquitinated with age and thus are not cleaned up by the proteasome and accumulate in the cell. The resulting protein accumulation leads to cell death,” Koyuncu says. “Remarkably, we saw that reducing the protein levels of these untagged proteins was sufficient to prolong longevity, while preventing their degradation by the proteasome shortened lifespan.” In addition to providing a comprehensive data set, the investigators showed that defining changes in the ubiquitin-modified proteome can lead to the discovery of new regulators of lifespan and aging traits. They focused their follow-up analyses on two specific proteins that lacked ubiquitin labeling during aging. IFB-2, a protein important for cell structure, and EPS-8, a modulator of a signaling pathway that regulates a variety of cellular processes. These proteins, which are no longer adequately labeled in aged organisms, affect longevity in a variety of tissues. Increased protein levels of IFB-2, for example, cause the intestine to fail to digest properly or absorb nutrients and also make it more susceptible to bacterial infections, which is a characteristic of aging animals. “Remarkably, knockdown of IFB-2 in adult C. elegans was enough to restore normal gut function,” Koyuncu says. Too much amounts of EPS-8 in cells over activate a specific signaling pathway (RAC) in muscle and brain cells. The team discovered here that the RAC signaling pathway determines longevity, muscle integrity and motility. “Our findings may point to new ways to delay the aging process and improve quality of life in old age. In particular, we have established a novel link between aging and general changes in the ubiquitin-modified proteome, a process that actively influences longevity,” said study coordinator David Vilchez, research group leader at CECAD and the Center for Molecular Medicine Cologne (CMMC). “Our results and rich datasets may have important implications for several research priorities, including aging, ubiquitination, and other cellular processes.” Reference: “Rewiring of the ubiquitinated proteome determines ageing in C. elegans” by Seda Koyuncu, Rute Loureiro, Hyun Ju Lee, Prerana Wagle, Marcus Krueger & David Vilchez, 28 July 2021, Nature. DOI: 10.1038/s41586-021-03781-z

Studies demonstrate the regeneration of mouse brain circuits with rat stem cells, providing new insights into neurological restoration and cross-species brain development. Credit: SciTechDaily.com Research teams have successfully regenerated mouse brain circuits using rat stem cells, showcasing a new method for restoring brain function and studying interspecies brain development. These findings open up possibilities for treating neurological diseases and understanding brain evolution, while also hinting at future clinical applications and ethical challenges in using similar techniques for human organ transplantation. Scientists Regenerate Neural Pathways in Mice With Cells From Rats Two independent research groups have successfully restored brain circuits in mice using neurons derived from rat stem cells. Recently published in the journal Cell, these studies provide important insights into brain tissue development and open up new possibilities for rejuvenating brain functions lost to diseases and aging. “This research helps to show the brain’s potential flexibility in using synthetic neural circuits to restore brain functions,” says Kristin Baldwin, a professor at Columbia University in New York and corresponding author of one of the two papers. Baldwin’s team restored mouse olfactory neural circuits, the interconnected neurons in the brain responsible for the sense of smell, and their function using stem cells from rats. Mouse hippocampus with rat cells (red) and nuclei of both mouse and rat cells (blue). Credit: M. Khadeesh Imtiaz, Columbia University Irving Medical Center Interspecies Genetic Engineering and Its Implications “Being able to generate brain tissues from one species inside another can help us understand brain development and evolution in different species,” says Jun Wu, an associate professor at the University of Texas Southwestern Medical Center in Dallas and corresponding author of the other paper. Wu’s team developed a CRISPR-based platform that could efficiently identify specific genes that drive the development of specific tissues. They tested the platform by silencing a gene needed for forebrain development in mice and then restoring the tissue using rat stem cells. Mice and rats are two distinct species that evolved independently for approximately 20 to 30 million years. In previous experiments, scientists were able to replace pancreases in mice using rat stem cells through a process called blastocyst complementation. For this process to work, researchers inject rat stem cells into mice blastocysts—early-stage embryos—that lack the ability to develop a pancreas due to genetic mutations. The rat stem cells then developed into the missing pancreas and complemented its function. Breakthroughs in Brain Tissue Regeneration But, to date, generating brain tissues using stem cells from a different species through blastocyst complementation has not been reported. Now, using CRISPR, Wu’s team tested seven different genes and found that knocking out Hesx1 could reliably generate mice that had no forebrain. The team then injected rat stem cells in blastocysts of Hesx1 knockout mice, and the rat cells filled in the niche to form a forebrain in mice. Rats have bigger brains than mice, but the rat-origin forebrains developed at the same pace and size as that of mice. In addition, rat neurons were able to transmit signals to the neighboring mouse neurons and vice versa. The researchers didn’t test whether the forebrain from rat stem cells changed mice’s behaviors. “There’s a lack of good behavioral tests to distinguish rats from mice,” Wu says. “But from our experiment, it seems like these mice with rat forebrain don’t behave out of the ordinary.” Advanced Applications and Future Prospects In the other study, Baldwin’s team used specific genes to either kill or silence mouse olfactory sensory neurons used for the sense of smell and injected rat stem cells into the mice embryos. The silencing model mimics what is seen in neurodevelopmental disorders, where certain neurons cannot communicate well with the brain. The killing model removed the neurons entirely, simulating degenerative diseases. They found blastocyst complementation restored mouse olfactory neural circuits differently depending on the model. When mouse neurons were present but silent, the rat neurons helped form better-organized brain regions compared to the killing model. However, when the team tested these rat-mouse chimeras by training them to find a hidden cookie buried in a cage, rat neurons were best at rescuing behaviors in the killing model. “This really surprising result allows us to look at what’s different between those two disease models and try to identify mechanisms that could help restore functions in either type of brain disease,” Baldwin says. Her team also tested blastocyst complementation in disease-model mice using cells from mice with normal olfactory systems. They showed that intraspecies complementation rescued cookie finding in both models. Exploring the Frontiers of Medical Science “Right now, people are being transplanted with stem cell-derived neurons for Parkinson’s disease and epilepsy in clinical trials. How well will that work? And will different genetic backgrounds between the patient and the transplanted cells pose a barrier? This study provides a system in which we can evaluate the possibilities for same species brain complementation at a much larger scale than a clinical trial,” Baldwin says. Blastocyst complementation is still far from clinical application in humans, but both studies suggest stem cells from different species can synchronize their development with the host’s brain. Scientists have also been experimenting with growing human organs in other species like pigs using blastocyst complementation. Last year, scientists generated embryonic kidneys using human stem cells in pigs, offering a potential solution for the many people on waitlists for transplants. “Our aspiration is to enrich pig organs with a certain percentage of human cells, with the aim of improving outcomes for organ recipients. But currently, there are still many technical and ethical challenges that we need to overcome before we can test this in clinical trials,” says Wu. Besides the studies’ implications in medicine, the teams are also interested in using this approach to study the brains of many wild rodents that were not accessible in the laboratory setting. “There are over 2,000 living rodent species in the world. Many of them behave differently from the rodents we commonly study in the lab. Interspecies neural blastocyst complementation can potentially open the door to study how the brains from those species develop, evolve, and function,” Wu says. For more on this research, see Mice Engineered With Rat Neurons Show Advanced Sensory Skills. References: “Functional sensory circuits built from neurons of two species” by Benjamin T. Throesch, Muhammad Khadeesh bin Imtiaz, Rodrigo Muñoz-Castañeda, Masahiro Sakurai, Andrea L. Hartzell, Kiely N. James, Alberto R. Rodriguez, Greg Martin, Giordano Lippi, Sergey Kupriyanov, Zhuhao Wu, Pavel Osten, Juan Carlos Izpisua Belmonte, Jun Wu and Kristin K. Baldwin, 25 April 2024, Cell. DOI: 10.1016/j.cell.2024.03.042 “Generation of rat forebrain tissues in mice” by Jia Huang, Bingbing He, Xiali Yang, Xin Long, Yinghui Wei, Leijie Li, Min Tang, Yanxia Gao, Yuan Fang, Wenqin Ying, Zikang Wang, Chao Li, Yingsi Zhou, Shuaishuai Li, Linyu Shi, Seungwon Choi, Haibo Zhou, Fan Guo, Hui Yang and Jun Wu, 25 April 2024, Cell. DOI: 10.1016/j.cell.2024.03.017

Illustration of a quantum wave packet in close vicinity of a conical intersection between two potential energy surfaces. The wave packet represents the collective motion of multiple atoms in the photoactive yellow protein. A part of the wave packet moves through the intersection from one potential energy surface to the other, while another part remains on the top surface, leading to a superposition of quantum states. Credit: DESY, Niels Breckwoldt Artificial intelligence affords unprecedented insights into how biomolecules work. A new analytical technique is able to provide hitherto unattainable insights into the extremely rapid dynamics of biomolecules. The team of developers, led by Abbas Ourmazd from the University of Wisconsin–Milwaukee and Robin Santra from DESY, is presenting its clever combination of quantum physics and molecular biology in the scientific journal Nature. The scientists used the technique to track the way in which the photoactive yellow protein (PYP) undergoes changes in its structure in less than a trillionth of a second after being excited by light. “In order to precisely understand biochemical processes in nature, such as photosynthesis in certain bacteria, it is important to know the detailed sequence of events,” Santra explains their underlying motivation. “When light strikes photoactive proteins, their spatial structure is altered, and this structural change determines what role a protein takes on in nature.” Until now, however, it has been almost impossible to track the exact sequence in which structural changes occur. Only the initial and final states of a molecule before and after a reaction can be determined and interpreted in theoretical terms. “But we don’t know exactly how the energy and shape changes in between the two,” says Santra. “It’s like seeing that someone has folded their hands, but you can’t see them interlacing their fingers to do so.” Whereas a hand is large enough and the movement is slow enough for us to follow it with our eyes, things are not that easy when looking at molecules. The energy state of a molecule can be determined with great precision using spectroscopy; and bright X-rays for example from an X-ray laser can be used to analyze the shape of a molecule. The extremely short wavelength of X-rays means that they can resolve very small spatial structures, such as the positions of the atoms within a molecule. However, the result is not an image like a photograph, but instead a characteristic interference pattern, which can be used to deduce the spatial structure that created it. Bright and short X-ray flashes Since the movements are extremely rapid at the molecular level, the scientists have to use extremely short X-ray pulses to prevent the image from being blurred. It was only with the advent of X-ray lasers that it became possible to produce sufficiently bright and short X-ray pulses to capture these dynamics. However, since molecular dynamics takes place in the realm of quantum physics where the laws of physics deviate from our everyday experience, the measurements can only be interpreted with the help of a quantum-physical analysis. A peculiar feature of photoactive proteins needs to be taken into consideration: the incident light excites their electron shell to enter a higher quantum state, and this causes an initial change in the shape of the molecule. This change in shape can in turn result in the excited and ground quantum states overlapping each other. In the resulting quantum jump, the excited state reverts to the ground state, whereby the shape of the molecule initially remains unchanged. The conical intersection between the quantum states therefore opens a pathway to a new spatial structure of the protein in the quantum mechanical ground state. The team led by Santra and Ourmazd has now succeeded for the first time in unraveling the structural dynamics of a photoactive protein at such a conical intersection. They did so by drawing on machine learning because a full description of the dynamics would in fact require every possible movement of all the particles involved to be considered. This quickly leads to unmanageable equations that cannot be solved. 6000 dimensions “The photoactive yellow protein we studied consists of some 2000 atoms,” explains Santra, who is a Lead Scientist at DESY and a professor of physics at Universität Hamburg. “Since every atom is basically free to move in all three spatial dimensions, there are a total of 6000 options for movement. That leads to a quantum mechanical equation with 6000 dimensions – which even the most powerful computers today are unable to solve.” However, computer analyses based on machine learning were able to identify patterns in the collective movement of the atoms in the complex molecule. “It’s like when a hand moves: there, too, we don’t look at each atom individually, but at their collective movement,” explains Santra. Unlike a hand, where the possibilities for collective movement are obvious, these options are not as easy to identify in the atoms of a molecule. However, using this technique, the computer was able to reduce the approximately 6000 dimensions to four. By demonstrating this new method, Santra’s team was also able to characterize a conical intersection of quantum states in a complex molecule made up of thousands of atoms for the first time. The detailed calculation shows how this conical intersection forms in four-dimensional space and how the photoactive yellow protein drops through it back to its initial state after being excited by light. The scientists can now describe this process in steps of a few dozen femtoseconds (quadrillionths of a second) and thus advance the understanding of photoactive processes. “As a result, quantum physics is providing new insights into a biological system, and biology is providing new ideas for quantum mechanical methodology,” says Santra, who is also a member of the Hamburg Cluster of Excellence “CUI: Advanced Imaging of Matter”. “The two fields are cross-fertilizing each other in the process.” Reference: “Few-fs resolution of a photoactive protein traversing a conical intersection” by A. Hosseinizadeh, N. Breckwoldt, R. Fung, R. Sepehr, M. Schmidt, P. Schwander, R. Santra and A. Ourmazd, 3 November 2021, Nature. DOI: 10.1038/s41586-021-04050-9

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