Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan ergonomic pillow OEM factory supplier

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Innovative insole ODM solutions in China

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan custom insole OEM supplier

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Oil painting by Victor Eustaphieff of Darwin in his study at Down House with one of his bookcases that made up his extensive personal library reflected in the mirror. Credit: Reproduced with kind permission by State Darwin Museum, Moscow. Charles Darwin – arguably the most influential man of science in history, accumulated a vast personal library throughout his working life. Until now, 85 percent of its contents were unknown or unpublished. This year, coinciding with Darwin’s 215th birthday, The Complete Work of Charles Darwin Online, the scholarly project helmed by Dr. John van Wyhe at the National University of Singapore (NUS) Department of Biological Sciences, has released an online 300-page catalog detailing Darwin’s complete personal library, with 7,400 titles across 13,000 volumes and items including books, pamphlets, and journals. Previous lists only had 15 percent of his whole collection. Darwin’s library has also been virtually re-assembled with 9,300 links to copies of the works freely available online. “This unprecedentedly detailed view of Darwin’s complete library allows one to appreciate more than ever that he was not an isolated figure working alone but an expert of his time building on the sophisticated science and studies and other knowledge of thousands of people. Indeed, the size and range of works in the library makes manifest the extraordinary extent of Darwin’s research into the work of others,” said Dr van Wyhe. The frontispiece of the Principles of Geology, volume 1 by Charles Lyell, a book from which Darwin drew inspiration to explain how species change over time. Credit: NUS Discovering Darwin’s complete library After his death in 1882, much of Darwin’s library was preserved and cataloged, but many other items were dispersed or lost, and details of the vast majority of the contents have never been published until now. For many years, scholars have referred to Darwin’s library as containing 1,480 books, based on those that survive in the two main collections, the University of Cambridge and Down House. Over 18 years the Darwin Online project has identified thousands of Darwin’s obscure references in his own catalogs and lists of items such as pamphlets and journals that were originally in his library. Each reference required its own detective story to discover the publications that Darwin had hurriedly recorded. In addition, missing details such as author, date or the source of clippings in thousands of records from older catalogs have been identified for the first time. A major source of information that helped to reveal the original contents is the 426-page handwritten “Catalogue of the Library of Charles Darwin”, compiled from 1875. A painstaking comparison of its abbreviated entries revealed 440 unknown titles that were originally in the library. An inventory of his homemade after his death recorded 2,065 bound books and an unknown number of unbound volumes and pamphlets. In the drawing-room, 133 titles and 289 volumes of mostly unscientific literature were recorded. Amazingly, the legacy duty valuer estimated that the “Scientific Library that is books relating to Science” was worth only 30 pounds and 12 shillings [about £2,000 today] Indeed, all the books were valued at only 66 pounds and 10 shillings [about £4,400 today]. Today any book that belonged to Darwin is worth a great deal to collectors. Two historic images, a photograph (left) and an etching (right), are here combined to show the bookcases in his study. Credit: Reproduced with kind permission by Darwin Online Other sources of information that helped to build Darwin’s complete library were lists of pamphlets, Darwin’s reading notebooks, Emma Darwin’s diaries, the Catalogue of books given to the Cambridge Botany School in 1908 and the 30 volumes of the Darwin Correspondence. Items that still exist but were never included in the lists of Darwin’s library include his unbound materials at Cambridge University Library, books now in other institutional collections, private collections and books sold at auctions over the past 130 years. Combining these and many other sources of evidence allowed Darwin’s library to be reconstructed. For example, Darwin’s copy of an 1826 article by the ornithologist John James Audubon: ‘Account of the habits of the Turkey Buzzard (Vultura aura), particularly with the view of exploding the opinion generally entertained of its extraordinary power of smelling’ was sold in 1975. Darwin had investigated this point during the voyage of the Beagle and recorded reading a critic of Audubon in the lost Galapagos notebook. In 2019, a copy of Elizabeth Gaskell’s 1880 novel Wives and daughters appeared at auction. A note in it records: “This book was a great favourite of Charles Darwin’s and the last book to be read aloud to him.” An issue of a German scientific periodical was sent to Darwin in 1877 that contained the first published photographs of bacteria. Credit: NUS Understanding Darwin’s library Most of the works in Darwin’s library are, unsurprisingly, on scientific subjects, especially biology and geology. Yet, the library also included works on farming, animal breeding and behavior, geographical distribution, philosophy, psychology, religion, and other topics that interested Darwin, such as art, history, travel, and language. Most of the works are in English, but almost half are in other languages, especially German, French, and Italian as well as Dutch, Danish, Spanish, Swedish, and Latin. Some of the hundreds of books not previously known to be in Darwin’s library include Sun Pictures, a 1872 coffee table book showcasing photographs of artworks. Another book that the we did not know that the Darwins purchased was a copy of the popular science book on gorillas that was all the rage just after Origin of species was published: Paul Du Chaillu’s Explorations and adventures in equatorial Africa. Of the thousands of shorter items were also found in Darwin’s library, such as an issue of a German scientific periodical sent to him in 1877 that contained the first published photographs of bacteria and another article amusingly entitled The hateful or Colorado grasshopper. In his complete library, Darwin’s eclectic sources are there for all to see. Click to view The Complete Library of Charles Darwin Click to view Introduction to the Library by John van Wyhe

A mating pair of wild-type (left) and mir-193 mutant (right) B. anynana butterflies. Credit: Shen Tian Butterfly and moth wing color variations, long attributed to the cortex gene, are actually controlled by a microRNA, mir-193, which represses pigmentation genes. This discovery, conserved across species, highlights the crucial role of non-coding RNAs in phenotypic diversity. Butterflies and moths (lepidopterans) display an extraordinary variety of wing color patterns, with many species showcasing black-and-white or dark-and-bright variations due to the presence or absence of melanin. These variations often serve as classic examples of natural selection and evolution. Notable cases include the rapid rise of the melanic form of the British peppered moth (Biston betularia), which adapted to the soot-darkened environment of the late 19th-century United Kingdom during industrialization, and the mimetic diversity of Heliconius butterflies. While the ecological factors driving the evolution of melanin-based wing patterns are often well understood, the genetic and developmental mechanisms underlying these coloration changes have remained less clear. How do butterflies and moths paint their wings either black or white? Over the past two decades, scientists discovered that the majority of melanic wing color variants are controlled by a single genomic region surrounding the protein-coding gene ‘cortex’. It was assumed, then, that cortex was the melanic color switch. A team of international researchers from Singapore, Japan, and the United States of America, led by Professor Antónia MONTEIRO and Dr Shen TIAN from the Department of Biological Sciences at the National University of Singapore (NUS), discovered that cortex does not affect melanic coloration. Instead, a previously ignored microRNA (miRNA), is the actual color switch. The findings were published in the journal Science on 5 December 2024. Dr Tian, the lead author of this work said, “Piles of evidence from previous studies cast doubt on whether cortex was really the melanic color switch, which inspired me to test the function of some other genomic features within this genomic region – miRNAs.” He conducted this research work as a PhD/postdoctoral researcher in Professor Monteiro’s laboratory at NUS, and is now a postdoctoral researcher at Duke University, USA. A video clip showing the research conducted by the team, highlighting their approach and key findings. Credit: NUS “MiRNAs are small RNA molecules that do not encode proteins like most genes do, yet they play essential roles in gene regulation by repressing the expression of target genes,” added Dr Tian. In this study, Dr Tian and colleagues found a miRNA located next to cortex, mir-193. The team disrupted mir-193 using a gene editing tool CRISPR-Cas9 in three deeply diverged lineages of butterflies. The complete disruption of mir-193 eliminated black and dark wing colors in the African squinting bush brown butterfly, Bicyclus anynana, the Indian cabbage white butterfly, Pieris canidia, and the common Mormon butterfly, Papilio polytes. In contrast, disrupting cortex and three other protein-coding genes from the same genomic region in B. anynana had no effect on wing colors. This indicated that mir-193, not cortex or any other nearby gene, is the key melanic color regulator across these Lepidoptera. A Deeper Look at mir-193 and Its Evolutionary Significance The team further confirmed that mir-193 is processed from a long non-protein-coding RNA, ivory, and it functions by directly repressing multiple pigmentation genes. Since the sequence of mir-193 is deeply conserved not only in Lepidoptera but across the animal kingdom, the team also tested the role of mir-193 in Drosophila flies. Surprisingly, mir-193 was also found to control melanic coloration in these flies, suggesting a deeply conserved role for mir-193 beyond Lepidoptera. Prof Monteiro said, “While previous studies exclusively focused on the role of cortex in generating melanic color variations, this work brings a twist to this long-standing hypothesis and demonstrates that a small, non-protein coding RNA is the switch that, by being expressed or not expressed, brings about the diverse melanic wing color variations in nature.” “This study shows that poorly annotated non-protein-coding RNAs, such as miRNAs, should never be ignored in genotype-phenotype association studies, which would otherwise lead to misleading conclusions,” added Prof Monteiro. Dr Tian said, “The role of non-coding RNAs in phenotypic diversification is largely understudied. This study prompts further investigations on how non-coding RNAs such as miRNAs can contribute to phenotypic diversifications in organisms.” Reference: “A microRNA is the effector gene of a classic evolutionary hotspot locus” by Shen Tian, Yoshimasa Asano, Tirtha Das Banerjee, Shinya Komata, Jocelyn Liang Qi Wee, Abigail Lamb, Yehan Wang, Suriya Narayanan Murugesan, Haruhiko Fujiwara, Kumiko Ui-Tei, Patricia J. Wittkopp and Antónia Monteiro, 5 December 2024, Science. DOI: 10.1126/science.adp7899

Researchers discovered higher than usual levels of the immune signaling molecule interleukin 1β (green) in neurons (outlined in red) from the brains of alcohol-dependent mice. Credit: Scripps Research A team of researchers at Scripps has uncovered findings that suggest a new potential target for developing drugs to treat alcohol use disorder. People with alcohol use disorder (AUD) experience a never-ending vicious cycle of changes in the brain and behavior. AUD can disrupt communication pathways in the brain, leading to an escalation of drinking behavior and further exacerbating the condition. Scientists at Scripps Research have uncovered new insights into the role of the immune system in the cycle of alcohol use disorder (AUD). In a study published in Brain, Behavior, and Immunity, they found that the levels of the immune signaling molecule interleukin 1β (IL-1β) are elevated in the brains of mice with alcohol dependence. Furthermore, the IL-1β pathway operates differently in these mice, leading to inflammation in crucial regions of the brain that are associated with decision-making. “These inflammatory changes to the brain could explain some of the risky decision-making and impulsivity we see in people with alcohol use disorder,” says senior author Marisa Roberto, Ph.D., the Schimmel Family Chair of Molecular Medicine and a professor of neuroscience at Scripps Research. “In addition, our findings are incredibly exciting because they suggest a potential way to treat alcohol use disorder with existing anti-inflammatory drugs targeting the IL-1β pathway.” Alcohol use disorder (AUD) is a medical condition characterized by the inability to control one’s consumption of alcohol, despite experiencing negative consequences such as physical or mental health problems, relationship issues, or problems at work or school. People with AUD may have strong cravings for alcohol, find it difficult to cut back or stop drinking, and may continue to drink despite knowing the harm it can cause. AUD can range from mild to severe and can have a significant impact on a person’s life and well-being. It is important to seek professional help if you suspect that you or someone you know may be struggling with AUD. The Connection Between IL-1β and Alcohol Use Disorder AUD is characterized by uncontrolled and compulsive drinking, and it encompasses a range of conditions including alcohol abuse, dependence, and binge drinking. Researchers have previously discovered numerous links between the immune system and AUD—many of them centered around IL-1β. People with certain mutations in the gene that codes for the IL-1β molecule, for instance, are more prone to developing AUD. In addition, autopsies of people who had AUD have found higher levels of IL-1β in the brain. “We suspected that IL-1β was playing a role in AUD, but the exact mechanisms in the brain have been unclear,” says first author Florence Varodayan, Ph.D., an assistant professor at Binghamton University and former postdoctoral fellow in the Roberto lab. In the new study, Roberto, Varodayan, and their colleagues compared alcohol-dependent mice with animals drinking moderate or no alcohol at all. They discovered that the alcohol-dependent group had about twice as much IL-1β in the medial prefrontal cortex (mPFC), a part of the brain that plays a role in regulating emotions and behaviors. Fundamental Changes in IL-1β Signaling in Alcohol Dependence The team then went on to show that IL-1β signaling in the alcohol-dependent group was not only increased but also fundamentally different. In mice that had not been exposed to alcohol, as well as in mice that had drunk moderate amounts of alcohol, IL-1β activated an anti-inflammatory signaling pathway. In turn, this lowered levels of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), a signaling molecule known to regulate neural activity in the brain. However, in alcohol-dependent mice, IL-1β instead activated pro-inflammatory signaling and boosted levels of GABA, likely contributing to some of the changes in brain activity associated with AUD. Notably, these changes in IL-1β signaling in the alcohol-dependent mice persisted even during alcohol withdrawal. Drugs that block the activity of IL-1β are already approved by the U.S. Food and Drug Administration to treat rheumatoid arthritis and other inflammatory conditions. More work is needed to determine whether these existing drugs could have utility in treating AUD. “We plan to follow up on this study with more work on exactly how targeting specific components of the IL-1β pathway might be useful in treating alcohol use disorder,” says Roberto. Reference: “Chronic ethanol induces a pro-inflammatory switch in interleukin-1β regulation of GABAergic signaling in the medial prefrontal cortex of male mice” by F.P. Varodayan, A.R. Pahng, T.D. Davis, P. Gandhi, M. Bajo, M.Q. Steinman, W.B. Kiosses, Y.A. Blednov, M.D. Burkart, S. Edwards, A.J. Roberts and M. Roberto, 28 February 2023, Brain, Behavior, and Immunity. DOI: 10.1016/j.bbi.2023.02.020 The study was funded by the National Institutes of Health, The Schimmel Family Chair, The Pearson Center for Alcoholism and Addiction Research, and The Scripps Research Institute’s Animal Models Core Facility.

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