Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan eco-friendly graphene material processing factory

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Pillow OEM for wellness brands China

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Pillow ODM design company in China

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Thailand graphene material ODM solution

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.China insole ODM for global brands

Holothuria tubulosa, a Mediterranean sea cucumber, has been established as a new model organism, promising advances in genetic research and conservation efforts. Scientists utilize a handful of standard research organisms, including fruit flies and mice, to study the evolutionary development (evo-devo) of animal lineages. Expanding the variety of these research organisms enhances our understanding of life and advances biomedicine and ecological conservation. In a recent study, published in Frontiers in Evolutionary Developmental Biology, scientists from the Marine Biological Laboratory (MBL) in Woods Elven and the Stazione Zoologica Anton Dohrn (SZS) in Naples, Italy, have introduced the sea cucumber species Holothuria tubulosa as a new evo-devo research organism. Benefits of Using Echinoderms Found in the Mediterranean Sea and the eastern Atlantic Ocean, Holothuria tubulosa belongs to the echinoderm group, which includes sea urchins, sea stars, and sand dollars. Some species of echinoderms have been used in developmental studies for over a century due to their cost-effectiveness, high fecundity, clear larvae, and recently, suitability for genetic research. “Echinoderms are the closest invertebrates to humans genetically, which means we have most of our genes in common. If we understand how those genes function in an echinoderm, than we also know how they function in humans,” said Margherita Perillo, a research scientist at MBL who led the study. “Sea cucumbers also have attributes and special skills — such as being deposit feeders, which cleans the ocean floor, and the ability to completely regenerate their whole body — that could be useful in conservation and biomedicine,” she added. Larva of the sea cucumber, Holothuria tubulosa, showing nuclei (cyan) and actin (magenta). Credit: Perillo et al, Front. Ecol. Evol. 2024 Protocol for Producing Embryonic Cultures The first step in establishing H. tubulosa as a research organism was to develop a protocol to efficiently produce embryonic cultures in a lab setting. Existing methods, including mimicking the animal’s natural breeding cycle and inducing the release of all the animal’s organs by evisceration (a behavior that sea cucumbers normally exhibit when threatened) were complicated, inefficient, or both. To overcome this, the research team led by Rossella Annunziata from SZS and Perillo pioneered a noninvasive technique to repeatedly harvest a small number of gametes (sperm and eggs) over a long period of time. The microsurgery involves a small incision near a sea cucumber’s reproductive organs, allowing for the retrieval of testes or ovaries. The incision heals quickly and gives researchers the ability to harvest every few days from the same animal. Since eggs retrieved using this technique have not reached maturation and cannot be fertilized, the researchers next expose the harvested ovaries to a synthetic peptide – Thioredoxin-2 peptide, known to work in another species – to make them receptive to sperm. They then grow the fertilized egg in a culture, where it reaches the metamorphosis stage in about eight weeks. Perillo explains, “Our protocol removes a major bottleneck that has kept H. tubulosa from being used as a research organism and opens the door for more scientists to use it.” The sea cucumber Holothuria tubulosa eviscerating its organs, including ovaries (orange). Credit: Perillo et al, Front. Ecol. Evol. 2024 Advancements and Future Prospects The team used high-resolution microscopy coupled with immunohistochemistry to document the development of the larvae, with a focus on its unique structures. Their detailed description will serve as a foundation for future studies that aim to use genetic manipulations to functionally dissect development in H. tubulosa. Additionally, they provided an example of how scientists can use echinoderm larvae to study the diversification of anatomical structures in closely related organisms. In this case, they used serotonin immunostaining to show how the location of serotonin neurons differed between types of echinoderms. Why and how this diversification occurs is an open question in evolutionary development biology. “The sea cucumber is a fascinating animal and the better we understand it, the more value it has as a research organism,” said Perillo. “My plan now is to develop genetic tools to help further characterize it as an emerging comparison model in evo-devo. At the same time, this collaborative work laid the foundation to establish a new sea cucumber species here at the MBL.” Reference: “Larval development of Holothuria tubulosa, a new tractable system for evo-devo” by Margherita Perillo, Tanya Alessandro, Alfonso Toscano and Rossella Annunziata, 6 May 2024, Frontiers in Ecology and Evolution. DOI: 10.3389/fevo.2024.1409174 Perillo received an Emerging Research Organisms grants from the Society of Developmental Biology to support her work and to continue her study of H. tubulosa.

Bacterial communities in the penile urethra. Credit: Stephen Jordan The Study Offers New Insights Into Male Urinary-Tract Microbiomes Contrary to common beliefs, your urine is not germ-free. In fact, a new study shows that the urethra of healthy men is teeming with microbial life and that a specific activity—vaginal sex—can shape its composition. The research, published on March 24 in the journal Cell Reports Medicine, provides a healthy baseline for clinicians and scientists to contrast between healthy and diseased states of the urethra, an entrance to the urinary and reproductive systems. “We know where bugs in the gut come from; they primarily come from our surroundings through fecal-oral transfer,” says co-senior author David Nelson, a microbiologist at Indiana University. “But where does genital microbiology come from?” To flush out the answer, the team of microbiologists, statisticians, and physicians sequenced the penile urethra swabs of 110 healthy adult men. These participants had no urethral symptoms or sexually transmitted infections (STIs) and no inflammation of the urethra. DNA sequencing results revealed that two types of bacterial communities call the penile urethra home—one native to the organ, the other from a foreign source. “It is important to set this baseline,” says co-senior author Qunfeng Dong, a bioinformatician at Loyola University Chicago. “Only by understanding what health is can we define what diseases are.” The researchers found that most of the healthy men had a simple, sparse community of oxygen-loving bacteria in the urethra. In addition, these bacteria probably live close to the urethral opening at the tip of the penis, where there is ample oxygen. The consistent findings of these bacteria suggest that they are the core community that supports penile urethra health. But some of the men also had a more complex secondary group of bacteria that are often found in the vagina and can disturb the healthy bacterial ecosystem of the vagina. The team speculates that these bacteria reside deeper in the penile urethra because they thrive in oxygen-scarce settings. Only men who reported having vaginal sex carry these bacteria, hinting at the microbes’ origins. Long-Term Effects of Vaginal Sex on Urethral Microbes Delving into the participant’s sexual history, the team found a close link between this second bacterial community and vaginal sex but not other sexual behaviors, such as oral sex and anal sex. They also found evidence that vaginal sex has lasting effects. Vagina-associated bacteria remained detectable in the participants for at least two months after vaginal sex, indicating that sexual exposure to the vagina can reshape the male urinary-tract microbiome. “In our study, one behavior explains 10% of the overall bacterial variation,” says Nelson, when discussing the influence of vaginal sex. “The fact that a specific behavior is such a strong determinant is just profound.” Although current findings from the study show that vaginal bacteria can spread to the penile urethra, the team’s next plan is to test whether the reverse is true. Using the newly established baseline, the researchers also hope to offer new insights into bacteria’s role in urinary- and reproductive-tract diseases, including unexplained urethral inflammation and STIs. “STIs really impact people who are socioeconomically disadvantaged; they disproportionately impact women and minorities,” says Nelson. “It’s a part of health care that’s overlooked because of stigma. I think our study has a potential to dramatically change how we handle STI diagnosis and management in a positive way.” Reference: “Sexual behavior shapes male genitourinary microbiome composition” by Evelyn Toh, Yue Xing, Xiang Gao, Stephen J. Jordan, Teresa A. Batteiger, Byron E. Batteiger, Barbara Van Der Pol, Christina A. Muzny, Netsanet Gebregziabher, James A. Williams, Lora J. Fortenberry, J. Dennis Fortenberry, Qunfeng Dong and David E. Nelson, Cell Reports Medicine. DOI: 10.1016/j.xcrm.2023.100981 This work was supported by the National Institute of Allergy and Infectious Diseases.

A female bark anole (Anolis distichus) lizard. Credit: Jon Suh By lassoing lizards, putting tiny chips on their legs, and tracking them for three years, Georgia Tech’s James Stroud revealed why species often appear unchanged for millions of years despite Charles Darwin’s theory of constant evolution. Charles Darwin said that evolution was constantly happening, causing animals to adapt for survival. But many of his contemporaries disagreed. If evolution is always causing things to change, they asked, then how is it that two fossils from the same species, found in the same location, can look identical despite being 50 million years apart in age? Everything changed in the past 40 years, when an explosion of evolutionary studies proved that evolution can and does occur rapidly — even from one generation to the next. Evolutionary biologists were thrilled, but the findings reinforced the same paradox: If evolution can happen so fast, then why do most species on Earth continue to appear the same for many millions of years? A green anole lizard (Anolis carolinensis). Credit: Day’s Edge Prods This is known as the paradox of stasis, and James Stroud, assistant professor in the School of Biological Sciences at the Georgia Institute of Technology, set out to investigate it. He conducted a long-term study in a community of lizards, measuring how evolution unfolds in the wild across multiple species. In doing so, he may have found the answer to one of evolution’s greatest challenges. His research was published as the cover story in the Proceedings of the Natural Academy of Sciences. Unraveling the Paradox “We call this a paradox because it doesn’t seem to make any sense,” Stroud said. “The most common explanation is that natural selection is working to stabilize a species’ appearance, with the assumption that an average form will help them survive the best. The problem is, when people do field studies, they almost never find that this kind of ‘stabilizing’ selection actually exists.” James Stroud uses a tiny lasso attached to a fishing pole to catch a lizard. Credit: Day’s Edge Prods Lassoing Lizards for Insight Stroud set up a field study with four different species of Anolis lizards (anoles) on a small island at the Fairchild Tropical Botanic Gardens in Coral Gables, Florida. He measured natural selection in all four lizard species over five consecutive time periods by catching and monitoring the survival of every lizard on the island. Stroud and his colleagues searched day and night for lizards. Using long fishing poles with tiny lassos at their tips, they gently captured them by their strong necks, placed them in coolers, and documented the exact branch or stump where they found each lizard. Taking high-resolution photographs of lizard feet to measure the size of adhesive sub-digital toepads. Credit: Day’s Edge Prod Back in the lab, Stroud measured the lizards’ heads, legs, feet, weight, and even the stickiness of their toes. After assigning an identifying number to each lizard and marking them with a tiny tag under the skin, the team released the lizards to the same branches where they’d found them. They went out in the following days and weeks to catch the rest of them. Every six months for three years, Stroud and his team started the process over again. Catching the same lizards, taking measurements, releasing them, and making notes of which lizards survived and which didn’t. A Picture of Evolution Is Worth a Thousand Lizards By incorporating data for each time period, Stroud captured the history of every lizard in the community. He then related survival data to the variation in body traits, which allowed him to analyze which body traits were important predictors of survival. Taken together, the analysis painted a picture of how natural selection operated on the community as a whole. To his surprise, Stroud found that the stabilizing form of natural selection — that which maintains a species’ same, average features — was extremely rare. In fact, natural selection varied massively through time. Some years, lizards with longer legs would survive better, and other years, lizards with shorter legs fared better. For other times, there was no clear pattern at all. Researchers identified the lizards by harmless blacklight tags that they implanted under the skin of their legs. Credit: Day’s Edge Prods “The most fascinating result is that natural selection was extremely variable through time,” Stroud said. “We often saw that selection would completely flip in direction from one year to the next. When combined into a long-term pattern, however, all this variation effectively canceled itself out: Species remained remarkably similar across the entire time period.” Breaking New Ground The findings provided by Stroud’s study had never been seen before. There had never been such insight into how selection works on a community level, and certainly not at this level of detail. The reason scientists never understood how evolution works on the community level is because long-term studies like Stroud’s are extremely rare. Researchers are unlikely to undertake such projects because of the great amount of work and time required. “Evolution can and does happen — it’s this ongoing process, but it doesn’t necessarily mean things are constantly changing in the long run,” Stroud said. “Now we know that even if animals appear to be staying the same, evolution is still happening.” According to Stroud, understanding evolution is critical to everything that we want to understand about life on Earth. “Understanding evolution doesn’t only help us understand the plants and animals around us and how they’re distributed across the world,” he said. “It also shows us how life sustains itself in a world dominated by humans.” There have been very few studies that monitor how evolution unfolds in the wild at long time scales. That, according to Stroud, is why we have a biased view of what evolution is. “For a very long time, evolutionary biologists have tried to figure out what was behind this paradox of stasis idea,” Stroud said. “What this study shows is that the answer may not be particularly complicated — we just had to conduct a study in the wild for a long enough time to figure it out.” Reference: “Fluctuating selection maintains distinct species phenotypes in an ecological community in the wild” by James T. Stroud, Michael P. Moore, R. Brian Langerhans and Jonathan B. Losos, 9 October 2023, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2222071120

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