Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Innovative pillow ODM solution in China

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Innovative pillow ODM solution in Thailand

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Taiwan pillow OEM manufacturing factory

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Custom graphene foam processing Indonesia

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.ODM pillow factory for sleep product brands

Researchers at Cambridge University have identified a process called graphitization, which they theorize could produce essential life-building molecules like proteins, phospholipids, and nucleotides on early Earth. This process, highlighted in a study in the journal Life, suggests that the high temperatures resulting from celestial impacts and interactions with iron and water could simplify chemical environments, making them conducive to the formation of life’s necessary components. Researchers at Cambridge University propose that essential molecules for life’s development might have originated from a process called graphitization. If confirmed through laboratory experiments, this could enable us to simulate conditions that are likely to have led to the emergence of life. How did the chemicals required for life get there? It has long been debated how the seemingly fortuitous conditions for life arose in nature, with many hypotheses reaching dead ends. However, researchers at the University of Cambridge have now modeled how these conditions could occur, producing the necessary ingredients for life in substantial quantities. Life is governed by molecules called proteins, phospholipids, and nucleotides. Past research suggests that useful molecules containing nitrogen like nitriles – cyanoacetylene(HC3N) and hydrogen cyanide(HCN) – and isonitriles – isocyanide(HNC) and methyl isocyanide(CH3NC) – could be used to make these building blocks of life. As of yet though, there has been no clear way to make all of these in the same environment in substantial amounts. In a recent study published in Life, the group has now found that through a process known as graphitization, significant quantities of these useful molecules can be theoretically made. If the model can be verified experimentally, this suggests that the process was a likely step for early Earth on its journey toward life. Why is this process more likely to have occurred than others? Much of the problem with previous models, is that a range of other products are created along with the nitriles. This makes a messy system that hinders the formation of life. ‘A big part of life is simplicity,’ said Dr Paul Rimmer, Assistant Professor of Experimental Astrophysics at the Cavendish Laboratory, and co-author of the study. ‘It’s order. It’s coming up with a way to get rid of some of the complexity by controlling what chemistry can happen.’ We don’t expect life to be produced in a messy environment. So, what is fascinating is how graphitization itself cleans the environment, since the process exclusively creates these nitriles and isonitriles, with mostly inert side-products. A schematic representation of the scenario we propose here for clean, high-yield production of prebiotic feedstock. Events move around clockwise from the top left: First, the Earth has a neutral atmosphere. This is reduced following a giant impact at 4.3 Ga by oxidation of the impactor’s metal core to produce a massive H2 atmosphere with significant methane and ammonia. This atmosphere quickly cools (in <1 kyr), with photochemistry producing a tholin-rich haze that deposits complex nitrogen-rich organics. These organics become progressively buried and graphitized by interaction with magma. The atmosphere clears as H2 is lost to space and becomes neutral again. Finally, magmatic gases interact with the graphite and are scrubbed to produce high yields of clean HCN, HC3N, and isonitriles. Credit: Oliver Shorttle ‘At first, we thought this would spoil everything, but actually, it makes everything so much better. It cleans the chemistry,’ said Rimmer. This means graphitization could provide the simplicity scientists are looking for, and the clean environment required for life. How does the process work? The Hadean eon was the earliest period in Earth’s history, when the Earth was very different from our modern Earth. Impacts with debris, sometimes the size of planets, were not unheard of. The study theorizes that when the early Earth was hit by an object roughly the size of the moon, around 4.3 billion years ago, the iron that it contained reacted with water on Earth. ‘Something the size of the moon hit early Earth, and it would have deposited a large amount of iron and other metals’ said co-author Dr Oliver Shorttle, Professor of natural philosophy at the Institute of Astronomy and Department of Earth Sciences in Cambridge. The products of the iron-water reaction condense into a tar on the surface of the Earth. The tar then reacts with magma at over 1500°C and the carbon in the tar becomes graphite- a highly stable form of carbon- and what we use in modern pencil leads! ‘Once the iron reacts with the water, a mist forms that would have condensed and mixed with the Earth’s crust. Upon heating, what’s left is, lo and behold, the useful nitrogen-containing compounds,’ said Shorttle. What evidence exists to support this idea? The evidence to support this theory partly comes from the presence of komatiitic rocks. Komatiite is a type of volcanic rock which are formed when very hot magma(>1500°C) cools. ‘Komatiite was originally found in South Africa. The rocks date back to around 3.5 billion years ago,’ said Shorttle. ‘Crucially, we know that these rocks only form at scorching temperatures, around 1700°C! That means the magma would already have been hot enough to heat the tar and create our useful nitriles.’ With the link confirmed, the authors suggest that nitrogen-containing compounds would be made via this method- since we see komatiite, we know the temperature of magma on early Earth sometimes must have been in excess of 1500°C. What next? Now experiments must try to recreate these conditions in the lab, and study whether the water, which is inevitably in the system, eats up the nitrogen compounds, breaking them apart. ‘Though we don’t know for sure that these molecules started out life on Earth, we do know that life’s building blocks must be made from molecules that survived in water,’ said Rimmer. ‘If future experiments show that the nitriles all fall apart, then we’ll have to look for a different way.’ Reference: “A Surface Hydrothermal Source of Nitriles and Isonitriles” by Paul B. Rimmer and Oliver Shorttle, 10 April 2024, Life. DOI: 10.3390/life14040498 The study was funded by Cambridge Planetary Science and Life in the Universe Research Grants.

Chromosomes (shown in pink) are shared by the spindle (blue). Membranes (green) are a risk factor for correct chromosome sharing. Credit: University of Warwick Research from the University of Warwick reveals new insights on a key cause of cancer formation during cell division (or mitosis), and points towards potential solutions for preventing it from occurring. When a cell divides abnormally, it does not share the correct number of chromosomes with the two new cells, which can lead to cancer. New research from Warwick Medical School has discovered why and how this happens, using “cell surgery.” Understanding the origin of abnormal cell division and cancer formation may lead to prevention. When a cell divides normally, it makes a duplicate copy of every chromosome and then shares them equally between the two new cells. This function is carried out by a complex machine in the cell called the mitotic spindle. If something goes wrong during this stage, the two new cells will be aneuploid, meaning that they will not have the correct number of chromosomes and will make mistakes when sharing genetic information. Cancer cells are aneuploid, so understanding how and why this happens is incredibly important in finding out how the disease originates. Professor Stephen Royle’s research team at Warwick Medical School has identified exactly this. Mitosis is the process through which a cell copies its chromosomes and then segregates them, producing two identical nuclei in preparation for cell division. Mitosis is generally followed by equal division of the cell’s content into two genetically identical daughter cells. Credit: NIH They found that some chromosomes can get lost and trapped in a tangle of membranes that exist in an area around the cell’s spindle, preventing the chromosomes from being shared properly and leading to abnormal cell division that can cause cancer. They made their discovery by performing a sort of ‘surgery’ on living cells. The researchers invented a way to remove the tangle of membranes in which chromosomes get trapped, and as a result, the chromosomes were rescued by the spindle, thus enabling normal healthy cell division. This proved, for the first time, that chromosomes getting caught in these membranes is a direct risk factor for the formation of cancerous cells. Understanding this risk can lead to more effective cancer prevention. Stephen Royle, Professor of Cell Biology at Warwick Medical School, commented: “Many scientists working on cell division focus on the spindle: how it works and why it makes mistakes in cancer. In this paper we shifted the spotlight and looked at membranes inside dividing cells.” Dr. Nuria Ferrandiz, lead author of the study, said: “We found that chromosomes can get trapped in membranes and this is a disaster for the dividing cell. It has the potential to change a normal cell into a cancer cell. Preventing this process may be a way to treat disease.” Reference: “Endomembranes promote chromosome missegregation by ensheathing misaligned chromosomes” by Nuria Ferrandiz, Laura Downie, Georgina P. Starling and Stephen J. Royle, 28 April 2022, Journal of Cell Biology. DOI: 10.1083/jcb.202203021

Scripps Institution of Oceanography Ph.D. student Kate Bauman streaks new Salinispora cultures for further study in a biosafety cabinet with lab director Bradley Moore. These bacterial cultures produce salinosporamide A, a potent anticancer agent currently in phase III clinical trials for glioblastoma. Credit: Erik Jepsen/UC San Diego Deep-sea microbe provides rich source of medically potent drugs. Years of toil in the laboratory have revealed how a marine bacterium makes a potent anti-cancer molecule. The anti-cancer molecule salinosporamide A, also called Marizomb, is in Phase III clinical trials to treat glioblastoma, a brain cancer. Scientists now for the first time understand the enzyme-driven process that activates the molecule. Researchers at UC San Diego’s Scripps Institution of Oceanography found that an enzyme called SalC assembles what the team calls the salinosporamide anti-cancer “warhead.” Scripps graduate student Katherine Bauman is the lead author of a paper that explains the assembly process in the March 21 issue of Nature Chemical Biology. The work solves a nearly 20-year riddle about how the marine bacterium makes the warhead that is unique to the salinosporamide molecule and opens the door to future biotechnology to manufacture new anti-cancer agents. “Now that scientists understand how this enzyme makes the salinosporamide A warhead, that discovery could be used in the future to use enzymes to produce other types of salinosporamides that could attack not only cancer but diseases of the immune system and infections caused by parasites,” said co-author Bradley Moore, a Distinguished Professor at Scripps Oceanography and the Skaggs School of Pharmacy and Pharmaceutical Sciences. Salinispora cultures in the Moore Lab at UC San Diego’s Scripps Institution of Oceanography. These bacterial cultures produce salinosporamide A, a potent anticancer currently in phase III clinical trials to treat glioblastoma. Credit: Erik Jepsen/UC San Diego The Enzyme Behind the Anti-Cancer Warhead Salisporamide has a long history at Scripps and UC San Diego. Microbiologist Paul Jensen and marine chemist Bill Fenical of Scripps Oceanography discovered both salinosporamide A and the marine organism that produces the molecule after collecting the microbe from sediments of the tropical Atlantic Ocean in 1990. Some of the clinical trials over the course of the drug’s development took place at Moores Cancer Center at UC San Diego Health. “This has been a very challenging 10-year project,” said Moore, who is Bauman’s advisor. “Kate’s been able to bring together 10 years’ worth of earlier work to get us across the finish line.” A big question for Bauman was to find out how many enzymes were responsible for folding the molecule into its active shape. Are multiple enzymes involved or just one? “I would have bet money on more than one. In the end, it was just SalC. That was surprising,” she said. Salinosporamide’s Unique Structure and Clinical Potential Moore says the salinosporamide molecule has a special ability to cross the blood-brain barrier, which accounts for its progress in clinical trials for glioblastoma. The molecule has a small but complex ring structure. It starts as a linear molecule that folds into a more complex circular shape. “The way nature makes it is beautifully simple. We as chemists can’t do what nature has done to make this molecule, but nature does it with a single enzyme,” he said. The enzyme involved is common in biology; it is one that participates in the production of fatty acids in humans and antibiotics like erythromycin in microbes. Bauman, Percival Yang-Ting Chen of Morphic Therapeutics in Waltham, Mass., and Daniella Trivella of Brazil’s National Center for Research in Energy and Materials, determined the molecular structure of SalC. For this purpose they used the Advanced Light Source, a powerful particle accelerator that generates X-ray light, at the U.S. Department of Energy’s Lawrence Berkeley National Laboratory. Future Applications and Biotechnology Opportunities “The SalC enzyme performs a reaction very different from a normal ketosynthase,” Bauman said. A normal ketosynthase is an enzyme that helps a molecule form a linear chain. SalC, by contrast, manufactures salinosporamide by forming two complex, reactive, ring structures. A single enzyme can form both of those ring structures that are hard for synthetic chemists to make in the lab. Armed with this information, scientists now can mutate the enzyme until they find forms that show promise for suppressing various types of disease. The marine bacterium involved, called Salinispora tropica, makes salinosporamide to avoid being eaten by its predators. But scientists have found that salinosporamide A also can treat cancer. They have isolated other salinosporamides, but salinosporamide A has features that the others lack – including biological activity that makes it hazardous to cancer cells. “Inhibiting that proteasome makes it a great anti-cancer agent,” said Bauman, speaking of the protein complex that degrades useless or impaired proteins. But there’s another type of proteasome found in immune cells. What if scientists could devise a slightly different salinosporamide than salinosporamide A? One that poorly inhibits the cancer-prone proteasome but excels at inhibiting the immunoproteasome? Such a salinosporamide could be a highly selective treatment for autoimmune diseases, the type that causes the immune system to turn upon the very body it should protect. “That’s the idea behind generating some of these other salinosoporamides. And access to this enzyme SalC that installs the complicated ring structure opens the door to that in the future,” Bauman said. As Bauman’s list of co-authors attests, Moore’s group began working on this project more than a decade ago. Former Moore Lab postdoctoral scientists who contributed are Tobias Gulder of Germany’s Technical University of Dresden; Daniela Trivella of Brazil’s National Center for Research in Energy and Materials; and Percival Yang-Ting Chen of Morphic Therapeutics in Waltham, Mass. Vikram V. Shende is a current postdoctoral scientist in the Moore Lab. The other two co-authors are longtime collaborators on the project: Sreekumar Vellalath and Daniel Romo of Baylor University. Reference: “Enzymatic assembly of the salinosporamide γ-lactam-ß-lactone anticancer warhead” by Katherine D. Bauman, Vikram V. Shende, Percival Yang-Ting Chen, Daniela B. B. Trivella, Tobias A. M. Gulder, Sreekumar Vellalath, Daniel Romo and Bradley S. Moore, 21 March 2022, Nature Chemical Biology. DOI: 10.1038/s41589-022-00993-w Bauman’s work is funded by a National Research Service Award from the National Institutes of Health. Further funding was provided by the Robert A. Welch Foundation and the São Paulo Research Foundation.

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