Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan OEM factory for footwear and bedding

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.ODM pillow for sleep brands Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Indonesia insole OEM manufacturer

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Thailand orthopedic insole OEM manufacturer

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan custom insole OEM supplier

Humbertium covidum, an invasive hammerhead worm found in Italy. Credit: Pierre Gros Two new species of potentially invasive hammerhead flatworms from Europe (France and Italy) and Africa (Mayotte) “Alien” species of predatory hammerhead worms – including a spectacularly iridescent green-blue specimen – identified in Europe and Africa. One of the consequences of globalization is the inadvertent spread of invasive plant and animal species. Land flatworms have invaded the entire world, principally via the plant trade. More than ten species are now widespread, such as Obama nungara (originally from Argentina), Platydemus manokwari (from New Guinea) and Bipalium kewense (from Southeast Asia). Diversibipalium mayottensis, an invasive species of hammerhead worm found in Mayotte. Credit: Laurent Charles An international team led by Professor Jean-Lou Justine from ISYEB (Muséum National d’Histoire Naturelle, Paris, France) reports the description of two new species of hammerhead flatworms. This is the first study of these species, reported in an article published in the Open Access journal PeerJ. Land flatworms are predators of soil animals, including earthworms, slugs, and snails. They are a threat to soil biodiversity and ecology when they are introduced in a new environment. Hammerhead flatworms are specialized members of this family showing a broadened head. A number of species of hammerhead flatworms have been described by scientists, not from specimens from their land of origin, but from specimens obtained from the countries already invaded. This is the case, for instance, for the two species found in the USA, Bipalium pennsylvanicum and Bipalium adventitium, which originate from Asia but were not reported from any Asian country. The two new species described in this new paper follow a similar pattern. The research highlights the problem of alien species, and their potential to become invasive. They are one of the major threats to biodiversity, with considerable cost impacts on the economy. A full range of techniques were used, including citizen science, field expeditions, macro photography, classical morphology, and new generation sequencing in molecular biology. Hammerhead flatworms include some “giants” among land flatworms, with one species reaching one meter in length. However, the new species described here are small, possibly explaining why they escaped the attention of researchers before. The first new species was named Humbertium covidum in reference to the work being completed during lockdowns caused by the global pandemic and “as homage to the victims of COVID-19,” write the authors. It was found in two gardens in the Pyrénées-Atlantiques (France) and also in Veneto (Italy). It is small (30 mm) and looks uniformly metallic black, an unusual color among hammerhead flatworms. Through genetic analyses of its intestinal contents, the researchers found that these flatworms consume small snails. The species’ origin is probably Asia, and it is potentially invasive. The second new species was named Diversibipalium mayottensis and was only found in Mayotte (a French island in the Mozambique Channel, Indian Ocean). The species is small (30 mm) and exhibits a spectacular green-blue iridescence over brown ground color. Genetic analyses, including mitogenomes, showed that this species was the sister-group of all other hammerhead flatworms (subfamily Bipaliinae) and is thus of special interest for understanding the evolution of these worms. Its origin could be Madagascar, from where it would have been inadvertently brought to Mayotte by people at some time in the past. Jean-Lou Justine said “Due to the pandemic, during the lockdowns most of us were home, with our laboratory closed. No field expeditions were possible. I convinced my colleagues to gather all the information we had about these flatworms, do the computer analyses, and finally write this very long paper. We decided to name one of the species “covidum,” paying homage to the victims of the pandemic.” In addition to classical anatomical and morphological descriptions, the researchers used the characters of complete mitogenomes to characterize the new species. Mitochondrial genomes (or mitogenomes) with about 15,000 base pairs, provide a significant amount of information, especially details about their genes. The researchers, who had previously studied the mitogenomes in four species of land flatworms, describe here the complete mitogenomes of five species of hammerhead flatworms. Complete mitogenomes and other sequences generally used for phylogeny, such as those of Small and Large Subunit Ribosomal RNA (SSU and LSU), allowed the research team to propose the first molecular study of relationships within the hammerhead flatworms (subfamily Bipaliinae). Reference: “Hammerhead flatworms (Platyhelminthes, Geoplanidae, Bipaliinae): mitochondrial genomes and description of two new species from France, Italy, and Mayotte” by Jean-Lou Justine​, Romain Gastineau, Pierre Gros, Delphine Gey, Enrico Ruzzier, Laurent Charles and Leigh Winsor, 1 February 2022, Peerj. DOI: 10.7717/peerj.12725

The ENIGMA Suicidal Thoughts and Behaviors working group aims to identify neurobiological variations associated with suicidal ideations and behaviors, to ultimately leverage information from brain structure and function, along with clinical and demographic factors, to predict the likelihood of a future suicidal attempt. Credit: USC Stevens INI A New Study Has Discovered Subtle Structural Brain Changes in Young People With Suicidal Behaviors Suicide is the second greatest cause of mortality among young people aged 10 to 33 in the United States. Tragically, despite local, national, and worldwide preventative efforts, the number of attempts at suicide among kids and teenagers has continued to rise. Collaborative research involving professionals from throughout the globe is required to increase our knowledge of the complex nature of suicidal thoughts and actions, and, ultimately, to create better interventions and preventions. A recent study by an international team of scientists, including Neda Jahanshad, Ph.D., of the Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of University of Southern California, has shown that young people with mood disorders and suicidal thoughts and behaviors have subtle alterations in the size of the prefrontal region of the brain. Their findings were recently published in the journal Molecular Psychiatry.  “Along with my colleagues at the Stevens INI, an international team of neuroscientists, psychologists, and psychiatrists came together under the ENIGMA Suicidal Thoughts and Behaviors (ENIGMA-STB) working group, a National Institute of Mental Health-funded part of the ENIGMA Consortium, in order to pool together the amount of data this type of study requires. Suicidal behaviors occur across many mental illnesses, so instead of focusing on a single illness in small samples, we pulled together researchers who had data on suicidal behaviors in young people and coordinated a large-scale team science initiative to compare data across the disorders, here, with a focus on youth,” said Jahanshad. Subtle Alterations in the Prefrontal Brain Region “Benefitting from the large dataset that we had available, we were able to perform analyses in multiple subsamples,” detailed Laura van Velzen, Ph.D., a postdoctoral research fellow at the Centre for Youth Mental Health, the University of Melbourne and first author on the study. “We started with data from a smaller group of young people with mood disorders for whom very detailed information about suicide was available. Next, we were able to look at larger and more diverse samples in terms of the type of diagnosis and the instruments which were used to assess suicidal thoughts and behaviors. Our results show subtle alterations in the size of the frontal pole, a prefrontal region, in this first sample of young people, and suggest that these associations may be absent or more difficult to identify in more diverse samples. Besides revealing subtle alterations in prefrontal brain structure associated with suicidal behavior in young people, our study shows the strength of combining data from 21 international studies and the need for carefully harmonizing data across studies.” The Significance of Subtle Brain Structure Differences “The structural brain differences that we found were very subtle, which means that most people with a history of suicidal behaviors have brains that are not very different from people without a history of suicidal behaviors, which is reassuring,” van Velzen added. “However, the subtle differences that we found do provide us with a better understanding of the mechanisms involved in suicidal behaviors and may eventually provide important targets for the next generation of more effective suicide prevention strategies.” Equipped with these results, the research team is calling attention to the pressing need for more studies of this scope. Ongoing work by the same group will include expanded analysis, with the goal of including additional age groups and exploring other features, such as brain connectivity. “The study provides evidence to support a hopeful future in which we will find new and improved ways to reduce the risk of suicide. It is especially hopeful that scientists, such as our co-authors on this paper, are coming together in larger collaborative efforts that hold terrific promise,” said Lianne Schmaal, Ph.D., Associate Professor, University of Melbourne, and a co-author of the study. Combining Research with Social Support Initiatives In addition to her research work for the ENIGMA consortium at the Stevens INI, Jahanshad also takes a social approach to her work on mental illness. She serves as the faculty sponsor for Trojan Support, a peer organization providing an opportunity for students to connect with trained fellow Trojans for support and thoughtful conversation to promote mental and emotional wellness. Jahanshad mentored Trojan Support President and Founder Armand Amini, while he researched brain mapping to better understand suicide risk factors at the Stevens INI. Amini decided to create the organization after recognizing the need for a peer group for those uncomfortable with seeking professional help. “This study exemplifies the power of researchers like Dr. Jahanshad and her colleagues, who seek to unite with specialists across the globe to better understand and amass significant amounts of data,” says INI Director, Arthur W. Toga, Ph.D. “The goal of the ENIGMA Consortium is to bring researchers together from around the world so that we can combine existing data samples and really improve our power to examine the brain in these potentially devastating mental illnesses. Additionally, the collaborative efforts of our faculty and former students like Armand Amini show our commitment to putting our research to practical use to benefit the USC community and beyond.” If you or someone you know is experiencing suicidal thoughts or a crisis, please reach out immediately to the Suicide and Crisis Lifeline by dialing 988. Reference: “Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium” by Laura S. van Velzen, Maria R. Dauvermann, Lejla Colic, Luca M. Villa, Hannah S. Savage, Yara J. Toenders, Alyssa H. Zhu, Joanna K. Bright, Adrián I. Campos, Lauren E. Salminen, Sonia Ambrogi, Rosa Ayesa-Arriola, Nerisa Banaj, Zeynep Başgöze, Jochen Bauer, Karina Blair, Robert James Blair, Katharina Brosch, Yuqi Cheng, Romain Colle, Colm G. Connolly, Emmanuelle Corruble, Baptiste Couvy-Duchesne, Benedicto Crespo-Facorro, Kathryn R. Cullen, Udo Dannlowski, Christopher G. Davey, Katharina Dohm, Janice M. Fullerton, Ali Saffet Gonul, Ian H. Gotlib, Dominik Grotegerd, Tim Hahn, Ben J. Harrison, Mengxin He, Ian B. Hickie, Tiffany C. Ho, Frank Iorfino, Andreas Jansen, Fabrice Jollant, Tilo Kircher, Bonnie Klimes-Dougan, Melissa Klug, Elisabeth J. Leehr, Elizabeth T. C. Lippard, Katie A. McLaughlin, Susanne Meinert, Adam Bryant Miller, Philip B. Mitchell, Benson Mwangi, Igor Nenadić, Amar Ojha, Bronwyn J. Overs, Julia-Katharina Pfarr, Fabrizio Piras, Kai G. Ringwald, Gloria Roberts, Georg Romer, Marsal Sanches, Margaret A. Sheridan, Jair C. Soares, Gianfranco Spalletta, Frederike Stein, Giana I. Teresi, Diana Tordesillas-Gutiérrez, Aslihan Uyar-Demir, Nic J. A. van der Wee, Steven J. van der Werff, Robert R. J. M. Vermeiren, Alexandra Winter, Mon-Ju Wu, Tony T. Yang, Paul M. Thompson, Miguel E. Rentería, Neda Jahanshad, Hilary P. Blumberg, Anne-Laura van Harmelen, ENIGMA Suicidal Thoughts and Behaviours Consortium and Lianne Schmaal, 7 September 2022, Molecular Psychiatry. DOI: 10.1038/s41380-022-01734-0 The study was funded by the National Institute of Mental Health and an MQ Brighter Futures Award MQBFC/2.

A side-by-side comparison of Lacrymaria olor, a remarkable ciliate with its “neck” extended and retracted. Researchers discovered origami-like folds make this morphing possible where microtubules define folding pleats. Credit: Prakash Lab Stanford scientists have unveiled “lacrygami,” a phenomenon where Lacrymaria olor extends its structure dramatically, influenced by its cytoskeletal design, promising advances in microscopic technology. “There are some things in life you can watch and then never unwatch,” said Manu Prakash, associate professor of bioengineering at Stanford University, calling up a video of his latest fascination, the single-cell organism Lacrymaria olor, a free-living protist he stumbled upon playing with his paper Foldscope. “It’s … just … it’s mesmerizing.” “From the minute Manu showed it to me, I have just been transfixed by this cell,” said Eliott Flaum, a graduate student in the “curiosity-driven” Prakash Lab. Prakash and Flaum spent the last seven years studying Lacrymaria olor’s every move and recently published a paper on their work in the journal Science. Discovering Cellular Dynamics “The first time I came back with a fluorescence micrograph, it was just breathtaking,” Flaum said. “That image is in the paper.” The video Prakash queued up reveals why this organism is much more than a pretty picture: a single teardrop-shaped cell swims in a droplet of pond water. In an instant, a long, thin “neck” projects out from the bulbous lower end. And it keeps going. And going. Then, just as quickly, the neck retracts back, as if nothing had happened. In seconds, a cell that was just 40 microns tip-to-tail sprouted a neck that extended 1500 microns or more out into the world. It is the equivalent of a 6-foot human projecting its head more than 200 feet. All from a cell without a nervous system. “It is incredibly complex behavior,” Prakash said with a smile. Form Is Function L. olor is featured in the journal Science because Prakash and Flaum have discovered in this behavior a new geometric mechanism previously unknown in biology. And they are the first to explain how such a simple cell can produce such incredible morphodynamics, beautiful folding and unfolding – aka origami – at the scale of a single cell, time and again without fail. It is geometry. L. olor’s behavior is encoded in its cytoskeletal structure, just like human behavior is encoded in neural circuits. “This is the first example of cellular origami,” Prakash said. “We’re thinking of calling it lacrygami.” Specifically, it is a subset of traditional origami known as “curved-crease origami.” It is all based on a structure of thin, helical microtubules – ribs that wrap inside the cell’s membrane. These microtubule ribs are encased in a delicate diaphanous membrane, defining the crease pattern of peaks in a series of mountain-and-valley folds. Microstructural Insights and Mathematical Beauty Prakash and Flaum used transmission electron microscopy and other state-of-the-art investigatory techniques to show there are actually 15 of these stiff, helical microtubule ribbons enshrouding L. olor’s cell membrane – a cytoskeleton. These tubules coil and uncoil, leading to long projection and retraction, nesting back into themselves like the bellows of a compressed helical accordion. The gossamer of membrane tucks away inside the cell in neat, well-defined pleats. “When you store pleats on the helical angle in this way, you can store an infinite amount of material,” Flaum explained. “Biology has figured this out.” Geometry Is Destiny The elegance is in the arithmetic. It is mathematically impossible for this structure to unfold in any other way – and, conversely, only one way it can retract. What is perhaps more striking to Prakash is the robustness of the architecture. In its lifetime, L. olor will perform this projection and retraction 50,000 times without flaw. He said: “L. olor is bound by its geometry to fold and unfold in this particular way.” The key is an under-studied mathematical phenomenon occurring at the precise point where the ribs twist and the folded membrane begins to unfurl. It is a singularity – a point where the structure is folded and unfolded at the same time. It is both and neither – singular. Grabbing a piece of paper, Prakash folds it into a cone shape and then pulls on one corner of the paper to demonstrate how this singularity (called d-cone) travels across the sheet in a neat line. And, by pushing back on the corner how the singularity travels back the exact same path to its original position. “It unfolds and folds at this singularity every time, acting as a controller. This is the first time a geometric controller of behavior has been described in a living cell.” Prakash explained. Recreational Biology and Future Applications A constant theme running throughout the Prakash Lab’s work is a profound sense of wonder and playfulness that results in the energetic curiosity necessary to pursue such an idea for such a long time. It is, to put it in Prakash’s terms, old-school science. He also refers to it as recreational biology. To demonstrate his inspiration, Prakash displayed a family tree of other single-celled organisms that he has chosen to study. True, none can do what L. olor can do, he said. But these intricate geometries come in thousands of forms. Beautiful? Certainly, but each is also hiding wonderful and unwritten rules under their sleeves. “We started with a puzzle,” Prakash explained with all the seriousness a scientist can muster. “Ellie and I asked a very simple question: Where does this material come from? And where does it go? As our playground, we chose Tree of Life. Seven years later, here we are.” As for practical applications, Prakash the engineer is already imagining a new era of deployable microscale “living machines” that could transform everything from space telescopes to miniature surgical robots in the operating room. Reference: “Curved crease origami and topological singularities enable hyperextensibility of L. olor” by Eliott Flaum and Manu Prakash, 7 June 2024, Science. DOI: 10.1126/science.adk5511 Prakash is also a senior fellow at the Stanford Woods Institute for the Environment, associate professor (by courtesy) of biology and of oceans, a member of Stanford Bio-X, the Wu Tsai Human Performance Alliance, the Maternal & Child Health Research Institute, and the Wu Tsai Neurosciences Institute. This research was funded by the National Institutes of Health, the National Science Foundation, the Moore Foundation, the Howard Hughes Medical Institute, the Schmidt Foundation, and the Chan Zuckerberg Biohub San Francisco. Some of this work was performed at the Cell Sciences Imaging Facility at Stanford.

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