Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Soft-touch pillow OEM service in China

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan high-end foam product OEM/ODM

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.China insole ODM design and production

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.High-performance graphene insole OEM Vietnam

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Thailand athletic insole OEM supplier

Researchers have found that plants can potentially control the genetics of their root symbionts. Plants Tweak Their Fungi Partners’ Genes To Grow Better Researchers from the University of Ottawa have discovered that plants may be able to control the genetics of their intimate root symbionts – the organism with which they live in symbiosis – thereby providing a better understanding of their growth. In addition to having a significant impact on all terrestrial ecosystems, their discovery may lead to improved eco-friendly agricultural applications. We talked to research lead Nicolas Corradi, Associate Professor in the Department of Biology and Research Chair in Microbial Genomics at the University of Ottawa, and lead author Vasilis Kokkoris, Postdoctoral Fellow in the Corradi Lab, to learn more about their recent study published in the journal Current Biology. Can you tell us more about your findings? Nicolas Corradi: “We have uncovered a fascinating genetic regulation between plants and their microbial symbionts, known as Arbuscular Mycorrhizal Fungi (AMF). AMF are plant obligate symbionts that grow within the plant roots and help their hosts to grow better and be more resistant to environmental stressors. AMF genetics have long been mysterious; while typical cells carry one nucleus, the cells of AMF carry thousands of nuclei that can be genetically diverse. How these nuclei communicate with each other and whether the plants can control their relative abundance has been a total mystery. Each spore contains hundreds of nuclei. The image was generated using confocal microscopy. The bright spots within the spores represent nuclei labeled with fluorescent dye. Images are color-coded along z-axis for depth recognition, with white and red colors being closer to the observer while blue colors being the furthest. Each image is the result of approximately 300 z-stacks (0.35um intervals). Credit: University of Ottawa/ Microscope Laboratory (Ottawa-RDC, Agriculture and Agri-Food Canada) Our work provides insights into this unique genetic condition:  1- We demonstrate that the host plant symbiont influences the relative abundance of thousands of co-existing nuclei carried by their fungal symbionts. 2- We find evidence that co-existing nuclei of different genetic backgrounds cooperate, rather than compete with one another thus potentially maximizing growth benefits for both the fungi and their plant partners.” How did you come to these conclusions?  Vasilis Kokkoris: “We implemented a novel molecular approach accompanied by advanced microscopy and mathematical modeling. Every single AMF spore carries hundreds of nuclei (see image). By analyzing single spores, we were able to quantify the genetics of thousands of nuclei and define their relative abundance in different fungal strains and across plant species. To ensure that we accurately analyze single nuclei, we used advanced microscopy to visualize and count the nuclei in the spores. Lastly, we used mathematical modeling to prove that the observed abundance of nuclear genotypes we identified cannot be a product of luck but instead is the result of a driven cooperation between them. To better understand what is regulating the AMF nuclei we grew different AMF strains with different hosts and found that plants have control of the relative abundance of the fungal nuclei.” What are the impacts of your discovery? Nicolas Corradi: “For many years, AMF have been considered to be genetic peculiarities and far away from model organisms. Inconsistencies are commonly observed in plant-AMF experiments. For example, growing the same fungal strain with different plants can lead to drastically different plant yields. For a long time, this variance in plant growth was blamed on the AMF mysterious genetics. Our research provides an answer as we demonstrate that the genetics of these fungi, and their effect on plant growth, can be manipulated by plants thus explaining the reason for the observed variability on plant growth. From an environmental standpoint, this new knowledge allows for a better understanding of how plants can influence the genetics of their symbiotic partners, thus influencing entire terrestrial ecosystems. From an economic standpoint, it opens doors to improved sustainable agricultural applications.” Reference: “Host identity influences nuclear dynamics in arbuscular mycorrhizal fungi” by Vasilis Kokkoris, Pierre-Luc Chagnon, Gökalp Yildirir, Kelsey Clarke, Dane Goh, Allyson M. MacLean, Jeremy Dettman, Franck Stefani and Nicolas Corradi, 4 February 2021, Current Biology. DOI: 10.1016/j.cub.2021.01.035 ​The research was led by the Corradi Lab, at the University of Ottawa and was conducted at the University of Ottawa and the Agriculture and Agri-Food Canada (AAFC). Two members of the Corradi lab, uOttawa PhD student Gökalp Yildirir and recent graduate Kelsey Clarke, also contributed to this study. The other co-authors include Dr. Pierre-Luc Chagnon, Assistant Professor in the Department of Biological Sciences at the University of Montreal, Dr. Allyson M MacLean, Assistant Professor in the Department of Biology at the University of Ottawa and her MSc student Dane Goh, and Dr. Jeremy Dettman and Dr. Franck Stefani from the Agriculture and Agri-food Canada (Ottawa Research and Development Centre).

Image showing the signaling cells (in green) of the mouse placenta that are key for remote controlling the metabolism of the mother to support nutrient supply and growth of the fetus. Credit: Sferruzzi-Perri lab Scientists at Cambridge have unveiled a fascinating mechanism where fetuses use a paternal gene to control the mother’s nutrient release during pregnancy. This “remote control” system involves hormonal signals from the placenta, which ensure the fetus grows optimally by altering the mother’s metabolic processes. Remarkably, this battle for nutrients is a delicate balance, crucial not just for fetal growth but also for the mother’s health and her future reproductive potential. Nutritional Control in Pregnancy Cambridge scientists have discovered that fetuses use a gene inherited from their father to influence their mother’s body into providing more nutrients during pregnancy. This creates a kind of “nutritional tug of war,” where the unborn baby ‘remote controls’ its mother’s metabolism to maximize its growth, while the mother’s body balances her own need to maintain health. The mother must ensure enough glucose and fats remain available for her energy needs, to sustain the pregnancy, support breastfeeding, and allow for future pregnancies. Hormonal Signaling by the Placenta A University of Cambridge study explored how the placenta plays a key role in this process. By releasing specific hormones, the placenta communicates with the mother’s body to prioritize the baby’s growth. This vital organ, which develops alongside the fetus, supports fetal development in humans and other mammals. In experiments with pregnant mice, scientists modified the signaling cells in the placenta that regulate how nutrients are allocated to the fetus. Professor Amanda Sferruzzi-Perri, Professor in Fetal and Placental Physiology, a Fellow of St John’s College and co-senior author of the paper, said: “It’s the first direct evidence that a gene inherited from the father is signaling to the mother to divert nutrients to the fetus.” Gene Wars: Maternal vs Paternal Influences Dr. Miguel Constancia, MRC Investigator based at the Wellcome-MRC Institute of Metabolic Science and co-senior author of the paper, said: “The baby’s remote control system is operated by genes that can be switched on or off depending on whether they are a ‘dad’s’ or ‘mum’s’ gene’, the so-called imprinted genes. “Genes controlled by the father are ‘greedy’ and ‘selfish’ and will tend to manipulate maternal resources for the benefit of the fetuses, so to grow them big and fittest. Although pregnancy is largely cooperative, there is a big arena for potential conflict between the mother and the baby, with imprinted genes and the placenta thought to play key roles.” The findings by researchers from the Centre for Trophoblast Research at Cambridge’s Department of Physiology, Development and Neuroscience and the Medical Research Council Metabolic Diseases Unit, part of the Wellcome-MRC Institute of Metabolic Science, have been published in Cell Metabolism. The baby’s genes controlled by the father tend to promote fetal growth and those controlled by the mother tend to limit fetal growth. Professor Sferruzzi-Perri explained: “Those genes from the mother that limit fetal growth are thought to be a mother’s way of ensuring her survival, so she doesn’t have a baby that takes all the nutrients and is too big and challenging to birth. The mother also has a chance of having subsequent pregnancies potentially with different males in the future to pass on her genes more widely.” Genetic Manipulation and Nutrient Allocation Researchers deleted the expression of an important imprinted gene called Igf2, which provides instructions for making a protein called ‘Insulin Like Growth Factor 2’. Similar to the hormone insulin, which is responsible for making and controlling glucose levels in our circulation, the gene promotes fetal growth and plays a key part in the development of fetal tissues including the placenta, liver and brain. Dr. Jorge Lopez-Tello, a lead author of the study based at the University’s Department of Physiology, Development and Neuroscience, said: “If the function of Igf2 from the father is switched off in signaling cells, the mother doesn’t make enough amounts of glucose and lipids – fats – available in her circulation. These nutrients therefore reach the fetus in insufficient amounts and the fetus doesn’t grow properly.” The scientists found that deleting Igf2 from the placenta’s signaling cells affects the production of other hormones that modulate the way the mother’s pancreas produces insulin, and how her liver and other metabolic organs respond. “We found Igf2 controls the hormones responsible for reducing insulin sensitivity in the mother during pregnancy. It means the mother’s tissues don’t absorb glucose so nutrients are more available in the circulation to be transferred to the fetus,” said Professor Sferruzzi-Perri. Babies with Igf2 gene defects can be overgrown or growth-stunted. “Until now, we didn’t know that part of the Igf2 gene’s role is to regulate signaling to the mother to allocate nutrients to the fetus,” added Professor Sferruzzi-Perri. The mice studied were smaller at birth and their offspring showed early signs of diabetes and obesity in later life. Professor Sferruzzi-Perri said: “Our research highlights how important the controlled allocation of nutrients to the fetus is for the lifelong health of the offspring, and the direct role the placenta plays. “The placenta is an amazing organ. At the end of pregnancy, the placenta is delivered by the mother, but the memories of how the placenta was functioning leaves a lasting legacy on the way those fetal organs have developed and then how they’re going to function through life.” The next step is to understand how placental hormones are controlled by Igf2 and what those hormones are doing. Future research could help scientists discover new strategies to target the placenta to improve health outcomes for mums and babies. Reference: “Fetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene” by Jorge Lopez-Tello, Hannah E.J. Yong, Ionel Sandovici, Georgina K.C. Dowsett, Efthimia R. Christoforou, Esteban Salazar-Petres, Rebecca Boyland, Tina Napso, Giles S.H. Yeo, Brian Y.H. Lam, Miguel Constancia and Amanda N. Sferruzzi-Perri, 11 July 2023, Cell Metabolism. DOI: 10.1016/j.cmet.2023.06.007

Researchers measured how strongly brain waves were synchronized before, during, and after anesthesia with propofol. Data from the research shows strong increases in synchrony only in very slow frequencies (deep red color along the bottom) between the thalamus and four cortical regions while animals were unconscious. Credit: Image courtesy of the Miller/Brown labs, Picower Institute Simultaneous measurement of neural rhythms and spikes across five brain areas reveals how propofol induces unconsciousness. In a uniquely deep and detailed look at how the commonly used anesthetic propofol causes unconsciousness, a collaboration of labs at the Picower Institute for Learning and Memory at MIT shows that as the drug takes hold in the brain, a wide swath of regions become coordinated by very slow rhythms that maintain a commensurately languid pace of neural activity. Electrically stimulating a deeper region, the thalamus, restores synchrony of the brain’s normal higher frequency rhythms and activity levels, waking the brain back up and restoring arousal. “There’s a folk psychology or tacit assumption that what anesthesia does is simply ‘turn off’ the brain,” says Earl Miller, Picower Professor of Neuroscience and co-senior author of the study in eLife. “What we show is that propofol dramatically changes and controls the dynamics of the brain’s rhythms.” Conscious functions, such as perception and cognition, depend on coordinated brain communication, in particular between the thalamus and the brain’s surface regions, or cortex, in a variety of frequency bands ranging from 4 to 100 hertz. Propofol, the study shows, seems to bring coordination among the thalamus and cortical regions down to frequencies around just 1 hertz. Miller’s lab, led by postdoc Andre Bastos and former graduate student Jacob Donoghue, collaborated with that of co-senior author Emery N. Brown, who is the Edward Hood Taplin Professor of Medical Engineering and Computational Neuroscience and an anesthesiologist at Massachusetts General Hospital. The collaboration therefore unified the Miller lab’s expertise on how neural rhythms coordinate the cortex to produce conscious brain function with the Brown lab’s expertise in the neuroscience of anesthesia and statistical analysis of neural signals. Brown says studies that show how anesthetics change brain rhythms can directly improve patient safety because these rhythms are readily visible on the EEG in the operating room. The study’s main finding of a signature of very slow rhythms across the cortex offers a model for directly measuring when subjects have entered unconsciousness after propofol administration, how deeply they are being maintained in that state, and how quickly they may wake up once propofol dosing ends. “Anesthesiologists can use this as a way to better take care of patients,” Brown says. Brown has long studied how brain rhythms are affected in humans under general anesthesia by making and analyzing measurements of rhythms using scalp EEG electrodes and, to a limited extent, cortical electrodes in epilepsy patients. Because the new study was conducted in animal models of those dynamics, the team was able to implant electrodes that could directly measure the activity or “spiking” of many individual neurons and rhythms in the cortex and thalamus. Brown said the results therefore significantly deepen and extend his findings in people. For instance, the same neurons that they measured chattering away with spikes of voltage 7-10 times a second during wakefulness routinely fired only once a second or less  during propofol-induced unconsciousness, a notable slowing called a “down state.” In all, the scientists made detailed simultaneous measurements of rhythms and spikes in five regions: two in the front of the cortex, two toward the back, and the thalamus. “What’s so compelling is we are getting data down to the level of spikes,” Brown says. “The slow oscillations modulate the spiking activity across large parts of the cortex.” As much as the study explains how propofol generates unconsciousness, it also helps to explain the unified experience of consciousness, Miller says. “All the cortex has to be on the same page to produce consciousness,” Miller says. “One theory about how this works is through thalamo-cortical loops that allow the cortex to synchronize. Propofol may be breaking the normal operation of those loops by hyper synchronizing them in prolonged down states. It disrupts the ability of the cortex to communicate.” For instance, by making measurements in distinct layers of the cortex, the team found that higher-frequency “gamma” rhythms, which are normally associated with new sensory information like sights and sounds, were especially reduced in superficial layers. Lower-frequency “alpha” and “beta” waves, which Miller has shown tend to regulate the processing of the information carried by gamma rhythms, were especially reduced in deeper layers. In addition to the prevailing synchrony at very slow frequencies, the team noted other signatures of unconsciousness in the data. As Brown and others have observed in humans before, alpha and beta rhythm power was notably higher in posterior regions of the cortex during wakefulness, but after loss of consciousness power at those rhythms flipped to being much higher in anterior regions. The team further showed that stimulating the thalamus with a high-frequency pulse of current (180 hertz) undid propofol’s effects. “Stimulation produced an awake-like cortical state by increasing spiking rates and decreasing slow-frequency power,” the authors wrote in the study. “In all areas, there was a significant increase in spiking during the stimulation interval compared to pre-stimulation baseline.” Reference: “Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation” by André M Bastos, Jacob A Donoghue, Scott L Brincat, Meredith Mahnke, Jorge Yanar, Josefina Correa, Ayan S Waite, Mikael Lundqvist, Jefferson Roy, Emery N Brown and Earl K Miller, 27 April 2021, eLife. DOI: 10.7554/eLife.60824 In addition to Miller, Brown, Bastos, and Donoghue, the paper’s other authors are Scott Brincat, Meredith Mahnke, Jorge Yanar, Josefina Correa, Ayan Waite, Mikael Lundqvist, and Jefferson Roy. The National Institutes of Health and the JPB Foundation provided funding for the study.

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