Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

🔗 Learn more or get in touch:
🌐 Website: https://www.deryou-tw.com/
📧 Email: shela.a9119@msa.hinet.net
📘 Facebook: facebook.com/deryou.tw
📷 Instagram: instagram.com/deryou.tw

Taiwan anti-bacterial pillow ODM design

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Pillow OEM for wellness brands Thailand

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Taiwan ODM expert for comfort products

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Private label insole and pillow OEM Vietnam

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Smart pillow ODM manufacturer Vietnam

Fruit fly germline stem cells, the cells that make sperm or eggs. Credit Jonathan Nelson/ Whitehead Institute The genetic makeup of many species, including humans, contains crucial components known as ribosomal DNA (rDNA) sequences. Due to their highly repetitive pattern, these DNA sequences tend to reduce in size over time, leading to cell death if they shrink excessively. If this happens in germ cells — cells that give rise to eggs and sperm — it can result in infertility and the potential extinction of the individual’s lineage. Scientists have long theorized that some mechanism works to preserve our rDNA over successive generations, thereby maintaining the fertility of humans and other species. However, the specifics of this process remained unclear until recently. New findings from Yukiko Yamashita, a member of the Whitehead Institute, and postdoc Jonathan Nelson, unveiled an unexpected defender of rDNA: a retrotransposon. Prior to this discovery, retrotransposons were predominantly considered genetic parasites because they seemed to exist only to replicate themselves. Their research, recently published in the journal PNAS, explains how this so-called parasite actually plays an essential role in maintaining rDNA and preserving fertility through the generations. The Puzzle of Why rDNA Does Not Disappear rDNA generates the RNA subunits of ribosomes, the cellular machines that make proteins, the cells’ essential workers, by translating genes. Our cells require many ribosomes to make all of the proteins they need to function, so rDNA is full of repeated copies of the sequence for making ribosome parts. The problem with this kind of repetitive DNA is that it’s easy for the cell to accidentally remove some of the identical repeats when replicating the genome during cell division. Over time, as cells go through multiple divisions, the number of repeats would be expected to get smaller and smaller. This problem would be particularly noticeable in the cells of aging individuals and in germ cells, the only cells that get passed from one generation to the next. If nothing were helping rDNA to recover its missing repeats, then each new generation would start out with fewer repeats than the last, until a generation did not have enough repeats left to make viable germ cells—and so that population would die out. Yamashita, who is also a professor of biology at the Massachusetts Institute of Technology and an Investigator with the Howard Hughes Medical Institute, studies germ cell immortality in male fruit flies (Drosophila melanogaster). That is, she studies how germ cells can keep making healthy sperm and eggs throughout many generations of individuals. Every other type of cell dies with the body it is born in, and so the genomes of these cells can accrue some damage over time—such as losing repeats in their rDNA—without much consequence. However, errors in the germ cell genome can accumulate over the generations, so germ cells must be especially careful to maintain their rDNA in order to preserve their immortality. When germ cells lose too many rDNA repeats, they are able to replace them with new repeats, but no one has known how they were able to do this. Nelson and Yamashita set out to find the answer. “Ribosomal DNA is repetitive and so is bound to be lost, and the logical consequence is that we should all lose the rDNA in our germ cells and the future generations would be totally gone,” Yamashita says. “So how come that hasn’t happened yet? This is the kind of question that’s so big you don’t even see it at first—you take it for granted that something is maintaining rDNA—but once we saw that the question was there, we needed to find the answer.” Retrotransposons: Not So Selfish After All What the researchers discovered is that rDNA is restored with the help of a retrotransposon, R2. Retrotransposons are genetic sequences whose primary function is to replicate themselves, even at the expense of the rest of the genome. They have been called genetic parasites, but their behavior is most similar to that of a virus, which manipulates cells into making copies of itself. The way a retrotransposon makes more copies of itself is by reversing the usual process of gene expression. When the DNA coding for a retrotransposon is read into RNA, that RNA can be read back into DNA. The retrotransposon then slices open the cell’s genome and inserts its new DNA, adding another copy of itself to the genome. This process not only balloons the size of a species’ genome over generations—nearly half of the human genome consists of transposable elements—but it can also cause damage to an individual cell. When a retrotransposon slices open the genome, especially if it then inserts itself into the middle of a necessary DNA sequence, that can render important genes unusable. However, Nelson and Yamashita found that the retrotransposon R2, which typically copies and inserts itself into fruit fly rDNA, can also help cells. In a dividing cell, there are two copies of each chromosome—one to go in each of the new daughter cells. R2 slices open both copies of the chromosome containing rDNA. When the cell tries to repair these breaks, the repetitive nature of the rDNA can essentially make it lose its place, so it stitches a stretch of rDNA repeats from one copy of the chromosome into the other copy of the chromosome instead. This means that one of the daughter cells will end up with more repeats in its rDNA than the original cell had, while the other daughter cell will have fewer repeats. The germ cells can then protect their immortality by making sure that the cell with more repeats in its rDNA is the one used to keep the germline going. Another paper from Yamashita’s lab, published in 2022, identified how germ cells make this selection. Germ cells divide asymmetrically, so one of the new daughter cells remains a germline stem cell, continuing to make more germ cells, and the other daughter cell differentiates or begins down the path of making sperm. Yamashita lab postdoc George Watase and Yamashita discovered a gene, which they named Indra, that creates a protein that attaches to the copy of the chromosome containing more rDNA repeats. This protein marks the daughter cell containing that chromosome to remain a stem cell, while the other daughter cell goes on to make sperm. Germ cells can combine these mechanisms, taking rDNA repeats from one chromosome to give to another and then earmarking the cell with more repeats, to constantly replenish the germline’s level of rDNA. This ensures that the number of rDNA repeats never gets too low across the population of germ cells, preserving the lineage of the cells and the individuals who carry them. Nelson and Yamashita’s work shows that R2 is not merely a selfish parasite, but instead plays a pivotal role in this process of germline rDNA rejuvenation. However, as a retrotransposon, R2 is also capable of causing damage. Nelson found that germ cells keep R2 inactive except in cases where the number of repeats in rDNA is too low. In this way, the cells may maximize the benefits of R2 and minimize its dangers, by only accepting the risk of damage when needed. This may allow the cell and retrotransposon to have a mutually beneficial relationship. Yamashita and Nelson speculate that other transposable elements may likewise provide unknown benefits to the cell. “A lot of transposable elements are thought of as existing because their ability to replicate in the genome is better than the ability of the host to defend itself from that replication,” Nelson says. “These elements make up large regions of the genome that we think of as non-functional, but what if the reason why there are so many of them is because they contribute some function that we just don’t understand yet?” References: “The retrotransposon R2 maintains Drosophila ribosomal DNA repeats” by Jonathan O. Nelson, Alyssa Slicko and Yukiko M. Yamashita, 30 May 2023, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2221613120 “Nonrandom sister chromatid segregation mediates rDNA copy number maintenance in Drosophila” by George J. Watase, Jonathan O. Nelson and Yukiko M. Yamashita, 27 July 2022, Science Advances. DOI: 10.1126/sciadv.abo4443

A new species of the extinct genus Ontocetus, named Ontocetus posti, has been discovered in the Lower Pleistocene deposits of the North Atlantic, displaying feeding adaptations similar to those of the modern walrus, Odobenus rosmarus. Credit: Jaime Bran Scientists discovered a new species, Ontocetus posti, showing feeding similarities with the modern walrus and reflecting convergent evolution. This species, adapted to suction-feeding, highlights the role of environmental changes in the evolutionary history of marine mammals, from its migration patterns to its extinction in the face of global cooling. A team of paleontologists, led by Dr. Mathieu Boisville from the University of Tsukuba in Japan, has uncovered a new species of the extinct genus Ontocetus from the Lower Pleistocene deposits in the North Atlantic. This species, named Ontocetus posti, displays surprising similarities in feeding adaptations to the modern walrus (Odobenus rosmarus), highlighting an intriguing case of convergent evolution. The research is published in the open-access journal PeerJ Life & Environment. The fossils of Ontocetus posti were discovered in Norwich, United Kingdom, and Antwerp, Belgium. These remains were initially thought to belong to another species, Ontocetus emmonsi; however, detailed analysis of the mandibles revealed a unique combination of features that distinguish it as a new species. These features include the presence of four post-canine teeth, a larger lower canine, and a fused and short mandibular symphysis. Such anatomical characteristics suggest that Ontocetus posti was quite well adapted to suction-feeding, somewhat similar to its modern relative, the walrus. Historical Migration and Extinction Originating from the North Pacific Ocean, the Ontocetus genus spread to the Atlantic during the Mio-Pliocene transition. This migration was probably facilitated by the Central American Seaway, a crucial oceanic passage before the closure of the Isthmus of Panama. The resulting global cooling starting during the Late Pliocene significantly impacted marine life, contributing to the extinction of Ontocetus posti during the Early Pleistocene and allowing the cold-adapted Odobenus rosmarus to emerge and eventually dominate. The discovery sheds light on the evolutionary history of walruses, emphasizing how environmental changes have shaped the adaptations and survival of marine mammals. The convergence of feeding adaptations between Ontocetus posti and the modern walrus illustrates the dynamic evolutionary processes that occur across different eras and environments. Reference: “New species of Ontocetus (Pinnipedia: Odobenidae) from the Lower Pleistocene of the North Atlantic shows similar feeding adaptation independent to the extant walrus (Odobenus rosmarus)” by Mathieu Boisville​, Narimane Chatar and Naoki Kohno, 13 August 2024, PeerJ. DOI: 10.7717/peerj.17666

Recent research shows that neurons in the visual cortex alter their responses to the same stimulus over time. New research from Washington University in St. Louis reveals that neurons in the visual cortex — the part of the brain that processes visual stimuli — change their responses to the same stimulus over time. Although other studies have documented “representational drift” in neurons in the parts of the brain associated with odor and spatial memory, this result is surprising because neural activity in the primary visual cortex is thought to be relatively stable. The study published today (August 27, 2021) in Nature Communications was led by Ji Xia, a recent PhD graduate of the laboratory of Ralf Wessel, professor of physics in Arts & Sciences. Xia is now a postdoctoral fellow at Columbia University. “We know that the brain is a flexible structure because we expect the neural activity in the brain to change over days when we learn, or when we gain experience — even as adults,” Xia said. “What is somewhat unexpected is that even when there is no learning, or no experience changes, neural activity still changes across days in different brain areas.” Researchers in Wessel’s group explore sensory information processing in the brain. Working with collaborators, they use novel data analysis to address questions of dynamics and computation in neural circuits of the visual cortex of the brain. Study co-senior author Michael J. Goard, from the Neuroscience Research Institute at the University of California, Santa Barbara, showed mice a single, short movie clip on a loop. (They used a section of the opening from a classic Orson Welles black-and-white film, de rigueur for today’s mouse vision studies.) While a mouse watched the movie, researchers simultaneously recorded activity in several hundred neurons in the primary visual cortex, using two-photon calcium imaging. The scientists repeated the viewing sessions weekly for up to seven weeks, recording the activity of the same neurons in the same mice as they watched the loop of the same 30-second movie clip. Then the physicists at Washington University parsed the data from the movie-watching mice, using new computational approaches to analyze the changes in neuronal population activity over time. The researchers discovered that single-neuron responses to natural movies are unstable across weeks. In other words, individual neurons did not respond the same way to the visual stimuli — what was happening on the screen at the exact same moment in the film — when the mouse watched the film one week as compared with another week. This research finding was consistent with a study published by their collaborators in the same journal issue, Xia said. However, in this particular study, the Washington University physicists were able to develop a way to decode the response to the visual stimuli across weeks if they factored in the population activity all of the neurons tracked for a given mouse — they just couldn’t do it using individual neurons alone. Although Xia mapped out a consistent representation of the movie clip using the population activity, the scientists still don’t know whether this representation from the primary visual cortex is what the downstream brain areas are actually reading out. Over the past 10 years, neuroscientists have increasingly documented similar examples of this “representational drift” in neural activity within different areas of the brain — with the first studies reporting drift in the activity of neurons in the hippocampus and the posterior parietal cortex. But even with those studies already in print, many scientists are not prepared to deal with the possibility of drift in other areas of the brain, Xia said. “People still don’t expect this kind of drift to be coming from the primary visual cortex,” she said. “The general belief is that those primary sensory cortices should be very reliable, because they are expected to faithfully encode the information from the sensory stimuli.” References: “Stable representation of a naturalistic movie emerges from episodic activity with gain variability” by Ji Xia, Tyler D. Marks, Michael J. Goard and Ralf Wessel, 27 August 2021, Nature Communications. DOI: 10.1038/s41467-021-25437-2 “Stimulus-dependent representational drift in primary visual cortex” by Tyler D. Marks, and Michael J. Goard, 27 August 2021, Nature Communications. DOI: 10.1038/s41467-021-25436-3

DVDV1551RTWW78V