Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Graphene insole OEM factory Vietnam

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Thailand OEM insole and pillow supplier

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Indonesia insole OEM manufacturer

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Arch support insole OEM from Vietnam

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Indonesia ODM expert for comfort products

Cat  and catnip Silver vine triggers euphoric behavior in cats and acts as a mosquito repellent. Catnip and silver vine have been known as cat attractant plants. Cat lovers use dry leaves of these plants and toys stuffed with the leaves to give joy to their pet cats. But how does this work? What is the biological significance of the responsive behavior? A research group at Iwate University, Nagoya University, Kyoto University, and University of Liverpool found that the behavior had more practical reasons than getting euphoria. “The first appearance of silver vine (“Matatabi” in Japanese) as a cat attractant in literature in Japan dates back to more than 300 years ago. A folklore Ukiyo-e drawn in 1859 shows a group of mice trying to tempt some cats with a smell of silver vine. Still, benefits of the cats’ response had remained unknown,” says Prof. Masao Miyazaki of Iwate University, a leader of the research project. The research group first identified the active ingredient of silver vine that induces the response. They isolated substances from the extract of silver vine leaves and administered each of them to cats to examine the response. The experiment revealed that nepetalactol, a novel substance, most strongly induces the characteristic behavior. “We applied nepetalactol to laboratory paper filters and tested with eighteen laboratory and seventeen feral cats. They displayed the typical response to silver vine. We also tested the substance with larger, non-domestic cats (jaguar, Amur leopard, and Eurasian lynx). They showed a similar reaction. We concluded nepetalactol is responsible for the typical feline reaction to silver vine,” said Reiko Uenoyama, the paper’s first author. Euphoria and the Feline Nervous System The second important finding by the researchers is the biological mechanism of the response by feline animals to silver vine. They hypothesized that the μ-opioid system, which is associated with euphoric effects in humans, is activated with the plant. “We tested β-endorphin levels before and after nepetalactol-induced response in cat blood. We found that silver vine activates the nervous system that is responsible for the euphorigenic reaction,” said Miyazaki. Does this mean cats play with silver vine to get euphoria? Alternatively, does silver vine have another function for cats? The research group believed that the plant has another biologically important function as the reaction was already shown in feline animals when they evolved from other species about 10 million years ago. A cat responds to silver vine leaves. Credit: Masao Miyazaki & Reiko Uenoyama “On the basis of some reports that nepetalactone, the feline attractant in catnip, has mosquito repellent activity, we thought that the response allows cats to transfer plant’s nepetalactol or nepetalactone on their fur for protection against mosquitoes. This led to a strong hypothesis when we found the mosquito repellent activity of nepetalactol.” said Uenoyama. A Chemical Shield: Rubbing for Mosquito Defense To examine whether cats purposefully transfer nepetalactol, the research group placed paper filters with nepetalactol on different parts of the cat cage (floor, walls, and ceiling). Although cats rubbed their faces and heads on the paper regardless of the place of the nepetalactol paper, they did not show the typical rolling when the paper was placed on a wall or ceiling. When cats rubbed against the nepetalactol paper, the substance was transferred to their faces and heads, indicating that the most important function of rubbing behavior is to apply the chemical to these parts of feline fur. “Next, we tested the mosquito repellent property of nepetalactol on cats. We counted the number of mosquitoes landing on cat heads with and without application of nepetalactol. The mosquitoes landed less on the nepetalactol heads. To see whether mosquitoes react the same in a more natural setting, we compared the mosquito reaction between cats that responded to silver vine leaves and nonresponsive cats. Mosquitoes avoided the responsive cats. From these results, we found that the cats’ reaction to silver vine is chemical defense against mosquitoes, and perhaps against viruses and parasitic insects. This was the most significant finding of our study,” said Miyazaki. Miyazaki and his colleagues see many possibilities to use the findings in research and practical application. “Why is this reaction limited to cats? Why don’t non-feline animals react to the plant? To find answers, we want to identify the gene responsible for the reaction. The findings of this study may be used in various applications, including development of new mosquito repellent products.” Reference: “The characteristic response of domestic cats to plant iridoids allows them to gain chemical defense against mosquitoes” by Reiko Uenoyama, Tamako Miyazaki, Jane L. Hurst, Robert J. Beynon, Masaatsu Adachi, Takanobu Murooka, Ibuki Onoda, Yu Miyazawa, Rieko Katayama, Tetsuro Yamashita, Shuji Kaneko, Toshio Nishikawa and Masao Miyazaki, 20 January 2021, Science Advances. DOI: 10.1126/sciadv.abd9135

New images of the SIRT6 sirtuin enzyme—which regulates aging and other metabolic processes—help explain how it is able to access genetic material within the cell. This cryo-electron microscopy map shows the enzyme in complex with the nucleosome, a tightly packed complex of DNA and proteins called histones. Credit: Song Tan Lab, Penn State Penn State researchers have revealed how sirtuin enzymes interact with nucleosomes to regulate aging and metabolic processes. Their findings, using cryo-electron microscopy, may inform drug discovery efforts targeting sirtuins for biomedical applications. New scientific research provides insight into how an enzyme that helps regulate aging and other metabolic processes accesses our genetic material to modulate gene expression within the cell. A team led by Penn State researchers has produced images of a sirtuin enzyme bound to a nucleosome—a tightly packed complex of DNA and proteins called histones—showing how the enzyme navigates the nucleosome complex to access both DNA and histone proteins and clarifying how it functions in humans and other animals. A paper describing the results was published on April 14 in the journal Science Advances. Sirtuins are a type of enzyme found in organisms ranging from bacteria to humans that play important roles in aging, sensing DNA damage, and suppressing tumors in various cancers. Because of these varied roles, pharmaceutical companies are exploring their potential for biomedical applications. Much effort has focused on the ability of some sirtuins to decrease gene expression by removing a chemical flag from histone proteins. Nucleosomes in Gene Expression “In our cells, DNA is not naked like we see it in textbooks; it is spooled around proteins called histones within a large complex called the nucleosome,” said Song Tan, Verne M. Willaman Professor of Molecular Biology at Penn State and an author of the paper. “This packaging can also contribute signals for turning on or turning off genes: Adding an ‘acetyl’ chemical flag to the histone packaging material turns on a gene, while removing the acetyl flag turns the gene off. Sirtuins can silence gene activity by removing the acetyl flag from histones packaged into nucleosomes. Understanding how sirtuins interact with the nucleosome to remove this flag could inform future drug discovery efforts.” Previous studies have focused on how sirtuins interact with short segments of histones in isolation, in part because such histone “tail” peptides are much easier to work with in the lab. According to Tan, the nucleosome is a hundred times larger than typical histone peptides used in these studies and are consequently much more complicated to work with. “We have visualized a sirtuin enzyme called SIRT6 on its physiologically relevant substrate—the entire nucleosome,” said Jean-Paul Armache, assistant professor of biochemistry and molecular biology at Penn State and an author of the paper. “And we found that SIRT6 interacts with multiple parts of the nucleosome, not only the histone where the acetyl flag is to be modified.” Using a powerful type of imaging called cryo-electron microscopy with instruments at the Penn State Cryo-Electron Microscopy Facility, the National Cancer Institute, and the Pacific Northwest Cryo-EM Center, the researchers identified how SIRT6 positions itself on the nucleosome in order to remove an acetyl group from the K9 position on the histone called H3. Following up with biochemical experiments—in collaboration with the lab of Craig Peterson at the University of Massachusetts Chan Medical School—helped confirm their results. Arginine Anchor The researchers found that SIRT6 binds to the nucleosome using a type of connection called an “arginine anchor.” This type of binding—described by Tan’s lab in 2014—is used by a variety of proteins that target a particularly acidic patch on the nucleosome’s surface. In this case, a structural feature of SIRT6 called an extended loop nestles into a divot in the acidic patch, somewhat like a pipe sitting in a ditch. “The arginine anchor is a common paradigm for how many chromatin proteins interact with the nucleosome,” said Tan. “When we mutated the SIRT6 arginine anchor, the activity at the K9 position was severely affected, supporting a critical role for the SIRT6’s arginine anchor. Surprisingly, this mutation also impacted SIRT6’s enzymatic activity at a different position, K56, located much further away.” Instead of SIRT6 binding to the nucleosome in two different ways to access the two different histone positions, it is possible that SIRT6 binds to access K9 in a way that might also provide access to K56. “SIRT6 binds to a partially unwrapped nucleosome, with DNA displaced from the end of the nucleosome,” said Armache. “This exposes the K56 position, and it is possible that SIRT6 could essentially lean down to reach that position. We would like to validate this hypothesis in the future. We also hope to explore how SIRT6 works alongside other enzymes and to better understand its role in the response to DNA damage.” Reference: “Cryo-EM structure of the human Sirtuin 6–nucleosome complex” by Un Seng Chio, Othman Rechiche, Alysia R. Bryll, Jiang Zhu, Erik M. Leith, Jessica L. Feldman, Craig L. Peterson, Song Tan and Jean-Paul Armache, 14 April 2023, Science Advances. DOI: 10.1126/sciadv.adf7586 In addition to Tan, Armache, and Peterson, the research team at Penn State includes postdoctoral scholars Un Seng Chio, Othman Rechiche, and Jiang Zhu and graduate student Erik Leith. The research team at the UMass Chan Medical School also includes Alysia Bryll and Jessica Feldman. This research was supported by the U.S. National Institutes of Health and the Pennsylvania Department of Health using Tobacco CURE funds.

Ants learn from experience and adjust their aggression based on past encounters with competitors. A study showed ants remembered aggressive rivals and responded with heightened aggression, while displaying less aggression towards passive opponents. Ants learn from past encounters, showing more aggression toward familiar aggressive rivals and less toward passive ones. This reveals ants can adapt their behavior based on experience. Ants are capable of learning from experience, as demonstrated by a team of evolutionary biologists from the University of Freiburg. The research was led by Dr. Volker Nehring, a research associate in the Evolutionary Biology and Animal Ecology group, alongside doctoral student Mélanie Bey. In the study, ants were repeatedly exposed to competitors from different nests. The ants remembered these interactions and adjusted their behavior accordingly. When they encountered ants from a nest previously associated with aggression, they responded with increased aggression. In contrast, ants that had only met passive individuals from another nest showed less aggressive behavior. These findings highlight ants’ ability to adapt their responses based on past experiences. The study was published in the journal Current Biology. Ants are aggressive towards their neighbours Ants use odors to distinguish between members of their own nest and those from other nests. Each nest has its own specific scent. Previous studies have already shown that ants behave aggressively towards their nearest neighbors in particular. They are especially likely to open their mandibles and bite, or spray acid and kill their competitors. They are less likely to carry out such aggressive manoeuvres against nests that are further away from their own. Until now, it was unclear why this is the case. Nehring’s team has now discovered that ants remember the smell of attackers. This is why they are more aggressive when confronted with competitors from nests they are familiar with. More aggressive behavior towards competitors from familiar nests The scientists conducted an experiment in two phases. In the first phase, ants gained various experiences: one group encountered ants from their own nest, the second group encountered aggressive ants from a rival nest A, and the third group encountered aggressive ants from rival nest B. A total of five encounters took place on consecutive days, with each encounter lasting one minute. In the subsequent test phase, the researchers examined how the ants from the different groups behaved when they encountered competitors from nest A. The ants that had already been confronted with conspecifics from this nest in the first phase behaved significantly more aggressively than those from the other two groups. To test the extent to which the higher aggression arises from the behavior of ants from a particular nest, the scientists repeated the experiment in a slightly modified form. In the first phase, they now distinguished between encounters with aggressive and passive ants. They ensured that an ant behaved passively by cutting off its antennae. In phase two of the experiment, the ants that had previously only encountered passive competitors behaved significantly less aggressively. “We often have the idea that insects function like pre-programmed robots,” says Nehring. “Our study provides new evidence that, on the contrary, ants also learn from their experiences and can hold a grudge.” Next, Nehring and his team will investigate whether and to what extent ants adapt their olfactory receptors to their experiences, thus reflecting what they have learned at this level as well. Reference: “Associative learning of non-nestmate cues improves enemy recognition in ants” by Mélanie Bey, Rebecca Endermann, Christina Raudies, Jonas Steinle and Volker Nehring, 31 December 2024, Current Biology. DOI: 10.1016/j.cub.2024.11.054 The research was funded by the German Research Foundation (project number NE1969/6-1).

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