Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Innovative insole ODM solutions in Vietnam

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Graphene cushion OEM factory in Vietnam

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Innovative insole ODM solutions in Indonesia

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan ergonomic pillow OEM factory supplier

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.China insole OEM manufacturer

Scallop Pleuronectites from the Triassic period with fluorescent color pattern, under UV light. Credit: Klaus Wolkenstein A geobiologist from Göttingen University has found a diversity of patterns in 240 million-year-old seashells. UV light allows you to view intricate structures in fossils that would be impossible to observe in normal daylight. This method has often been used on fossilized seashells from the Earth’s current geological era to reveal color patterns that had long since faded away. According to a new study from the University of Göttingen, fluorescent color patterns may even be detected in 240 million-year-old shells from the Earth’s Mesozoic Era. This makes them the oldest fluorescent color patterns discovered so far. This study’s findings were published in the journal Palaeontology. Colour pattern variations in the fossil scallop Pleuronectites. Credit: Klaus Wolkenstein Traces of color patterns are extremely rare in Mesozoic Era fossils. However, UV light examination of scallops from the Triassic era — right at the start of the Mesozoic Era — reveals that color patterns are preserved much more often than previously believed. UV light, which is undetectable to the human eye, excites organic compounds in the fossils, causing them to glow. This exposes a surprising variety of color patterns, including many kinds of stripes, zigzags, and flame patterns. The diversity of color patterns is comparable to that of modern seashells seen on a beach. Different fluorescent colors in the fossil scallop Pleuronectites. Credit: Klaus Wolkenstein However, the color patterns of today’s scallops do not show any fluorescence. “In the case of the Triassic shells, fluorescent compounds were only formed in the course of fossilization through oxidation of the original pigments,” explains Dr. Klaus Wolkenstein from the Geosciences Centre at the University of Göttingen, who is currently carrying out research at the University of Bonn. Surprisingly, the fossil shells show different fluorescent colors, depending on the region where they were found. “The color spectrum ranges from yellow to red with all the transitions in between, which suggests that there were clear regional differences in the fossilization of these scallops,” adds Wolkenstein. Reference: “Fluorescent colour patterns in the basal pectinid Pleuronectites from the Middle Triassic of Central Europe: origin, fate and taxonomic implications of fluorescence” by Klaus Wolkenstein, 27 October 2022, Palaeontology. DOI: 10.1111/pala.12625

A recent study in Neuron details how neurons with “mixed selectivity” empower our brains to manage multiple computations simultaneously, enhancing cognitive flexibility. This capability allows neurons, particularly in the medial prefrontal cortex, to participate in a variety of mental tasks, boosting both cognitive capacity and creativity. The study also discusses mechanisms such as oscillations and neuromodulators that focus these neurons on relevant tasks, underscoring the vital role of mixed selectivity in brain functionality. Credit: SciTechDaily.com Researchers reveal that neurons exhibiting “mixed selectivity” enable our brains to handle multiple computations simultaneously, providing the flexibility needed for complex cognitive tasks. Many neurons exhibit “mixed selectivity,” meaning they can integrate multiple inputs and participate in multiple computations. Mechanisms such as oscillations and neuromodulators recruit their participation and tune them to focus on the relevant information. Every day our brains strive to optimize a trade-off: With lots of things happening around us even as we also harbor many internal drives and memories, somehow our thoughts must be flexible yet focused enough to guide everything we have to do. In a new paper published in the journal Neuron, a team of neuroscientists describes how the brain achieves the cognitive capacity to incorporate all the information that’s relevant without becoming overwhelmed by what’s not. The Role of Mixed Selectivity The authors argue that the flexibility arises from a key property observed in many neurons: “mixed selectivity.” While many neuroscientists used to think each cell had just one dedicated function, more recent evidence has shown that many neurons can instead participate in a variety of computational ensembles, each working in parallel. In other words, when a rabbit considers nibbling on some lettuce in a garden, a single neuron might be involved in not only assessing how hungry it feels but also whether it can hear a hawk overhead or smell a coyote in the trees and how far away the lettuce is. The brain does not multitask, said paper co-author Earl K. Miller, Picower Professor in The Picower Institute for Learning and Memory at MIT and a pioneer of the mixed selectivity idea, but many cells do have the capacity to be roped into multiple computational efforts (essentially “thoughts”). In the new paper, the authors describe specific mechanisms the brain employs to recruit neurons into different computations and to ensure that those neurons represent the right number of dimensions of a complex task. “These neurons wear multiple hats,” Miller said. “With mixed selectivity you can have a representational space that’s as complex as it needs to be and no more complex. That’s what flexible cognition is all about.” Co-author Kay Tye, Professor at The Salk Institute and the University of California at San Diego, said mixed selectivity among neurons particularly in the medial prefrontal cortex is key to enabling many mental abilities. “The mPFC is like a hum of whispers that represents so much information through highly flexible and dynamic ensembles,” Tye said. “Mixed selectivity is the property that endows us with our flexibility, cognitive capacity, and ability to be creative. It is the secret to maximizing computational power which is essentially the underpinnings of intelligence.” Origins of an Idea The idea of mixed selectivity germinated in 2000 when Miller and colleague John Duncan defended a surprising result from a study of cognition in Miller’s lab. As animals sorted images into categories, about 30 percent of the neurons in the prefrontal cortex of the brain seemed to be involved. Skeptics who believed that every neuron had a dedicated function scoffed that the brain would devote so many cells to just one task. Miller and Duncan’s answer was that perhaps cells had the flexibility to be involved in many computations. The ability to serve on one cerebral task force, as it were, did not preclude them from being able to serve many others. But what benefit does mixed selectivity convey? In 2013 Miller teamed up with two co-authors of the new paper, Mattia Rigotti of IBM Research and Stefano Fusi of Columbia University, to show how mixed selectivity endows the brain with powerful computational flexibility. Essentially, an ensemble of neurons with mixed selectivity can accommodate many more dimensions of information about a task than a population of neurons with invariant functions. “Since our original work, we’ve made progress understanding the theory of mixed selectivity through the lens of classical machine learning ideas,” Rigotti said. “On the other hand, questions dear to experimentalists about the mechanisms implementing it at a cellular level had been comparatively under-explored. This collaboration and this new paper set out to fill that gap.” In the new paper the authors imagine a mouse who is considering whether to eat a berry. It might smell delicious (that’s one dimension). It might be poisonous (that’s another). Yet another dimension or two of the problem could come in the form of a social cue. If the mouse smells the berry scent on a fellow mouse’s breath, then the berry is probably OK to eat (depending on the apparent health of the fellow mouse). A neural ensemble with mixed selectivity would be able to integrate all that. Recruiting Neurons While mixed selectivity has the backing of copious evidence—it has been observed across the cortex and in other brain areas such as the hippocampus and amygdala—there are still open questions. For instance, how are neurons recruited to tasks and how do neurons that are so “open-minded” remain tuned only to what really matters to the mission? In the new study, the researchers who also include Marcus Benna of UC San Diego and Felix Taschbach of The Salk Institute, define the forms of mixed selectivity that researchers have observed, and argue that when oscillations (also known as “brain waves”) and neuromodulators (chemicals such as serotonin or dopamine that influence neural function) recruit neurons into computational ensembles, they also help them “gate” what’s important for that purpose. To be sure, some neurons are dedicated to a specific input, but the authors note they are an exception rather than the rule. The authors say these cells have “pure selectivity.” They only care if the rabbit sees lettuce. Some neurons exhibit “linear mixed selectivity,” which means their response predictably depends on multiple inputs adding up (the rabbit sees lettuce and feels hungry). The neurons that add the most dimensional flexibility are the “nonlinear mixed selectivity” ones that can account for multiple independent variables without necessarily summing them. Instead they might weigh a whole set of independent conditions (e.g. there’s lettuce, I’m hungry, I hear no hawks, I smell no coyotes, but the lettuce is far and I see a pretty sturdy fence). So what brings neurons into the fold to focus on the salient factors, however many there are? One mechanism is oscillations, which are produced in the brain when many neurons all maintain their electrical activity at the same rhythm. This coordinated activity enables information sharing, essentially tuning them together like a bunch of cars all playing the same radio station (maybe the broadcast is about a hawk circling overhead). Another mechanism the authors highlight is neuromodulators. These are chemicals that upon reaching receptors within cells can influence their activity as well. A burst of acetylcholine, for instance, might similarly attune neurons with the right receptors to certain activity or information (like maybe that feeling of hunger). “These two mechanisms likely work together to dynamically form functional networks,” the authors write. Understanding mixed selectivity, they continue, is critical to understanding cognition. “Mixed selectivity is ubiquitous,” they conclude. “It is present across species and across functions from high-level cognition to ‘automatic’ sensorimotor processes such as object recognition. The widespread presence of mixed selectivity underscores its fundamental role in providing the brain with the scalable processing power needed for complex thought and action.” Reference: “Mixed selectivity: Cellular computations for complexity” by Kay M. Tye, Earl K. Miller, Felix H. Taschbach, Marcus K. Benna, Mattia Rigotti and Stefano Fusi, 9 May 2024, Neuron. DOI: 10.1016/j.neuron.2024.04.017

In this colon tumor, which has a mutation that gives it a high degree of DNA mismatch repair deficiency, T cells (labeled black, green, and red) have accumulated primarily in the supportive tissues (pink regions), while very few have infiltrated tumor cells (islands surrounded by the supportive tissues). Credit: Courtesy of the researchers The findings could help doctors identify cancer patients who would benefit the most from drugs called checkpoint blockade inhibitors. Cancer drugs known as checkpoint blockade inhibitors have proven effective for some cancer patients. These drugs work by taking the brakes off the body’s T cell response, stimulating those immune cells to destroy tumors. Some studies have shown that these drugs work better in patients whose tumors have a very large number of mutated proteins, which scientists believe is because those proteins offer plentiful targets for T cells to attack. However, for at least 50 percent of patients whose tumors show a high mutational burden, checkpoint blockade inhibitors don’t work at all. A new study from MIT reveals a possible explanation for why that is. In a study of mice, the researchers found that measuring the diversity of mutations within a tumor generated much more accurate predictions of whether the treatment would succeed than measuring the overall number of mutations. If validated in clinical trials, this information could help doctors to better determine which patients will benefit from checkpoint blockade inhibitors. Key Insights “While very powerful in the right settings, immune checkpoint therapies are not effective for all cancer patients. This work makes clear the role of genetic heterogeneity in cancer in determining the effectiveness of these treatments,” says Tyler Jacks, the David H. Koch Professor of Biology and a member of MIT’s Koch Institute for Cancer Research. Jacks; Peter Westcott, a former MIT postdoc in the Jacks lab who is now an assistant professor at Cold Spring Harbor Laboratory; and Isidro Cortes-Ciriano, a research group leader at EMBL’s European Bioinformatics Institute (EMBL-EBI), are the senior authors of the paper, which was published on September 14 in the journal Nature Genetics. Diversity in Mutations Across all types of cancer, a small percentage of tumors have what is called a high tumor mutational burden (TMB), meaning they have a very large number of mutations in each cell. A subset of these tumors has defects related to DNA repair, most commonly in a repair system known as DNA mismatch repair. Because these tumors have so many mutated proteins, they are believed to be good candidates for immunotherapy treatment, as they offer a plethora of potential targets for T cells to attack. Over the past few years, the FDA has approved a checkpoint blockade inhibitor called pembrolizumab, which activates T cells by blocking a protein called PD-1, to treat several types of tumors that have a high TMB. However, subsequent studies of patients who received this drug found that more than half of them did not respond well or only showed short-lived responses, even though their tumors had a high mutational burden. The MIT team set out to explore why some patients respond better than others, by designing mouse models that closely mimic the progression of tumors with high TMB. These mouse models carry mutations in genes that drive cancer development in the colon and lung, as well as a mutation that shuts down the DNA mismatch repair system in these tumors as they begin to develop. This causes the tumors to generate many additional mutations. When the researchers treated these mice with checkpoint blockade inhibitors, they were surprised to find that none of them responded well to the treatment. “We verified that we were very efficiently inactivating the DNA repair pathway, resulting in lots of mutations. The tumors looked just like they look in human cancers, but they were not more infiltrated by T cells, and they were not responding to immunotherapy,” Westcott says. Intratumoral Heterogeneity The researchers discovered that this lack of response appears to be the result of a phenomenon known as intratumoral heterogeneity. This means that, while the tumors have many mutations, each cell in the tumor tends to have different mutations than most of the other cells. As a result, each individual cancer mutation is “subclonal,” meaning that it is expressed in a minority of cells. (A “clonal” mutation is one that is expressed in all of the cells.) In further experiments, the researchers explored what happened as they changed the heterogeneity of lung tumors in mice. They found that in tumors with clonal mutations, checkpoint blockade inhibitors were very effective. However, as they increased the heterogeneity by mixing tumor cells with different mutations, they found that the treatment became less effective. “That shows us that intratumoral heterogeneity is actually confounding the immune response, and you really only get the strong immune checkpoint blockade responses when you have a clonal tumor,” Westcott says. Failure to Activate It appears that this weak T cell response occurs because the T cells simply don’t see enough of any particular cancerous protein, or antigen, to become activated, the researchers say. When the researchers implanted mice with tumors that contained subclonal levels of proteins that normally induce a strong immune response, the T cells failed to become powerful enough to attack the tumor. “You can have these potently immunogenic tumor cells that otherwise should lead to a profound T cell response, but at this low clonal fraction, they completely go stealth, and the immune system fails to recognize them,” Westcott says. “There’s not enough of the antigen that the T cells recognize, so they’re insufficiently primed and don’t acquire the ability to kill tumor cells.” To see if these findings might extend to human patients, the researchers analyzed data from two small clinical trials of people who had been treated with checkpoint blockade inhibitors for either colorectal or stomach cancer. After analyzing the sequences of the patients’ tumors, they found that patients’ whose tumors were more homogeneous responded better to the treatment. Conclusion and Implications “Our understanding of cancer is improving all the time, and this translates into better patient outcomes,” Cortes-Ciriano says. “Survival rates following a cancer diagnosis have significantly improved in the past 20 years, thanks to advanced research and clinical studies. We know that each patient’s cancer is different and will require a tailored approach. Personalized medicine must take into account new research that is helping us understand why cancer treatments work for some patients but not all.” The findings also suggest that treating patients with drugs that block the DNA mismatch repair pathway, in hopes of generating more mutations that T cells could target, may not help and could be harmful, the researchers say. One such drug is now in clinical trials. “If you try to mutate an existing cancer, where you already have many cancer cells at the primary site and others that may have disseminated throughout the body, you’re going to create a super heterogeneous collection of cancer genomes. And what we showed is that with this high intratumoral heterogeneity, the T cell response is confused and there is absolutely no response to immune checkpoint therapy,” Westcott says. For more on this research, see Why Does Immunotherapy Not Always Work? Reference: “Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity” by Peter M. K. Westcott, Francesc Muyas, Haley Hauck, Olivia C. Smith, Nathan J. Sacks, Zackery A. Ely, Alex M. Jaeger, William M. Rideout III, Daniel Zhang, Arjun Bhutkar, Mary C. Beytagh, David A. Canner, Grissel C. Jaramillo, Roderick T. Bronson, Santiago Naranjo, Abbey Jin, J. J. Patten, Amanda M. Cruz, Sean-Luc Shanahan, Isidro Cortes-Ciriano and Tyler Jacks, 14 September 2023, Nature Genetics. DOI: 10.1038/s41588-023-01499-4 The research was funded by the Koch Institute Support (core) Grant from the U.S. National Cancer Institute, the Howard Hughes Medical Institute, and a Damon Runyon Fellowship Award.

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