Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Innovative insole ODM solutions in Indonesia

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Smart pillow ODM manufacturer Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Taiwan orthopedic insole OEM manufacturing site

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Cushion insole OEM solution Thailand

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene insole manufacturer in China

A new study has identified the set of neurons that controls sickness behaviors. New Research Reveals New Information About Sickness Behaviors When we’re feeling under the weather, we tend to eat, drink, and exercise less. We’re not the only ones either; while fighting an infection, the majority of animals lower the same three behaviors. Recent research has identified the cluster of neurons that drive these responses, known as sickness behaviors. Researchers discovered that a particular population of cells in the brainstem can cause three telltale sickness behaviors in mice by triggering immune responses. Furthermore, inhibiting these neurons dampens each of these behavioral aspects of the sickness response. The results, published in Nature, establish a direct relationship between inflammation and neural pathways that regulate behavior, providing insight into how the immune system interacts with the brain. “We are still in the early days of trying to understand the brain’s role in infection,” says Jeffrey M. Friedman, Marilyn M. Simpson Professor at The Rockefeller University. “But with these results, we now have a unique opportunity to ask: What does your brain look like when you’re sick?” Brain cells that express the neuropeptide ADCYAP1, tagged here with a fluorescent protein, induce some sickness behaviors. Credit: Laboratory of Molecular Genetics at The Rockefeller University Sickness behaviors have been proven to be crucial in an animal’s recovery from an infection. Prior research has backed that idea by revealing that forcing sick animals to eat increases mortality dramatically. “These behavioral changes during infection are really important for survival,” says lead author Anoj Ilanges, a former graduate student in Friedman’s lab, now a group leader at the HHMI Janelia Research Campus. However, it has never been understood how the brain coordinates the almost universal urge to reject food and cuddle up beneath the covers with the onset of infection. As a result, Friedman and Ilanges set out to map the brain areas responsible for sickness behaviors in mice. Linking the Brainstem to Immune Responses The team began by exposing mice to LPS, a piece of bacterial cell wall that activates the immune system and potently induces sickness behavior. Shortly after an injection of LPS, there was a spike in activity in a brainstem region known as the dorsal vagal complex, among a population of neurons expressing the neuropeptide ADCYAP1. To confirm that they had found the right brain cells, the researchers then activated those neurons in healthy mice and they found that the animals ate, drank, and moved around less. In contrast, when the ADCYAP1 neurons were deactivated, the effect of LPS on these behaviors was significantly reduced. “We didn’t know if the same or different neurons regulated each of these behaviors,” Friedman says, “We found it surprising that a single neuronal population appears to regulate each of these components of the sickness response.” Dorsal Vagal Complex The authors were not, however, altogether surprised that this brainstem region was involved in mediating sickness behaviors. The dorsal vagal complex is one of a precious few physiological crossroads of the central nervous system, where an absence of the blood-brain barrier enables circulating factors in the blood to pass information directly to the brain. “This region has emerged as a kind of alert center for the brain, conveying information about aversive or noxious substances that, more often than not, reduce food intake,” Friedman says. In the coming months, Friedman’s team at Rockefeller intends to incorporate these findings into their overall goal of understanding the physiological signals and neural circuitry that regulate feeding behavior. They are specifically interested in understanding why even mice engineered to eat voraciously will nonetheless stop eating when exposed to bacterial infections. Meanwhile, Ilanges plans to investigate what role other brain regions play in response to infections, expanding our knowledge of the brain’s role during this critical process. “We looked at one region of the brain, but there are many others that become activated with the immune response,” he says. “This opens the door to asking what the brain is doing, holistically, during infection.” Reference: “Brainstem ADCYAP1+ neurons control multiple aspects of sickness behaviour” by Anoj Ilanges, Rani Shiao, Jordan Shaked, Ji-Dung Luo, Xiaofei Yu, and Jeffrey M. Friedman, 7 September 2022, Nature. DOI: 10.1038/s41586-022-05161-7

The research on mice sheds light on how brain activity is fine-tuned. A New Study Explores How New Information Is Across the Sleep-Wake Cycle Researchers discovered a new daily rhythm in a kind of synapse that dampens brain activity using a mouse model. These neural connections, known as inhibitory synapses, are rebalanced as we sleep to allow us to consolidate new information into lasting memories. The results, which were published in the journal PLOS Biology, may help explain how subtle synaptic changes improve memory in humans. Researchers from the National Institute of Neurological Disorders and Stroke (NINDS), which is part of the National Institutes of Health, led the study. “Inhibition is important for every aspect of brain function. But for over two decades, most sleep studies have focused on understanding excitatory synapses,” said Dr. Wei Lu, senior investigator at NINDS. “This is a timely study to try to understand how sleep and wakefulness regulate the plasticity of inhibitory synapses.” Wakefulness and Synaptic Plasticity Kunwei Wu, Ph.D., a postdoctoral fellow in Dr. Lu’s lab, investigated what occurs at inhibitory synapses in mice during sleep and wakefulness. Electrical recordings from neurons in the hippocampus, a brain region involved in memory formation, revealed a previously unknown pattern of activity. During wakefulness, steady “tonic” inhibitory activity increased but fast “phasic” inhibition decreased. They also discovered a far larger activity-dependent enhancement of inhibitory electrical responses in awake mouse neurons, suggesting that wakefulness, rather than sleep, might strengthen these synapses to a greater extent. Inhibitory neurons use the neurotransmitter gamma-aminobutyric acid (GABA) to reduce nervous system activity. These neurons release GABA molecules into the synaptic cleft, the space between neurons where neurotransmitters diffuse, at inhibitory synapses. The molecules bind to GABAA receptors on the surface of neighboring excitatory neurons, causing them to fire less often. Key Role of α5-GABAA Receptors Further experiments showed that the synaptic changes during wakefulness were driven by an increased number of α5-GABAA receptors. When the receptors were blocked in awake mice, the activity-dependent enhancement of phasic electrical responses diminished. This suggests that the accumulation of GABAA receptors during wakefulness may be key to building stronger, more efficient inhibitory synapses, a fundamental process known as synaptic plasticity. “When you are learning new information during the day, neurons are bombarded with excitatory signals from the cortex and many other areas of the brain. To transition this information into a memory, you first need to regulate and refine it—that’s where inhibition comes in,” said Dr. Lu. The Role of Parvalbumin and Somatostatin Interneurons Prior studies have shown that synaptic changes in the hippocampus may be driven by signals that arise from inhibitory interneurons, a special type of cell that comprises only about 10-20% of neurons in the brain. There are over 20 different subtypes of interneurons in the hippocampus, but recent studies have highlighted two types, known as parvalbumin and somatostatin, that are critically involved in synapse regulation. To identify which interneuron was responsible for the plasticity they observed, Dr. Lu’s team used optogenetics, a technique that uses light to turn cells on or off, and found that wakefulness led to more α5-GABAA receptors and stronger connections from parvalbumin, but not somatostatin, interneurons. Implications for Memory and Neurological Disorders Humans and mice share similar neural circuits underlying memory storage and other essential cognitive processes. This mechanism may be a way for inhibitory inputs to precisely control the ebb and flow of information between neurons and throughout entire brain networks. “Inhibition is actually quite powerful because it allows the brain to perform in a fine-tuned manner, which essentially underlies all cognition,” said Dr. Lu. Because inhibition is essential for nearly every aspect of brain function, this study could contribute to helping scientists understand not just sleep-wake cycles, but neurological disorders rooted in abnormal brain rhythms, such as epilepsy. In the future, Dr. Lu’s group plans to explore the molecular basis of GABAA receptor trafficking to inhibitory synapses. Reference: “Sleep and wake cycles dynamically modulate hippocampal inhibitory synaptic plasticity” by Kunwei Wu, Wenyan Han and Wei Lu, 1 November 2022, PLOS Biology. DOI: 10.1371/journal.pbio.3001812 The study was partly funded by the Intramural Research Program at the NINDS.

Fluorescent images of human neurons (stained with red, green, and blue) growing on coatings with fast-moving molecules (left) or conventional laminin (right) for 60 days. Neurons spread homogenously and showed more complex branching on the highly mobile coating developed at Northwestern. Credit: Northwestern University Researchers Pushed the Age Limit of Human Neurons Further Than Previously Possible A team of researchers led by Northwestern University has achieved a breakthrough by producing the most mature neurons to date from human induced pluripotent stem cells (iPSCs). This advancement opens up new avenues for medical research and the possibility of transplantation therapies for conditions such as neurodegenerative diseases and traumatic injuries. Previous efforts to turn stem cells into neurons have resulted in functionally immature neurons that resemble those from the early stages of development. The limited maturation achieved through current stem cell culture methods restricts their potential for studying neurodegeneration. The study was recently published in the journal Cell Stem Cell. To create the mature neurons, the team used “dancing molecules,” a breakthrough technique introduced last year by Northwestern professor Samuel I. Stupp. The team first differentiated human iPSCs into motor and cortical neurons and then placed them onto coatings of synthetic nanofibers containing the rapidly moving dancing molecules. Fluorescent image of a human neuron (red) growing on the coating with fast-moving molecules (green) for 60 days. Credit: Northwestern University Not only were the enriched neurons more mature, but they also demonstrated enhanced signaling capabilities and greater branching ability, which is required for neurons to make synaptic contact with one another. And, unlike typical stem cell-derived neurons which tend to clump together, these neurons did not aggregate, making them less challenging to maintain. With further development, the researchers believe these mature neurons could be transplanted into patients as a promising therapy for spinal cord injuries as well as neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson’s disease, Alzheimer’s disease, or multiple sclerosis. The mature neurons also present new opportunities for studying neurodegenerative diseases like ALS and other age-related illnesses in culture dish-based in vitro models. By advancing the age of neurons in cellular cultures, researchers could improve experiments to better understand late-onset diseases. Fluorescent images of human neurons (stained with red, green, and blue) growing on coatings with fast-moving molecules (left) or conventional laminin (right) for 72 hours. Neurons attached and spread homogeneously on the highly mobile coating but remained clumped together on the laminin coating. Credit:Northwestern University “This is the first time we have been able to trigger advanced functional maturation of human iPSC-derived neurons by plating them on a synthetic matrix,” said Northwestern’s Evangelos Kiskinis, co-corresponding author of the study. “It’s important because there are many applications that require researchers to use purified populations of neurons. Most stem cell-based labs use mouse or rat neurons co-cultured with human stem cell-derived neurons. But that does not allow scientists to investigate what happens in human neurons because you end up working with a mixture of mouse and human cells.” “When you have an iPSC that you manage to turn into a neuron, it’s going to be a young neuron,” said Stupp, co-corresponding author of the study. “But, in order for it to be useful in a therapeutic sense, you need a mature neuron. Otherwise, it is like asking a baby to carry out a function that requires an adult human being. We have confirmed that neurons coated with our nanofibers achieve more maturity than other methods, and mature neurons are better able to establish the synaptic connections that are fundamental to neuronal function.” Kiskinis is an assistant professor of neurology and neuroscience at Northwestern University Feinberg School of Medicine, a New York Stem Cell Foundation-Robertson Investigator and a core faculty member of the Les Turner ALS Center. Stupp is the Board of Trustees Professor of Materials Science and Engineering, Chemistry, Medicine and Biomedical Engineering at Northwestern, where he is the founding director of the Simpson Querrey Institute for BioNanotechnology (SQI) and its affiliated research center, the Center for Regenerative Nanomedicine. Stupp has appointments in the McCormick School of Engineering, Weinberg College of Arts and Sciences, and Feinberg School of Medicine. Synchronized ‘Dancing’ Abilities To develop the mature neurons, the researchers used nanofibers composed of “dancing molecules,” a material that Stupp’s lab developed as a potential treatment for acute spinal cord injuries. In previous research published in the journal Science, Stupp discovered how to tune the motion of molecules, so they can find and properly engage with constantly moving cellular receptors. By mimicking the motion of biological molecules, the synthetic materials can communicate with cells. A key innovation of Stupp’s research was discovering how to control the collective motion of more than 100,000 molecules within the nanofibers. Because cellular receptors in the human body can move at swift rates — sometimes at timescales of milliseconds — they become difficult-to-hit moving targets. “Imagine dividing a second into 1,000 time periods,” Stupp said. “That’s how fast receptors could move. These timescales are so fast that they are difficult to grasp.” In the new study, Stupp and Kiskinis found that nanofibers tuned to contain molecules with the most motion led to the most enhanced neurons. In other words, neurons cultured on more dynamic coatings — essentially scaffolds composed of many nanofibers — were also the neurons that became the most mature, least likely to aggregate, and had more intense signaling capabilities. “The reason we think this works is because the receptors move very fast on the cell membrane and the signaling molecules of our scaffolds also move very fast,” Stupp said. “They are more likely to be synchronized. If two dancers are not in sync, then the pairing doesn’t work. The receptors become activated by the signals through very specific spatial encounters. It also is possible that our fast-moving molecules enhance receptor movement, which in turn helps cluster them to benefit signaling.” Neurons With ALS Signature Provide a New Window Into the Disease Stupp and Kiskinis believe their mature neurons will give insights into aging-related illnesses and become better candidates for testing various drug therapies in cellular cultures. Using the dancing molecules, the researchers were able to advance human neurons to much older ages than previously possible, enabling scientists to study the onset of neurodegenerative diseases. As part of the research, Kiskinis and his team took skin cells from a patient with ALS and converted them into patient-specific iPSCs. Then, they differentiated those stem cells into motor neurons, which is the cell type afflicted in this neurodegenerative disease. Finally, the researchers cultured neurons on the novel synthetic coating materials to further develop ALS signatures. Not only did this give Kiskinis a new window into ALS, but these “ALS neurons” also could be used to test potential therapies. “For the first time, we have been able to see adult-onset neurological protein aggregation in the stem cell-derived ALS patient motor neurons. This represents a breakthrough for us,” Kiskinis said. “It’s unclear how the aggregation triggers the disease. It’s what we are hoping to find out for the first time.” Hopes for Future Treatment for Spinal Cord Injuries, Neurodegenerative Diseases Further down the road, iPSC-derived mature, enhanced neurons also could be transplanted into patients with spinal cord injuries or neurodegenerative diseases. For example, physicians could take skin cells from a patient with ALS or Parkinson’s disease, convert them into iPSCs, and then culture those cells on the coating to create healthy, highly functional neurons. Transplanting healthy neurons into a patient could replace damaged or lost neurons, potentially restoring lost cognition or sensations. And, because the initial cells came from the patient, the new, iPSC-derived neurons would genetically match the patient, eliminating the possibility of rejection. “Cell replacement therapy can be very challenging for a disease like ALS, as transplanted motor neurons in the spinal cord will need to project their long axons to the appropriate muscle sites in the periphery but could be more straightforward for Parkinson’s disease,” Kiskinis said. “Either way this technology will be transformative.” “It is possible to take cells from a patient, transform them into stem cells and then differentiate them into different types of cells,” Stupp said. “But the yield for those cells tends to be low, and achieving proper maturation is a big issue. We could integrate our coating into large-scale manufacturing of patient-derived neurons for cell transplantation therapies without immune rejection.” References: “Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons” by Zaida Álvarez, J. Alberto Ortega, Kohei Sato, Ivan R. Sasselli, Alexandra N. Kolberg-Edelbrock, Ruomeng Qiu, Kelly A. Marshall, Thao Phuong Nguyen, Cara S. Smith, Katharina A. Quinlan, Vasileios Papakis, Zois Syrgiannis, Nicholas A. Sather, Chiara Musumeci, Elisabeth Engel, Samuel I. Stupp and Evangelos Kiskinis, 12 January 2023, Cell Stem Cell. DOI: 10.1016/j.stem.2022.12.010 “Bioactive scaffolds with enhanced supramolecular motion promote recovery from spinal cord injury” by Z. Álvarez, A. N. Kolberg-Edelbrock, I. R. Sasselli, J. A. Ortega, R. Qiu, Z. Syrgiannis, P. A. Mirau, F. Chen, S. M. Chin, S. Weigand, E. Kiskinis and S. I. Stupp, 11 November 2021, Science. DOI: 10.1126/science.abh3602 The study was funded by the National Institutes of Health, the Les Turner ALS Foundation, the New York Stem Cell Foundation, the U.S. Department of Energy, and Paralyzed Veterans of America Research Foundation.

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