Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Indonesia athletic insole OEM supplier

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Arch support insole OEM from Thailand

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Taiwan ODM expert factory for comfort product development

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.ESG-compliant OEM manufacturer in Indonesia

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Breathable insole ODM development Thailand

Jet lag is a temporary sleep disorder that occurs after long-distance travel across multiple time zones. The condition is caused by a mismatch between the traveler’s internal body clock and the new external time environment, resulting in symptoms such as fatigue, insomnia, and decreased alertness. A recent study investigated the impact of disrupting the circadian rhythm on adult neurogenesis. Researchers at the University of Massachusetts Amherst have zeroed in on the primary cause of negative health consequences stemming from disruptions to the body’s circadian rhythms, commonly experienced during jet lag or shift work. The study, published recently in the journal eNeuro, reveals that the circadian clock gene Cryptochrome 1 (Cry 1) plays a crucial role in regulating adult neurogenesis — the continuous creation of neurons in the hippocampus region of the brain. Adult neurogenesis is vital for learning and memory, and disturbances in this process have been associated with dementia and mental health disorders. “Circadian disruption impacts a lot of things,” says lead author Michael Seifu Bahiru, a Ph.D. candidate in the lab of Eric Bittman, Professor Emeritus of Biology. “There are links to cancer, diabetes, and hypertension, as well as adverse impacts on neurogenesis.” Cell birth and survival in the adult hippocampus are regulated by a circadian clock, so its disruption may throw off the process of neurogenesis. In the U.S. alone, some 30 million people experience phase shifts in their circadian rhythms as they work rotating schedules. Michael Seifu Bahiru is a Ph.D. candidate in the lab of Eric Bittman, Professor Emeritus of Biology at UMass Amherst. Credit: UMass Amherst Jet Lag vs. Light Cycle Shifts Until recently, the researchers have faced a sort of chicken-or-egg question. “We always wondered what actually is the root cause of the ailments from circadian disruption?” Bahiru says. “Does the problem come from the act of shifting or the shift itself?” Bittman explains further, “It’s possible it’s just changing the light cycle that affects neurogenesis, that jerking your clock around is bad for you, as opposed to the jet lag, which is the time delay that it takes for all circadian-dependent systems in your body to adjust to this change in daylight.” Their findings support the hypothesis that it’s this internal misalignment, this state of desynchrony between and within organs that occurs during jet lag, that is responsible for the adverse impact on neurogenesis – and, they suspect, other adverse health effects from circadian disruption. To test their hypothesis, they studied cell birth and differentiation in Syrian hamsters with a recessive mutation in the Cry 1 gene that speeds up the clock in constant conditions and dramatically accelerates its ability to shift in response to light. Bittman named the mutation, discovered in previous research, duper. The research team also tested a control group of hamsters without the duper mutation. Both underwent the same sequence of changes in the light cycle. Circadian Misalignment and Neurogenesis They simulated jet lag in the form of eight-hour advances and delays at eight 16-day intervals. A cell birth marker was given in the middle of the experiment. Results showed that jet lag has little effect on cell birth but steers the fate of newborn cells away from becoming neurons. Dupers are immune to this effect of phase shifts. “As predicted, the duper animals re-entrained quicker, but also were resistant to the negative effects of the jet lag protocol, whereas the control – the wild type hamsters – had reduced neurogenesis,” Bahiju says. “The findings indicate that circadian misalignment is critical in jet lag,” the paper concludes. The ultimate goal of Bittman’s lab is to advance understanding of the pathways involved in human biological clocks, which could lead to the prevention of or treatment for the effects of jet lag, shift work, and circadian rhythm disorders. This latest research is the next step toward that goal. Now the team will turn to “a big unanswered question,” Bittman says – “whether it’s the operation of circadian clocks in the hippocampus that is being directly regulated by shifts of the light-dark cycle, or whether neurogenesis is controlled by biological clocks running in cells elsewhere in the body.” Another possibility, which Bittman thinks is more likely, is that the master pacemaker in the suprachiasmatic nucleus of the hypothalamus in the brain detects the light shift and then relays it to the stem cell population that has to divide and differentiate in the hippocampus. Reference: “Adult Neurogenesis Is Altered by Circadian Phase Shifts and the Duper Mutation in Female Syrian Hamsters” by Michael Seifu Bahiru and Eric L. Bittman, 6 March 2023, eNeuro. DOI: 10.1523/ENEURO.0359-22.2023 The study was funded by the National Institutes of Health.

Researchers from Tel Aviv University and the University of Colorado have demonstrated that sunflowers, when planted densely, engage in random movements to avoid shading each other, effectively maximizing their collective photosynthesis. This finding provides crucial insights into plant behavior and circumnutation. A study reveals that densely planted sunflowers use random movements to ensure optimal sunlight capture, highlighting circumnutation’s role in plant growth and mutual support. A team of researchers from Tel Aviv University has discovered that plants growing in dense environments can optimize sunlight capture and minimize mutual shading through inherent random movements, known as circumnutations. This research, conducted in collaboration with the University of Colorado, Boulder, reveals the importance of these movements in enhancing photosynthesis on a collective level, solving a long-standing scientific puzzle dating back to Darwin’s initial observations. Insights into Plant Movement and Growth Patterns “Previous studies have shown that if sunflowers are densely planted in a field where they shade each other they grow in a zigzag pattern – one forward and one back – so as not to be in each other’s shadow. This way they grow side by side to maximize illumination from the sun, and therefore photosynthesis, on a collective level. In fact, plants know how to distinguish between the shadow of a building and the green shadow of a leaf,” said lead researcher Prof. Yasmine Meroz from the School of Plant Sciences and Food Security, Wise Faculty of Life Sciences at Tel Aviv University. “If they sense the shadow of a building – they usually don’t change their growth direction, because they “know” that will have no effect. But if they sense the shadow of a plant, they will grow in a direction away from the shadow.” Prof. Yasmine Meroz. Credit: Tel Aviv University In the current study, recently published in Physical Review X, the researchers investigated how sunflowers “know” to grow in an optimal way (i.e. maximize capture of sunlight for the collective) and analyzed the growth dynamics of the sunflowers in the laboratory, where they exhibit a zig-zag pattern. Prof. Meroz and her team grew sunflowers in a high-density environment and photographed them during growth, taking pictures every few minutes. The photographs were then combined to create a time-lapse movie. By following the movement of each individual sunflower, the researchers observed that the flowers were “dancing” a lot. Scientific Findings on Sunflower Movement According to the researchers, Darwin was the first to recognize that all plants grow while exhibiting a kind of cyclical movement (“circumnutation”) – both stems and roots show this behavior. But until today, – except for a few cases such as climbing plants, which grow in huge circular movements to look for something to grab onto – it was not clear whether it was an artifact or a critical feature of growth. Why would a plant invest energy to grow in random directions? Sunflowers. Credit: Tel Aviv University Implications of Circumnutation in Sunflowers Prof. Meroz explained: “As part of our research, we conducted a physical analysis that captured the behavior of each sunflower within the sunflower collective, and we saw that the sunflowers ‘dance’ to find the best angle so each flower would not block the sunlight of their neighbor. We quantified this movement statistically and showed through computer simulations that these random movements are used collectively to minimize the amount of shadow. It was also very surprising to find that the distribution of the sunflower’s “steps” was very wide, ranging over three orders of magnitude, from close to zero displacement to a movement of two centimeters every few minutes in one direction or another.” Conclusion and Observations on Plant Dynamics In conclusion, Prof. Meroz adds: “The sunflower plant takes advantage of the fact that it can use both small and slow steps as well as large and fast ones to find the optimum arrangement for the collective. That is, if the range of steps was smaller or larger the arrangement would result in more mutual shading and less photosynthesis. This is somewhat like a crowded dance party, where individuals dance around to get more space: if they move too much they will interfere with the other dancers, but if they move too little the crowding problem will not be solved, as it will be very crowded in one corner of the square and empty on the other side. Sunflowers show a similar communication dynamic – a combination of response to the shade of neighboring plants, along with random movements regardless of external stimuli.” Reference: “Noisy Circumnutations Facilitate Self-Organized Shade Avoidance in Sunflowers” by Chantal Nguyen, Imri Dromi, Ahron Kempinski, Gabriella E. C. Gall, Orit Peleg and Yasmine Meroz, 15 August 2024, Physical Review X. DOI: 10.1103/PhysRevX.14.031027

A new study from Malave et al. suggests that in the brains of L-Dopa-treated Parkinson’s patients the lack of Shh signaling to cholinergic neurons results in L-Dopa induced dyskinesia. Credit: Santiago Uribe-Cano Researchers at The Graduate Center, CUNY, and the CUNY School of Medicine find that increased signaling of the protein could suppress debilitating involuntary movements that are a side effect of dopamine replacement therapy. Levodopa, or L-dopa, is considered the most effective treatment for Parkinson’s disease today. After a few years of treatment, however, almost all patients develop a debilitating side effect called L-dopa-induced dyskinesia, or LID, which causes involuntary movements in the limbs, face, and torso. Deep brain stimulation can alleviate LID, but the procedure is highly invasive and not all patients are eligible. Now, a new study led by researchers at the Graduate Center, CUNY, and the CUNY School of Medicine shows that drugs that increase signaling by a protein called sonic hedgehog, or Shh, can inhibit LID. Such a treatment would have the potential to help most Parkinson’s patients, the authors said. The study appears in the journal Communications Biology.  “In rodent and non-human primate models, the administration of L-dopa together with sonic hedgehog agonists attenuate the expression of LID,” said Lauren Malave, Ph.D., first author and postdoctoral fellow at Columbia University, previously a Ph.D. student in the lab of Professor Andreas Kottmann, Ph.D., at the CUNY School of Medicine at City College of New York and the Graduate Center. “We provide novel insight into the underlying mechanisms behind LID formation and provide a potential therapeutic solution.” Parkinson’s disease is caused by the death of dopamine neurons, which is why the disease is treated with medications that are converted to dopamine once they enter the body. Key to the new study, though, is that these neurons also produce neurotransmitters other than dopamine, including GABA, glutamate, and Shh. Shh has not previously been considered a neurotransmitter, but the new paper shows that it does in fact act as a neuromodulator. The researchers found that dopamine neurons use Shh to communicate with cholinergic neurons, which scientists have thought might play a role in LID. They then used animal models of Parkinson’s disease to show that decreased Shh signaling in the basal ganglia, caused by death of dopamine neurons, facilitates LID. On the other hand, mimicking increased signaling by Shh reduced LID. Because of this, the authors suggest that the imbalance between dopamine and Shh after L-dopa treatment is a major cause of LID. The next steps will be to develop new therapeutics that act downstream in the Shh pathway in cholinergic neurons and begin clinical trials. “Deep brain stimulation doesn’t help everyone, it’s very invasive, and not all people are eligible for the surgery. The procedure is also not accessible to everyone,” said Kottmann, who was the corresponding author on the paper. “What we find in this study is that in several animal models, by replacing not only dopamine but dopamine together with agonists that mimic the effects of sonic hedgehog, these dyskinesias can be very much suppressed.” Reference: “Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia” by Lauren Malave, Dustin R. Zuelke, Santiago Uribe-Cano, Lev Starikov, Heike Rebholz, Eitan Friedman, Chuan Qin, Qin Li, Erwan Bezard and Andreas H. Kottmann, 22 September 2021, Communications Biology. DOI: 10.1038/s42003-021-02567-3 This research was supported by the American Parkinson Disease Association and the National Institutes of Health and the Research Foundation of the City University of New York.

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