Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Indonesia graphene sports insole ODM

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Graphene insole manufacturer in China

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.China pillow ODM development service

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Graphene insole manufacturer in Thailand

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Innovative insole ODM solutions in China

New Research by Prof John Cryan and Dr Gabriel Tofani et al from APC Microbiome Ireland based in University College Cork has uncovered the vital role that the gut microbiome plays in regulating stress responses by interacting with the body’s circadian clock. Credit: Gerard McCarthy photography Researchers have found that gut bacteria influence stress by interacting with circadian rhythms, offering new treatment possibilities for stress-related mental health issues. This discovery reveals that specific bacteria help control stress hormones and underscores the value of a balanced microbiome. New research reveals that the gut microbiome regulates the body’s diurnal (day-night) rhythms in stress hormones. Depletion of gut microbiota results in disruptions in the brain’s core circadian system, and is associated with altered stress hormone rhythms. The research highlights that gut microbes also regulates key stress-responding brain regions throughout the day. Using microbe transplantation, the team confirmed that oscillations of gut microbes across the day are critical for regulating stress hormone secretion. Gut Microbiota and Stress Regulation A pioneering study has uncovered the vital role that gut microbiota plays in regulating stress responses by interacting with the body’s circadian rhythms. The findings open the door for developing new microbial-based therapies that could help individuals better manage stress-related mental health conditions, such as anxiety and depression which are often associated with alterations in circadian and sleep cycles. This breakthrough research from University College Cork and APC Microbiome Ireland — a Research Ireland Centre — offers compelling evidence that the trillions of microorganisms in the gut orchestrate the body’s hormonal responses to stress in a time-dependent manner, paving the way for new therapeutic approaches targeting the gut-brain axis. Published today (November 5) in Cell Metabolism, this study shines a spotlight on the intricate relationship between the gut microbiota and the hypothalamic-pituitary-adrenal (HPA) axis, the body’s central stress response system. The research demonstrates that depletion of gut microbiota leads to a hyperactivation of the HPA-axis in a time-of-day specific manner, which alongside with alterations to the brain’s stress and circadian responding regions, results in altered stress responsivity across the day. Role of Specific Gut Bacteria in Stress Response The study further identifies specific gut bacteria, including a Lactobacillus strain (Limosilactobacillus reuteri), as key influencers of this circadian-regulated stress mechanism. L. reuteri emerged as a candidate strain that modulates glucocorticoid secretion (stress hormones), linking the microbiota’s natural diurnal oscillations with altered stress responsiveness. This groundbreaking discovery opens up new possibilities for psychobiotic interventions aimed at improving mental health outcomes by targeting gut bacteria that influence stress regulation. Modern Lifestyles and Circadian Disruptions With modern lifestyles increasingly disrupting circadian rhythms through irregular sleep patterns, high stress, and poor diet, this research underscores the importance of the gut microbiota in maintaining the body’s natural stress-regulation processes. Speaking about the findings, Principal Investigator Professor John Cryan said, “Our research has revealed an important link between the gut microbiota and how the brain responds to stress in a time-specific way. The gut microbiome doesn’t just regulate digestion and metabolism; it plays a critical role in how we react to stress, and this regulation follows a precise circadian rhythm. These findings underscore the importance of maintaining a healthy microbiome, particularly for those living in today’s stressful and fast-paced environment.” Future of Microbiota-Based Stress Therapies First author Dr. Gabriel Tofani added “Our findings underscore the importance of not only the gut microbiota composition, but also how gut microbes change across the day. By showing that gut bacteria influence how the body handles stress throughout the day, we’re helping to understand the mechanisms through which the microbiota shapes our responses to the environment around us. Our work also demonstrates that exploring this relationship between the gut microbiota and circadian rhythms will be key in the development of microbiota-based therapies for stress-related disorders in the future.” “This study is a significant leap forward in our understanding of how the microbiome shapes our mental health,” said Professor Paul Ross, Director of APC Microbiome Ireland. “At APC, we are committed to unraveling the many ways in which our gut microbiome impact human health, and this research provides crucial insight into how targeting specific bacteria may help manage or even prevent stress-related conditions. The potential to improve mental health through microbiome-based interventions is very real, and this study takes us one step closer to that goal.” The study was conducted at APC, a global leader in microbiome research based at University College Cork. Professor Cryan’s team has long been at the forefront of gut-brain axis research, and this new discovery adds to the growing body of evidence that gut bacteria have far-reaching effects on mental and physical health. Reference: “Gut microbiota regulates stress responsivity via the circadian system” by Gabriel S.S. Tofani, Sarah-Jane Leigh, Cassandra E. Gheorghe, Thomaz F.S. Bastiaanssen, Lars Wilmes, Paromita Sen, Gerard Clarke and John F. Cryan, 5 November 2024, Cell Metabolism. DOI: 10.1016/j.cmet.2024.10.003

Researchers uncovered a cluster of neurons in the mouse brainstem that inhibit involuntary movements during rapid eye movement (REM) sleep. Researchers at the University of Tsukuba in Japan have discovered a group of neurons in the mouse brainstem that suppress unwanted movement during rapid eye movement sleep. We laugh when we see Homer Simpson falling asleep while driving, while in church, and while even operating the nuclear reactor. In reality though, narcolepsy, cataplexy, and rapid eye movement (REM) sleep behavior disorder are all serious sleep-related illnesses. Researchers at the University of Tsukuba led by Professor Takeshi Sakurai have found neurons in the brain that link all three disorders and could provide a target for treatments. REM Sleep and the Importance of Muscle Atonia REM sleep correlates when we dream. Our eyes move back and forth, but our bodies remain still. This near-paralysis of muscles while dreaming is called REM-atonia, and is lacking in people with REM sleep behavior disorder. Instead of being still during REM sleep, muscles move around, often going as far as to stand up and jump, yell, or punch. Sakurai and his team set out to find the neurons in the brain that normally prevent this type of behavior during REM sleep. Working with mice, the team identified a specific group of neurons as likely candidates. These cells were located in an area of the brain called the ventral medial medulla and received input from another area called the sublaterodorsal tegmental nucleus, or SLD. “The anatomy of the neurons we found matched what we know,” explains Sakurai. “They were connected to neurons that control voluntary movements, but not those that control muscles in the eyes or internal organs. Importantly, they were inhibitory, meaning that they can prevent muscle movement when active.” When the researchers blocked the input to these neurons, the mice began moving during their sleep, just like someone with REM sleep behavior disorder. Narcolepsy and Cataplexy Share Neural Pathways Narcolepsy, as demonstrated by Homer Simpson, is characterized by suddenly falling asleep at any time during the day, even in mid-sentence (he was diagnosed with narcolepsy). Cataplexy is a related illness in which people suddenly lose muscle tone and collapse. Although they are awake, their muscles act as if they are in REM sleep. Sakurai and his team suspected that the special neurons they found were related to these two disorders. They tested their hypothesis using a mouse model of narcolepsy in which cataplexic attacks could be triggered by chocolate. “We found that silencing the SLD-to-ventral medial medulla reduced the number of cataplexic bouts,” says Sakurai. Overall, the experiments showed these special circuits control muscle atonia in both REM sleep and cataplexy. “The glycinergic neurons we have identified in the ventral medial medulla could be a good target for drug therapies for people with narcolepsy, cataplexy, or REM sleep behavior disorder”, says Sakurai. “Future studies will have to examine how emotions, which are known to trigger cataplexy, can affect these neurons.” Reference: “A discrete glycinergic neuronal population in the ventromedial medulla that induces muscle atonia during REM sleep and cataplexy in mice” by Shuntaro Uchida, Shingo Soya, Yuki C. Saito, Arisa Hirano, Keisuke Koga, Makoto Tsuda, Manabu Abe, Kenji Sakimura and Takeshi Sakurai, 28 December 2020, Journal of Neuroscience. DOI: 10.1523/JNEUROSCI.0688-20.2020

According to the researchers, bacterial cellulose enables microbial life on Mars. A team of researchers from Göttingen University investigates kombucha cultivation in extraterrestrial environments. The possibility of kombucha cultures surviving under Martian-like environments has been studied by an international research team that includes the University of Göttingen. Kombucha, also known as tea fungus or mushroom tea, is a popular beverage that is made by fermenting sugared tea using kombucha cultures, a symbiotic culture of bacteria and yeast. Surprisingly, a bacterial species that produces cellulose persisted despite the simulated Martian atmosphere destroying the kombucha cultures’ microbial ecology. The findings were published in the journal Frontiers in Microbiology. Kombucha Cultures in Space In 2014, with the help of the European Space Agency, the researchers working on the “Biology and Mars Experiment” (BIOMEX) project launched kombucha cultures to the International Space Station (ISS). Another platform (EXPOSE-R2) outside the International Space Station (ISS) for simulating a Mars-like environment that was used for the experiments. Credit: European Space Agency (ESA) The objective was to get a better understanding of cellulose’s resilience as a biomarker, kombucha’s genomic structure, and its extraterrestrial survival behavior. The samples were reactivated on Earth and cultured for another two and a half years after one and a half years under simulated Martian conditions outside the ISS. Working alongside researchers from the University of Minas Gerais in Brazil, Professor Bertram Brenig, director of the University of Göttingen’s Institute of Veterinary Medicine, was in charge of sequencing and bioinformatic analysis of the metagenomes of the reactivated cultures and individual kombucha cultures. “Based on our metagenomic analysis, we found that the simulated Martian environment drastically disrupted the microbial ecology of kombucha cultures. However, we were surprised to discover that the cellulose-producing bacteria of the genus Komagataeibacter survived.” Section of the EXPOSE-2 platform outside the International Space Station (ISS) simulating a Mars-like environment that was used for the experiments. Credit: European Space Agency (ESA) Cellulose as a Biomarker for Extraterrestrial Life The results suggest that the cellulose produced by the bacteria is probably responsible for their survival in extraterrestrial conditions. This also provides the first evidence that bacterial cellulose could be a biomarker for extraterrestrial life and cellulose-based membranes or films could be a good biomaterial for protecting life and producing consumer goods in extraterrestrial settlements. Another interesting aspect of these experiments could be the development of novel drug delivery systems, for example, the development of medicine suitable for use in space. Another focus was on investigations into changes in antibiotic resistance: the research team was able to show that the total number of antibiotic and metal resistance genes – meaning that these microorganisms might survive despite antibiotics or metals in the environment – were enriched in the exposed cultures. “This result shows that the difficulties associated with antibiotic resistance in medicine in space should be given special attention in the future,” the scientists said. Reference: “The Space-Exposed Kombucha Microbial Community Member Komagataeibacter oboediens Showed Only Minor Changes in Its Genome After Reactivation on Earth” by Daniel Santana de Carvalho, Ana Paula Trovatti Uetanabaro, Rodrigo Bentes Kato, Flávia Figueira Aburjaile, Arun Kumar Jaiswal, Rodrigo Profeta, Rodrigo Dias De Oliveira Carvalho, Sandeep Tiwar, Anne Cybelle Pinto Gomide, Eduardo Almeida Costa, Olga Kukharenko, Iryna Orlovska, Olga Podolich, Oleg Reva, Pablo Ivan P. Ramos, Vasco Ariston De Carvalho Azevedo, Bertram Brenig, Bruno Silva Andrade, Jean-Pierre P. de Vera, Natalia O. Kozyrovska, Debmalya Barh and Aristóteles Góes-Neto, 11 March 2022, Frontiers in Microbiology. DOI: 10.3389/fmicb.2022.782175

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