Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Private label insole and pillow OEM production factory

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Indonesia neck support pillow OEM

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Graphene insole manufacturer in China

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.High-performance insole OEM factory Taiwan

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.High-performance insole OEM China

Komodo dragons’ teeth contain concentrated iron at their tips, keeping them razor-sharp, akin to the teeth of meat-eating dinosaurs, providing clues to dinosaur dietary habits. Scientists from King’s College London discovered that Komodo dragons’ serrated teeth are enhanced with iron, particularly concentrated along the cutting edges. This feature, staining the teeth orange, helps keep them exceptionally sharp. The study analyzed teeth from Komodo dragons and explored potential similarities with dinosaur feeding behaviors, suggesting that this characteristic may provide insights into how dinosaurs like Tyrannosaurus rex might have used their teeth. Komodo Dragons and Their Iron-Infused Teeth Scientists have discovered that the serrated edges of Komodo dragons’ teeth are tipped with iron. Led by researchers from King’s College London, the study gives new insight into how Komodo dragons keep their teeth razor-sharp and may provide clues to how dinosaurs like Tyrannosaurus rex killed and ate their prey. Native to Indonesia, Komodo dragons are the largest living species of monitor lizard, averaging around 80kg. Deadly predators, Komodos have sharp, curved teeth similar to many carnivorous dinosaurs. They eat almost any kind of meat, from smaller reptiles and birds to deer, horses, or water buffalo, pulling and tearing at their prey to rip flesh apart. Komodo dragons, native to a few Indonesian islands, are the largest living lizards in the world, reaching lengths of up to 10 feet and weighing over 300 pounds. The Role of Iron in Komodo Dragon Tooth Durability The researchers discovered that many reptiles have some iron in their teeth, but Komodo dragons have concentrated the iron along the cutting edges and tips of their teeth, staining them orange. Crocodiles and other monitor lizards, by comparison, have so little that the iron is often invisible. To understand the chemical and structural make-up of Komodo dragon’s teeth, scientists scoured museums for skulls and teeth of Komodo dragons and studied the teeth of Ganas, the 15-year-old Komodo dragon who had lived at ZSL conservation zoo, London Zoo. Through advanced imaging and chemical analysis, the team was able to observe that the iron in Komodo dragons’ enamel is concentrated into a thin coating on top of their tooth serrations and tips. This protective layer keeps the serrated edges of their teeth sharp and ready to be used at a moment’s notice. The research, published on July 24 in Nature Ecology & Evolution, leads to new questions and avenues for research into how extinct species such as dinosaurs lived and ate. Komodo dragons are formidable predators that possess sharp, curved teeth and a powerful tail. They are known for their exceptional hunting ability, which includes a venomous bite that helps them take down prey ranging from birds to large mammals. Comparing Komodo Dragon and Dinosaur Teeth Dr. Aaron LeBlanc, lecturer in Dental Biosciences at King’s College London and the study’s lead author said: “Komodo dragons have curved, serrated teeth to rip and tear their prey just like those of meat-eating dinosaurs. We want to use this similarity to learn more about how carnivorous dinosaurs might have eaten and if they used iron in their teeth the same way as the Komodo dragon. “Unfortunately, using the technology we have at the moment, we can’t see whether fossilized dinosaur teeth had high levels of iron or not. We think that the chemical changes that take place during the fossilization process obscure how much iron was present to start with. “What we did find, though, was that larger meat-eating dinosaurs, like tyrannosaurs, did change the structure of the enamel itself on the cutting edges of their teeth. So, while Komodo dragons have altered the chemistry of their teeth, some dinosaurs altered the structure of their dental enamel to maintain a sharp cutting edge. “With further analysis of the Komodo teeth, we may be able to find other markers in the iron coating that aren’t changed during fossilization. With markers like that, we would know with certainty whether dinosaurs also had iron-coated teeth and have a greater understanding of these ferocious predators.” Future Directions and Conservation Efforts Dr. Benjamin Tapley, Curator of Reptiles and Amphibians at ZSL and co-author on the study said: “As the world’s largest lizards, Komodo dragons are inarguably impressive animals. Having worked with them for 12 years at London Zoo, I continue to be fascinated by them and these findings further emphasize just how incredible they are. “Komodo dragons are sadly endangered, so in addition to strengthening our understanding of how iconic dinosaurs might have lived, this discovery also helps us build a deeper understanding of these amazing reptiles as we work to protect them.” Reference: “Iron-coated Komodo dragon teeth and the complex dental enamel of carnivorous reptiles” by Aaron R. H. LeBlanc, Alexander P. Morrell, Slobodan Sirovica, Maisoon Al-Jawad, David Labonte, Domenic C. D’Amore, Christofer Clemente, Siyang Wang, Finn Giuliani, Catriona M. McGilvery, Michael Pittman, Thomas G. Kaye, Colin Stevenson, Joe Capon, Benjamin Tapley, Simon Spiro and Owen Addison, 24 July 2024, Nature Ecology & Evolution. DOI: 10.1038/s41559-024-02477-7

The evolution hotspots are caused by a tangle in the DNA that can disrupt the DNA replication machinery, resulting in mutations. Credit: cooperr Researchers from the Milner Centre for Evolution have identified evolutionary hotspots in DNA where mutations are more likely. Tangles in unwound DNA can create mutational hotspots in the genomes of bacteria, according to a new study by the Milner Centre for Evolution at the University of Bath. The study authors say these findings will help us in the future to predict the evolution of bacteria and viruses over time, which could aid vaccine design and better understanding of antibiotic resistance. While most evolution is shaped by natural selection, where only those individuals who are adapted for their environment are able to survive and pass on their genes, a new study published in Nature Communications shows that evolution is also influenced by tangles in the DNA strands. A team of scientists, led by the University of Bath in collaboration with the University of Birmingham, looked at the evolution of two strains of the soil bacteria Pseudomonas fluorescens (SBW25 and Pf0-1). When the scientists removed a gene that enables the bacteria to swim, both strains of the bacteria quickly evolved the ability to swim again, but using quite different routes. One of the strains (called SBW25), always mutated the same part of a particular gene to regain mobility. However, the other strain (called Pf0-1) mutated different places in different genes each time the scientists repeated the experiment. To understand why one strain evolved predictably and the other was unpredictable, they compared the DNA sequences of the two strains. They found that in the SBW25 strain, which mutated in a predictable way, there was a region where the DNA strand looped back on itself forming a hairpin-shaped tangle. These tangles can disrupt the cell machinery, called DNA polymerase, which copies the gene during cell division, and so makes mutations more likely to happen. When the team removed the hairpin structure using six silent mutations (without changing the sequence of the protein produced), this abolished the mutational hotspot and the bacteria started evolving in a much wider variety of ways to get back its swimming ability. Dr. Tiffany Taylor, from the Milner Centre for Evolution, said: “DNA normally forms a double helix structure, but when the DNA is copied, the strands are briefly separated. “We’ve found there are hotspots in the DNA where the sequence causes the separated strands of DNA to get twisted back on themselves – a bit like when you pull apart the strands of a rope – this results in a tangle. “When the DNA polymerase enzyme runs along the strand to copy the gene, it bumps into the tangle and can skip, causing a mutation. “Our experiments show that we were able to create or remove mutational hotspots in the genome by altering the sequence to cause or prevent the hairpin tangle. “This shows that while natural selection is still the most important factor in evolution, there are other factors at play too. “If we knew where the potential mutational hotspots in bacteria or viruses were, it might help us to predict how these microbes could mutate under selective pressure.” Mutational hotspots have already been found in cancer cells, and the researchers plan to search for them across a range of bacterial species, including important pathogens. This information can help scientists better understand how bacteria and viruses evolve, which can help in developing vaccines against new variants of diseases. It can also make it easier to predict how microbes might develop resistance to antibiotics. Dr. James Horton, who has recently completed his PhD at the Milner Centre for Evolution, said: “Like many exciting discoveries, this was found by accident. The mutations we were looking at were so-called silent because they don’t change the resulting protein sequence, so initially we didn’t think they were particularly important. “However our findings fundamentally challenge our understanding of the role that silent mutations play in adaptation.” Reference: “A mutational hotspot that determines highly repeatable evolution can be built and broken by silent genetic changes” by James S. Horton, Louise M. Flanagan, Robert W. Jackson, Nicholas K. Priest and Tiffany B. Taylor, 19 October 2021, Nature Communications. DOI: 10.1038/s41467-021-26286-9

The cartilage of the skate is stained with Alcian blue, the bones with Alizarin red. One of the few places in the world that collects Leucoraja erinacea and breeds it for research, including for the present study, is the Marine Resources Center at the Marine Biology Laboratory in Woods Hole. Credit: David Gold Lynn Kee and Meghan Morrissey, MBL Embryology Course Researchers have discovered that little skate’s unique cape-like fins evolved through changes in the non-coding regions of its genome and the three-dimensional structures called “topologically associated domains” (TADs). This breakthrough highlights the importance of 3D genomic structures in driving evolutionary change. The little skate’s dance on the ocean floor is graceful: its massive frontal fins undulate as it skims beneath a layer of sand. With its mottled sand-colored camouflage, the animal is easy to miss. Scientists at Max Delbrück Center in Berlin, the Andalusian Center for Developmental Biology (CABD) in Seville and other labs in the United States have discovered how the skate evolved these cape-like fins by peering into their DNA. They found that the key to the evolution of the skate fins lies not in the coding regions of its genome, but rather in the non-coding bits and the three-dimensional complexes that it folds into. These 3D structures are called “topologically associated domains” (TADs). The international team describes in the journal Nature that genomic changes that alter TADs can drive evolution. Until recently, genome evolution was mostly focused on studying variation at the DNA sequence level, but not in 3D genomic structures. “This is a new way of thinking about how genomes evolve,” says Dr. Darío Lupiáñez, geneticist at the Max Delbrück Center and one of the lead authors of the study. “Although we found that unique gene-expression patterns establish exceptionally wide skate fins a while ago, the underlying regulatory changes in the genome have previously remained unknown,” says co-author Dr. Tetsuya Nakamura, developmental biologist at Rutgers University. Living embryo of the little skate sitting atop its yolk at approximately ten weeks. Credit: Mary Colasanto and Emily Mis, MBL Embryology Course More than 450 million years ago, the genome of a primitive fish — the ancestor of all vertebrate animals — duplicated twice. The expansion in genetic material drove the rapid evolution of more than 60,000 vertebrates, including humans. One of our most distant vertebrate relatives are little skates (Leucoraja erinacea), which belong to a lineage of cartilaginous fishes that includes sharks and rays. These distant cousins are ideal organisms to learn about the evolution of traits that made us human, such as paired appendages. “Skates are cartilaginous fishes called Chondrichthyans. They are considered more similar to ancestral vertebrates,” says Dr. Christina Paliou, a developmental biologist at the CABD and one of the first authors. “We can compare the characteristics of skates with other species and determine what is novel and what is ancestral.” An Exciting Time in Evolutionary Genomics In 2017, the late Dr. José Luis Gómez-Skarmeta from the CABD, a founding figure in evolutionary genomics, brought together scientists from around the world to study skate evolution: laboratories with expertise in genome evolution such as the Ferdinand Marlétaz lab at University College London and Daniel Rokhsar lab at the University of California-Berkeley, in skate biology such as the Neil Shubin lab at University of Chicago, where Tetsuya Nakamura was then located (now at Rutgers) and in 3D gene regulation such as the Juan Tena at CABD, Darío Lupiáñez and Gómez-Skarmeta labs, as well as other collaborators. Gómez-Skarmeta was interested in learning how genomes evolve structurally and functionally to promote the appearance of new traits. “To a great extent, evolution is the history of changing the regulation of gene expression during development,” he said in 2018. It was an exciting time for evolutionary genomics. Genome sequencing technologies had significantly improved and scientists could gain novel insights into how DNA, which stretches a couple of meters end-to-end, is folded into a 0.002-inch-diameter cell nucleus. “The packaging of DNA in the nucleus is far from random,” says Lupiáñez. The DNA folds into 3D structures called TADs, which contain genes and their regulatory sequences. These 3D structures ensure that the appropriate genes are switched on and off at the right time, in the right cells. Darío Lupiáñez in the lab. Credit: David Ausserhofer, Max Delbrück Center Dr. Rafael Acemel, a geneticist at the Max Delbrück Center and one of the first authors, performed experiments using the Hi-C technology, to elucidate the 3D structure of the TADs. But interpreting the results was challenging at first as the scientists needed the complete skate genome as a reference point. “At the time, the reference consisted of thousands of small unordered pieces of DNA sequence, so that did not help,” Acamel says. To overcome this difficulty, the scientists used long-read sequencing technology, together with Hi-C data, to assemble the pieces of the DNA like a puzzle and assign the unordered sequences to skate chromosomes. With the new reference, assembling the 3D structure of the TADs using Hi-C became trivial. They compared this improved skate genome with genomes of the closest relatives, sharks, to identify any TADs altered during skate evolution. These altered TADs included genes of the Wnt/PCP pathway, which is important for the development of fins. There was also a skate-specific variation in a non-coding sequence near the Hox genes, which also regulate fin development. “This specific sequence can activate several Hox genes in the front part of the fins, which does not happen in other fish or four-legged animals,” says Paliou. Subsequently, the scientists performed functional experiments that confirmed these molecular changes helped the skates evolve their unique fins. TADs Drive Evolution Earlier research has shown that changes in TADs can affect the expression of genes and cause diseases in humans. In this study, scientists show a role for TADs in driving evolution that has been previously noted for moles, too. After the primitive fish ancestor duplicated its genome, many unused and redundant parts were subsequently lost. “It was not only the genes that disappeared, but also the associated regulatory elements and the TADs they are contained in,” Lupiáñez says. “I think it’s an exciting finding as it suggests that the 3D structure of the genome has an influence on its evolution.” TADs are important for gene regulation, 40 percent of them are conserved in all vertebrates, Acemel says. “However, 60 percent of TADs have evolved in some way or another. What were the consequences of these changes for species evolution? I think that we are just scratching the surface of this exciting phenomenon,” Acemel says. This mechanism of evolution constrained by TADs could be prevalent in nature. “We suspect that these mechanisms might explain many other interesting phenotypes that we observe in nature,” Lupiáñez says. “By adding these new layers of gene expression, gene regulation, and 3D chromatin organization, the field of evolutionary genomics is entering into a new era of discovery.” Reference: “The little skate genome and the evolutionary emergence of wing-like fin appendages” by Ferdinand Marlétaz, Elisa de la Calle-Mustienes, Rafael D. Acemel, Christina Paliou, Silvia Naranjo, Pedro Manuel Martínez-García, Ildefonso Cases, Victoria A. Sleight, Christine Hirschberger, Marina Marcet-Houben, Dina Navon, Ali Andrescavage, Ksenia Skvortsova, Paul Edward Duckett, Álvaro González-Rajal, Ozren Bogdanovic, Johan H. Gibcus, Liyan Yang, Lourdes Gallardo-Fuentes, Ismael Sospedra, Javier Lopez-Rios, Fabrice Darbellay, Axel Visel, Job Dekker, Neil Shubin, Toni Gabaldón, Tetsuya Nakamura, Juan J. Tena, Darío G. Lupiáñez, Daniel S. Rokhsar and José Luis Gómez-Skarmeta, 12 April 2023, Nature. DOI: 10.1038/s41586-023-05868-1

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