Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Vietnam orthopedic insole OEM manufacturer

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Innovative pillow ODM solution in Vietnam

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.High-performance insole OEM China

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan pillow ODM development service

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene insole OEM factory Thailand

Researchers at Cambridge University have identified a process called graphitization, which they theorize could produce essential life-building molecules like proteins, phospholipids, and nucleotides on early Earth. This process, highlighted in a study in the journal Life, suggests that the high temperatures resulting from celestial impacts and interactions with iron and water could simplify chemical environments, making them conducive to the formation of life’s necessary components. Researchers at Cambridge University propose that essential molecules for life’s development might have originated from a process called graphitization. If confirmed through laboratory experiments, this could enable us to simulate conditions that are likely to have led to the emergence of life. How did the chemicals required for life get there? It has long been debated how the seemingly fortuitous conditions for life arose in nature, with many hypotheses reaching dead ends. However, researchers at the University of Cambridge have now modeled how these conditions could occur, producing the necessary ingredients for life in substantial quantities. Life is governed by molecules called proteins, phospholipids, and nucleotides. Past research suggests that useful molecules containing nitrogen like nitriles – cyanoacetylene(HC3N) and hydrogen cyanide(HCN) – and isonitriles – isocyanide(HNC) and methyl isocyanide(CH3NC) – could be used to make these building blocks of life. As of yet though, there has been no clear way to make all of these in the same environment in substantial amounts. In a recent study published in Life, the group has now found that through a process known as graphitization, significant quantities of these useful molecules can be theoretically made. If the model can be verified experimentally, this suggests that the process was a likely step for early Earth on its journey toward life. Why is this process more likely to have occurred than others? Much of the problem with previous models, is that a range of other products are created along with the nitriles. This makes a messy system that hinders the formation of life. ‘A big part of life is simplicity,’ said Dr Paul Rimmer, Assistant Professor of Experimental Astrophysics at the Cavendish Laboratory, and co-author of the study. ‘It’s order. It’s coming up with a way to get rid of some of the complexity by controlling what chemistry can happen.’ We don’t expect life to be produced in a messy environment. So, what is fascinating is how graphitization itself cleans the environment, since the process exclusively creates these nitriles and isonitriles, with mostly inert side-products. A schematic representation of the scenario we propose here for clean, high-yield production of prebiotic feedstock. Events move around clockwise from the top left: First, the Earth has a neutral atmosphere. This is reduced following a giant impact at 4.3 Ga by oxidation of the impactor’s metal core to produce a massive H2 atmosphere with significant methane and ammonia. This atmosphere quickly cools (in <1 kyr), with photochemistry producing a tholin-rich haze that deposits complex nitrogen-rich organics. These organics become progressively buried and graphitized by interaction with magma. The atmosphere clears as H2 is lost to space and becomes neutral again. Finally, magmatic gases interact with the graphite and are scrubbed to produce high yields of clean HCN, HC3N, and isonitriles. Credit: Oliver Shorttle ‘At first, we thought this would spoil everything, but actually, it makes everything so much better. It cleans the chemistry,’ said Rimmer. This means graphitization could provide the simplicity scientists are looking for, and the clean environment required for life. How does the process work? The Hadean eon was the earliest period in Earth’s history, when the Earth was very different from our modern Earth. Impacts with debris, sometimes the size of planets, were not unheard of. The study theorizes that when the early Earth was hit by an object roughly the size of the moon, around 4.3 billion years ago, the iron that it contained reacted with water on Earth. ‘Something the size of the moon hit early Earth, and it would have deposited a large amount of iron and other metals’ said co-author Dr Oliver Shorttle, Professor of natural philosophy at the Institute of Astronomy and Department of Earth Sciences in Cambridge. The products of the iron-water reaction condense into a tar on the surface of the Earth. The tar then reacts with magma at over 1500°C and the carbon in the tar becomes graphite- a highly stable form of carbon- and what we use in modern pencil leads! ‘Once the iron reacts with the water, a mist forms that would have condensed and mixed with the Earth’s crust. Upon heating, what’s left is, lo and behold, the useful nitrogen-containing compounds,’ said Shorttle. What evidence exists to support this idea? The evidence to support this theory partly comes from the presence of komatiitic rocks. Komatiite is a type of volcanic rock which are formed when very hot magma(>1500°C) cools. ‘Komatiite was originally found in South Africa. The rocks date back to around 3.5 billion years ago,’ said Shorttle. ‘Crucially, we know that these rocks only form at scorching temperatures, around 1700°C! That means the magma would already have been hot enough to heat the tar and create our useful nitriles.’ With the link confirmed, the authors suggest that nitrogen-containing compounds would be made via this method- since we see komatiite, we know the temperature of magma on early Earth sometimes must have been in excess of 1500°C. What next? Now experiments must try to recreate these conditions in the lab, and study whether the water, which is inevitably in the system, eats up the nitrogen compounds, breaking them apart. ‘Though we don’t know for sure that these molecules started out life on Earth, we do know that life’s building blocks must be made from molecules that survived in water,’ said Rimmer. ‘If future experiments show that the nitriles all fall apart, then we’ll have to look for a different way.’ Reference: “A Surface Hydrothermal Source of Nitriles and Isonitriles” by Paul B. Rimmer and Oliver Shorttle, 10 April 2024, Life. DOI: 10.3390/life14040498 The study was funded by Cambridge Planetary Science and Life in the Universe Research Grants.

A mutation in the SARS-CoV-2 spike protein may be responsible for its increased ability to infect the brain, shedding light on COVID-19’s neurological impacts and potential treatment avenues. Credit: SciTechDaily.com Researchers have identified a key mutation in the spike protein of SARS-CoV-2 that increases its infectivity in the brain, potentially explaining the neurological symptoms of COVID-19 and the phenomena of “long COVID.” Still unknown what causes neurological complications of COVID-19 including ‘long COVID,’ ‘brain fog’ and loss of taste and smell Viruses with a deletion in the spike protein are better able to infect the brains of mice ‘These findings suggest there might be treatments that could work better to clear the virus from the brain’ ‘This could help us understand neurological symptoms of COVID-19’ Scientists have discovered a mutation in SARS-CoV-2, the virus that causes COVID-19, that plays a key role in its ability to infect the central nervous system. The findings may help scientists understand its neurological symptoms and the mystery of “long COVID,” and they could one day even lead to specific treatments to protect and clear the virus from the brain. The new collaborative study between scientists at Northwestern University and the University of Illinois-Chicago uncovered a series of mutations in the SARS-CoV-2 spike protein (the outer part of the virus that helps it penetrate cells) that enhanced the virus’ ability to infect the brains of mice. Implications for Brain Infection and Treatment “Looking at the genomes of viruses found in the brain compared to the lung, we found that viruses with a specific deletion in spike were much better at infecting the brains of these animals,” said co-corresponding author Judd Hultquist, assistant professor of medicine (infectious diseases) and microbiology-immunology at Northwestern University Feinberg School of Medicine. “This was completely unexpected, but very exciting.” The study will be published today (August 23) in the journal Nature Microbiology. Co-corresponding author Judd Hultquist in his lab at Northwestern University Feinberg School of Medicine. Credit: Northwestern University Changes in Spike Help the Virus Infect Different Cells in the Body In this study, researchers infected mice with SARS-CoV-2 and sequenced the genomes of viruses that replicated in the brain versus the lung. In the lung, the spike protein looked very similar to the virus used to infect the mice. In the brain, however, most viruses had a deletion or mutation in a critical region of spike that dictates how it enters a cell. When viruses with this deletion were used to directly infect the brains of mice, it was largely repaired when it traveled to the lungs. “In order for the virus to traffic from the lung to the brain, it required changes in the spike protein that are already known to dictate how the virus gets into different types of cells,” Hultquist said. “We think this region of spike is a critical regulator of whether or not the virus gets into the brain, and it could have large implications for the treatment and management of neurological symptoms reported by COVID-19 patients.” Neurological Symptoms and Long COVID Insights SARS-CoV-2 has long been associated with various neurological symptoms, such as the loss of smell and taste, “brain fog” and “long COVID.” “It’s still not known if long COVID is caused by direct infection of cells in the brain or due to some adverse immune response that persists beyond the infection,” Hultquist said. “If it is caused by infection of cells in the central nervous system, our study suggests there may be specific treatments that could work better than others in clearing the virus from this compartment.” Reference: “Evolution of SARS-CoV-2 in the murine central nervous system drives viral diversification” by Jacob Class, Lacy M. Simons, Ramon Lorenzo-Redondo, Jazmin Galván Achi, Laura Cooper, Tanushree Dangi, Pablo Penaloza-MacMaster, Egon A. Ozer, Sarah E. Lutz, Lijun Rong, Judd F. Hultquist and Justin M. Richner, 23 August 2024, Nature Microbiology. DOI: 10.1038/s41564-024-01786-8 Other Northwestern authors on the study include Lacy M. Simons, Tanushree Dangi, Egon A. Ozer, Pablo Penaloza-MacMaster, and Ramon Lorenzo-Redondo. Funding for this study, “Evolution of SARS-CoV-2 in the murine central nervous system drives viral diversification,” was provided by the National Institutes of Health (grants R01AI150672; R56DE033249; R21AI163912 and U19AI135964); the Department of Defense (grant MS200290); and through institutional support for the Center for Pathogen Genomics and Microbial Evolution and the Northwestern University Clinical & Translational Sciences Institute (NUCATS).

New research shows genome duplication in the ancestor of modern gymnosperms, a group of seed plants that includes cypresses and pines, might have directly contributed to the origin of the group over 350 million years ago. Credit: Kristen Grace/Florida Museum of Natural History Plants are DNA hoarders. Adhering to the maxim of never throwing anything out that might be useful later, they often duplicate their entire genome and hang on to the added genetic baggage. All those extra genes are then free to mutate and produce new physical traits, hastening the tempo of evolution. A new study shows that such duplication events have been vitally important throughout the evolutionary history of gymnosperms, a diverse group of seed plants that includes pines, cypresses, sequoias, ginkgos, and cycads. Published on July 19, 2021, in Nature Plants, the research indicates that a genome duplication in the ancestor of modern gymnosperms might have directly contributed to the origin of the group over 350 million years ago. Subsequent duplications provided raw material for the evolution of innovative traits that enabled these plants to persist in dramatically changing ecosystems, laying the foundation for a recent resurgence over the last 20 million years. “This event at the start of their evolution created an opportunity for genes to evolve and create totally new functions that potentially helped gymnosperms transition to new habitats and aided in their ecological ascendance,” said Gregory Stull, a recent doctoral graduate of the Florida Museum of Natural History and lead author of the study. Some conifer and cycad species have highly restricted distributions and are at risk of going extinct due to climate change and habitat loss. These conifers, Araucaria goroensis, also known as the monkey puzzle tree, and Dacrydium araucarioides are unique to New Caledonia. Credit: Nicolas Anger Taking a closer look at gymnosperms While having more than two sets of chromosomes – a phenomenon called polyploidy – is rare in animals, in plants it is commonplace. Most of the fruits and vegetables we eat, for example, are polyploids, often involving hybridization between two closely related species. Many plants, including wheat, peanuts, coffee, oats, and strawberries, benefit from having multiple divergent copies of DNA, which can lead to faster growth rates and an increase in size and weight. Until now, however, it’s been unclear how polyploidy may have influenced the evolution of gymnosperms. Although they have some of the largest genomes in the plant kingdom, they have low chromosome numbers, which for decades prompted scientists to assume that polyploidy wasn’t as prevalent or important in these plants. Gymnosperm genetics are also complex. Their large genomes make them challenging to study, and much of their DNA consists of repeating sequences that don’t code for anything. Some gymnosperm traits, such as cone structure, color, shape and size, may have arisen as a result of multiple genome duplications. This is a female cone of the species Callitris pancheri. Credit: Nicolas Anger “What makes gymnosperm genomes complex is they seem to have a proclivity for accumulating lots of repetitive elements,” said study co-author Douglas Soltis, Florida Museum curator and University of Florida distinguished professor. “Things like ginkgos, cycads, pines and other conifers are loaded with all this repetitive stuff that has nothing to do with genome duplication.” However, a recent collaborative effort among plant biologists, including Soltis, to obtain massive numbers of genetic sequences from more than 1,000 plants has opened new doors for scientists attempting to piece together the long history of land plant evolution. Stull, now a postdoctoral researcher at the Chinese Academy of Sciences’ Kunming Institute of Botany, and his colleagues used a combination of these data and newly generated sequences to give gymnosperms another look. Genome duplication gave rise to gymnosperms By comparing the DNA of living gymnosperms, the researchers were able to peer back in time, uncovering evidence for multiple ancient genome duplication events that coincided with the origin of major groups. Gymnosperms have undergone significant extinctions throughout their long history, making it difficult to decipher the exact nature of their relationships. But the genomes of all living gymnosperms share the signature of an ancient duplication in the distant past, more than 350 million years ago. More than 100 million years later, another duplication gave rise to the pine family, while a third led to the origin of podocarps, a group containing mostly trees and shrubs that today are primarily restricted to the Southern Hemisphere. In each case, analyses revealed a strong link between duplicated DNA and the evolution of unique traits. While future studies are needed to determine exactly which traits arose due to polyploidy, possible candidates include the strange egglike roots of cycads that harbor nitrogen-fixing bacteria and the diverse cone structures found across modern conifers. Podocarp cones, for example, are highly modified and look deceptively like fruit, said Stull: “Their cones are very fleshy, have various colors, and are dispersed by different animals.” Competition and climate change led to extinction and diversification Stull and his colleagues also wanted to know whether genome duplications influenced the rate at which new gymnosperm species evolved through time. But instead of a clear-cut pattern, they found a complex interplay of extinction and diversification amidst a backdrop of a significantly changing global climates. Today, there are about 1,000 gymnosperm species, which may not seem like many when compared with the 300,000 or so species of flowering plants. But in their heyday, gymnosperms were much more diverse. Gymnosperms were still thriving prior to the asteroid extinction event 66 million years ago, best known for the demise of dinosaurs. But the dramatic ecological changes brought about by the impact tipped the scales: After the dinosaurs disappeared, flowering plants quickly began outcompeting gymnosperm lineages, which suffered major bouts of extinction as a result. Some groups were snuffed out entirely, while others barely managed to survive to the present. The once-flourishing ginkgo family, for example, is today represented by a single living species. But the results from this study indicate that at least some gymnosperm groups made a comeback starting around 20 million years ago, coinciding with Earth’s transition to a cooler, drier climate. “We see points in history where gymnosperms didn’t just continue to decline, but they actually diversified in species numbers as well, which makes for a more dynamic picture of their evolutionary history,” said co-author Pamela Soltis, Florida Museum curator and UF distinguished professor. While some gymnosperms failed to cope with the dual specter of climate change and competition, others had an advantage in certain habitats due to the very traits that caused them to lose out in their ancient rivalry with flowering plants. Groups such as pines, spruces, firs and junipers got fresh starts. “In some respects, gymnosperms maybe aren’t that flexible,” Pamela Soltis said. “They kind of have to ‘wait around’ until climate is more favorable in order for them to diversify.” In some environments, gymnosperms adapted to live at the extremes. In pine forests of southeastern North America, longleaf pines are adapted to frequent fires that incinerate their competition, and conifers dominate the boreal forests of the far north. But take away the fire or the cold, and flowering plants quickly start to encroach. While gymnosperms are still in the process of diversifying, they’ve been interrupted by human-made changes to the environment. Currently, more than 40% of gymnosperms are threatened by extinction due to the cumulative pressures of climate change and habitat loss. Future studies clarifying how their underlying genetics enabled them to persist to the present may give scientists a better framework for ensuring they survive well into the future. “Even though some conifer and cycad groups have diversified considerably over the past 20 million years, many species have highly restricted distributions and are at risk of extinction,” Stull said. “Efforts to reduce habitat loss are likely essential for conserving the many species currently threatened by extinction.” The researchers published their findings in Nature Plants. Reference: “Gene duplications and phylogenomic conflict underlie major pulses of phenotypic evolution in gymnosperms” by Gregory W. Stull, Xiao-Jian Qu, Caroline Parins-Fukuchi, Ying-Ying Yang, Jun-Bo Yang, Zhi-Yun Yang, Yi Hu, Hong Ma, Pamela S. Soltis, Douglas E. Soltis, De-Zhu Li, Stephen A. Smith and Ting-Shuang Yi, 19 July 2021, Nature Plants. DOI: 10.1038/s41477-021-00964-4 Other co-authors of the study are Xiao-Jian Qu of Shandong Normal University; Caroline Parins-Fukuchi of the University of Chicago; Ying-Ying Yang, Jun-Bo Yang, Zhi-Yun Yang, De-Zhu Li and Ting-Shuang Yi of the Chinese Academy of Sciences; Yi Hu and Hong Ma of Pennsylvania State University; and Stephen Smith of the University of Michigan. Funding for the research was provided by the Chinese Academy of Sciences, the National Natural Science Foundation of China, the Yunling International High-end Experts Program of Yunnan Province and the Natural Science Foundation of Shandong Province. Stull also received support from the CAS President’s International Fellowship Initiative and the China Postdoctoral Science Foundation’s International Postdoctoral Exchange Program.

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