Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Thailand flexible graphene product manufacturing

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Orthopedic pillow OEM solutions Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Taiwan graphene product OEM service

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Vietnam eco-friendly graphene material processing

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Indonesia sustainable material ODM solutions

Researchers at the Duke Lemur Center have been changing up their care to more closely match the seasonal fluctuations they experience in the wild. Credit: Photo by David Haring, Duke Lemur Center Duke Lemur Center recreates the seasonal swings of native habitat, helping to unlock the secrets of hibernation. If you binged on high-calorie snacks and then spent the winter crashed on the couch in a months-long food coma, you’d likely wake up worse for wear. Unless you happen to be a fat-tailed dwarf lemur. This squirrel-sized primate lives in the forests of Madagascar, where it spends up to seven months each year mostly motionless and chilling, using the minimum energy necessary to withstand the winter. While zonked, it lives off of fat stored in its tail. Animals that hibernate in the wild rarely do so in zoos and sanctuaries, with their climate controls and year-round access to food. But now our closest hibernating relative has gone into true, deep hibernation in captivity for the first time at the Duke Lemur Center. “They did not disappoint,” said research scientist Marina Blanco, who led the project. “Indeed, our dwarf lemurs hibernated just like their wild kin do in western Madagascar.” Why Hibernation Matters—for Lemurs and Humans The researchers say recreating some of the seasonal fluctuations of the lemurs’ native habitat might be good for the well-being of a species hardwired for hibernation, and also may yield insights into metabolic disorders in humans. “Hibernation is literally in their DNA,” Blanco said. Because dwarf lemurs are a closer genetic match to humans than other hibernators, such as bears and bats, researchers say studying their torpor may help humans safely enter and emerge from similar suspended states during surgery. Credit: Lydia Greene Blanco has studied dwarf lemurs for 15 years in Madagascar, fitting them with tracking collars to locate them when they are hibernating in their tree holes or underground burrows. But what she and others observed in the wild didn’t square with how the animals behaved when cared for in captivity. Can Captive Lemurs Still Hibernate? Captive dwarf lemurs are fed extra during the summer so they can bulk up like they do in the wild, and then they’ll hunker down and let their heart rate and temperature drop for short bouts — a physiological condition known as torpor. But they rarely stay in this suspended state for longer than 24 hours. Which got Blanco wondering: After years in captivity, do dwarf lemurs still have what it takes to survive seasonal swings like their wild counterparts do? And what can these animals teach us about how to safely put the human body on pause too, slowing the body’s processes long enough for, say, life-saving surgery or even space travel? To find out, Duke Lemur Center staff teamed up to build fake tree hollows out of wooden boxes and placed them in the dwarf lemurs’ indoor enclosures, as a haven for them to wait out the winter. To mimic the seasonal changes the lemurs experience over the course of the year in Madagascar, the team also gradually adjusted the lights from 12 hours a day to a more “winter-like” 9.5 hours, and lowered the thermostat from 77 degrees Fahrenheit (25 degrees Celsius) to the low 50s. Like other hibernators, dwarf lemurs gorge on fruit and nearly double their weight before winter hibernation. Much of this extra body fat is stored in their tails, giving the fat-tailed dwarf lemur its name. Credit: David Haring The animals were offered food if they were awake and active, and weighed every two weeks, but otherwise, they were left to lie. It worked. In the March 11, 2021, issue of the journal Scientific Reports, the researchers show for the first time that fat-tailed dwarf lemurs can hibernate quite well in captivity. For four months, the eight lemurs in the study spent some 70% of their time in metabolic slow-motion: curled up, cool to the touch, barely moving or breathing for up to 11 days at a stretch, showing little interest in food — akin to their wild counterparts. Now that spring is afoot in North Carolina and the temperatures are warming, the lemurs are waking up. Their first physical exams after they emerged showed them to be 22% to 35% lighter than they were at the start but otherwise healthy. Their heart rates are back up from just eight beats per minute to about 200, and their appetites have returned. “We’ve been able to replicate their wild conditions well enough to get them to replicate their natural patterns,” said Erin Ehmke, who directs research at the center. Females were the hibernation champs, out-storing the males and maintaining more of their winter weight. They need what’s left of their fat stores for the months of pregnancy and lactation that typically follow after they wake up, Blanco said. Hibernation as a Human Health Blueprint Study co-author Lydia Greene says the next step is to use non-invasive research techniques such as metabolite analysis and sensors in their enclosures to better understand what dwarf lemurs do to prepare their bodies and eventually bounce back from months of standby mode — work that could lead to new treatments for heart attacks, strokes, and other life-threatening conditions in humans. Blanco suspects the impressive energy-saving capabilities of these lemurs may also relate to another trait they possess: longevity. The oldest dwarf lemur on record, Jonas, died at the Duke Lemur Center at the age of 29. The fact that dwarf lemurs live longer than non-hibernating species their size suggests that something intrinsic to their biological machinery may protect against aging. “But until now, if you wanted to study hibernation in these primates, you needed to go to Madagascar to find them in the act,” Blanco said. “Now we can study hibernation here and do more close monitoring.” Reference: “On the modulation and maintenance of hibernation in captive dwarf lemurs” by Marina B. Blanco, Lydia K. Greene, Robert Schopler, Cathy V. Williams, Danielle Lynch, Jenna Browning, Kay Welser, Melanie Simmons, Peter H. Klopfer and Erin E. Ehmke, 11 March 2021, Scientific Reports. DOI: 10.1038/s41598-021-84727-3 This research was supported by the Duke Lemur Center.

Conservation efforts often occur reactively once a species is already threatened, but a study published in Current Biology proposes using existing data to predict which unthreatened species could become endangered, allowing for proactive prevention. Lead author Marcel Cardillo and his team examined global change factors, such as climate change, human population growth, and land use changes, in conjunction with species’ intrinsic vulnerabilities. They predict up to 20% of land mammals will have two or more risk factors by 2100, with Sub-Saharan Africa and southeastern Australia facing a “perfect storm” of risk factors. The researchers highlight the need to consider Indigenous communities in conservation efforts, citing Australia’s Indigenous Protected Areas as a model for fostering coexistence between humans and animals. A new study suggests using conservation data to proactively predict and prevent species from becoming threatened, potentially benefiting up to 20% of land mammals by 2100. The research emphasizes the need for conservation approaches that respect Indigenous communities and foster human-animal coexistence. Most conservation efforts are reactive. Typically, a species must reach threatened status before action is taken to prevent extinction, such as establishing protected areas. A new study published today (April 10) in the journal Current Biology shows that we can use existing conservation data to predict which currently unthreatened species could become threatened and take proactive action to prevent their decline before it is too late. “Conservation funding is really limited,” says lead author Marcel Cardillo of Australian National University. “Ideally, what we need is some way of anticipating species that may not be threatened at the moment but have a high chance of becoming threatened in the future. Prevention is better than cure.” To predict “over-the-horizon” extinction risk, Cardillo and colleagues looked at three aspects of global change—climate change, human population growth, and the rate of change in land use—together with intrinsic biological features that could make some species more vulnerable. The team predicts that up to 20% of land mammals will have a combination of two or more of these risk factors by the year 2100. Concentrations of terrestrial mammal species with multiple future risk factors. Credit: Current Biology/Cardillo et al. “Globally, the percentage of terrestrial mammal species that our models predict will have at least one of the four future risk factors by 2100 ranges from 40% under a middle-of-the-road emissions scenario with broad species dispersal to 58% under a fossil-fueled development scenario with no dispersal,” say the authors. High-Risk Regions and Species “There’s a congruence of multiple future risk factors in Sub-Saharan African and southeastern Australia: climate change (which is expected to be particularly severe in Africa), human population growth, and changes in land use,” says Cardillo. “And there are a lot of large mammal species that are likely to be more sensitive to these things. It’s pretty much the perfect storm.” Larger mammals in particular, like elephants, rhinos, giraffes, and kangaroos, are often more susceptible to population decline since their reproductive patterns influence how quickly their populations can bounce back from disturbances. Compared to smaller mammals, such as rodents, which reproduce quickly and in larger numbers, bigger mammals, such as elephants, have long gestational periods and produce fewer offspring at a time. “Traditionally, conservation has relied heavily on declaring protected areas,” says Cardillo. “The basic idea is that you remove or mitigate what is causing the species to become threatened.” “But increasingly, it’s being recognized that that’s very much a Western view of conservation because it dictates separating people from nature,” says Cardillo. “It’s a sort of view of nature where humans don’t play a role, and that’s something that doesn’t sit well with a lot of cultures in many parts of the world.” Incorporating Indigenous-Led Conservation In preventing animal extinction, the researchers say we must also be aware of how conservation impacts Indigenous communities. Sub-Saharan Africa is home to many Indigenous populations, and Western ideas of conservation, although well-intended, may have negative impacts. Australia has already begun tackling this issue by establishing Indigenous Protected Areas (IPAs), which are owned by Indigenous peoples and operate with the help of rangers from local communities. In these regions, humans and animals can coexist, as established through collaboration between governments and private landowners outside of these protected areas. “There’s an important part to play for broad-scale modeling studies because they can provide a broad framework and context for planning,” says Cardillo. “But science is only a very small part of the mix. We hope our model acts as a catalyst for bringing about some kind of change in the outlook for conservation.” Reference: “Priorities for conserving the world’s terrestrial mammals based on over-the-horizon extinction risk” by Cardillo et al., 10 April 2023, Current Biology. DOI: 10.1016/j.cub.2023.02.063

Researchers from the Salk Institute, in a global collaboration, have produced a detailed atlas of human brain cells by analyzing over half a million cells. The study, part of the NIH’s BRAIN Initiative, marks a pivotal shift in understanding brain cell diversity and function. The new research, part of the NIH BRAIN Initiative, paves the way toward treating, preventing, and curing brain disorders. Salk Institute researchers, as part of a larger collaboration with research teams around the world, analyzed more than half a million brain cells from three human brains to assemble an atlas of hundreds of cell types that make up a human brain in unprecedented detail. The research, published in a special issue of the journal Science on October 13, 2023, is the first time that techniques to identify brain cell subtypes originally developed and applied in mice have been applied to human brains. “These papers represent the first tests of whether these approaches can work in human brain samples, and we were excited at just how well they translated,” says Professor Joseph Ecker, director of Salk’s Genomic Analysis Laboratory and a Howard Hughes Medical Institute investigator. “This is really the beginning of a new era in brain science, where we will be able to better understand how brains develop, age, and are affected by disease.” The BRAIN Initiative and Brain Cell Diversity The new work is part of the National Institute of Health’s Brain Research Through Advancing Innovative Neurotechnologies Initiative, or The BRAIN Initiative, an effort launched in 2014 to describe the full plethora of cells—as characterized by many different techniques—in mammalian brains. Salk is one of three institutions awarded grants to act as central players in generating data for the NIH BRAIN Initiative Cell Census Network, BICCN. An abstract representation of cell diversity in the brain. Individual nuclei are colored in the bright hues of t-SNE plots used in epigenomics analysis to distinguish individual brain cell types. Layers of background color represent the local environmental factors of each brain region that influence cell function. Credit: Michael Nunn Every cell in a human brain contains the same sequence of DNA, but in different cell types different genes are copied onto strands of RNA for use as protein blueprints. This ultimate variation in which proteins are found in which cells—and at what levels—allows the vast diversity in types of brain cells and the complexity of the brain. Knowing which cells rely on which DNA sequences to function is critical not only to understanding how the brain works, but also how mutations in DNA can cause brain disorders and, relatedly, how to treat those disorders. “Once we scale up our techniques to a large number of brains, we can start to tackle questions that we haven’t been able to in the past,” says Margarita Behrens, a research professor in Salk’s Computational Neurobiology Laboratory and a co-principal investigator of the new work. From Mice to Men: Adapting Research Techniques In 2020, Ecker and Behrens led the Salk team that profiled 161 types of cells in the mouse brain, based on methyl chemical markers along DNA that specify when genes are turned on or off. This kind of DNA regulation, called methylation, is one level of cellular identity. In the new paper, the researchers used the same tools to determine the methylation patterns of DNA in more than 500,000 brain cells from 46 regions in the brains of three healthy adult male organ donors. While mouse brains are largely the same from animal to animal, and contain about 80 million neurons, human brains vary much more and contain about 80 billion neurons. “It’s a big jump from mice to humans and also introduces some technical challenges that we had to overcome,” says Behrens. “But we were able to adapt things that we had figured out in mice and still get very high quality results with human brains.” Innovative Techniques and Collaborative Efforts At the same time, the researchers also used a second technique, which analyzed the three-dimensional structure of DNA molecules in each cell to get additional information about what DNA sequences are being actively used. Areas of DNA that are exposed are more likely to be accessed by cells than stretches of DNA that are tightly folded up. “This is the first time we’ve looked at these dynamic genome structures at a whole new level of cell type granularity in the brain, and how those structures may regulate which genes are active in which cell types,” says Jingtian Zhou, co-first author of the new paper and a postdoctoral researcher in Ecker’s lab. Other research teams whose work is also published in the special issue of Science used cells from the same three human brains to test their own cell profiling techniques, including a group at UC San Diego led by Bing Ren—also a co-author in Ecker and Behrens’ study. Ren’s team revealed a link between specific brain cell types and neuropsychiatric disorders, including schizophrenia, bipolar disorder, Alzheimer’s disease, and major depression. Additionally, the team developed artificial intelligence deep learning models that predict risk for these disorders. A diagram demonstrating how “barCodes” (“scMCodes”) can be used to identify and classify cell types in the brain. The image shows an anatomical brain cross section, an abstraction of the brain with regions represented as colored circles (blue, red, green, and yellow), and a barcode to represent the technique used by the scientists. Credit: Salk Institute Other groups in the global collaboration focused on measuring levels of RNA to group cells together into subtypes. The groups found a high level of correspondence in each brain region between which genes were activated, based on the DNA studies by Ecker and Behrens’ team, and which genes were found to be transcribed into RNA. The Road Ahead: More Discoveries Await Since the new Salk research was intended as a pilot study to test the efficacy of the techniques in human brains, the researchers say they can’t yet draw conclusions about how many cell types they might uncover in the human brain or how those types differ between mice and humans. “The potential to find unique cell types in humans that we don’t see in mice is really exciting,” says Wei Tian, co-first author of the new paper and a staff scientist in Ecker’s lab. “We’ve made amazing progress but there are always more questions to ask.” In 2022, the NIH Brain Initiative launched a new BRAIN Initiative Cell Atlas Network (BICAN), which will follow up the BICCN efforts. At Salk, a new Center for Multiomic Human Brain Cell Atlas funded through BICAN aims to study cells from over a dozen human brains and ask questions about how the brain changes during development, over people’s lifespans, and with disease. That more detailed work on a larger number of brains, Ecker says, will pave the way toward a better understanding of how certain brain cell types go awry in brain disorders and diseases. “We want to have a full understanding of the brain across the lifespan so that we can pinpoint exactly when, how, and in which cell types things go wrong with disease—and potentially prevent or reverse those harmful changes,” says Ecker. Reference: “Single-cell DNA methylation and 3D genome architecture in the human brain” by Wei Tian, Jingtian Zhou, Anna Bartlett, Qiurui Zeng, Hanqing Liu, Rosa G. Castanon, Mia Kenworthy, Jordan Altshul, Cynthia Valadon, Andrew Aldridge, Joseph R. Nery, Huaming Chen, Jiaying Xu, Nicholas D. Johnson, Jacinta Lucero, Julia K. Osteen, Nora Emerson, Jon Rink, Jasper Lee, Yang E. Li, Kimberly Siletti, Michelle Liem, Naomi Claffey, Carolyn O’Connor, Anna Marie Yanny, Julie Nyhus, Nick Dee, Tamara Casper, Nadiya Shapovalova, Daniel Hirschstein, Song-Lin Ding, Rebecca Hodge, Boaz P. Levi, C. Dirk Keene, Sten Linnarsson, Ed Lein, Bing Ren, M. Margarita Behrens and Joseph R. Ecker, 13 October 2023, Science. DOI: 10.1126/science.adf5357 Other authors of the paper are Anna Bartlett, Qiurui Zeng, Hanqing Liu, Rosa G. Castanon, Mia Kenworthy, Jordan Altshul, Cynthia Valadon, Andrew Aldridge, Joseph R. Nery, Huaming Chen, Jiaying Xu, Nicholas D. Johnson, Jacinta Lucero, Julia K. Osteen, Nora Emerson, Jon Rink, Jasper Lee, Michelle Liem, Naomi Claffey and Caz O’Connor of Salk; Yang Li and Bing Ren of the Ludwig Institute for Cancer Research at UC San Diego; Kimberly Siletti and Sten Linnarsson of the Karolinska Institutet; Anna Marie Yanny, Julie Nyhus, Nick Dee, Tamara Casper, Nadiya Shapovalova, Daniel Hirschstein, Rebecca Hodge, Boaz P. Levi and Ed Lein of the Allen Institute for Brain Science; and C. Dirk Keene of the University of Washington. The work was supported by grants from the National Institute of Mental Health (U01MH121282, UM1 MH130994, NIMH U01MH114812), the National Institutes of Health BRAIN Initiative (NCI CCSG: P30 014195),  the Nancy and Buster Alvord Endowment, and the Howard Hughes Medical Institute.

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