Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan insole ODM service provider

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.China graphene product OEM service

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Thailand graphene product OEM service

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Graphene insole manufacturer in Vietnam

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Custom foam pillow OEM production factory in Taiwan

Researchers mapped 6,000 eye proteins and developed an AI-based “proteomic clock” to predict age. The study revealed accelerated aging in certain diseases and identified proteins linked to Parkinson’s, suggesting an avenue for early diagnosis. The findings could revolutionize precision medicine and clinical trial approaches. An AI-powered proteomic clock from eye fluid reveals disease-driven aging and may enable early Parkinson’s detection. A team of researchers has mapped almost 6,000 proteins from different cell types within the eye by analyzing tiny drops of eye fluid that are routinely removed during surgery. In a study recently published in the journal Cell, the researchers used an AI model to create a “proteomic clock” from this data that can predict a healthy person’s age based on their protein profile. The clock revealed that diseases such as diabetic retinopathy and uveitis cause accelerated aging within specific cell types. Surprisingly, the researchers also detected proteins associated with Parkinson’s disease within eye fluid, which they say could offer a pathway to earlier Parkinson’s diagnoses. Eye as a Window to Diseases “What’s amazing about the eye is we can look inside and see diseases happening in real-time,” says senior author Vinit Mahajan, a surgeon and professor of ophthalmology at Stanford University. “Our primary focus was to connect those anatomical changes to what’s happening at the molecular level inside the eyes of our patients.” The eye is a difficult organ to sample in living patients because, like the brain, it is non-regenerative, and taking a tissue biopsy would cause irreparable damage. An alternative method is to use liquid biopsies—samples of fluid taken from near the cells or tissues of interest. Though liquid biopsies can provide a snapshot of what proteins are present in the region of interest, they have thus far been limited in their ability to measure large numbers of proteins within the small volumes of fluid, and they are also unable to provide information on which cells produced which proteins, which is important for diagnosing and treating diseases. Advanced Protein Mapping and Findings To map protein production by different types of cells within the eye, Mahajan’s team used a high-resolution method to characterize proteins in 120 liquid biopsies taken from the aqueous or vitreous humor of patients undergoing eye surgery. Altogether, they identified 5,953 proteins—ten times the number of proteins previously characterized in similar studies. Using a software tool they created called TEMPO, the researchers were able to trace each protein back to specific cell types. To investigate the relationship between disease and molecular aging, the researchers built an AI machine-learning model that can predict the molecular age of the eye based on a subset of 26 proteins. The model was able to accurately predict the age of healthy eyes but showed that diseases were associated with significant molecular aging. For diabetic retinopathy, the degree of aging increased with disease progression and this aging was accelerated by as much as 30 years for individuals with severe (proliferative) diabetic retinopathy. These signs of aging were sometimes observable before the patient displayed clinical symptoms of the underlying disease and lingered in patients who had been successfully treated. The researchers also detected several proteins that are associated with Parkinson’s disease. These proteins are usually identified postmortem and current diagnostic methods aren’t capable of testing for them, which is one reason Parkinson’s diagnoses are so difficult. Screening for these markers in eye fluid could enable earlier diagnosis of Parkinson’s disease and later therapeutic monitoring. Implications and Future Directions The authors say that these results suggest that aging may be organ- or even cell-specific, which could yield advances in precision medicine and clinical trial design. “These findings demonstrate that our organs are aging at different rates,” says first author and ophthalmologist Julian Wolf of Stanford University. “The use of targeted anti-aging drugs could be the next step in preventative, precision medicine.” “If we’re going to use molecular therapies, we should be characterizing the molecules in our patients,” says Mahajan. “I think reclassifying patients based on their molecular patterns and which cells are being affected can really improve clinical trials, drug selection, and drug outcomes.” Next, the researchers plan to characterize samples from a larger number of patients and a broader range of eye diseases. They also say that their method could be used to characterize other difficult-to-sample tissues. For example, liquid biopsies of cerebrospinal fluid could be used to study or diagnose the brain, synovial fluid could be used to study joints, and urine could be used to study the kidneys. Reference: “Liquid-biopsy proteomics combined with AI identifies cellular drivers of eye aging and disease in vivo” by Julian Wolf, Ditte K. Rasmussen, Young Joo Sun, Jennifer T. Vu, Elena Wang, Camilo Espinosa, Fabio Bigini, Robert T. Chang, Artis A. Montague, Peter H. Tang, Prithvi Mruthyunjaya, Nima Aghaeepour, Antoine Dufour, Alexander G. Bassuk and Vinit B. Mahajan, 19 October 2023, Cell. DOI: 10.1016/j.cell.2023.09.012 This research was supported by the National Institutes of Health, Stanford University, Research to Prevent Blindness, the VitreoRetinal Surgery Foundation, the Lundbeck Foundation, and the BrightFocus Foundation.

Last Chance Lake in British Columbia, Canada is a modern analog for soda lakes that may have supported the emergence of cells on the early Earth. Credit: Zachary R. Cohen A study suggests that soda lakes, characterized by high levels of dissolved sodium and carbonate, might have provided the right conditions for the first cells. These early cells may have been composed of RNA inside lipid membranes. But RNA function requires divalent cations such as Mg2+, which disrupt primitive membranes made of fatty acids. The question arises whether the relatively low concentrations of Mg2+ found in soda lakes may have allowed both RNA and membranes to function together. Exploring the Viability of Early Life in Soda Lakes To explore this possibility, Zachary Cohen and colleagues collected water from Last Chance Lake and Goodenough Lake in Canada after seasonal evaporation. These soda lakes each contained ~1 M Na+ and ~1 mM Mg2+ at pH 10. The authors found that spontaneous extension of short RNA primers occurred in lake water at a rate comparable to the rates in standard laboratory conditions. The authors added fatty acids, which could have been available on the early Earth, to the lake water to see if the molecules would assemble into membranes. Findings and Implications The membranes formed in dilute water that simulates a rainfall event, and the membranes persisted even when surrounded by concentrated lake water from the dry season. According to the authors, soda lakes on the early Earth could have supported key features of protocell development, with RNA copying and ribozyme activity taking place in the dry season and vesicle formation occurring during the wet season. Reference: “Natural soda lakes provide compatible conditions for RNA and membrane function that could have enabled the origin of life” by Zachary R Cohen, Dian Ding, Lijun Zhou, Saurja DasGupta, Sebastian Haas, Kimberly P Sinclair, Zoe R Todd, Roy A Black, Jack W Szostak and David C Catling, 19 March 2024, PNAS Nexus. DOI: 10.1093/pnasnexus/pgae084

When analyzing the brain of the mice whose Cullin 3-Gen has been partially deactivated, the scientists found malformations of the cortex. Credit: © IST Austria Scientists at IST Austria discover how a high-risk gene for developing autism spectrum disorder affects brain development. Within the European Union alone, about three million people are affected by an autism spectrum disorder (ASD). Some are only mildly affected and can live independent lives. Others have severe disabilities. What the different forms have in common is difficulty with social interaction and communication, as well as repetitive-stereotypic behaviors. Mutations in a few hundred genes are associated with ASD. One of them is called Cullin 3, and it is a high-risk gene: A mutation of this gene almost certainly leads to a disorder. But how exactly does this gene affect the brain? To learn more about it, Jasmin Morandell and Lena Schwarz, PhD students at Professor Gaia Novarino’s research group, turned to mice whose Cullin 3 gene has been partially deactivated and compared them to their healthy siblings. Their results have just been published in the journal Nature Communications. In a series of behavioral and motoric tests, the team wanted to see if the modified mice mimicked some of the characteristics of patients with this form of autism and could therefore be used as model organisms. In one of these tests, the so-called three-chamber sociability test, a mouse could freely explore three adjacent chambers of a box connected by little doors. Now, the scientists put two other mice in the outer boxes: One was already familiar to the studied mouse, the other mouse it had never met. “Healthy mice usually prefer the new over the already familiar mouse,” Jasmin Morandell, co-first author of the study, explains. The mouse with the altered Cullin 3 gene, however, showed no sign of recognition. Furthermore, the mice had motor coordination deficits as well as other ASD-relevant cognitive impairments. With the help of this mouse model, the team was then able to get to the bottom of the mechanisms that bring about these changes. “If the Cullin 3 gene is deactivated, the Plastin 3 protein accumulates, causing cells to migrate slower and over shorter distances,” PhD student Lena Schwarz explains. Credit: Lena Schwarz, IST Austria A Dangerous Accumulation of Proteins While studying the mouse brain, the researchers noticed a very subtle but consistent change in the position of some brain cells. These so-called neurons or nerve cells originate from a special region in the brain. From there, they migrate toward the uppermost layers until they find their designated place in the cortex. It is a very sensitive process, where even small changes in the speed at which they travel can change the structure of the cortex. By marking the migrating neurons, the scientists could trace their movements. “We could observe migration deficits – the neurons are stranded in the lower cortex layers,” Lena Schwarz, the other co-first author of the study, describes. But why are the cells not moving as they should? Immunofluorescence staining allows scientists to study the migrating cells (white) in the mouse brain. Credit: © IST Austria The answer lies in the important role Cullin 3 plays at the end of life of proteins. When their time has come, the gene Cullin 3 tags them for degradation – a process that has to be tightly regulated to prevent proteins from accumulating. To find out, which proteins are misregulated when Cullin 3 is defective, Morandell and Schwarz systematically analyzed the protein composition of the mouse brain. “We were looking at proteins that accumulate in the mutant brain and found a protein called Plastin 3. Then Gaia came across a poster describing the work of IST Austria’s Schur group in the hallway, and we got very excited,” says Jasmin Morandell. “They independently had been working on Plastin 3 as a regulator of cell motility and had complementary results to ours. That’s when we started working together,” Professor Gaia Novarino remembers. It turned out that the protein Plastin 3, which was previously unknown in the context of neuronal cell migration, actually plays an important role in this process. “If the Cullin 3 gene is deactivated, the Plastin 3 protein accumulates, causing cells to migrate slower and over shorter distances. This is exactly what we saw happening in the cortex of the Cullin 3 mutant mice,” says PhD student Lena Schwarz. A Risky Pathway? All this is taking place during a very early stage of brain development around halfway through pregnancy – long before anyone would notice any difference in the fetus. “Determining these critical windows during brain development could be extremely important to fine-tune the treatment of patients with specific forms of ASD,” explains Novarino, who is committed to improving diagnosis and treatment options for people with ASD. “Following up with the research on Plastin 3 could pave the way for some therapeutics. Inhibiting the accumulation of this protein could eventually alleviate some of the symptoms patients have,” Schwarz says. “We now know that defective Cullin 3 leads to increased levels of Plastin 3. This tight correlation shows that Plastin 3 protein levels may be an important factor for the control of cell-intrinsic movements,” says Jasmin Morandell. She recently graduated and may use her expertise in brain development to study Huntington’s disease. Lena Schwarz will next turn to additional high-risk ASD genes to see how other proteins in the degradation pathway may be linked to ASD. For the present study, the Novarino group joined forces with the Danzl and Schur groups and a colleague from the University of Rome. “Finishing this extensive study in around two and a half years despite the pandemic was only possible with the support from our neighbors at IST Austria,” Novarino praises the multidisciplinarity at the Institute. Reference: “Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development” by Jasmin Morandell, Lena A. Schwarz, Bernadette Basilico, Saren Tasciyan, Georgi Dimchev, Armel Nicolas, Christoph Sommer, Caroline Kreuzinger, Christoph P. Dotter, Lisa S. Knaus, Zoe Dobler, Emanuele Cacci, Florian K. M. Schur, Johann G. Danzl and Gaia Novarino, 24 May 2021, Nature Communications. DOI: 10.1038/s41467-021-23123-x Funding: European Union’s Horizon 2020 research and innovation program (ERC) and by the Austrian Science Fund (FWF) to Gaia Novarino and to Johann Georg Danzl.

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