Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Vietnam athletic insole OEM supplier

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.China OEM insole and pillow supplier

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Orthopedic pillow OEM solutions Thailand

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.High-performance graphene insole OEM Taiwan

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Orthopedic pillow OEM solutions Indonesia

In meerkat societies, the matriarch serves as the clear leader. Cooperation and aggression. Meerkats are showing us that one may not be possible without the other. In a study appearing this week in the journal Nature Communications, a team of researchers led by Christine Drea, professor of Evolutionary Anthropology at Duke University, shows that testosterone-fueled aggression may be a crucial part in the evolution of cooperation in meerkat societies. Meerkat societies have a clear boss: the matriarch. Along with her lucky mate, she rules over a group of subordinate females and males of all ages. According to these new results, her dominion depends almost entirely on her very high levels of testosterone. Subordinates help raise the matriarch’s pups. They are cooperative breeders who can’t raise their offspring by themselves. Parents need the help of their group to find food and protect their young while they are busy finding food for themselves. New research finds that testosterone-fueled aggression by the matriarch is a crucial part in the evolution of cooperation in meerkat societies. Credit: Charli Davies But the matriarchs aren’t exactly benevolent leaders. To ensure that the subordinates give her pups undivided attention, she will often attack pregnant subordinates, expelling them from the group, or killing their newborn pups. As a result, few of the adult subordinate females in a clan manage to have surviving pups in any given year. A successful matriarch, on the other hand, can have as many as three or four successful litters in a good year. In addition to preventing the subordinate females from reproducing, matriarchs dominate by pushing and shoving, biting and growling, and they mark their turf by rubbing their behinds against rocks and shrubs, spreading a pungent scent-marking substance produced in glands hidden under their tail. Now, researchers have found that the matriarch’s bossiness, and therefore her success, is due to very high levels of testosterone. “We always think of male competition being driven by testosterone, but here we’re showing that it’s driving female competition too,” said Drea. New research finds that testosterone-fueled aggression by the matriarch is a crucial part in the evolution of cooperation in meerkat societies. Credit: Charli Davies To test how testosterone levels relate to the matriarch’s success, the research team worked with 22 clans of meerkats at the Kuruman River Reserve, in South Africa’s Kalahari Desert. These meerkats have been studied for decades and are habituated to humans. This allowed researchers to study the matriarchs’ behavior throughout their pregnancies – taking note of all the times they showed aggressive behaviors – and to collect the blood and feces used to measure their testosterone levels through time. “In non-pregnant matriarchs, testosterone values are equivalent to the males’, and just a little bit lower in subordinate females. But when matriarchs get pregnant, they ramp up,” said Drea. Both the matriarchs’ aggressiveness and testosterone levels increased together as their pregnancies progressed. Once born, their pups were also aggressive, furiously demanding care and feeding from the subordinates like spoiled little brats. But is testosterone actually driving all of this aggressiveness? To answer that, researchers treated some matriarchs with flutamide, a testosterone-receptor blocker that prevents testosterone’s action in the body. Matriarchs treated with flutamide didn’t shove, bite, or growl as much. They also didn’t mark their territory quite as often. Subordinates picked up on that and stopped being so deferential. Their boss had lost her edge. The boss’ offspring also lost their edge. Without the testosterone boost they would have gotten in their mom’s womb, their behavior changed. Pups from matriarchs treated with flutamide were calmer and less aggressive towards the subordinates. “The subordinate females and their pups are also aggressive, but not as much as the matriarchs and their pups” said Drea. “It’s this difference that gives matriarchs their edge, and it’s this difference that we completely erased with testosterone blockers.” The cross-generational effect of hormones means that testosterone doesn’t simply help the matriarch have more pups. It also helps her pups get a great start in life by bullying the subordinates. Since blocking the matriarch’s testosterone changes the pups’ behavior, hormones may be driving the maintenance of a cooperative family dynasty. “Here we have experimental results revealing a new mechanism for the evolution of cooperative breeding,” Drea said, “one that is based on testosterone-mediated aggression and competition between females.” “Females are not primarily competing for food,” she said. “Competition is about ensuring that other individuals help raise their kids. And testosterone helps them win that reproductive battle.” The researchers say that the matriarch’s testosterone-fueled aggression is the glue that holds the cooperative group together. If females were treated with testosterone blockers for longer, they expect that the matriarch would be overthrown, and the group’s structure would be temporarily destabilized. “When people think about cooperation, they usually think about altruism or helping others,” Drea said. “This study is showing that cooperation can also arise through aggressive means, and quite effectively.” Reference: “An Intergenerational Androgenic Mechanism of Female Intrasexual Competition in the Cooperatively Breeding Meerkat” by Christine M. Drea, Charli S. Davies, Lydia K. Greene, Jessica Mitchell, Dimitri V. Blondel, Caroline L. Shearer, Joseph T. Feldblum, Kristin A. Dimac-Stohl, Kendra N. Smyth-Kabay and Tim H. Clutton-Brock, 17 December 2021, Nature Communications. DOI: 10.1038/s41467-021-27496-x This research was funded by the National Science Foundation (IOS-1021633 to C.M.D.). Researchers relied on records maintained by the Kalahari Meerkat Project, which has been supported by European Research Council Grant (No 294494 to T.C.-B.) and Swiss National Science Foundation Grant (31003A 13676 to M. Manser). Cambridge, Duke, and Zurich Universities supported the Kalahari Meerkat Project during the span of this study.

Scientists discovered that the original SARS-CoV-2 strain could bind to sugars called sialic acids on human cells, a trait not retained by later strains such as Delta and Omicron. Utilizing high-resolution imaging and innovative analysis methods, they identified the binding mechanism’s location and investigated its evolutionary significance. This discovery has provided insights into viral transmission and potential zoonotic origin. The original SARS-CoV-2 strain was found to bind to sialic acids (a class of sugars) on human cells, a trait not seen in later strains. This discovery, made by the Rosalind Franklin Institute and University of Oxford, offers insights into the virus’s transmission and evolution, correlates with previous findings on illness severity, and presents new analysis techniques for exploring viral structures. The original SARS-CoV-2 viral strain that emerged in early 2020 was able to latch on to sugars known as sialic acids, found on the surface of human cells, an ability that later strains did not retain. This binding was found using a combination of magnetic resonance and extremely precise high-resolution imaging, conducted at the Rosalind Franklin Institute and University of Oxford, and published recently in the journal Science. This unique ability in the early strain also raises the possibility that this is how the virus first transferred from animals to humans. Comparison With Subsequent Variants Subsequent variants of concern, such as Delta and Omicron, do not have this ability to grab sialic acid and rely on receptors on their crown spikes to attach to proteins called ACE2 on human cells. Research Methods and Techniques An international team led by scientists at the Rosalind Franklin Institute used magnetic resonance and complex imaging techniques to investigate further. Using a nuclear magnetic resonance (NMR) spectroscopy technique called saturation transfer difference, they developed a new, sophisticated analysis method to address the complex problem. They have called the technique universal saturation transfer analysis (uSTA). Professor Ben Davis of the Rosalind Franklin Institute and University of Oxford, one of the paper’s senior authors, said: “Two of the ongoing mysteries of the coronavirus pandemic are the mechanisms behind viral transmission and the origins of the zoonotic leap. “There is evidence that some influenza viruses can grab sialic acid on the surface of human host cells, and this has been seen in Middle Eastern Respiratory Syndrome (MERS), which is a coronavirus. Although SARS-CoV-2 variants of concern had not shown this mechanism, our research finds that the viral strain that emerged in early 2020 could use this as a way of getting into human cells.” The Binding Mechanism and Evolution of the Virus The binding mechanism is found on the end of the N-terminal domain, which is a part of the virus that evolves more rapidly. The domain has previously been implicated in sialic acid binding but until the Rosalind Franklin Institute team applied high-resolution precision imaging and analysis this was unproven. As to why the virus has discarded the sugar-binding feature as it has evolved into new variants, Professor Davis hypothesizes that it may be necessary for the initial zoonotic leap into humans from animals but can then be hidden until it is required again – particularly if the feature is broadly detrimental to the virus’s mission of replication and infection within humans. Correlation With Earlier Evidence and Implications The finding correlates with evidence from the first wave in Italy. The Italian Genomics Consortium saw a correlation between the severity of COVID-19 illness and genetics, as patients with a particular gene mutation – one that affects the type of sialic acid on cells – were underrepresented in intensive care units. This suggested the virus was finding it easier to infect some genotypes compared to others. Professor James Naismith, Director of the Rosalind Franklin Institute says: “With our ultra-high precision imaging and new method of analysis we can see a previously unknown structure at the very end of the SARS-CoV-2 spike. The amazing thing is that our finding correlates with what the Italian researchers noted in the first wave, suggesting that this was a key role in early infection. “The new technique can be used by others to shed light on other viral structures and answer extremely detailed questions. This work is an example of the unique technologies the Rosalind Franklin Institute was set up to develop.” Reference: “Pathogen-sugar interactions revealed by universal saturation transfer analysis” by Charles J. Buchanan, Ben Gaunt, Peter J. Harrison, Yun Yang, Jiwei Liu, Aziz Khan, Andrew M. Giltrap, Audrey Le Bas, Philip N. Ward, Kapil Gupta, Maud Dumoux, Tiong Kit Tan, Lisa Schimaski, Sergio Daga, Nicola Picchiotti, Margherita Baldassarri, Elisa Benetti, Chiara Fallerini, Francesca Fava, Annarita Giliberti, Panagiotis I. Koukos, Matthew J. Davy, Abirami Lakshminarayanan, Xiaochao Xue, Georgios Papadakis, Lachlan P. Deimel, Virgínia Casablancas-Antràs, Timothy D. W. Claridge, Alexandre M. J. J. Bonvin, Quentin J. Sattentau, Simone Furini, Marco Gori, Jiandong Huo, Raymond J. Owens, Christiane Schaffitzel, Imre Berger, Alessandra Renieri, GEN-COVID Multicenter Study, James H. Naismith, Andrew J. Baldwin and Benjamin G. Davis, 23 June 2023, Science. DOI: 10.1126/science.abm3125

Smithsonian scientists propose a lunar biorepository for Earth’s biodiversity, leveraging the moon’s cold, permanently shadowed craters for cryogenic preservation. This innovative plan, inspired by the Svalbard Global Seed Vault, seeks to address challenges such as radiation and microgravity, and involves collaboration across several Smithsonian institutes. By cryopreserving biological material from the most at-risk species, this initiative aims to provide a safeguard against natural disasters and support future space exploration. Credit: SciTechDaily.com A proposed lunar biorepository may allow for the storage of genetic samples without the need for electricity or liquid nitrogen. New research led by scientists at the Smithsonian proposes a plan to safeguard Earth’s imperiled biodiversity by cryogenically preserving biological material on the moon. The moon’s permanently shadowed craters are cold enough for cryogenic preservation without the need for electricity or liquid nitrogen, according to the researchers. The paper, published in BioScience and written in collaboration with researchers from the Smithsonian’s National Zoo and Conservation Biology Institute (NZCBI), Smithsonian’s National Museum of Natural History, Smithsonian’s National Air and Space Museum, and others, outlines a roadmap to create a lunar biorepository, including ideas for governance, the types of biological material to be stored and a plan for experiments to understand and address challenges such as radiation and microgravity. The study also demonstrates the successful cryopreservation of skin samples from a fish, which are now stored at the National Museum of Natural History. Vision and Inspiration “Initially, a lunar biorepository would target the most at-risk species on Earth today, but our ultimate goal would be to cryopreserve most species on Earth,” said Mary Hagedorn, a research cryobiologist at NZCBI and lead author of the paper. “We hope that by sharing our vision, our group can find additional partners to expand the conversation, discuss threats and opportunities, and conduct the necessary research and testing to make this biorepository a reality.” The proposal takes inspiration from the Global Seed Vault in Svalbard, Norway, which contains more than 1 million frozen seed varieties and functions as a backup for the world’s crop biodiversity in case of global disaster. By virtue of its location in the Arctic nearly 400 feet underground, the vault was intended to be capable of keeping its seed collection frozen without electricity. However, in 2017, thawing permafrost threatened the collection with a flood of meltwater. The seed vault has since been waterproofed, but the incident showed that even an Arctic, subterranean bunker could be vulnerable to climate change. Scientists cryopreserved skin samples from a starry goby, a common reef fish. The samples will undergo radiation exposure testing to prepare for biological material to be sent to the moon. Credit: Zerhan Jafar, Smithsonian National Museum of Natural History Unlike seeds, animal cells require much lower storage temperatures for preservation (-320 degrees Fahrenheit or -196 degrees Celsius). On Earth, cryopreservation of animal cells requires a supply of liquid nitrogen, electricity, and human staff. Each of these three elements is potentially vulnerable to disruptions that could destroy an entire collection, Hagedorn said. To reduce these vulnerabilities, scientists needed a way to passively maintain cryopreservation storage temperatures. Since such cold temperatures do not naturally exist on Earth, Hagedorn and her co-authors looked to the moon. The moon’s polar regions feature numerous craters that never receive sunlight due to their orientation and depth. These so-called permanently shadowed regions can be −410 degrees Fahrenheit (−246 degrees Celsius)—more than cold enough for passive cryopreservation storage. To block out the DNA-damaging radiation present in space, samples could be stored underground or inside a structure with thick walls made of moon rocks. Current Research and Future Directions At the Hawaiʻi Institute of Marine Biology, the research team cryopreserved skin samples from a reef fish called the starry goby. The fins contain a type of skin cell called fibroblasts, the primary material to be stored in the National Museum of Natural History’s biorepository. When it comes to cryopreservation, fibroblasts have several advantages over other types of commonly cryopreserved cells such as sperm, eggs, and embryos. Science cannot yet reliably preserve the sperm, eggs, and embryos of most wildlife species. However, for many species, fibroblasts can be cryopreserved easily. In addition, fibroblasts can be collected from an animal’s skin, which is simpler than harvesting eggs or sperm. For species that do not have skin per se, such as invertebrates, Hagedorn said the team may use a diversity of types of samples depending on the species, including larvae and other reproductive materials. The next steps are to begin a series of radiation exposure tests for the cryopreserved fibroblasts on Earth to help design packaging that could safely deliver samples to the moon. The team is actively seeking partners and support to conduct additional experiments on Earth and aboard the International Space Station. Such experiments would provide robust testing for the prototype packaging’s ability to withstand the radiation and microgravity associated with space travel and storage on the moon. If their idea becomes a reality, the researchers envision the lunar biorepository as a public entity to include public and private funders, scientific partners, countries, and public representatives with mechanisms for cooperative governance akin to the Svalbard Global Seed Bank. “We aren’t saying what if the Earth fails—if the Earth is biologically destroyed this biorepository won’t matter,” Hagedorn said. “This is meant to help offset natural disasters and, potentially, to augment space travel. Life is precious and, as far as we know, rare in the universe. This biorepository provides another, parallel approach to conserving Earth’s precious biodiversity.” Reference: “Safeguarding Earth’s biodiversity by creating a lunar biorepository” by Mary Hagedorn, Lynne R Parenti, Robert A Craddock, Pierre Comizzoli, Paula Mabee, Bonnie Meinke, Susan M Wolf, John C Bischof, Rebecca D Sandlin, Shannon N Tessier and Mehmet Toner, 31 July 2024, BioScience. DOI: 10.1093/biosci/biae058

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