Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Indonesia insole OEM manufacturer

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Memory foam pillow OEM factory China

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.China insole ODM for global brands

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.ESG-compliant OEM manufacturer in Vietnam

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Vietnam graphene product OEM service

Researchers developed an algorithm to link similar cell types across evolutionary distances. Researchers created an algorithm to identify similar cell types from species – including fish, mice, flatworms and sponges – that have diverged for hundreds of millions of years, which could help fill in gaps in our understanding of evolution. Cells are the building blocks of life, present in every living organism. But how similar do you think your cells are to a mouse? A fish? A worm? Comparing cell types in different species across the tree of life can help biologists understand how cell types arose and how they have adapted to the functional needs of different life forms. This has been of increasing interest to evolutionary biologists in recent years because new technology now allows sequencing and identifying all cells throughout whole organisms. “There’s essentially a wave in the scientific community to classify all types of cells in a wide variety of different organisms,” explained Bo Wang, an assistant professor of bioengineering at Stanford University. In response to this opportunity, Wang’s lab developed an algorithm to link similar cell types across evolutionary distances. Their method, detailed in a paper published on May 4, 2021, in eLife, is designed to compare cell types in different species. For their research, the team used seven species to compare 21 different pairings and were able to identify cell types present in all species along with their similarities and differences. Comparing cell types According to Alexander Tarashansky, a graduate student in bioengineering who works in Wang’s laboratory, the idea to create the algorithm came when Wang walked into the lab one day and asked him if he could analyze cell-type datasets from two different worms the lab studies at the same time. “I was struck by how stark the differences are between them,” said Tarashansky, who was lead author of the paper and is a Stanford Bio-X Interdisciplinary Fellow. “We thought that they should have similar cell types, but when we try analyzing them using standard techniques, the method doesn’t recognize them as being similar.” He wondered if it was a problem with the technique or if the cell types were just too different to match across species. Tarashansky then began working on the algorithm to better match cell types across species. “Let’s say I want to compare a sponge to a human,” said Tarashansky. “It’s really not clear which sponge gene corresponds to which human gene because as organisms evolve, genes duplicate, they change, they duplicate again. And so now you have one gene in the sponge that may be related to many genes in humans.” Instead of trying to find a one-to-one gene match like previous methods for data matching, the researchers’ mapping method matches the one gene in the sponge to all potentially corresponding human genes. Then the algorithm proceeds to figure out which is the right one. Tarashansky says trying to find only one-to-one gene pairs has limited scientists looking to map cell types in the past. “I think the main innovation here is that we account for features that have changed over the course of hundreds of millions of years of evolution for long-range comparisons.” “How can we use the ever-evolving genes to recognize the same cell type that are also constantly changing in different species?” Said Wang, who is senior author of the paper. “Evolution has been understood using genes and organismal traits, I think we are now at an exciting turning point to bridge the scales by looking at how cells evolve.” Filling in the tree of life Using their mapping approach, the team discovered a number of conserved genes and cell type families across species. Tarashansky said a highlight of the research was when they were comparing stem cells between two very different flatworms. “The fact that we did find one-to-one matches in their stem cell populations was really exciting,” he said. “I think that basically unlocked a lot of new and exciting information about how stem cells look inside a parasitic flatworm that infects hundreds of millions of people all over the world.” The results of the team’s mapping also suggest there’s a strong conservation of characteristics of neurons and muscle cells from very simple animal types, such as sponges, to more complex mammals like mice and humans. “That really suggests those cell types arose very early on in animal evolution,” Wang said. Now that the team has built the tool for cell comparison, researchers can continue to collect data on a wide variety of species for analysis. As more datasets from more species are collected and compared, biologists will be able to trace the trajectory of cell types in different organisms and the ability to recognize novel cell types will improve. “If you only have sponges and then worms and you’re missing everything in between, it’s hard to know how the sponge cell types evolved or how their ancestors have diversified into sponges and worms,” said Tarashansky. “We want to fill in as many nodes along the tree of life as possible to be able to facilitate this type of evolutionary analysis and transfer of knowledge across species.” Reference: “Mapping single-cell atlases throughout Metazoa unravels cell type evolution” by Alexander J Tarashansky, Jacob M Musser, Margarita Khariton, Pengyang Li, Detlev Arendt, Stephen R Quake and Bo Wang, 4 May 2021, eLife. DOI: 10.7554/eLife.66747 Additional Stanford co-authors include graduate students Margarita Khariton and Pengyang Li, and Stephen Quake, the Lee Otterson Professor of Bioengineering and professor of applied physics and co-president of the Chan Zuckerberg Biohub. Other co-authors are from the European Molecular Biology Laboratory and the University of Heidelberg. Wang is also a member of Stanford Bio-X and the Wu Tsai Neurosciences Institute. Quake is also a member of Bio-X, the Stanford Cardiovascular Institute, the Stanford Cancer Institute and the Wu Tsai Neurosciences Institute. This research was funded by Stanford Bio-X, a Beckman Young Investigator Award and the National Institutes of Health. Wang and Quake will be building on this work as part of the Wu Tsai Neurosciences Institute-funded Neuro-Omics Initiative.

A new study reveals that plant evolution consists of long periods of gradual changes punctuated by brief bursts of large-scale innovations, particularly in response to environmental challenges. This challenges the previously held notion that plants evolved with a sudden change early in their history, similar to animals. A Study Reveals That Plant Evolution Was a Gradual Process Punctuated by Bursts of Innovation A recent study has uncovered intriguing insights into the evolution of plant biology, effectively rewriting the history of how they evolved over the past billion years. Published in the journal Nature Plants, the research reveals that plants gradually developed their range of anatomical designs throughout the passage of time, punctuated by episodic bursts of innovation to overcome and adapt to environmental challenges. Such findings overturn the long-held belief that, much like animals, the fundamental range of plant types evolved in a big burst of sudden change early in their evolutionary history. A diverse community of land plants, ranging from mosses to flowering species, grow together in a boggy stream in the Cairngorms National Park, Scotland. Credit: Sandy Hetherington, The University of Edinburgh, UK Co-lead author Philip Donoghue, Professor of Palaeobiology at the University of Bristol, said: “Although plants are extraordinarily diverse in their design and organization, they share a common ancestor which originated at sea more than a billion years ago. “We wanted to test whether they really evolved with a big bang early on in their history or whether their evolution was a slower and more continual process. Surprisingly, the results revealed plant evolution was a bit of a mix, with long periods of gradual change interrupted by short bursts of large-scale innovation, overcoming the challenges of living on dry land.” To test this theory the team of scientists analyzed the similarities and differences of 248 groups of plants, ranging from single-celled pond scum and seaweed to land plants including everything from mosses and ferns, to pines, conifers, and flowering plants. They also looked at 160 extinct groups known only from the fossil record, including species from the Devonian Rhynie Chert which lived more than 400 million years ago. More than 130,000 observations were generated by breaking down plant designs into their components and recording those present or absent in each of the main groups, living and fossil. Computerized statistical techniques measured the overall similarities and differences between groups and how they varied over time. The moss, Polytrichum commune, which is one of the closest living relatives of the ancestral land plant. Credit: Silvia Pressel, The Natural History Museum The scientists also tried to work out what led to these evolutionary innovations, like the introduction of spores, seeds, roots, leaves, pollen, and flowers. Genome Doubling and Evolutionary Innovation Co-lead author Dr James Clark, Research Associate in Biological Sciences at the University of Bristol, said: “We found changes in plant anatomical design occur in association with events in which the entire cellular genetic make-up was doubled. This has happened many times in plant evolutionary history, as a result of errors in the genome-copying process, creating duplicate copies of genes that are free to mutate and evolve new functions.” But the major pulses of plant anatomical evolution were found to be associated with the challenge of living and reproducing in increasingly dry environments, connected to the progressive emergence of plants from the sea on to land. Co-lead author Dr. Sandy Hetherington’s fascination with the evolution of land plants began as a budding geologist at the University of Bristol and now continues in his work at the University of Edinburgh. He said: “Overall the pattern of episodic pulses in the evolution of plant anatomical designs matches that seen in other multi-cellular kingdoms of complex life, like animals and fungi. This suggests it is a general pattern and blueprint for complex multicellular life from its inception.” Reference: “Evolution of phenotypic disparity in the plant kingdom” by James W. Clark, Alexander J. Hetherington, Jennifer L. Morris, Silvia Pressel, Jeffrey G. Duckett, Mark N. Puttick, Harald Schneider, Paul Kenrick, Charles H. Wellman and Philip C. J. Donoghue, 4 September 2023, Nature Plants. DOI: 10.1038/s41477-023-01513-x

Research reveals that Ohio’s white-tailed deer carry the COVID-19 virus, with the virus variants evolving three times faster in deer than in humans. The implications for potential cross-species transmission in the future remain unclear. Study Finds Deer Are Virus Reservoirs, Promoting Ongoing Mutation New research has found that white-tailed deer across Ohio have been infected with the virus that causes COVID-19. Alarmingly, the results also show that viral variants evolve about three times faster in deer than in humans. Scientists collected 1,522 nasal swabs from free-ranging deer in 83 of the state’s 88 counties between November 2021 and March 2022. More than 10% of the samples were positive for the SARS-CoV-2 virus, and at least one positive case was found in 59% of the counties in which testing took place. Genomic Analysis and Findings Genomic analysis showed that at least 30 infections in deer had been introduced by humans – a figure that surprised the research team. “We generally talk about interspecies transmission as a rare event, but this wasn’t a huge sampling, and we’re able to document 30 spillovers. It seems to be moving between people and animals quite easily,” said Andrew Bowman, associate professor of veterinary preventive medicine at The Ohio State University and co-senior author of the study. “And the evidence is growing that humans can get it from deer – which isn’t radically surprising. It’s probably not a one-way pipeline.” The combined findings suggest that the white-tailed deer species is a reservoir for SARS-CoV-2 that enables continuing mutation, and that the virus’s circulation in deer could lead to its spread to other wildlife and livestock. The study is published today (August 28, 2023) in the journal Nature Communications. Previous Observations and Expansions Bowman and colleagues previously reported detection of SARS-CoV-2 infections in white-tailed deer in nine Ohio locations in December 2021, and are continuing to monitor deer for infection by more recent variants. “We expanded across Ohio to see if this was a localized problem – and we find it in lots of places, so it’s not just a localized event,” Bowman said. “Some of the thought back then was that maybe it’s just in urban deer because they’re in closer contact with people. But in rural parts of the state, we’re finding plenty of positive deer.” Beyond the detection of active infections, researchers also found through blood samples containing antibodies – indicating previous exposure to the virus – that an estimated 23.5% of deer in Ohio had been infected at one time or another. Variant Analysis The 80 whole-genome sequences obtained from the collected samples represented groups of various viral variants: the highly contagious delta variant, the predominant human strain in the United States in the early fall of 2021 that accounted for almost 90% of the sequences, and alpha, the first named variant of concern that had circulated in humans in the spring of 2021. The analysis revealed that the genetic composition of delta variants in deer matched dominant lineages found in humans at the time, pointing to the spillover events, and that deer-to-deer transmission followed in clusters, some spanning multiple counties. “There’s probably a timing component to what we found – we were near the end of a delta peak in humans, and then we see a lot of delta in deer,” Bowman said. “But we were well past the last alpha detection in humans. So the idea that deer are holding onto lineages that have since gone extinct in humans is something we were worried about.” The study did suggest that COVID-19 vaccination is likely to help protect people against severe disease in the event of a spillover back to humans. An analysis of the effects of deer variants on Siberian hamsters, an animal model for SARS-CoV-2 studies, showed that vaccinated hamsters did not get as sick from infection as unvaccinated animals. Rapid Evolution in Deer Disturbingly, the variants circulating in deer are expected to continue to change. An investigation of the mutations found in the samples provided evidence of more rapid evolution of both alpha and delta variants in deer compared to humans. “Not only are deer getting infected with and maintaining SARS-CoV-2, but the rate of change is accelerated in deer – potentially away from what has infected humans,” Bowman said. How the virus is transmitted from humans to white-tailed deer remains a mystery. And so far, even with about 30 million free-ranging deer in the U.S., no substantial outbreaks of deer-origin strains have occurred in humans. Potential Implications Circulation among animals, however, remains highly likely. Bowman noted that about 70% of free-ranging deer in Ohio have not been infected or exposed to the virus, “so that’s a large body of naive animals that the virus could spread through rather uninhibited.” “Having that animal host in play creates things we need to watch out for,” he said. “If this trajectory continues for years and we have a virus that becomes deer-adapted, then does that become the pathway into other animal hosts, wildlife or domestic? We just don’t know.” Reference: “Accelerated evolution of SARS-CoV-2 in free-ranging white-tailed deer” by Dillon S. McBride, Sofya K. Garushyants, John Franks, Andrew F. Magee, Steven H. Overend, Devra Huey, Amanda M. Williams, Seth A. Faith, Ahmed Kandeil, Sanja Trifkovic, Lance Miller, Trushar Jeevan, Anami Patel, Jacqueline M. Nolting, Michael J. Tonkovich, J. Tyler Genders, Andrew J. Montoney, Kevin Kasnyik, Timothy J. Linder, Sarah N. Bevins, Julianna B. Lenoch, Jeffrey C. Chandler, Thomas J. DeLiberto, Eugene V. Koonin, Marc A. Suchard, Philippe Lemey, Richard J. Webby, Martha I. Nelson and Andrew S. Bowman, 28 August 2023, Nature Communications. DOI: 10.1038/s41467-023-40706-y Martha Nelson of the National Library of Medicine was co-corresponding author of the study. Ohio State co-authors Dillon McBride, Steven Overend, Devra Huey, Amanda Williams, Seth Faith and Jacqueline Nolting worked on the study with co-authors from St. Jude Children’s Research Hospital; the University of California, Los Angeles; the National Research Centre in Giza, Egypt; PathAI Diagnostics; the Ohio Department of Natural Resources; the U.S. Department of Agriculture; Columbus and Franklin County Metroparks; and the Rega Institute for Medical Research in Belgium. This work was supported by the National Institute of Allergy and Infectious Diseases and Ohio State’s Infectious Diseases Institute.

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